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The map label for this gene is cobB [H]

Identifier: 222110807

GI number: 222110807

Start: 1702938

End: 1703720

Strand: Direct

Name: cobB [H]

Synonym: Dtpsy_1612

Alternate gene names: 222110807

Gene position: 1702938-1703720 (Clockwise)

Preceding gene: 222110806

Following gene: 222110808

Centisome position: 44.85

GC content: 74.2

Gene sequence:

>783_bases
ATGACGGACGATGCCGGAACGTCCGGCCCCTGCACCCCGCTGGACGAGGTGCGGGCGTGGGTGCGCGATGCGCGCCGCAT
CGCGGTGCTGACAGGCGCAGGCATCAGCGCCGAGTCGGGCGTCCCCACGTTCCGGGATGCGCAGACGGGCTATTGGGCGC
AGTTCAACCCCATGGAGATGGCCAGCGAGACCGGCTTCAGGGCCCAGCCCGCGCGGGTGTGGGACTGGTACGCCCACCGC
CGCGGCTTGCTCGCGGGCGTGCAGCCCAACGCGGGCCACCGGGCGCTGGCGGCGTTTGCGCAGCACGGGCGCGGGCGGCT
GACGCTCATCACCCAGAACGTGGACGGCCTGCACCAGCGCGCCGGCAGCCCGGATGTGCTGTGCCTGCATGGTGACCTGA
CGGCCGACCGCTGGCTCGACCGTCCGCGTGCCTGCTGCGATCTGGCCGACGCTGCGCCCGGCCACCCGCCGCGCTGTCCC
ACCTGCGGCAACCTGGTACGCCCTGGCGTGGTCTGGTTCGGCGAGGCCTTGCCGCTGCCGGTGCTGGCCGCGGCGCAGCA
GGCGGCGCAGTCCTGCGAGCTGATGTTGGTGGTGGGCACCGCGGGCGCCGTGTACCCGGCCGCAGGGCTAGCGCACCAGG
CGCGCCATGCCGGTGCGCGCGTGGTGGTGGTCAACACCGCGGCCAGCGAGCTGGACGGTATCGCCCACGCCGTGCTGCGC
GGCCCGGCGGCGCGGCTGTTGCCGTTGCTGCTGGACGGGCCGCCGATGGTTGAGGCGCCATAA

Upstream 100 bases:

>100_bases
TGGACGGGCCCTTGCGCGGCCTGGACGAGGCCGGCTGCCAGGCGCTGGCCGAGCGACTGGTCGCCATGGTCGAGCAGGGC
CTGCTGGCCGAGGCCGCGGC

Downstream 100 bases:

>100_bases
TCGGCAGGTCTTCAGGGCGGGGTGGAATTCCCCACCGGCGGTAGGCGGCGCATGGAGGTTTTCTTGCACCGCGAGCCCGC
GAGCGCCCCGGTTGCCATCA

Product: silent information regulator protein sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MTDDAGTSGPCTPLDEVRAWVRDARRIAVLTGAGISAESGVPTFRDAQTGYWAQFNPMEMASETGFRAQPARVWDWYAHR
RGLLAGVQPNAGHRALAAFAQHGRGRLTLITQNVDGLHQRAGSPDVLCLHGDLTADRWLDRPRACCDLADAAPGHPPRCP
TCGNLVRPGVVWFGEALPLPVLAAAQQAAQSCELMLVVGTAGAVYPAAGLAHQARHAGARVVVVNTAASELDGIAHAVLR
GPAARLLPLLLDGPPMVEAP

Sequences:

>Translated_260_residues
MTDDAGTSGPCTPLDEVRAWVRDARRIAVLTGAGISAESGVPTFRDAQTGYWAQFNPMEMASETGFRAQPARVWDWYAHR
RGLLAGVQPNAGHRALAAFAQHGRGRLTLITQNVDGLHQRAGSPDVLCLHGDLTADRWLDRPRACCDLADAAPGHPPRCP
TCGNLVRPGVVWFGEALPLPVLAAAQQAAQSCELMLVVGTAGAVYPAAGLAHQARHAGARVVVVNTAASELDGIAHAVLR
GPAARLLPLLLDGPPMVEAP
>Mature_259_residues
TDDAGTSGPCTPLDEVRAWVRDARRIAVLTGAGISAESGVPTFRDAQTGYWAQFNPMEMASETGFRAQPARVWDWYAHRR
GLLAGVQPNAGHRALAAFAQHGRGRLTLITQNVDGLHQRAGSPDVLCLHGDLTADRWLDRPRACCDLADAAPGHPPRCPT
CGNLVRPGVVWFGEALPLPVLAAAQQAAQSCELMLVVGTAGAVYPAAGLAHQARHAGARVVVVNTAASELDGIAHAVLRG
PAARLLPLLLDGPPMVEAP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=257, Percent_Identity=37.3540856031128, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI6912664, Length=268, Percent_Identity=36.1940298507463, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI13787215, Length=246, Percent_Identity=37.3983739837398, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI6912662, Length=276, Percent_Identity=26.0869565217391, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI6912660, Length=212, Percent_Identity=30.188679245283, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI7657575, Length=227, Percent_Identity=26.431718061674, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI63054862, Length=204, Percent_Identity=29.9019607843137, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI13775602, Length=230, Percent_Identity=27.3913043478261, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI13775600, Length=230, Percent_Identity=27.3913043478261, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI308199517, Length=229, Percent_Identity=37.5545851528384, Blast_Score=137, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28571445, Length=258, Percent_Identity=27.5193798449612, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648389, Length=200, Percent_Identity=27.5, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17137536, Length=232, Percent_Identity=26.7241379310345, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28571443, Length=199, Percent_Identity=26.1306532663317, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571441, Length=199, Percent_Identity=26.1306532663317, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27383; Mature: 27252

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDAGTSGPCTPLDEVRAWVRDARRIAVLTGAGISAESGVPTFRDAQTGYWAQFNPMEM
CCCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECCHHHH
ASETGFRAQPARVWDWYAHRRGLLAGVQPNAGHRALAAFAQHGRGRLTLITQNVDGLHQR
HHCCCCCCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHH
AGSPDVLCLHGDLTADRWLDRPRACCDLADAAPGHPPRCPTCGNLVRPGVVWFGEALPLP
CCCCCEEEEECCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCEEECCCCCHH
VLAAAQQAAQSCELMLVVGTAGAVYPAAGLAHQARHAGARVVVVNTAASELDGIAHAVLR
HHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHH
GPAARLLPLLLDGPPMVEAP
CCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TDDAGTSGPCTPLDEVRAWVRDARRIAVLTGAGISAESGVPTFRDAQTGYWAQFNPMEM
CCCCCCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCEECCHHHH
ASETGFRAQPARVWDWYAHRRGLLAGVQPNAGHRALAAFAQHGRGRLTLITQNVDGLHQR
HHCCCCCCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHH
AGSPDVLCLHGDLTADRWLDRPRACCDLADAAPGHPPRCPTCGNLVRPGVVWFGEALPLP
CCCCCEEEEECCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCHHCCCCEEECCCCCHH
VLAAAQQAAQSCELMLVVGTAGAVYPAAGLAHQARHAGARVVVVNTAASELDGIAHAVLR
HHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHH
GPAARLLPLLLDGPPMVEAP
CCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]