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The map label for this gene is hemH [H]

Identifier: 222111244

GI number: 222111244

Start: 2198040

End: 2199098

Strand: Direct

Name: hemH [H]

Synonym: Dtpsy_2052

Alternate gene names: 222111244

Gene position: 2198040-2199098 (Clockwise)

Preceding gene: 222111242

Following gene: 222111245

Centisome position: 57.9

GC content: 68.93

Gene sequence:

>1059_bases
ATGCCCGCCTCGCCTTCTCACCATGCCGCACAGACGGCCTCAGCCTCTTCGATCCCGACCGCCGCAGCACGCGAAAGCAC
CGCCATTCTGCTGAGCAACCTGGGCACGCCAGACGCCCCCACCGCACCAGCGCTGCGCCGCTATCTGGCGCAGTTCCTGG
GCGACCCGCGGGTGGTGGAAATTCCGCGGGCGCTGTGGCTGCCTCTGCTGTACGGGATCATCCTGCGCACGCGGCCGGCC
AAGTCGGCCGCCAAGTACGCCAGCATCTGGACGGAAGAAGGCTCCCCGCTCGCCGTATGGACGGCCAAGCAAGCGGTGAT
GCTGCGCGGCTGGCTGGGCGAGGCCGGCCAGCCGGTGCGTGTACTGCCCGCCATGCGCTACGGTCAGCCGGCCATTGGTG
CGCAGCTGCAGGTGCTGCAAGACGCCGGCGTGCGCCGCGTGCTGGTGCTGCCGCTGTACCCGCAGTACTCGGCCACGACC
ACCGCCAGCGTGTTCGACGACGTGGCCGCGTGGGTGCGCCGCTCGCGTTGCTTTCCCGAGCTGCGCTTCGTGAACGACTA
CCACGACCACCCGGACTACATTGCCGCGCTGGCCCAGTCGGTGCGCGCGCACTGGCAGCGCGAGGGCGGCCCGGCGGACA
AGCTGGTGATGAGCTTTCACGGCATTCCCGAACGCAATGTGCGATTGGGTGACCCCTACGCGGAGCAATGCCGCACCACG
GCCCGGCTGCTCGCGCAGGCGCTGGGGCTGGGCGAAGACCGGTACCTGCTGACCTTCCAGTCGCGCTTCGGCAAGGCCCG
CTGGCTGGAGCCCTACACCGAACCCTCGCTGGTGGCACTGGCACAGGGCGGCACACGCCGTGTGGACGTGATGTGCCCAG
GCTTCACCAGCGACTGCCTGGAAACGCTGGAGGAGATCAACCAGGAGGCACGCGAGGCCTTCCTGCACGCAGGCGGCCAG
GACTTCCGCTACATCCCCTGCCTGAACGACAACCCCGCCTGGATCACTGCCTTGAGCCGCATCGCACAACAGCACCTGGC
GGGCTGGAGCCAGCCATGA

Upstream 100 bases:

>100_bases
TAGGCCATAGGGTGTCATCCAGGTCAAGAGTGATGGCGCGGATGCGGGAAATATCGAGCATGGCCTGAGCATACCGCCCG
GCATTTGCCACAATCACCGC

Downstream 100 bases:

>100_bases
GCGCGCCCTGCACGGCACTCGCACCCGGCCAGCTGCGCCTGAGCATCCGCCCCGAGAGCCTGGGCTTTGACGACACGCGC
GCGCTGGTGGCCGAGCCCCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPASPSHHAAQTASASSIPTAAARESTAILLSNLGTPDAPTAPALRRYLAQFLGDPRVVEIPRALWLPLLYGIILRTRPA
KSAAKYASIWTEEGSPLAVWTAKQAVMLRGWLGEAGQPVRVLPAMRYGQPAIGAQLQVLQDAGVRRVLVLPLYPQYSATT
TASVFDDVAAWVRRSRCFPELRFVNDYHDHPDYIAALAQSVRAHWQREGGPADKLVMSFHGIPERNVRLGDPYAEQCRTT
ARLLAQALGLGEDRYLLTFQSRFGKARWLEPYTEPSLVALAQGGTRRVDVMCPGFTSDCLETLEEINQEAREAFLHAGGQ
DFRYIPCLNDNPAWITALSRIAQQHLAGWSQP

Sequences:

>Translated_352_residues
MPASPSHHAAQTASASSIPTAAARESTAILLSNLGTPDAPTAPALRRYLAQFLGDPRVVEIPRALWLPLLYGIILRTRPA
KSAAKYASIWTEEGSPLAVWTAKQAVMLRGWLGEAGQPVRVLPAMRYGQPAIGAQLQVLQDAGVRRVLVLPLYPQYSATT
TASVFDDVAAWVRRSRCFPELRFVNDYHDHPDYIAALAQSVRAHWQREGGPADKLVMSFHGIPERNVRLGDPYAEQCRTT
ARLLAQALGLGEDRYLLTFQSRFGKARWLEPYTEPSLVALAQGGTRRVDVMCPGFTSDCLETLEEINQEAREAFLHAGGQ
DFRYIPCLNDNPAWITALSRIAQQHLAGWSQP
>Mature_351_residues
PASPSHHAAQTASASSIPTAAARESTAILLSNLGTPDAPTAPALRRYLAQFLGDPRVVEIPRALWLPLLYGIILRTRPAK
SAAKYASIWTEEGSPLAVWTAKQAVMLRGWLGEAGQPVRVLPAMRYGQPAIGAQLQVLQDAGVRRVLVLPLYPQYSATTT
ASVFDDVAAWVRRSRCFPELRFVNDYHDHPDYIAALAQSVRAHWQREGGPADKLVMSFHGIPERNVRLGDPYAEQCRTTA
RLLAQALGLGEDRYLLTFQSRFGKARWLEPYTEPSLVALAQGGTRRVDVMCPGFTSDCLETLEEINQEAREAFLHAGGQD
FRYIPCLNDNPAWITALSRIAQQHLAGWSQP

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=340, Percent_Identity=25.5882352941176, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI60499025, Length=340, Percent_Identity=25.5882352941176, Blast_Score=101, Evalue=8e-22,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=48.2649842271293, Blast_Score=295, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324750, Length=349, Percent_Identity=25.214899713467, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=25.0746268656716, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24651774, Length=265, Percent_Identity=24.9056603773585, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38835; Mature: 38703

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPSHHAAQTASASSIPTAAARESTAILLSNLGTPDAPTAPALRRYLAQFLGDPRVVE
CCCCCCCHHHHHCCCCCCCCHHHHCHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
IPRALWLPLLYGIILRTRPAKSAAKYASIWTEEGSPLAVWTAKQAVMLRGWLGEAGQPVR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCCEE
VLPAMRYGQPAIGAQLQVLQDAGVRRVLVLPLYPQYSATTTASVFDDVAAWVRRSRCFPE
ECCHHHCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCH
LRFVNDYHDHPDYIAALAQSVRAHWQREGGPADKLVMSFHGIPERNVRLGDPYAEQCRTT
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ARLLAQALGLGEDRYLLTFQSRFGKARWLEPYTEPSLVALAQGGTRRVDVMCPGFTSDCL
HHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHH
ETLEEINQEAREAFLHAGGQDFRYIPCLNDNPAWITALSRIAQQHLAGWSQP
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PASPSHHAAQTASASSIPTAAARESTAILLSNLGTPDAPTAPALRRYLAQFLGDPRVVE
CCCCCCHHHHHCCCCCCCCHHHHCHHHHHEECCCCCCCCCHHHHHHHHHHHHCCCCEEE
IPRALWLPLLYGIILRTRPAKSAAKYASIWTEEGSPLAVWTAKQAVMLRGWLGEAGQPVR
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCCEE
VLPAMRYGQPAIGAQLQVLQDAGVRRVLVLPLYPQYSATTTASVFDDVAAWVRRSRCFPE
ECCHHHCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCH
LRFVNDYHDHPDYIAALAQSVRAHWQREGGPADKLVMSFHGIPERNVRLGDPYAEQCRTT
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
ARLLAQALGLGEDRYLLTFQSRFGKARWLEPYTEPSLVALAQGGTRRVDVMCPGFTSDCL
HHHHHHHHCCCCCCEEEEEHHHCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHH
ETLEEINQEAREAFLHAGGQDFRYIPCLNDNPAWITALSRIAQQHLAGWSQP
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA