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The map label for this gene is moaA [H]

Identifier: 222111161

GI number: 222111161

Start: 2106881

End: 2108017

Strand: Direct

Name: moaA [H]

Synonym: Dtpsy_1969

Alternate gene names: 222111161

Gene position: 2106881-2108017 (Clockwise)

Preceding gene: 222111159

Following gene: 222111162

Centisome position: 55.49

GC content: 69.66

Gene sequence:

>1137_bases
ATGGCTGAACGTGTCATTCCCCTCGTGGACCAGCGCAGCAAGGTGCTGCAGCCCCCTGCGCTCCTGGCCGCGGCACCCGC
TACCGGACTGCTGCAGGACACGCTCTCCCGTCCCTTGCGCGACCTGCGCATCAGCGTGACGGACCGCTGCAACTTCCGCT
GCGGCTACTGCATGCCCAAGGAAGTGTTCGACAAGCACTACCGCTACCTGCCGCACAGCGACCTGCTGAGCTTTGAAGAG
ATCACGCGGCTGGCGCGCCTGTTCATGGCGCATGGGGTGCGCAAGATCCGCCTCACCGGCGGTGAGCCGCTGCTGCGCAA
GGACCTGGAGAACCTGGTTGCCCAGTTGGCGGAACTGCGCACGCTGGAGGGCCGCGTGCCCGACCTCACGCTGACCACCA
ATGGATCGCTGCTGGCGCGCAAGGCGCGCGCCCTCAAGGCCGCGGGCCTGCGGCGCGTCACCGTGAGCCTGGACAGCCTG
CAGGACGACGTGTTCCGCCGCATGAACGACGTGGACTTTCCGGTGGCCGACGTACTCGCCGGTATCGAGGCCGCGCAGGC
GGTGGGCCTGGAGCACATCAAGGTCAACATGGTGGTCAAGCGCGGCACCAACGACCACGAGATCCCGGCGATGGCGCGCC
ACTTTCGCGGCACCGGCATCACGCTGCGCTTCATCGAATACATGGACGTGGGCGCCACCAACGGCTGGCGCATGGATGAG
GTGCTGCCCTCCGCCGAGGTCATCGCGCGGCTGCAGGCCGAGCTGCCGCTGGTGCCGCTGGCCGCGCAGTCCGCCGGCGA
GACCGCCAAGCGTTGGGGCTACGCCGGCCCCGACGGTCGCCACGACCCGCGCTTGGGCGAAGTGGGCGTGATCAGCAGCG
TCACGCAGGCCTTCTGCGGCGACTGCAACCGCGCGCGCCTGTCCATGGAGGGGCGGCTGTACCTGTGCCTGTTTGCCTCG
CAAGGCTGGGACCTGCGCAGCCTGCTGCGCGGCAGCGCCGGCGACGCGCAGATCAGCGCCGCCATCGCCCACATCTGGCA
GGGGCGCGGCGACCGCTATTCCGAGCTGCGCGCCAGCCTGCCACCCGAGACGGGCGGCGGCCAGCGGCGCATCGAGATGA
GCTACATCGGCGGCTGA

Upstream 100 bases:

>100_bases
CAAAGGCACCTCATGTCGCTGCCGTGACAGCAGATTGATCAACATCAATTTAGCGGACGGCCGCCATACCCCTACGACGC
CGATGGGGCACAATTTCGCC

Downstream 100 bases:

>100_bases
GCCGCCGCCGCGTCGCACGGACCGGCCCCGGCGCGCCGTTCACCACCCTTCTTCTTTCCCATGATCGACACCCACGACAT
CACAGGCCTCATCCTCGCCG

Product: molybdenum cofactor biosynthesis protein a

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MAERVIPLVDQRSKVLQPPALLAAAPATGLLQDTLSRPLRDLRISVTDRCNFRCGYCMPKEVFDKHYRYLPHSDLLSFEE
ITRLARLFMAHGVRKIRLTGGEPLLRKDLENLVAQLAELRTLEGRVPDLTLTTNGSLLARKARALKAAGLRRVTVSLDSL
QDDVFRRMNDVDFPVADVLAGIEAAQAVGLEHIKVNMVVKRGTNDHEIPAMARHFRGTGITLRFIEYMDVGATNGWRMDE
VLPSAEVIARLQAELPLVPLAAQSAGETAKRWGYAGPDGRHDPRLGEVGVISSVTQAFCGDCNRARLSMEGRLYLCLFAS
QGWDLRSLLRGSAGDAQISAAIAHIWQGRGDRYSELRASLPPETGGGQRRIEMSYIGG

Sequences:

>Translated_378_residues
MAERVIPLVDQRSKVLQPPALLAAAPATGLLQDTLSRPLRDLRISVTDRCNFRCGYCMPKEVFDKHYRYLPHSDLLSFEE
ITRLARLFMAHGVRKIRLTGGEPLLRKDLENLVAQLAELRTLEGRVPDLTLTTNGSLLARKARALKAAGLRRVTVSLDSL
QDDVFRRMNDVDFPVADVLAGIEAAQAVGLEHIKVNMVVKRGTNDHEIPAMARHFRGTGITLRFIEYMDVGATNGWRMDE
VLPSAEVIARLQAELPLVPLAAQSAGETAKRWGYAGPDGRHDPRLGEVGVISSVTQAFCGDCNRARLSMEGRLYLCLFAS
QGWDLRSLLRGSAGDAQISAAIAHIWQGRGDRYSELRASLPPETGGGQRRIEMSYIGG
>Mature_377_residues
AERVIPLVDQRSKVLQPPALLAAAPATGLLQDTLSRPLRDLRISVTDRCNFRCGYCMPKEVFDKHYRYLPHSDLLSFEEI
TRLARLFMAHGVRKIRLTGGEPLLRKDLENLVAQLAELRTLEGRVPDLTLTTNGSLLARKARALKAAGLRRVTVSLDSLQ
DDVFRRMNDVDFPVADVLAGIEAAQAVGLEHIKVNMVVKRGTNDHEIPAMARHFRGTGITLRFIEYMDVGATNGWRMDEV
LPSAEVIARLQAELPLVPLAAQSAGETAKRWGYAGPDGRHDPRLGEVGVISSVTQAFCGDCNRARLSMEGRLYLCLFASQ
GWDLRSLLRGSAGDAQISAAIAHIWQGRGDRYSELRASLPPETGGGQRRIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=320, Percent_Identity=36.875, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI22027536, Length=320, Percent_Identity=36.875, Blast_Score=192, Evalue=6e-49,
Organism=Escherichia coli, GI1786999, Length=320, Percent_Identity=34.6875, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17561210, Length=327, Percent_Identity=33.0275229357798, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI32566331, Length=326, Percent_Identity=32.2085889570552, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI32566329, Length=327, Percent_Identity=32.1100917431193, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI28574490, Length=337, Percent_Identity=36.7952522255193, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI28574488, Length=325, Percent_Identity=36.6153846153846, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41690; Mature: 41558

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERVIPLVDQRSKVLQPPALLAAAPATGLLQDTLSRPLRDLRISVTDRCNFRCGYCMPK
CCCCCCCHHHCHHHHCCCCHHHHCCCCHHHHHHHHHCCHHHHEEEEECCCCCEECCCCCH
EVFDKHYRYLPHSDLLSFEEITRLARLFMAHGVRKIRLTGGEPLLRKDLENLVAQLAELR
HHHHHHHHCCCCHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
TLEGRVPDLTLTTNGSLLARKARALKAAGLRRVTVSLDSLQDDVFRRMNDVDFPVADVLA
HHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHH
GIEAAQAVGLEHIKVNMVVKRGTNDHEIPAMARHFRGTGITLRFIEYMDVGATNGWRMDE
HHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCHHH
VLPSAEVIARLQAELPLVPLAAQSAGETAKRWGYAGPDGRHDPRLGEVGVISSVTQAFCG
HCCHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
DCNRARLSMEGRLYLCLFASQGWDLRSLLRGSAGDAQISAAIAHIWQGRGDRYSELRASL
CCCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
PPETGGGQRRIEMSYIGG
CCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
AERVIPLVDQRSKVLQPPALLAAAPATGLLQDTLSRPLRDLRISVTDRCNFRCGYCMPK
CCCCCCHHHCHHHHCCCCHHHHCCCCHHHHHHHHHCCHHHHEEEEECCCCCEECCCCCH
EVFDKHYRYLPHSDLLSFEEITRLARLFMAHGVRKIRLTGGEPLLRKDLENLVAQLAELR
HHHHHHHHCCCCHHCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
TLEGRVPDLTLTTNGSLLARKARALKAAGLRRVTVSLDSLQDDVFRRMNDVDFPVADVLA
HHCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCHHHHHH
GIEAAQAVGLEHIKVNMVVKRGTNDHEIPAMARHFRGTGITLRFIEYMDVGATNGWRMDE
HHHHHHHHCCEEEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCHHH
VLPSAEVIARLQAELPLVPLAAQSAGETAKRWGYAGPDGRHDPRLGEVGVISSVTQAFCG
HCCHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
DCNRARLSMEGRLYLCLFASQGWDLRSLLRGSAGDAQISAAIAHIWQGRGDRYSELRASL
CCCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
PPETGGGQRRIEMSYIGG
CCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]