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The map label for this gene is lytS [H]

Identifier: 222150359

GI number: 222150359

Start: 114570

End: 116321

Strand: Direct

Name: lytS [H]

Synonym: MCCL_0109

Alternate gene names: 222150359

Gene position: 114570-116321 (Clockwise)

Preceding gene: 222150358

Following gene: 222150360

Centisome position: 5.45

GC content: 37.33

Gene sequence:

>1752_bases
ATGTTTAGTTTATTTATTCTATTGTTAGAACGTGTTGGATTGATTATTATTGTTGCATACTTATTGATGAATGTTCCTTA
CTTTAAGAAGATGATGTCTGAACGCTCAAATCTATCTTCTCAAATACAATTATTGATTGTGTTCGGTTTATTTGCAGCGG
TATCCAACTTTACAGGTGTTGAAATACGTAATAATGAAATACTATCAAGCCAGATATTCAGTAAGATATCAGACGATGCA
GTTATTGCCAATACACGAGTCCTTACAATAAGTGTCGCGGGCTTAATAGGTGGACCGGTTGTGGGTATTGGAGTCGGGAT
TGTATCAGGAATTACGCGCTATCTGATTGGTGGAGTAGACGCATATACATATGTGATCTCATCAGCGCTTATTGGTCTTA
CTTCGGGATATTTCGGTTATCGTGCGATGACAAACAACCGTTATCCGAATGTGCTTACGGGAGTGATACTCGGTGCAATT
ATGGAAGTCATTCAGATGATCTGCATCATTGTTTTTGCTACGAATACAGAATATGCCATAGATATTGTGAAGCTCATTGC
TTTACCGATGATACTGATTAATAGTCTAGGTGTGGCTATATTCTTATCCATTATTATCTCTACAATTCAGCAGGAACAGC
GTATGCGTGCTGTACAGACACATGATGTGTTGAATCTGGCGAATCAAACATTACCTTATTTCAGAGCGGGACTAAATGAA
GCATCTGCGACACAGGCAGCGCAAATTATAAAAGATTTAATGAAAGTATCGGCTGTATCAATCACTAATAAGACTGATAT
ATTAGCACATGTCGGAGCAGCAAGTGATCATCATGTGCCGCGCAAGAAAATTATTACCGACCTTTCGAAACAAGTTATCA
AATCCGGTGAAATTAAAGAAGCACATAATAGGCATGAAATTGGTTGTACGCATCCTGGATGCCCGCTTGAAGGTGCGATT
GTTATCCCTTTATATGTACATAACGAAGTAACAGGCACATTAAAACTGTACTTTACAGATAGCAATAAATTGACTTATGT
CGAACGTCGTCTTGCTGAAGGTTTAGCAAATATATTCTCAAGTCAGATTGAACTCGGTGAAATAGAAACGCAATCGAAAT
TATTGAAAGATGCGGAAATTAAATCATTACAAGCACAAGTAAATCCACATTTTTTCTTTAATGCAATGAATACAATATCA
GCACTTATTCGCGTGGATAGTGAGAGAGCAAGAGAACTTCTGCTTAATTTAAGTAACTTTTTCCGTTCAAATTTACAAGG
TGCAAAAAGTACGAGCATCACAATTGAAAAAGAAATTCAGCAAGTAGAAGCTTATTTAGCGCTGGAACAAGCACGATTTC
CGGAACGTTTTAACATTCATTTTGATATAGATGAGGCATTGAAGTATGCGAAAGTGCCGCCCTTTATCATTCAAATATTA
GTTGAGAACGCGATAAAACATGCATTTCATAATAGAAAGTCTAACAATGATGTTTACGTCAAAGTGAAAGAGGGACAACA
GACGATTGAAATATCTGTAGAAGATAATGGGTTTGGTATTCCGGAAGAAAAGCGTGCACACATCGGACACAACGAAGTAA
CATCTACTTCTGGGACTGGAAGTGCACTTGAGAACTTAAATAAACGTCTCATCGGATTGTACAATAGTAATGCGCAACTA
AATTTTACGACAAGTGATTCGGGTACTAAGTTTTATACATCTATACCTTTAGAGAGGGAGGAAGATGCATGA

Upstream 100 bases:

>100_bases
ATATATGAAGCGCTTATTGACTTCGAAGAAAATAGGAAATAATATTTCTTTTTCTGACAAGTACTAATTGTTCACGTTAT
AATGATGGTGGAGGTATGCT

Downstream 100 bases:

>100_bases
GAATATTAATTGTAGATGATGAACCATTAGCAAGAAATGAGCTGCGTTATTTACTTAATAACATCGATAATACATTAGTG
GTTGATGAAGCGGATTCTGT

Product: hypothetical protein

Products: NA

Alternate protein names: Autolysin sensor kinase [H]

Number of amino acids: Translated: 583; Mature: 583

Protein sequence:

>583_residues
MFSLFILLLERVGLIIIVAYLLMNVPYFKKMMSERSNLSSQIQLLIVFGLFAAVSNFTGVEIRNNEILSSQIFSKISDDA
VIANTRVLTISVAGLIGGPVVGIGVGIVSGITRYLIGGVDAYTYVISSALIGLTSGYFGYRAMTNNRYPNVLTGVILGAI
MEVIQMICIIVFATNTEYAIDIVKLIALPMILINSLGVAIFLSIIISTIQQEQRMRAVQTHDVLNLANQTLPYFRAGLNE
ASATQAAQIIKDLMKVSAVSITNKTDILAHVGAASDHHVPRKKIITDLSKQVIKSGEIKEAHNRHEIGCTHPGCPLEGAI
VIPLYVHNEVTGTLKLYFTDSNKLTYVERRLAEGLANIFSSQIELGEIETQSKLLKDAEIKSLQAQVNPHFFFNAMNTIS
ALIRVDSERARELLLNLSNFFRSNLQGAKSTSITIEKEIQQVEAYLALEQARFPERFNIHFDIDEALKYAKVPPFIIQIL
VENAIKHAFHNRKSNNDVYVKVKEGQQTIEISVEDNGFGIPEEKRAHIGHNEVTSTSGTGSALENLNKRLIGLYNSNAQL
NFTTSDSGTKFYTSIPLEREEDA

Sequences:

>Translated_583_residues
MFSLFILLLERVGLIIIVAYLLMNVPYFKKMMSERSNLSSQIQLLIVFGLFAAVSNFTGVEIRNNEILSSQIFSKISDDA
VIANTRVLTISVAGLIGGPVVGIGVGIVSGITRYLIGGVDAYTYVISSALIGLTSGYFGYRAMTNNRYPNVLTGVILGAI
MEVIQMICIIVFATNTEYAIDIVKLIALPMILINSLGVAIFLSIIISTIQQEQRMRAVQTHDVLNLANQTLPYFRAGLNE
ASATQAAQIIKDLMKVSAVSITNKTDILAHVGAASDHHVPRKKIITDLSKQVIKSGEIKEAHNRHEIGCTHPGCPLEGAI
VIPLYVHNEVTGTLKLYFTDSNKLTYVERRLAEGLANIFSSQIELGEIETQSKLLKDAEIKSLQAQVNPHFFFNAMNTIS
ALIRVDSERARELLLNLSNFFRSNLQGAKSTSITIEKEIQQVEAYLALEQARFPERFNIHFDIDEALKYAKVPPFIIQIL
VENAIKHAFHNRKSNNDVYVKVKEGQQTIEISVEDNGFGIPEEKRAHIGHNEVTSTSGTGSALENLNKRLIGLYNSNAQL
NFTTSDSGTKFYTSIPLEREEDA
>Mature_583_residues
MFSLFILLLERVGLIIIVAYLLMNVPYFKKMMSERSNLSSQIQLLIVFGLFAAVSNFTGVEIRNNEILSSQIFSKISDDA
VIANTRVLTISVAGLIGGPVVGIGVGIVSGITRYLIGGVDAYTYVISSALIGLTSGYFGYRAMTNNRYPNVLTGVILGAI
MEVIQMICIIVFATNTEYAIDIVKLIALPMILINSLGVAIFLSIIISTIQQEQRMRAVQTHDVLNLANQTLPYFRAGLNE
ASATQAAQIIKDLMKVSAVSITNKTDILAHVGAASDHHVPRKKIITDLSKQVIKSGEIKEAHNRHEIGCTHPGCPLEGAI
VIPLYVHNEVTGTLKLYFTDSNKLTYVERRLAEGLANIFSSQIELGEIETQSKLLKDAEIKSLQAQVNPHFFFNAMNTIS
ALIRVDSERARELLLNLSNFFRSNLQGAKSTSITIEKEIQQVEAYLALEQARFPERFNIHFDIDEALKYAKVPPFIIQIL
VENAIKHAFHNRKSNNDVYVKVKEGQQTIEISVEDNGFGIPEEKRAHIGHNEVTSTSGTGSALENLNKRLIGLYNSNAQL
NFTTSDSGTKFYTSIPLEREEDA

Specific function: Member of the two-component regulatory system lytR/lytS that probably regulates genes involved in cell wall metabolism [H]

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=588, Percent_Identity=31.8027210884354, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1788446, Length=586, Percent_Identity=33.7883959044369, Blast_Score=283, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64425; Mature: 64425

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSLFILLLERVGLIIIVAYLLMNVPYFKKMMSERSNLSSQIQLLIVFGLFAAVSNFTGV
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCE
EIRNNEILSSQIFSKISDDAVIANTRVLTISVAGLIGGPVVGIGVGIVSGITRYLIGGVD
EEECCHHHHHHHHHHCCCCEEEECCEEEEEEEECHHCCCHHHHHHHHHHHHHHHHHCCHH
AYTYVISSALIGLTSGYFGYRAMTNNRYPNVLTGVILGAIMEVIQMICIIVFATNTEYAI
HHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHH
DIVKLIALPMILINSLGVAIFLSIIISTIQQEQRMRAVQTHDVLNLANQTLPYFRAGLNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ASATQAAQIIKDLMKVSAVSITNKTDILAHVGAASDHHVPRKKIITDLSKQVIKSGEIKE
HHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHH
AHNRHEIGCTHPGCPLEGAIVIPLYVHNEVTGTLKLYFTDSNKLTYVERRLAEGLANIFS
HCCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
SQIELGEIETQSKLLKDAEIKSLQAQVNPHFFFNAMNTISALIRVDSERARELLLNLSNF
CCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FRSNLQGAKSTSITIEKEIQQVEAYLALEQARFPERFNIHFDIDEALKYAKVPPFIIQIL
HHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCHHHHHHH
VENAIKHAFHNRKSNNDVYVKVKEGQQTIEISVEDNGFGIPEEKRAHIGHNEVTSTSGTG
HHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCH
SALENLNKRLIGLYNSNAQLNFTTSDSGTKFYTSIPLEREEDA
HHHHHHHHHEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MFSLFILLLERVGLIIIVAYLLMNVPYFKKMMSERSNLSSQIQLLIVFGLFAAVSNFTGV
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCE
EIRNNEILSSQIFSKISDDAVIANTRVLTISVAGLIGGPVVGIGVGIVSGITRYLIGGVD
EEECCHHHHHHHHHHCCCCEEEECCEEEEEEEECHHCCCHHHHHHHHHHHHHHHHHCCHH
AYTYVISSALIGLTSGYFGYRAMTNNRYPNVLTGVILGAIMEVIQMICIIVFATNTEYAI
HHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCHHHH
DIVKLIALPMILINSLGVAIFLSIIISTIQQEQRMRAVQTHDVLNLANQTLPYFRAGLNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ASATQAAQIIKDLMKVSAVSITNKTDILAHVGAASDHHVPRKKIITDLSKQVIKSGEIKE
HHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHH
AHNRHEIGCTHPGCPLEGAIVIPLYVHNEVTGTLKLYFTDSNKLTYVERRLAEGLANIFS
HCCCCCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHH
SQIELGEIETQSKLLKDAEIKSLQAQVNPHFFFNAMNTISALIRVDSERARELLLNLSNF
CCCHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
FRSNLQGAKSTSITIEKEIQQVEAYLALEQARFPERFNIHFDIDEALKYAKVPPFIIQIL
HHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHCCCHHHHHHH
VENAIKHAFHNRKSNNDVYVKVKEGQQTIEISVEDNGFGIPEEKRAHIGHNEVTSTSGTG
HHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCH
SALENLNKRLIGLYNSNAQLNFTTSDSGTKFYTSIPLEREEDA
HHHHHHHHHEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA