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The map label for this gene is mutS [H]

Identifier: 222150502

GI number: 222150502

Start: 253622

End: 255247

Strand: Direct

Name: mutS [H]

Synonym: MCCL_0252

Alternate gene names: 222150502

Gene position: 253622-255247 (Clockwise)

Preceding gene: 222150501

Following gene: 222150503

Centisome position: 12.06

GC content: 34.81

Gene sequence:

>1626_bases
ATGCAGAGTTTCTGGGTTTATGTATTAATTACGATTGTGCTAATTGGCGTAGGTATTGGTTATAGCATTTATGACAGCAT
TCAACTGAAGCGTAAAATAAAAACATTGTTCAACAAGCAGGCGACACTTTTCAAACAAAAAGGTAATCATATTATGTTTG
ATCATTATTATAGGCATATTAGTAAAGCTGAGGCGCGATGTATTGATAATATTACATGGAATGATCTAAGTATGGATCAG
TTATTTCATCGTATAAACTATCACTTTACATCTGTTGGTGAGGAATATACATATACGTTACTGCGTAATTTCCCAGGACA
TCATGTTGATGAAACAATGTTGAATAGGGTTACTGAGGATGTAAGATATCGTGAGAAATTGTCATTTATATTAGCGAAAC
TTGGTAGAAATGCGAATAATGATGCAAGCCGGTTTACAGTGCATTATCAGAAAAAAGAGCACTACAACAAGCTGATGATA
CTCGTAAGTTTCTTACCTATACTGAGTTTAGCTATGTTCTACTTCGGTGTTTCTATTGGTATATTCAGTGTAATCCTTGC
AATGGGTGTCGTTATGGGGCTATCAGTAAAGTTTCAGTCGCAAAGTGATCTCGTTTATAACGATTTATTCTATGCAATTA
AGATTATTGATACGGCAAACGAAATAATGAAGTTGAACGGCCGTAAATCAAATGATAGTAAGATGAAGTCCGTTAAGTGG
ATGAGCTATTTTATGTTAAATGATAATAAGAATGAAGGGAACATTGCGCTTACAATGATTAATGCGATTAAGCAGATGTT
TTTAATTGATTATCATTTGTATCATCGCGCGCTTGCGATACTTCATAAGCATCAAGAAGATTTCGCTTCATATTTCAAAG
TAGTAGGACAAGCAGATGCAAGTTATAGTACTGCTTTATGGCGAACAACATTACCATATTACGCTATTCCTAAAGCGGCT
GAAGAAAAAGTGCTTGAAGCGGAGGAAGTGTATCACCCGTTACTTGATCGTGCTGTAGCGAATGATTTTAAGTATAAGCA
TTCTGTACTGTTAACAGGATCTAATGCCTCGGGGAAATCTACGTTTATGAAAACGATGGCGATAAATTTAGTAATGGCTC
AAGGTCTGAATACATCGACAAGTGAAAGATTTGTGTATCAACCAGGAATCATAGCCACTTCAATGAATTTAGAAGATAGT
TTAGCGAAAGGTGATAGTTACTTTATCGCAGAAATTAAATCTGTGAAGCGCCTCTTAGAAGTGCTTAAATTGACATTACC
GACGTATATATTCATTGATGAAATATTGCGTGGAACGAATACGAAAGAACGCATTGCTTCAGCAACTGCAATACTAGACT
ATTTGAATTTACATCAAAACAGTTTGCTATTTGCAGCAACACATGATATTGAATTAACTGAAATATTGACACACTTTGAT
TTTTATTACTTTAAAGAAACGCTGACTGAAGATAATGATATAACATTTGATTATACAATCAGAAAAGGTGTTACAACGAC
TTCGAATGCAATAGAACTCATGCGTATTCACAATTATCCGGAAAGTATATATGATCACGCAAAAACGCAGCTCAAGCAAT
TAGAACAACTGAATGTGGGGAAATAA

Upstream 100 bases:

>100_bases
AGACGAGACTATTAGAAATTATTAAAACGGATGAACCAGAGTTTTAATAATCTCGTGCATATGTTTTAGATGTGATTTAG
AAAATTAACGGAGGTTCAGC

Downstream 100 bases:

>100_bases
GCACCGGATACGCGGTGCTTTTTATTATATATGTTAAAAATACTTTACATAATGTTAAGTATATTGTACATTTATGATGA
GGTGAACAACATGCTAAAGT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MQSFWVYVLITIVLIGVGIGYSIYDSIQLKRKIKTLFNKQATLFKQKGNHIMFDHYYRHISKAEARCIDNITWNDLSMDQ
LFHRINYHFTSVGEEYTYTLLRNFPGHHVDETMLNRVTEDVRYREKLSFILAKLGRNANNDASRFTVHYQKKEHYNKLMI
LVSFLPILSLAMFYFGVSIGIFSVILAMGVVMGLSVKFQSQSDLVYNDLFYAIKIIDTANEIMKLNGRKSNDSKMKSVKW
MSYFMLNDNKNEGNIALTMINAIKQMFLIDYHLYHRALAILHKHQEDFASYFKVVGQADASYSTALWRTTLPYYAIPKAA
EEKVLEAEEVYHPLLDRAVANDFKYKHSVLLTGSNASGKSTFMKTMAINLVMAQGLNTSTSERFVYQPGIIATSMNLEDS
LAKGDSYFIAEIKSVKRLLEVLKLTLPTYIFIDEILRGTNTKERIASATAILDYLNLHQNSLLFAATHDIELTEILTHFD
FYYFKETLTEDNDITFDYTIRKGVTTTSNAIELMRIHNYPESIYDHAKTQLKQLEQLNVGK

Sequences:

>Translated_541_residues
MQSFWVYVLITIVLIGVGIGYSIYDSIQLKRKIKTLFNKQATLFKQKGNHIMFDHYYRHISKAEARCIDNITWNDLSMDQ
LFHRINYHFTSVGEEYTYTLLRNFPGHHVDETMLNRVTEDVRYREKLSFILAKLGRNANNDASRFTVHYQKKEHYNKLMI
LVSFLPILSLAMFYFGVSIGIFSVILAMGVVMGLSVKFQSQSDLVYNDLFYAIKIIDTANEIMKLNGRKSNDSKMKSVKW
MSYFMLNDNKNEGNIALTMINAIKQMFLIDYHLYHRALAILHKHQEDFASYFKVVGQADASYSTALWRTTLPYYAIPKAA
EEKVLEAEEVYHPLLDRAVANDFKYKHSVLLTGSNASGKSTFMKTMAINLVMAQGLNTSTSERFVYQPGIIATSMNLEDS
LAKGDSYFIAEIKSVKRLLEVLKLTLPTYIFIDEILRGTNTKERIASATAILDYLNLHQNSLLFAATHDIELTEILTHFD
FYYFKETLTEDNDITFDYTIRKGVTTTSNAIELMRIHNYPESIYDHAKTQLKQLEQLNVGK
>Mature_541_residues
MQSFWVYVLITIVLIGVGIGYSIYDSIQLKRKIKTLFNKQATLFKQKGNHIMFDHYYRHISKAEARCIDNITWNDLSMDQ
LFHRINYHFTSVGEEYTYTLLRNFPGHHVDETMLNRVTEDVRYREKLSFILAKLGRNANNDASRFTVHYQKKEHYNKLMI
LVSFLPILSLAMFYFGVSIGIFSVILAMGVVMGLSVKFQSQSDLVYNDLFYAIKIIDTANEIMKLNGRKSNDSKMKSVKW
MSYFMLNDNKNEGNIALTMINAIKQMFLIDYHLYHRALAILHKHQEDFASYFKVVGQADASYSTALWRTTLPYYAIPKAA
EEKVLEAEEVYHPLLDRAVANDFKYKHSVLLTGSNASGKSTFMKTMAINLVMAQGLNTSTSERFVYQPGIIATSMNLEDS
LAKGDSYFIAEIKSVKRLLEVLKLTLPTYIFIDEILRGTNTKERIASATAILDYLNLHQNSLLFAATHDIELTEILTHFD
FYYFKETLTEDNDITFDYTIRKGVTTTSNAIELMRIHNYPESIYDHAKTQLKQLEQLNVGK

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=288, Percent_Identity=26.7361111111111, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI284813531, Length=253, Percent_Identity=25.6916996047431, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789089, Length=281, Percent_Identity=23.1316725978648, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508445, Length=324, Percent_Identity=25.6172839506173, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=228, Percent_Identity=27.1929824561404, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=191, Percent_Identity=28.7958115183246, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24584320, Length=263, Percent_Identity=28.1368821292776, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 62450; Mature: 62450

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure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C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA