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The map label for this gene is glmS [H]

Identifier: 222150574

GI number: 222150574

Start: 338377

End: 340179

Strand: Direct

Name: glmS [H]

Synonym: MCCL_0324

Alternate gene names: 222150574

Gene position: 338377-340179 (Clockwise)

Preceding gene: 222150573

Following gene: 222150575

Centisome position: 16.1

GC content: 40.32

Gene sequence:

>1803_bases
ATGTGTGGTATCGTAGGTTATATTGGAACAGAGGATGCAAAAGAGATCCTTTTAAAAGGTTTAGAAAAATTAGAATATCG
TGGGTATGATTCAGCAGGGATCGCTGTACGTAACGGAGAAGATGTACGTGTCTACAAAGAGAAAGGCCGTATCGCAGAAC
TTCGTAAGGTTGTAGATTCAGACTTTGATACAACGACTGGTATTGGACATACACGTTGGGCAACACATGGTGTGCCTAAT
CACGAAAACTCTCATCCGCATCAATCTGAAAGCGAGCGTTTCACATTAGTGCATAACGGTGTGATCGAGAACTACGAGCA
ATTAAAGAATGAATATTTGTCAGGTGTGACTTTCAAATCAGATACTGATACAGAAATTATCGTTCAACTTATAGAACACT
TCTCTAAGCAAGGATTAGAAACAGAAGCAGCTTTCGTTCAAGTATTAAAATTATTACATGGTTCATATGCTTTAGGTTTA
TTAGATATACAGAACCCAGACGTTATCTACGTTGCGAAGAACAAATCTCCTTTACTTGTAGGTTTAGGTGATGGATTCAA
CGTTATCGCATCAGACGCGATGGCGATGTTACAAGTAACAGATACTTATACAGAATTACACGATGGTGAAGTTGTTCTTG
TAACGAAAGAAAGCATCGACATCAAAGACCTAGAAGGTAAGAAAGTGAAACGTAAACCTTACAAAGCTGAAATCGATGCA
TCAGATATCGAAAAAGGAACATATGCACACTACATGCTTAAAGAAATTAACGAGCAGCCTGCTGCGATGCGTAACATCAT
CCAGGAATATCAAGATGAAAAGGGCAACTTAAAGATCGATAAAGATATCGTTAAAGCAGTACGTAAAGCGGACCGTATCC
ATATCATTGCCTGTGGTACATCTTATAATGCAGGTCTCGTTGGTAAAGAATACTTAGAGAAATGGGCAGGTATTCCAACA
GAGGTACATGTCGCTTCTGAATTCGTCTACAACATGCCATTACTGTCTAAGAAACCATTATTCATCTTTATCTCACAATC
AGGTGAGACAGCGGATAGCCGTGCAGTATTAGTTGAAACGAAGAAATTAGGACATCCTGCACTGACAATTACAAACGTAG
CAGGTTCAACATTATCACGTGAAGCGGATCATACATTGATTCTTCATGCAGGACCTGAGATTGCAGTGGCGTCTACAAAG
GCTTACACTGCACAGATCGCAGTATTATCAATCTTAGCGCAAGTCGCTGCAGCAGATGCAGGTATTGATACTGGTATTGA
TCTATTACCAGAACTTGCGAAAGTGACTTCAGCGATTACAACAGTGATCGATGATGCTGAATTAATGGAGAAAATTGCTA
CGGACTTCTTAGCAACCACACGTAACTGTTTCTTCATCGGACGTACGATGGATTATTATGTAGGTGTTGAAGGTGCGTTA
AAGCTTAAAGAAATCTCTTACATCCAGACAGAAGGATTTGCAGGTGGAGAGTTAAAGCACGGTACAATCGCATTAATTGA
AGAAGGGACACCAGTTATTGCATTAGCAACTCAGGAACGTGTGAACCTATCAATTCGCGGTAACGTGAAAGAAGTTGTAG
CACGTGGTGCACATCCATGTATCATTTCAATGGATGGATTAAACCAGGAAGGCGACACTTATGTGATTCCTCATGTTCAT
GAAATGCTAGCACCGTTAGTATCGGTTGTAACAACGCAGTTAATCGCATACTACGCAGCGTTACACCGTGGAGCTGACGT
AGATAAACCACGTAACTTAGCAAAATCTGTAACAGTTGAATAG

Upstream 100 bases:

>100_bases
ACCACCTGGGCAACTGGGTGAACAAAACGCATCAGCACCGCATAATAAGACTACTAAACAAAAATACAAATTGAATTGGA
ATTAGCAGGAGGAAATTATT

Downstream 100 bases:

>100_bases
AATACTGAAGCAACAGTGAAACGCATTTGCGTCTCACTGTTTTTTTGTTTAGAAACAAGTAATATGGATAGTGTTAAATA
ACGAATATCATTGTGTAAGG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MCGIVGYIGTEDAKEILLKGLEKLEYRGYDSAGIAVRNGEDVRVYKEKGRIAELRKVVDSDFDTTTGIGHTRWATHGVPN
HENSHPHQSESERFTLVHNGVIENYEQLKNEYLSGVTFKSDTDTEIIVQLIEHFSKQGLETEAAFVQVLKLLHGSYALGL
LDIQNPDVIYVAKNKSPLLVGLGDGFNVIASDAMAMLQVTDTYTELHDGEVVLVTKESIDIKDLEGKKVKRKPYKAEIDA
SDIEKGTYAHYMLKEINEQPAAMRNIIQEYQDEKGNLKIDKDIVKAVRKADRIHIIACGTSYNAGLVGKEYLEKWAGIPT
EVHVASEFVYNMPLLSKKPLFIFISQSGETADSRAVLVETKKLGHPALTITNVAGSTLSREADHTLILHAGPEIAVASTK
AYTAQIAVLSILAQVAAADAGIDTGIDLLPELAKVTSAITTVIDDAELMEKIATDFLATTRNCFFIGRTMDYYVGVEGAL
KLKEISYIQTEGFAGGELKHGTIALIEEGTPVIALATQERVNLSIRGNVKEVVARGAHPCIISMDGLNQEGDTYVIPHVH
EMLAPLVSVVTTQLIAYYAALHRGADVDKPRNLAKSVTVE

Sequences:

>Translated_600_residues
MCGIVGYIGTEDAKEILLKGLEKLEYRGYDSAGIAVRNGEDVRVYKEKGRIAELRKVVDSDFDTTTGIGHTRWATHGVPN
HENSHPHQSESERFTLVHNGVIENYEQLKNEYLSGVTFKSDTDTEIIVQLIEHFSKQGLETEAAFVQVLKLLHGSYALGL
LDIQNPDVIYVAKNKSPLLVGLGDGFNVIASDAMAMLQVTDTYTELHDGEVVLVTKESIDIKDLEGKKVKRKPYKAEIDA
SDIEKGTYAHYMLKEINEQPAAMRNIIQEYQDEKGNLKIDKDIVKAVRKADRIHIIACGTSYNAGLVGKEYLEKWAGIPT
EVHVASEFVYNMPLLSKKPLFIFISQSGETADSRAVLVETKKLGHPALTITNVAGSTLSREADHTLILHAGPEIAVASTK
AYTAQIAVLSILAQVAAADAGIDTGIDLLPELAKVTSAITTVIDDAELMEKIATDFLATTRNCFFIGRTMDYYVGVEGAL
KLKEISYIQTEGFAGGELKHGTIALIEEGTPVIALATQERVNLSIRGNVKEVVARGAHPCIISMDGLNQEGDTYVIPHVH
EMLAPLVSVVTTQLIAYYAALHRGADVDKPRNLAKSVTVE
>Mature_600_residues
MCGIVGYIGTEDAKEILLKGLEKLEYRGYDSAGIAVRNGEDVRVYKEKGRIAELRKVVDSDFDTTTGIGHTRWATHGVPN
HENSHPHQSESERFTLVHNGVIENYEQLKNEYLSGVTFKSDTDTEIIVQLIEHFSKQGLETEAAFVQVLKLLHGSYALGL
LDIQNPDVIYVAKNKSPLLVGLGDGFNVIASDAMAMLQVTDTYTELHDGEVVLVTKESIDIKDLEGKKVKRKPYKAEIDA
SDIEKGTYAHYMLKEINEQPAAMRNIIQEYQDEKGNLKIDKDIVKAVRKADRIHIIACGTSYNAGLVGKEYLEKWAGIPT
EVHVASEFVYNMPLLSKKPLFIFISQSGETADSRAVLVETKKLGHPALTITNVAGSTLSREADHTLILHAGPEIAVASTK
AYTAQIAVLSILAQVAAADAGIDTGIDLLPELAKVTSAITTVIDDAELMEKIATDFLATTRNCFFIGRTMDYYVGVEGAL
KLKEISYIQTEGFAGGELKHGTIALIEEGTPVIALATQERVNLSIRGNVKEVVARGAHPCIISMDGLNQEGDTYVIPHVH
EMLAPLVSVVTTQLIAYYAALHRGADVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=689, Percent_Identity=34.1074020319303, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=34.3884892086331, Blast_Score=338, Evalue=1e-92,
Organism=Homo sapiens, GI29570798, Length=259, Percent_Identity=26.6409266409266, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=42.9967426710098, Blast_Score=459, Evalue=1e-130,
Organism=Escherichia coli, GI1788651, Length=242, Percent_Identity=24.7933884297521, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17539970, Length=426, Percent_Identity=33.3333333333333, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=33.256351039261, Blast_Score=218, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=33.256351039261, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322745, Length=447, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=9e-63,
Organism=Saccharomyces cerevisiae, GI6323731, Length=379, Percent_Identity=29.023746701847, Blast_Score=164, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.5365853658537, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI21357745, Length=693, Percent_Identity=33.044733044733, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI28573187, Length=271, Percent_Identity=28.7822878228782, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65642; Mature: 65642

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGTEDAKEILLKGLEKLEYRGYDSAGIAVRNGEDVRVYKEKGRIAELRKVVDS
CCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHCC
DFDTTTGIGHTRWATHGVPNHENSHPHQSESERFTLVHNGVIENYEQLKNEYLSGVTFKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCEECC
DTDTEIIVQLIEHFSKQGLETEAAFVQVLKLLHGSYALGLLDIQNPDVIYVAKNKSPLLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GLGDGFNVIASDAMAMLQVTDTYTELHDGEVVLVTKESIDIKDLEGKKVKRKPYKAEIDA
ECCCCCHHHHHHHHHHHEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCH
SDIEKGTYAHYMLKEINEQPAAMRNIIQEYQDEKGNLKIDKDIVKAVRKADRIHIIACGT
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCEEEEEECC
SYNAGLVGKEYLEKWAGIPTEVHVASEFVYNMPLLSKKPLFIFISQSGETADSRAVLVET
CCCCCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
KKLGHPALTITNVAGSTLSREADHTLILHAGPEIAVASTKAYTAQIAVLSILAQVAAADA
HHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
GIDTGIDLLPELAKVTSAITTVIDDAELMEKIATDFLATTRNCFFIGRTMDYYVGVEGAL
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCE
KLKEISYIQTEGFAGGELKHGTIALIEEGTPVIALATQERVNLSIRGNVKEVVARGAHPC
EEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEECCCHHHHHHCCCCCE
IISMDGLNQEGDTYVIPHVHEMLAPLVSVVTTQLIAYYAALHRGADVDKPRNLAKSVTVE
EEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGTEDAKEILLKGLEKLEYRGYDSAGIAVRNGEDVRVYKEKGRIAELRKVVDS
CCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEECCCCHHHHHHHHHCC
DFDTTTGIGHTRWATHGVPNHENSHPHQSESERFTLVHNGVIENYEQLKNEYLSGVTFKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCEECC
DTDTEIIVQLIEHFSKQGLETEAAFVQVLKLLHGSYALGLLDIQNPDVIYVAKNKSPLLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GLGDGFNVIASDAMAMLQVTDTYTELHDGEVVLVTKESIDIKDLEGKKVKRKPYKAEIDA
ECCCCCHHHHHHHHHHHEEHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCH
SDIEKGTYAHYMLKEINEQPAAMRNIIQEYQDEKGNLKIDKDIVKAVRKADRIHIIACGT
HHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEECHHHHHHHHCCCCEEEEEECC
SYNAGLVGKEYLEKWAGIPTEVHVASEFVYNMPLLSKKPLFIFISQSGETADSRAVLVET
CCCCCCCCHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCEEEEEE
KKLGHPALTITNVAGSTLSREADHTLILHAGPEIAVASTKAYTAQIAVLSILAQVAAADA
HHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
GIDTGIDLLPELAKVTSAITTVIDDAELMEKIATDFLATTRNCFFIGRTMDYYVGVEGAL
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCE
KLKEISYIQTEGFAGGELKHGTIALIEEGTPVIALATQERVNLSIRGNVKEVVARGAHPC
EEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEECCCHHHHHHCCCCCE
IISMDGLNQEGDTYVIPHVHEMLAPLVSVVTTQLIAYYAALHRGADVDKPRNLAKSVTVE
EEEECCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA