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The map label for this gene is tpi [H]

Identifier: 222150773

GI number: 222150773

Start: 555684

End: 556430

Strand: Direct

Name: tpi [H]

Synonym: MCCL_0523

Alternate gene names: 222150773

Gene position: 555684-556430 (Clockwise)

Preceding gene: 222150772

Following gene: 222150774

Centisome position: 26.43

GC content: 40.16

Gene sequence:

>747_bases
ATGAGAAAACCAATTATCGCAGGAAACTGGAAAATGAACAAAACGGTAAAAGAAGCGAAAGCATTTGTTTCAAGCTTACC
AGAGTTACCGGCAGAAGGTGTTGATGCAGTAATTTGTGCACCACATATTCAACTAGATGCAATTATTTCTGCTAATGTAA
AAAACTTACAAGTTGGCGCTCAAAACTGTTATTTTGAAGATAGCGGTGCGTTCACTGGTGAAACATCTCCAGCAGCATTA
AAGGATCTAGGTGTACAGTATGTAGTTTTAGGACATTCTGAACGTCGTGAATATTTCGGTGAAACAGACGAAGATATTAA
TAAGAAAGCATTGGCAGTATTTAAACATGGGATGACACCGATCATTTGTTGTGGCGAAACAGACGAAGAACGTGAATCAG
GTCAGTTTGAAGATAAAGTCGGTGCTCAAGTAAGCAACGCACTTAAAGGTTTTGACGCTGAACAAGTGAAACAGCTTGTT
ATTGCCTATGAACCTATCTGGGCAATCGGCACAGGTAAATCTGCAACAAGTGAAGATGCTGAAGCAAGCTGTAAGTTCGT
GCGTTCAGTTGTGGAAAAAGACTTCGGTAAAGATGCAGCTGAAGCTGTACGTATCCAATATGGCGGCTCTGTTAAACCAG
GTAATATCAAGGAATATATGGCAAACGAAAACATCGATGGTGCATTAGTAGGTGGCGCATCGTTAGAAGTGGATTCTTTT
GTTCAATTGTTAGAAGGTGCTAAGTAA

Upstream 100 bases:

>100_bases
ACATATCTCAACAGGCGGTGGCGCTTCGTTAGAGTACTTAGAAGGTAAAGAACTACCAGGTATTAAATCAATTTCTGACA
AATAAAAAGGAGTTTTATAA

Downstream 100 bases:

>100_bases
TGAAAAGCCCGACAGCTTTAATCATTTTAGATGGTTTTGCAAACCGTAAAGAAACCTTTGGGAATGCAGTAGCGCAAGCT
CATAAACCAAATTTTGACCG

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MRKPIIAGNWKMNKTVKEAKAFVSSLPELPAEGVDAVICAPHIQLDAIISANVKNLQVGAQNCYFEDSGAFTGETSPAAL
KDLGVQYVVLGHSERREYFGETDEDINKKALAVFKHGMTPIICCGETDEERESGQFEDKVGAQVSNALKGFDAEQVKQLV
IAYEPIWAIGTGKSATSEDAEASCKFVRSVVEKDFGKDAAEAVRIQYGGSVKPGNIKEYMANENIDGALVGGASLEVDSF
VQLLEGAK

Sequences:

>Translated_248_residues
MRKPIIAGNWKMNKTVKEAKAFVSSLPELPAEGVDAVICAPHIQLDAIISANVKNLQVGAQNCYFEDSGAFTGETSPAAL
KDLGVQYVVLGHSERREYFGETDEDINKKALAVFKHGMTPIICCGETDEERESGQFEDKVGAQVSNALKGFDAEQVKQLV
IAYEPIWAIGTGKSATSEDAEASCKFVRSVVEKDFGKDAAEAVRIQYGGSVKPGNIKEYMANENIDGALVGGASLEVDSF
VQLLEGAK
>Mature_248_residues
MRKPIIAGNWKMNKTVKEAKAFVSSLPELPAEGVDAVICAPHIQLDAIISANVKNLQVGAQNCYFEDSGAFTGETSPAAL
KDLGVQYVVLGHSERREYFGETDEDINKKALAVFKHGMTPIICCGETDEERESGQFEDKVGAQVSNALKGFDAEQVKQLV
IAYEPIWAIGTGKSATSEDAEASCKFVRSVVEKDFGKDAAEAVRIQYGGSVKPGNIKEYMANENIDGALVGGASLEVDSF
VQLLEGAK

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=247, Percent_Identity=40.080971659919, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI226529917, Length=247, Percent_Identity=40.080971659919, Blast_Score=164, Evalue=8e-41,
Organism=Escherichia coli, GI1790353, Length=251, Percent_Identity=45.8167330677291, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17536593, Length=245, Percent_Identity=42.4489795918367, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320255, Length=246, Percent_Identity=41.0569105691057, Blast_Score=169, Evalue=5e-43,
Organism=Drosophila melanogaster, GI28572008, Length=248, Percent_Identity=42.3387096774194, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28572006, Length=248, Percent_Identity=42.3387096774194, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28572004, Length=248, Percent_Identity=42.3387096774194, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26654; Mature: 26654

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKPIIAGNWKMNKTVKEAKAFVSSLPELPAEGVDAVICAPHIQLDAIISANVKNLQVGA
CCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEHEEECCCCEEEECC
QNCYFEDSGAFTGETSPAALKDLGVQYVVLGHSERREYFGETDEDINKKALAVFKHGMTP
CCCEECCCCCCCCCCCCHHHHHCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHCCCCE
IICCGETDEERESGQFEDKVGAQVSNALKGFDAEQVKQLVIAYEPIWAIGTGKSATSEDA
EEEECCCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCHH
EASCKFVRSVVEKDFGKDAAEAVRIQYGGSVKPGNIKEYMANENIDGALVGGASLEVDSF
HHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCHHHHHCCCCCCEEEECCCCCCHHHH
VQLLEGAK
HHHHHCCC
>Mature Secondary Structure
MRKPIIAGNWKMNKTVKEAKAFVSSLPELPAEGVDAVICAPHIQLDAIISANVKNLQVGA
CCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEEHEEECCCCEEEECC
QNCYFEDSGAFTGETSPAALKDLGVQYVVLGHSERREYFGETDEDINKKALAVFKHGMTP
CCCEECCCCCCCCCCCCHHHHHCCEEEEEECCHHHHHHCCCCCCHHHHHHHHHHHCCCCE
IICCGETDEERESGQFEDKVGAQVSNALKGFDAEQVKQLVIAYEPIWAIGTGKSATSEDA
EEEECCCCCHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCHH
EASCKFVRSVVEKDFGKDAAEAVRIQYGGSVKPGNIKEYMANENIDGALVGGASLEVDSF
HHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCHHHHHCCCCCCEEEECCCCCCHHHH
VQLLEGAK
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA