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The map label for this gene is aphA [H]

Identifier: 222110839

GI number: 222110839

Start: 1736278

End: 1737315

Strand: Direct

Name: aphA [H]

Synonym: Dtpsy_1645

Alternate gene names: 222110839

Gene position: 1736278-1737315 (Clockwise)

Preceding gene: 222110838

Following gene: 222110840

Centisome position: 45.73

GC content: 65.22

Gene sequence:

>1038_bases
ATGATCACCTTCCATAACCCGCTGCAGCACACCCACGCTCCCGAGCACGAATTTTTCCGCGGCGAGCGTGTACCGTGTTT
CGAGAACCCGACGCGCGCGGCCTATGTGGAAGCCGCTTTGACTGCGCGGGGTCATGTACTGCACCCCCCGGATGTGGATT
GCGCTGAGATCCTGGCAAAGATCCATGCGCCGAGCTACCTGGCTTTTCTGGCTTCGGCGTGGCAGCAGTGGCTGTCGCTG
GGTGAAGGGCAGGACCGTGTGCAGCCGTTTCCGTCGGTATGGCCGGTACGCACATTGCGCTCGGATGTAGAGCCCGACAA
TTTCATTGCCAAGCTGGGGCTGTACTCCATGGACAACGGCTCGCCGCTTGCAGCGGGCACCTGGACGGCAGCCAAAGCAG
GCGCCGACGCGGCGGCCAGTGCCGCGGCGCGCCTGGCGGCTGGCGAGCGCGCCGCGTTCTGCAGCACACGCCCGCCGGGG
CACCATGCAGGCCCCGATTTCATGGGCGGGTACTGCTTCTTGAACAACGCGGCCGTGGCGGCCCAATGGCTGCGCGACCA
CGGCGCGGCCCGTGTGGCCGTGTTAGACGTGGATTACCACCACGGCAATGGCACGCAGAGCATCTTCTATGACCGTGCGG
ACGTGCTCTTCGTCAGCATCCATGGCGATCCCCACACCGAATACCCCTTCTATCTGGGACATGCCGATGAAACCGGCGCA
GGCCTCGGTGCGGGCTGCAACCTGAACCTGCCTCTGCCGGCCGGAACCGATGCTGCCACTTGGTTTGCGGCCTTGGAGCA
GGCCTGCGCGCGCATCGCCGCTTTTGGAGCGGATGCCCTGGTGGTCTCGCTCGGACTGGATACCTATGAGGGCGATCCGA
TCTCGCGCTTTCGGCTGGCGACGACGGATTTTCTGCGGCTGGGTGCGCGGCTGCGTGGTGTGGGACTGCCCACCGTGCTG
GTGCTGGAAGGCGGCTACGCAGCGGCGGCGCTGGGAACGAATGCGGTGAATGTGCTCGAGGGTTTCGAGCAGGCATGA

Upstream 100 bases:

>100_bases
GCCGGTATGGCCGCAAGGGGTTTTTTCTTGGCGCTGAGGTCGTGAGGGACTGCCGGCGTCGATGACAATCCGGCAGTCGC
GATTGACTTGGCCGCCGTCG

Downstream 100 bases:

>100_bases
CAACGGAGGCATGAGCGATGAGTGAGATGGTCGATTGCGTCGTGGTGGGCGCGGGGGTGGTGGGGCTGGCGGTGGCGCGC
GCATTGGCGCTGCAAGGGCG

Product: histone deacetylase superfamily

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MITFHNPLQHTHAPEHEFFRGERVPCFENPTRAAYVEAALTARGHVLHPPDVDCAEILAKIHAPSYLAFLASAWQQWLSL
GEGQDRVQPFPSVWPVRTLRSDVEPDNFIAKLGLYSMDNGSPLAAGTWTAAKAGADAAASAAARLAAGERAAFCSTRPPG
HHAGPDFMGGYCFLNNAAVAAQWLRDHGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSIHGDPHTEYPFYLGHADETGA
GLGAGCNLNLPLPAGTDAATWFAALEQACARIAAFGADALVVSLGLDTYEGDPISRFRLATTDFLRLGARLRGVGLPTVL
VLEGGYAAAALGTNAVNVLEGFEQA

Sequences:

>Translated_345_residues
MITFHNPLQHTHAPEHEFFRGERVPCFENPTRAAYVEAALTARGHVLHPPDVDCAEILAKIHAPSYLAFLASAWQQWLSL
GEGQDRVQPFPSVWPVRTLRSDVEPDNFIAKLGLYSMDNGSPLAAGTWTAAKAGADAAASAAARLAAGERAAFCSTRPPG
HHAGPDFMGGYCFLNNAAVAAQWLRDHGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSIHGDPHTEYPFYLGHADETGA
GLGAGCNLNLPLPAGTDAATWFAALEQACARIAAFGADALVVSLGLDTYEGDPISRFRLATTDFLRLGARLRGVGLPTVL
VLEGGYAAAALGTNAVNVLEGFEQA
>Mature_345_residues
MITFHNPLQHTHAPEHEFFRGERVPCFENPTRAAYVEAALTARGHVLHPPDVDCAEILAKIHAPSYLAFLASAWQQWLSL
GEGQDRVQPFPSVWPVRTLRSDVEPDNFIAKLGLYSMDNGSPLAAGTWTAAKAGADAAASAAARLAAGERAAFCSTRPPG
HHAGPDFMGGYCFLNNAAVAAQWLRDHGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSIHGDPHTEYPFYLGHADETGA
GLGAGCNLNLPLPAGTDAATWFAALEQACARIAAFGADALVVSLGLDTYEGDPISRFRLATTDFLRLGARLRGVGLPTVL
VLEGGYAAAALGTNAVNVLEGFEQA

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI17158039, Length=229, Percent_Identity=33.1877729257642, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI30795204, Length=229, Percent_Identity=33.1877729257642, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI30795202, Length=229, Percent_Identity=33.1877729257642, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI153085395, Length=198, Percent_Identity=36.3636363636364, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI148539870, Length=215, Percent_Identity=34.4186046511628, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI169234807, Length=241, Percent_Identity=34.0248962655602, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI13128864, Length=195, Percent_Identity=35.8974358974359, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI20070354, Length=191, Percent_Identity=34.5549738219895, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI62750347, Length=200, Percent_Identity=34.5, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI62750349, Length=200, Percent_Identity=34.5, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI8923769, Length=309, Percent_Identity=27.1844660194175, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI13128860, Length=237, Percent_Identity=25.3164556962025, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI262073088, Length=172, Percent_Identity=29.0697674418605, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI226529806, Length=99, Percent_Identity=42.4242424242424, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI293336691, Length=265, Percent_Identity=22.2641509433962, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540334, Length=237, Percent_Identity=32.9113924050633, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206283, Length=238, Percent_Identity=33.1932773109244, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17540332, Length=238, Percent_Identity=33.1932773109244, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17537347, Length=222, Percent_Identity=32.8828828828829, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI193209491, Length=345, Percent_Identity=26.9565217391304, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17508561, Length=298, Percent_Identity=26.510067114094, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17534739, Length=291, Percent_Identity=24.7422680412371, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17561978, Length=281, Percent_Identity=23.8434163701068, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6324307, Length=221, Percent_Identity=33.4841628959276, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323999, Length=235, Percent_Identity=28.5106382978723, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321244, Length=239, Percent_Identity=25.5230125523013, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6325141, Length=89, Percent_Identity=41.5730337078652, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281360899, Length=238, Percent_Identity=34.453781512605, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24642144, Length=238, Percent_Identity=34.453781512605, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24642146, Length=238, Percent_Identity=34.453781512605, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24642142, Length=238, Percent_Identity=34.453781512605, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281360801, Length=235, Percent_Identity=34.0425531914894, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI281360799, Length=235, Percent_Identity=34.0425531914894, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641720, Length=235, Percent_Identity=34.0425531914894, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24657891, Length=249, Percent_Identity=27.3092369477912, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644244, Length=225, Percent_Identity=27.5555555555556, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36700; Mature: 36700

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITFHNPLQHTHAPEHEFFRGERVPCFENPTRAAYVEAALTARGHVLHPPDVDCAEILAK
CCCCCCCHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
IHAPSYLAFLASAWQQWLSLGEGQDRVQPFPSVWPVRTLRSDVEPDNFIAKLGLYSMDNG
HCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHCCCHHHHHHHHCCEECCCC
SPLAAGTWTAAKAGADAAASAAARLAAGERAAFCSTRPPGHHAGPDFMGGYCFLNNAAVA
CCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEECCHHHH
AQWLRDHGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSIHGDPHTEYPFYLGHADETGA
HHHHHHCCCEEEEEEEEEEECCCCCCEEEEECCEEEEEEEECCCCCCCCEEECCCCCCCC
GLGAGCNLNLPLPAGTDAATWFAALEQACARIAAFGADALVVSLGLDTYEGDPISRFRLA
CCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHEEHH
TTDFLRLGARLRGVGLPTVLVLEGGYAAAALGTNAVNVLEGFEQA
HHHHHHHHHHHCCCCCCEEEEEECCCEEEHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MITFHNPLQHTHAPEHEFFRGERVPCFENPTRAAYVEAALTARGHVLHPPDVDCAEILAK
CCCCCCCHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
IHAPSYLAFLASAWQQWLSLGEGQDRVQPFPSVWPVRTLRSDVEPDNFIAKLGLYSMDNG
HCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHCCCHHHHHHHHCCEECCCC
SPLAAGTWTAAKAGADAAASAAARLAAGERAAFCSTRPPGHHAGPDFMGGYCFLNNAAVA
CCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCEEEECCHHHH
AQWLRDHGAARVAVLDVDYHHGNGTQSIFYDRADVLFVSIHGDPHTEYPFYLGHADETGA
HHHHHHCCCEEEEEEEEEEECCCCCCEEEEECCEEEEEEEECCCCCCCCEEECCCCCCCC
GLGAGCNLNLPLPAGTDAATWFAALEQACARIAAFGADALVVSLGLDTYEGDPISRFRLA
CCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHEEHH
TTDFLRLGARLRGVGLPTVLVLEGGYAAAALGTNAVNVLEGFEQA
HHHHHHHHHHHCCCCCCEEEEEECCCEEEHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]