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The map label for this gene is metC [H]

Identifier: 222110796

GI number: 222110796

Start: 1694413

End: 1695660

Strand: Direct

Name: metC [H]

Synonym: Dtpsy_1601

Alternate gene names: 222110796

Gene position: 1694413-1695660 (Clockwise)

Preceding gene: 222110795

Following gene: 222110797

Centisome position: 44.63

GC content: 68.99

Gene sequence:

>1248_bases
ATGAAGCAGCCCTCCACACCCGACCTGTCCACCCGCCTCATTCACCACGAGTACACACCGCCGCAGGGTTTCCATGCCCC
GCAGCCAGCGGTGCACAAGGCGTCCACCGTCATCTTCCCCAACGTCGCCGCAATGCGCGCGCGCGAGTGGAAGGACAAGA
GCAGCTACACCTACGGGCTGCACGGCACACCCACGACCTACCAGCTGGAAGAGCGCCTGGCCACGCTGGAAGGCGGGCTG
CAGTGTCTGCTGGTGCCCAGCGGATTGGCCGCCATTTCCACCGTATCGCTGGCGCTGCTGCGCCAGGGTGACGAGGTGCT
GATCCCGGACAACGCCTATGGTCCCAACAAGGCACTGGCCGAGGTGGAGCTGCGCCACTACGGCATCCGCCACCGTATCT
ATGACCCCTTGGACCCGGCGGACCTCGCATCCAAGATCACCGACGCCACGCGGCTGGTGTGGCTGGAGGCGCCGGGCTCC
GTAACGTTGGAGTTCCCCGACCTGGTGGAGCAAGTGCGCATCTGCCGCGCACGCGGCGTGGCTACGGTGCTGGACAACAC
TTGGGGCGCGGGCCTGGCTTTCGCACCCTTCGACCTGCTGGGCCATGGTGCGGGTGCCGAGGGCGCGTTGGGCGTGGACG
TATCCGTGCATGCGCTCACCAAGTACCCCAGCGGCGGCGGCGATGTGCTGATGGGCAGCATCACCACGCGCGACGAGGGC
TTGCACCTGCGCATCAAGCTCACGCACATGCGGCTCGGGCTCGGGGTGGGGGCGAACGACGTGGAAGCGGTCTTGCGGGC
GCTGCCCAGCATGGCGCTGCGCTACCACGCGCACGATGCGGCCGCGCGCGACCTGGCGCAGTGGATGGGCTTGCAGCCCG
CGGTGGCACAGGTGCTGCACCCGGCGCTGCCCGGATCGCCGGGCCATGCGCAGTGGAAGGCGCTGTGCGGCGCAGCCAAT
GGTGGGCAGGGCGCTGCCGCCGGCCTGTTCAGCGTGGTCATTGACGCACGCCACAGCCAGGCGCAGGTGGATGCCTTTTG
CGACGGCCTGCGCCTGTTCAAGCTGGGATACAGCTGGGGCGGGCCGATGAGCCTGGTGGTGCCCTACGACCTGCCCAGCA
TGCGCACGGGCGCCACCGCGCATCTGCGGCCCGGCACCGTGGTGCGCTTCTCCGTGGGACTGGAGGCCGTGGACGACCTG
CGTGCCGACCTGGCCCAGGCGATGCACCAGGCCTTTGGAACTGCCTGA

Upstream 100 bases:

>100_bases
GATCGCGCAGGCCGTACCGGGCGTGACCTCGGTGGTCAACAACCTCACCATCTCCAGCGGCGGCTGAGCCTGGGCGGGGG
ACAGGCTCTACCATCGGCGC

Downstream 100 bases:

>100_bases
TGCGTTGGCGGCTGGTGCGGCGATGCTGGTAGTTTCCTTGATGGTGGTCAGGCATTCAGGTGGTTAAGGTGGCAGCAACG
CCACTGCCGCAGCGATGCCG

Product: cys/met metabolism pyridoxal-phosphate-dependent protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MKQPSTPDLSTRLIHHEYTPPQGFHAPQPAVHKASTVIFPNVAAMRAREWKDKSSYTYGLHGTPTTYQLEERLATLEGGL
QCLLVPSGLAAISTVSLALLRQGDEVLIPDNAYGPNKALAEVELRHYGIRHRIYDPLDPADLASKITDATRLVWLEAPGS
VTLEFPDLVEQVRICRARGVATVLDNTWGAGLAFAPFDLLGHGAGAEGALGVDVSVHALTKYPSGGGDVLMGSITTRDEG
LHLRIKLTHMRLGLGVGANDVEAVLRALPSMALRYHAHDAAARDLAQWMGLQPAVAQVLHPALPGSPGHAQWKALCGAAN
GGQGAAAGLFSVVIDARHSQAQVDAFCDGLRLFKLGYSWGGPMSLVVPYDLPSMRTGATAHLRPGTVVRFSVGLEAVDDL
RADLAQAMHQAFGTA

