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The map label for this gene is phbA [H]

Identifier: 222110876

GI number: 222110876

Start: 1783808

End: 1784986

Strand: Direct

Name: phbA [H]

Synonym: Dtpsy_1682

Alternate gene names: 222110876

Gene position: 1783808-1784986 (Clockwise)

Preceding gene: 222110875

Following gene: 222110877

Centisome position: 46.98

GC content: 68.28

Gene sequence:

>1179_bases
ATGGAAGACATCGTCATCGTTTCCGCCGTGCGCACGCCCGTGGGCAAGTTTGGCGGCGCACTGGCCAAGACCCCCGCGAC
CGATCTGGGCGCCATCGTCATCCGTGAGGCGCTGGCACGCGCCCGCGTCGCTCCCGATCAGGTGGGCGAGGTCATCATGG
GCCAGGTGCTTGCGGCCGGCTGTGGCCAGAACCCGGCCCGCCAGGCCATGATGAAGGCGGGGCTGGCCCAGGAGACGCCC
GCGCTCACCATCAACGCCGTGTGCGGCTCGGGTCTCAAGGCCGTGATGCTGGCCGCCCAGGCCGTGGCGACGGGCGACAG
CGAGATCGTCGTGGCCGGCGGCCAGGAGAACATGAGCCTGGCACCGCACGTGCTCAATGGCTCGCGCGAAGGCCAGCGCA
TGGGCGACTGGAAGCTGGTCGACACCATGATCGTCGACGGCCTGTGGGACGTGTACAACCAGTACCACATGGGCATCACG
GCCGAGAACGTGGCCAGGCAGCACGGCATCACGCGCGAGATGCAGGATGCGCTGGCCCTGGCCAGCCAGCAAAAGGCCGC
CGCCGCCCAGGACGCAGGGCGCTTCACGGACGAGATCGTGCCGGTGACACTTGCGCAGAAGAAGGGCGACCCCGTCATAT
TCGCGGCAGACGAATATCTCAACCGCAAAACCAGTGCCGAAGCTCTGGCTGGCCTGCGCCCCGCTTTCGACAAGGCCGGC
TCGGTCACGGCGGGCAATGCCTCGGGCATCAATGACGGTGCGGCCGCCGTGGTGGTGATGAGTGCCACCAAGGCTGCGGC
CCTGGGCCTGCAACCGCTGGCCCGCATTGCGGCCTACGGCACCAGCGGACTGGACCCCGCCACCATGGGCATGGGCCCGG
TGCCGGCATCCCGCAAGGCACTGCAGCGCGCGGGCTGGAGCGTGGGCGATGTGGACCTGTTCGAACTCAACGAGGCCTTC
GCTGCCCAGGCGTGCGCGGTGAACAAGGAGCTCGGCATCGATCCCGCCAAGGTCAACGTGAATGGCGGCGCCATCGCCAT
CGGTCACCCCATCGGCGCCTCGGGCTGCCGCGTGTTGGTGACCCTGCTGCACGAAATGCAGCGCCGCGATGCCAGGAAGG
GCCTGGCTGCGCTGTGCATTGGTGGAGGCATGGGCGTGTCCATGGCATTGGCGCGTTAA

Upstream 100 bases:

>100_bases
GCGGGGTGACTACGCAATAGTCCTGACACCGGGCCGACAGACAATGGCTACTGGCCTGCGGCCGTGCAGCCGGCAGGTGC
CACTCCCGAAAGGACACACC

Downstream 100 bases:

>100_bases
GCAGAGCACCGGCGTTGTCATGACTCAGAAGGCCGTAGGGGACGCCCATGCGGCCTTTTTTTATGACTATGTCTCCATTG
AGTAAAAAGAGCCGATAGCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MEDIVIVSAVRTPVGKFGGALAKTPATDLGAIVIREALARARVAPDQVGEVIMGQVLAAGCGQNPARQAMMKAGLAQETP
ALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSLAPHVLNGSREGQRMGDWKLVDTMIVDGLWDVYNQYHMGIT
AENVARQHGITREMQDALALASQQKAAAAQDAGRFTDEIVPVTLAQKKGDPVIFAADEYLNRKTSAEALAGLRPAFDKAG
SVTAGNASGINDGAAAVVVMSATKAAALGLQPLARIAAYGTSGLDPATMGMGPVPASRKALQRAGWSVGDVDLFELNEAF
AAQACAVNKELGIDPAKVNVNGGAIAIGHPIGASGCRVLVTLLHEMQRRDARKGLAALCIGGGMGVSMALAR

Sequences:

>Translated_392_residues
MEDIVIVSAVRTPVGKFGGALAKTPATDLGAIVIREALARARVAPDQVGEVIMGQVLAAGCGQNPARQAMMKAGLAQETP
ALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSLAPHVLNGSREGQRMGDWKLVDTMIVDGLWDVYNQYHMGIT
AENVARQHGITREMQDALALASQQKAAAAQDAGRFTDEIVPVTLAQKKGDPVIFAADEYLNRKTSAEALAGLRPAFDKAG
SVTAGNASGINDGAAAVVVMSATKAAALGLQPLARIAAYGTSGLDPATMGMGPVPASRKALQRAGWSVGDVDLFELNEAF
AAQACAVNKELGIDPAKVNVNGGAIAIGHPIGASGCRVLVTLLHEMQRRDARKGLAALCIGGGMGVSMALAR
>Mature_392_residues
MEDIVIVSAVRTPVGKFGGALAKTPATDLGAIVIREALARARVAPDQVGEVIMGQVLAAGCGQNPARQAMMKAGLAQETP
ALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSLAPHVLNGSREGQRMGDWKLVDTMIVDGLWDVYNQYHMGIT
AENVARQHGITREMQDALALASQQKAAAAQDAGRFTDEIVPVTLAQKKGDPVIFAADEYLNRKTSAEALAGLRPAFDKAG
SVTAGNASGINDGAAAVVVMSATKAAALGLQPLARIAAYGTSGLDPATMGMGPVPASRKALQRAGWSVGDVDLFELNEAF
AAQACAVNKELGIDPAKVNVNGGAIAIGHPIGASGCRVLVTLLHEMQRRDARKGLAALCIGGGMGVSMALAR

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=54.4529262086514, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=44.6428571428571, Blast_Score=331, Evalue=9e-91,
Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=43.2569974554707, Blast_Score=315, Evalue=3e-86,
Organism=Homo sapiens, GI4501853, Length=389, Percent_Identity=42.4164524421594, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=31.924882629108, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI194353979, Length=386, Percent_Identity=32.6424870466321, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=59.6938775510204, Blast_Score=468, Evalue=1e-133,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=61.0687022900763, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=46.4197530864198, Blast_Score=324, Evalue=8e-90,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=43.0348258706468, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1788683, Length=420, Percent_Identity=34.5238095238095, Blast_Score=206, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=46.4102564102564, Blast_Score=337, Evalue=9e-93,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=41.0852713178295, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.9312977099237, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17535917, Length=393, Percent_Identity=32.824427480916, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=32, Blast_Score=171, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=42.7848101265823, Blast_Score=298, Evalue=9e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=38.7341772151899, Blast_Score=222, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=56.3775510204082, Blast_Score=440, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24640423, Length=391, Percent_Identity=45.5242966751918, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=42.4164524421594, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI17137578, Length=431, Percent_Identity=32.4825986078886, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40153; Mature: 40153

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDIVIVSAVRTPVGKFGGALAKTPATDLGAIVIREALARARVAPDQVGEVIMGQVLAAG
CCCEEEEEHHHCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
CGQNPARQAMMKAGLAQETPALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSL
CCCCHHHHHHHHHCCCCCCCCEEEECHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLNGSREGQRMGDWKLVDTMIVDGLWDVYNQYHMGITAENVARQHGITREMQDALAL
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHH
ASQQKAAAAQDAGRFTDEIVPVTLAQKKGDPVIFAADEYLNRKTSAEALAGLRPAFDKAG
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEECHHHHCCHHHHHHHHCCCHHHHCCC
SVTAGNASGINDGAAAVVVMSATKAAALGLQPLARIAAYGTSGLDPATMGMGPVPASRKA
CEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHH
LQRAGWSVGDVDLFELNEAFAAQACAVNKELGIDPAKVNVNGGAIAIGHPIGASGCRVLV
HHHCCCCCCCEEHHHHHHHHHHHHHHCCHHCCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMQRRDARKGLAALCIGGGMGVSMALAR
HHHHHHHHHHHHCCCEEEEECCCCCCHHEECC
>Mature Secondary Structure
MEDIVIVSAVRTPVGKFGGALAKTPATDLGAIVIREALARARVAPDQVGEVIMGQVLAAG
CCCEEEEEHHHCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
CGQNPARQAMMKAGLAQETPALTINAVCGSGLKAVMLAAQAVATGDSEIVVAGGQENMSL
CCCCHHHHHHHHHCCCCCCCCEEEECHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLNGSREGQRMGDWKLVDTMIVDGLWDVYNQYHMGITAENVARQHGITREMQDALAL
CCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHH
ASQQKAAAAQDAGRFTDEIVPVTLAQKKGDPVIFAADEYLNRKTSAEALAGLRPAFDKAG
HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEECHHHHCCHHHHHHHHCCCHHHHCCC
SVTAGNASGINDGAAAVVVMSATKAAALGLQPLARIAAYGTSGLDPATMGMGPVPASRKA
CEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHH
LQRAGWSVGDVDLFELNEAFAAQACAVNKELGIDPAKVNVNGGAIAIGHPIGASGCRVLV
HHHCCCCCCCEEHHHHHHHHHHHHHHCCHHCCCCCCEEEECCCEEEECCCCCCHHHHHHH
TLLHEMQRRDARKGLAALCIGGGMGVSMALAR
HHHHHHHHHHHHCCCEEEEECCCCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2670935; 2670936 [H]