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The map label for this gene is uvrB [H]

Identifier: 222110830

GI number: 222110830

Start: 1727364

End: 1729460

Strand: Direct

Name: uvrB [H]

Synonym: Dtpsy_1636

Alternate gene names: 222110830

Gene position: 1727364-1729460 (Clockwise)

Preceding gene: 222110828

Following gene: 222110831

Centisome position: 45.5

GC content: 62.99

Gene sequence:

>2097_bases
ATGCATGAAGTCACCTCTGAGCCGGCCGCTGGCGCGGCGGACGGGCAGTTCGTCCAGTTTCCAGGTTCGCCCTTTTCGTT
GTACCAGCCATACCCGCCCGCCGGCGACCAGCCCGAGGCCATCGCCAAGCTGGTGGAGGGCGTGCAGGACGGCGAGGTGT
TCCAGACCCTGCTGGGGGTGACGGGCTCGGGCAAGACCTTCACCATGGCGAACGTGATCGCCCGCCTGGGACGGCCGGCC
ATCATCTTCGCGCCCAACAAGACGCTGGCCGCACAGCTGTACAGCGAGTTCCGCGAGTTCTTCCCCAAGAACGCCGTGGA
GTACTTCGTGAGCTATTACGACTACTACCAGCCCGAGGCCTACGTGCCTCAGCGCGACCTGTTCATCGAGAAGGACAGCG
CCATCAACGAGCACATCGAGCAGATGCGCCTGTCGTGCACCAAGAGCTTGCTGGAGCGGCGCGATGTGGTCATCGTGGCT
ACGGTGTCGGCCATCTACGGCATTGGCGAGCCCGAGAGCTACCACCGCATGATCATGACGCTGCGCGTGGGTGACCAGCT
GAGCCAGCGTGACGCGATCGCGCAGCTGATCCGCATGCAGTACCAGCGCAACGAGCAGGACTTCAGCCGGGGCAAGTTCC
GCGTGCGTGGCGACACCATCGATGTGTTCCCAGCCGAGCATTCCGAGCTGGCGGTGCGCATCGAACTGTTCGACGACGAG
GTGGAAAGCCTGCAGCTGTTCGACCCGCTCACGGGGCGTATCCAGCAAAAAATCCCGCGCTTCACGGTGTACCCCAGCAG
CCATTACGTGACGCCGCGCGACAAGGTGCTGGCGGCCGTGGAGACCATCAAGCAGGAACTGGACGAGCGGCTCAAGTTCT
TCGTGGCCGAGGGCAAGTTGGTGGAGGCGCAACGGCTGGAGCAGCGCACGCGCTTCGACCTGGAAATGCTCAGCGAAGTG
GGGCACTGCAAGGGCATCGAGAACTACACGCGCCACCTGTCGGGTTCTGCGCCTGGCGAGCCGCCGAGCACGCTGACCGA
CTACCTCCCGCCCGATGCGCTGATGTTCCTGGATGAGAGCCACCAGATGATCGGGCAACTCAACGCCATGTACAACGGCG
ACCGCGCGCGTAAGACCACGCTGGTCGAGTACGGCTTTCGCCTGCCGTCGGCATTGGACAACCGGCCGCTCAAGTTCGAG
GAGTTCGAGCAGCGCATGCGGCAGGTGGTGTTTGTATCGGCCACTCCGGCTGATTATGAGAAGGAGCACTCGGGCCAGGT
GGTGGACCAGGTGGTACGGCCCACCGGCTTGGTGGACCCGGAGGTGGAGGTGCGTCCCGCTACCCATCAGGTGGATGATG
TGCTGCAAGAAATACGCATTTGCACGCAAAAGAATCAACGCGTACTCATTACGACGCTGACGAAGCGCATGGCGGAGCAA
CTGACCGATTACCTGAGCGACAACGGGGTCAAGGTGCGCTATCTGCACTCCGATATCGACACTGTGGAGCGCGTGGAAAT
CATTCGCGACCTGCGCCTGGGAGCCTTCGATGTCCTGGTGGGGATCAACCTGCTGCGTGAGGGGCTGGACATTCCTGAGG
TCTCCCTGGTGGCCATCCTGGATGCCGACAAGGAGGGTTTCCTGCGCGCCGAACGCAGCCTGATCCAGACCATCGGCCGG
GCGGCGCGCAACCTGCACGGCAAGGCCATCCTGTATGCCGACCGGATCACCGACTCAATGCGCAAGGCGATCAGCGAAAC
GGAACGCCGCCGCGCCAAACAGATCGCATACAACGAGGCCCGGGGTATTACGCCGCGCAGCATCGTCAAGCAGGTGCGAG
ACCTGATTGACGGCGTGTACAGCGAGAAGGCAGGCCAGGAAGCCCAGCGACTCCGCGAAGACGCGGCGCGGCAGGCCGAA
CTGGAGGAGATGTCCGAAAAGGACATTGCGCGCGAAATCAAGCGGCTGGAAAAGCTCATGCTGGAACACGCCCGCAACCT
GGAGTTTGAGCAGGCTGCTCGGGTGCGCGATCAATTGACCCGTCTCAAGGACCGGGTGTTCGGAGCGCATGGCGGCGATC
AAATCCCTGCCGCATGA

Upstream 100 bases:

>100_bases
CTTGAGGGGATGGAAATCTGACGACGGGACCTCACCTACGGTAGGCTTTCGGTCCACTCTTGATTTTAACGGCCGCCCCC
GCGCGCCGTTTACCTCCGCC

Downstream 100 bases:

>100_bases
CCCGGTTTTGCGACCCTGCAGGAGAAAACGCGACTGTTTAGTCTAGTTACCCGACAAAATTAATAGGGATTTGTGCTATA
CTTGTCTCAAATACTCAAGA

Product: excinuclease ABC subunit b

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MHEVTSEPAAGAADGQFVQFPGSPFSLYQPYPPAGDQPEAIAKLVEGVQDGEVFQTLLGVTGSGKTFTMANVIARLGRPA
IIFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSCTKSLLERRDVVIVA
TVSAIYGIGEPESYHRMIMTLRVGDQLSQRDAIAQLIRMQYQRNEQDFSRGKFRVRGDTIDVFPAEHSELAVRIELFDDE
VESLQLFDPLTGRIQQKIPRFTVYPSSHYVTPRDKVLAAVETIKQELDERLKFFVAEGKLVEAQRLEQRTRFDLEMLSEV
GHCKGIENYTRHLSGSAPGEPPSTLTDYLPPDALMFLDESHQMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFE
EFEQRMRQVVFVSATPADYEKEHSGQVVDQVVRPTGLVDPEVEVRPATHQVDDVLQEIRICTQKNQRVLITTLTKRMAEQ
LTDYLSDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNLHGKAILYADRITDSMRKAISETERRRAKQIAYNEARGITPRSIVKQVRDLIDGVYSEKAGQEAQRLREDAARQAE
LEEMSEKDIAREIKRLEKLMLEHARNLEFEQAARVRDQLTRLKDRVFGAHGGDQIPAA

Sequences:

>Translated_698_residues
MHEVTSEPAAGAADGQFVQFPGSPFSLYQPYPPAGDQPEAIAKLVEGVQDGEVFQTLLGVTGSGKTFTMANVIARLGRPA
IIFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSCTKSLLERRDVVIVA
TVSAIYGIGEPESYHRMIMTLRVGDQLSQRDAIAQLIRMQYQRNEQDFSRGKFRVRGDTIDVFPAEHSELAVRIELFDDE
VESLQLFDPLTGRIQQKIPRFTVYPSSHYVTPRDKVLAAVETIKQELDERLKFFVAEGKLVEAQRLEQRTRFDLEMLSEV
GHCKGIENYTRHLSGSAPGEPPSTLTDYLPPDALMFLDESHQMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFE
EFEQRMRQVVFVSATPADYEKEHSGQVVDQVVRPTGLVDPEVEVRPATHQVDDVLQEIRICTQKNQRVLITTLTKRMAEQ
LTDYLSDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNLHGKAILYADRITDSMRKAISETERRRAKQIAYNEARGITPRSIVKQVRDLIDGVYSEKAGQEAQRLREDAARQAE
LEEMSEKDIAREIKRLEKLMLEHARNLEFEQAARVRDQLTRLKDRVFGAHGGDQIPAA
>Mature_698_residues
MHEVTSEPAAGAADGQFVQFPGSPFSLYQPYPPAGDQPEAIAKLVEGVQDGEVFQTLLGVTGSGKTFTMANVIARLGRPA
IIFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEAYVPQRDLFIEKDSAINEHIEQMRLSCTKSLLERRDVVIVA
TVSAIYGIGEPESYHRMIMTLRVGDQLSQRDAIAQLIRMQYQRNEQDFSRGKFRVRGDTIDVFPAEHSELAVRIELFDDE
VESLQLFDPLTGRIQQKIPRFTVYPSSHYVTPRDKVLAAVETIKQELDERLKFFVAEGKLVEAQRLEQRTRFDLEMLSEV
GHCKGIENYTRHLSGSAPGEPPSTLTDYLPPDALMFLDESHQMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFE
EFEQRMRQVVFVSATPADYEKEHSGQVVDQVVRPTGLVDPEVEVRPATHQVDDVLQEIRICTQKNQRVLITTLTKRMAEQ
LTDYLSDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRAERSLIQTIGR
AARNLHGKAILYADRITDSMRKAISETERRRAKQIAYNEARGITPRSIVKQVRDLIDGVYSEKAGQEAQRLREDAARQAE
LEEMSEKDIAREIKRLEKLMLEHARNLEFEQAARVRDQLTRLKDRVFGAHGGDQIPAA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=64.381520119225, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=246, Percent_Identity=27.6422764227642, Blast_Score=76, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 79383; Mature: 79383

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEVTSEPAAGAADGQFVQFPGSPFSLYQPYPPAGDQPEAIAKLVEGVQDGEVFQTLLGV
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCC
TGSGKTFTMANVIARLGRPAIIFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEA
CCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSAINEHIEQMRLSCTKSLLERRDVVIVATVSAIYGIGEPESYHRMIMT
CCCCHHCEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHH
LRVGDQLSQRDAIAQLIRMQYQRNEQDFSRGKFRVRGDTIDVFPAEHSELAVRIELFDDE
HHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCH
VESLQLFDPLTGRIQQKIPRFTVYPSSHYVTPRDKVLAAVETIKQELDERLKFFVAEGKL
HHHHHHHCHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VEAQRLEQRTRFDLEMLSEVGHCKGIENYTRHLSGSAPGEPPSTLTDYLPPDALMFLDES
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEHHHHH
HQMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFEEFEQRMRQVVFVSATPADYE
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCCC
KEHSGQVVDQVVRPTGLVDPEVEVRPATHQVDDVLQEIRICTQKNQRVLITTLTKRMAEQ
HHHCCHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
LTDYLSDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAIL
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNLHGKAILYADRITDSMRKAISETERRRAKQIAYNEA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGITPRSIVKQVRDLIDGVYSEKAGQEAQRLREDAARQAELEEMSEKDIAREIKRLEKLM
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEHARNLEFEQAARVRDQLTRLKDRVFGAHGGDQIPAA
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MHEVTSEPAAGAADGQFVQFPGSPFSLYQPYPPAGDQPEAIAKLVEGVQDGEVFQTLLGV
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHCC
TGSGKTFTMANVIARLGRPAIIFAPNKTLAAQLYSEFREFFPKNAVEYFVSYYDYYQPEA
CCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCC
YVPQRDLFIEKDSAINEHIEQMRLSCTKSLLERRDVVIVATVSAIYGIGEPESYHRMIMT
CCCCHHCEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHCCCCCHHHHHHHHH
LRVGDQLSQRDAIAQLIRMQYQRNEQDFSRGKFRVRGDTIDVFPAEHSELAVRIELFDDE
HHHCCHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCEEEECCCCCCCEEEEEEEECCH
VESLQLFDPLTGRIQQKIPRFTVYPSSHYVTPRDKVLAAVETIKQELDERLKFFVAEGKL
HHHHHHHCHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VEAQRLEQRTRFDLEMLSEVGHCKGIENYTRHLSGSAPGEPPSTLTDYLPPDALMFLDES
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCHHHCCCCCCEEHHHHH
HQMIGQLNAMYNGDRARKTTLVEYGFRLPSALDNRPLKFEEFEQRMRQVVFVSATPADYE
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHEEEEECCCCCCC
KEHSGQVVDQVVRPTGLVDPEVEVRPATHQVDDVLQEIRICTQKNQRVLITTLTKRMAEQ
HHHCCHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHH
LTDYLSDNGVKVRYLHSDIDTVERVEIIRDLRLGAFDVLVGINLLREGLDIPEVSLVAIL
HHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEEEE
DADKEGFLRAERSLIQTIGRAARNLHGKAILYADRITDSMRKAISETERRRAKQIAYNEA
ECCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGITPRSIVKQVRDLIDGVYSEKAGQEAQRLREDAARQAELEEMSEKDIAREIKRLEKLM
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEHARNLEFEQAARVRDQLTRLKDRVFGAHGGDQIPAA
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA