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The map label for this gene is mmuM [H]

Identifier: 222150580

GI number: 222150580

Start: 346571

End: 347458

Strand: Direct

Name: mmuM [H]

Synonym: MCCL_0330

Alternate gene names: 222150580

Gene position: 346571-347458 (Clockwise)

Preceding gene: 222150579

Following gene: 222150581

Centisome position: 16.49

GC content: 43.81

Gene sequence:

>888_bases
ATGCAGCTACGAGATAAGTTACAGCAAGACATCGTGATATTAGACGGGGGCTTTGGAACGACCGTAGAACAATTCGGATA
TGACGTGAAACACGAACTATGGTCATCGAACTTAATCCAGTCCAATCCGGAAGCGGTGTATAAGGTCCATAAAGCATTCG
TAGATAGCGGTGCAGAGATTATACTGACCAATACGTATCAGGCATCTGTACAATCATTCTTAAATATTGGCATTGATAAA
GCAACAGCATGCACATATTTAGCGACAGCGGTGGAACTCGCAACGCGCGCAGCAAGCAATCGAACAATCATTGCAGGATC
ACTCGGGCCGTATGGTGCGATGCTCGGTAATGGCTCAGAGTATACAGGGGACTATGAAGAAACTGAAGCTGATTATATTC
AGTATCATAAAGAACGACTAGATATACTAATCGAAGCAGGTGTAAGTGTCTTTGCGTTTGAGACCATTCCTAACATAGAA
GAAATTAAAGCAGTGAGAACACTGCTGCTTGATTATCCACATATTGAGGCATGGATTTCAGTGACACTGAAAGATCATGA
TCATCTGTCAGATGGCACACCACTTGAAGCAGTGATTGAAGTAGTGAATGAGATTGAAAATGTATTAGCATTCGGTGTGA
ACTGTACAAGCGTGAACGTCATCGATGCAGCGGTGGATAAGTTGATTACACTAAGTGACAAGCCGTTAATACTCTACCCT
AATAGTGGACGTCAATATGATGCGGTTCACAAAGTATGGATTGATCAGGAGGATGCATCGCTTGTTGAAGCGGCACCACG
CTGGAAAGAAAAAGGGGTTAAGATCATCGGCGGATGCTGTCAGGTAGGGCCGGGGGAGATAAAGGAACTTGGGACTGCTT
TAAAATAG

Upstream 100 bases:

>100_bases
TTTGACCCGAACCAAAGACTTGCGACACTGATTGGATTACCATTCTGTATTATCGTCGGACTAATTCATTATTTCCTGAA
GAAGAAAGGGGCACATATTC

Downstream 100 bases:

>100_bases
AAGTTAATATACAAACAATTAAATATAATAAAGAAATAATAATAGTGTATCTTGATAACCTTATTTTGTATATAATAATA
CAAAATATACAAAATAAGGA

Product: homocysteine methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MQLRDKLQQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEIILTNTYQASVQSFLNIGIDK
ATACTYLATAVELATRAASNRTIIAGSLGPYGAMLGNGSEYTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIE
EIKAVRTLLLDYPHIEAWISVTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLILYP
NSGRQYDAVHKVWIDQEDASLVEAAPRWKEKGVKIIGGCCQVGPGEIKELGTALK

Sequences:

>Translated_295_residues
MQLRDKLQQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEIILTNTYQASVQSFLNIGIDK
ATACTYLATAVELATRAASNRTIIAGSLGPYGAMLGNGSEYTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIE
EIKAVRTLLLDYPHIEAWISVTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLILYP
NSGRQYDAVHKVWIDQEDASLVEAAPRWKEKGVKIIGGCCQVGPGEIKELGTALK
>Mature_295_residues
MQLRDKLQQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEIILTNTYQASVQSFLNIGIDK
ATACTYLATAVELATRAASNRTIIAGSLGPYGAMLGNGSEYTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIE
EIKAVRTLLLDYPHIEAWISVTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLILYP
NSGRQYDAVHKVWIDQEDASLVEAAPRWKEKGVKIIGGCCQVGPGEIKELGTALK

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=326, Percent_Identity=25.4601226993865, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1786456, Length=294, Percent_Identity=39.1156462585034, Blast_Score=237, Evalue=7e-64,
Organism=Escherichia coli, GI1790450, Length=331, Percent_Identity=24.4712990936556, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17569783, Length=248, Percent_Identity=27.8225806451613, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535405, Length=330, Percent_Identity=24.2424242424242, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324982, Length=313, Percent_Identity=30.9904153354633, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6322966, Length=307, Percent_Identity=31.2703583061889, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24585077, Length=321, Percent_Identity=33.0218068535826, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI20129603, Length=324, Percent_Identity=32.4074074074074, Blast_Score=157, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 32332; Mature: 32332

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRDKLQQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEI
CCHHHHHHCCEEEEECCCCCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
ILTNTYQASVQSFLNIGIDKATACTYLATAVELATRAASNRTIIAGSLGPYGAMLGNGSE
EEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCC
YTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIEEIKAVRTLLLDYPHIEAWIS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
VTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLILYP
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHEEECCCCEEEEC
NSGRQYDAVHKVWIDQEDASLVEAAPRWKEKGVKIIGGCCQVGPGEIKELGTALK
CCCCCHHHHHHEECCCCCHHHHHHCCCHHHCCCEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MQLRDKLQQDIVILDGGFGTTVEQFGYDVKHELWSSNLIQSNPEAVYKVHKAFVDSGAEI
CCHHHHHHCCEEEEECCCCCCHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEE
ILTNTYQASVQSFLNIGIDKATACTYLATAVELATRAASNRTIIAGSLGPYGAMLGNGSE
EEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHCCCCCC
YTGDYEETEADYIQYHKERLDILIEAGVSVFAFETIPNIEEIKAVRTLLLDYPHIEAWIS
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEE
VTLKDHDHLSDGTPLEAVIEVVNEIENVLAFGVNCTSVNVIDAAVDKLITLSDKPLILYP
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHEEECCCCEEEEC
NSGRQYDAVHKVWIDQEDASLVEAAPRWKEKGVKIIGGCCQVGPGEIKELGTALK
CCCCCHHHHHHEECCCCCHHHHHHCCCHHHCCCEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]