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The map label for this gene is prpC [H]

Identifier: 222111094

GI number: 222111094

Start: 2030855

End: 2031658

Strand: Direct

Name: prpC [H]

Synonym: Dtpsy_1901

Alternate gene names: 222111094

Gene position: 2030855-2031658 (Clockwise)

Preceding gene: 222111092

Following gene: 222111100

Centisome position: 53.49

GC content: 65.05

Gene sequence:

>804_bases
ATGACCAAAGCGTTCCGCCTCATTGCGTCGACCGGCATCCACAAGGGTGACCGCGAGTACCAGCAAGACCAGGTCGCCCT
GCTGTCGCACCCGCGTTTCAATGGATGCGTACTGGGCGTGGTGGCCGATGGCATGGGTGGCCGCAGCGGAGGACGCAAGG
CGTCCGACCAGGTGATGCTCACCGCGCGCCAGTTGTTTGAACGCTACTCGCCAGAAACGGACGACGCCGCCGCCCTGCTC
AAGCACATCGTGGAGGAGGCGCACATCGTGATCCGCCTCACCGCGATTTCCGCGGAACAGGAGCCACACAGCACCATCGC
GGCATTCGTGATCAACCCACGCGGCGATTGCCACTGGGCCCACGCAGGGGACTCGCGCATCTACCACTTTCAGGGGGGGC
GGCTGGTGTTCCGCACCAGCGACCACTCCTATGTGCAGGCGCTCGTGGACCGTGGCGAGATCACGGAAGCCGAGGCCAAC
ACCCACCCCCACTCCAACATCCTCGTCGGCTGTCTGGGCACCGAGAGCGACCCTCCCATCACCACCCACCTGATTCCGCA
GATGCAGCCGGGCGACGTGCTGTTGGCTTGCAGCGACGGCGTGTGGCACTACTTCTCACCTGCGGAACTGGCGTCGGTCC
TGGATTCGCTGACGCCGCGCGAGGCCACCGAGTTCCTCATCGACAAGGCGCGCTCGCGCGCACGCGGGGGCGGCGACAAC
CTGTCGCTCGCCATCGTGAAGATCGAAACGCTGGTAGAGGAAAAGAAGCCTCCACGCTTGGCGCAACTCACACCCGCCAC
CTAA

Upstream 100 bases:

>100_bases
AGACGCACCAGCGATGACAAGGCCCGGGAGTTGATCATAATAGGCGGCTCCCCCCGCTTTCGCGACTGCGAGGCGGCCTT
TCGTCCTCCGCTCCAATCCC

Downstream 100 bases:

>100_bases
AACGCGCGTGGAAGACGGCCCCGCATGGGCCGTGGCGTCCACCGGGCCCTAAAGGGCACTCAACGGTCGCTGCTCGCGGC
CGGGGCCGGCGGCGGCAATG

Product: protein serine/threonine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTKAFRLIASTGIHKGDREYQQDQVALLSHPRFNGCVLGVVADGMGGRSGGRKASDQVMLTARQLFERYSPETDDAAALL
KHIVEEAHIVIRLTAISAEQEPHSTIAAFVINPRGDCHWAHAGDSRIYHFQGGRLVFRTSDHSYVQALVDRGEITEAEAN
THPHSNILVGCLGTESDPPITTHLIPQMQPGDVLLACSDGVWHYFSPAELASVLDSLTPREATEFLIDKARSRARGGGDN
LSLAIVKIETLVEEKKPPRLAQLTPAT

Sequences:

>Translated_267_residues
MTKAFRLIASTGIHKGDREYQQDQVALLSHPRFNGCVLGVVADGMGGRSGGRKASDQVMLTARQLFERYSPETDDAAALL
KHIVEEAHIVIRLTAISAEQEPHSTIAAFVINPRGDCHWAHAGDSRIYHFQGGRLVFRTSDHSYVQALVDRGEITEAEAN
THPHSNILVGCLGTESDPPITTHLIPQMQPGDVLLACSDGVWHYFSPAELASVLDSLTPREATEFLIDKARSRARGGGDN
LSLAIVKIETLVEEKKPPRLAQLTPAT
>Mature_266_residues
TKAFRLIASTGIHKGDREYQQDQVALLSHPRFNGCVLGVVADGMGGRSGGRKASDQVMLTARQLFERYSPETDDAAALLK
HIVEEAHIVIRLTAISAEQEPHSTIAAFVINPRGDCHWAHAGDSRIYHFQGGRLVFRTSDHSYVQALVDRGEITEAEANT
HPHSNILVGCLGTESDPPITTHLIPQMQPGDVLLACSDGVWHYFSPAELASVLDSLTPREATEFLIDKARSRARGGGDNL
SLAIVKIETLVEEKKPPRLAQLTPAT

Specific function: Protein phosphatase that dephosphorylates prkC and fusA (elongation factor G). PrpC and prkC are cotranscribed, which suggests that they form a functional couple in vivo, prpC's primary role being possibly to counter the action of prkC. May be involved in

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 29116; Mature: 28985

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKAFRLIASTGIHKGDREYQQDQVALLSHPRFNGCVLGVVADGMGGRSGGRKASDQVML
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHH
TARQLFERYSPETDDAAALLKHIVEEAHIVIRLTAISAEQEPHSTIAAFVINPRGDCHWA
HHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCEEEEEEECCCCCEEEE
HAGDSRIYHFQGGRLVFRTSDHSYVQALVDRGEITEAEANTHPHSNILVGCLGTESDPPI
ECCCCEEEEEECCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCE
TTHLIPQMQPGDVLLACSDGVWHYFSPAELASVLDSLTPREATEFLIDKARSRARGGGDN
EEEECCCCCCCCEEEEECCCCEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
LSLAIVKIETLVEEKKPPRLAQLTPAT
EEEEEEEEEHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKAFRLIASTGIHKGDREYQQDQVALLSHPRFNGCVLGVVADGMGGRSGGRKASDQVML
CHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHH
TARQLFERYSPETDDAAALLKHIVEEAHIVIRLTAISAEQEPHSTIAAFVINPRGDCHWA
HHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCEEEEEEECCCCCEEEE
HAGDSRIYHFQGGRLVFRTSDHSYVQALVDRGEITEAEANTHPHSNILVGCLGTESDPPI
ECCCCEEEEEECCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCE
TTHLIPQMQPGDVLLACSDGVWHYFSPAELASVLDSLTPREATEFLIDKARSRARGGGDN
EEEECCCCCCCCEEEEECCCCEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCC
LSLAIVKIETLVEEKKPPRLAQLTPAT
EEEEEEEEEHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]