Sequences:

>Translated_415_residues
MKQPSTPDLSTRLIHHEYTPPQGFHAPQPAVHKASTVIFPNVAAMRAREWKDKSSYTYGLHGTPTTYQLEERLATLEGGL
QCLLVPSGLAAISTVSLALLRQGDEVLIPDNAYGPNKALAEVELRHYGIRHRIYDPLDPADLASKITDATRLVWLEAPGS
VTLEFPDLVEQVRICRARGVATVLDNTWGAGLAFAPFDLLGHGAGAEGALGVDVSVHALTKYPSGGGDVLMGSITTRDEG
LHLRIKLTHMRLGLGVGANDVEAVLRALPSMALRYHAHDAAARDLAQWMGLQPAVAQVLHPALPGSPGHAQWKALCGAAN
GGQGAAAGLFSVVIDARHSQAQVDAFCDGLRLFKLGYSWGGPMSLVVPYDLPSMRTGATAHLRPGTVVRFSVGLEAVDDL
RADLAQAMHQAFGTA
>Mature_415_residues
MKQPSTPDLSTRLIHHEYTPPQGFHAPQPAVHKASTVIFPNVAAMRAREWKDKSSYTYGLHGTPTTYQLEERLATLEGGL
QCLLVPSGLAAISTVSLALLRQGDEVLIPDNAYGPNKALAEVELRHYGIRHRIYDPLDPADLASKITDATRLVWLEAPGS
VTLEFPDLVEQVRICRARGVATVLDNTWGAGLAFAPFDLLGHGAGAEGALGVDVSVHALTKYPSGGGDVLMGSITTRDEG
LHLRIKLTHMRLGLGVGANDVEAVLRALPSMALRYHAHDAAARDLAQWMGLQPAVAQVLHPALPGSPGHAQWKALCGAAN
GGQGAAAGLFSVVIDARHSQAQVDAFCDGLRLFKLGYSWGGPMSLVVPYDLPSMRTGATAHLRPGTVVRFSVGLEAVDDL
RADLAQAMHQAFGTA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=411, Percent_Identity=29.4403892944039, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI299473759, Length=410, Percent_Identity=26.0975609756098, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI25453487, Length=410, Percent_Identity=26.0975609756098, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1789383, Length=403, Percent_Identity=32.0099255583127, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1790375, Length=388, Percent_Identity=27.319587628866, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560056, Length=371, Percent_Identity=30.188679245283, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17538055, Length=367, Percent_Identity=29.4277929155313, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI71980708, Length=389, Percent_Identity=25.4498714652956, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321170, Length=334, Percent_Identity=32.9341317365269, Blast_Score=182, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6319307, Length=369, Percent_Identity=27.6422764227642, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=394, Percent_Identity=27.1573604060914, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321254, Length=388, Percent_Identity=24.4845360824742, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922554, Length=368, Percent_Identity=32.8804347826087, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44186; Mature: 44186

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQPSTPDLSTRLIHHEYTPPQGFHAPQPAVHKASTVIFPNVAAMRAREWKDKSSYTYGL
CCCCCCCCHHHHEEEECCCCCCCCCCCCCCHHCCCEEECCCHHHHHHHHCCCCCCEEEEC
HGTPTTYQLEERLATLEGGLQCLLVPSGLAAISTVSLALLRQGDEVLIPDNAYGPNKALA
CCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHH
EVELRHYGIRHRIYDPLDPADLASKITDATRLVWLEAPGSVTLEFPDLVEQVRICRARGV
HHHHHHHCHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCEEEECHHHHHHHHHHHHCCC
ATVLDNTWGAGLAFAPFDLLGHGAGAEGALGVDVSVHALTKYPSGGGDVLMGSITTRDEG
CEECCCCCCCCEEECCHHHHCCCCCCCCCEECEEEEEEEECCCCCCCCEEEEEEEECCCC
LHLRIKLTHMRLGLGVGANDVEAVLRALPSMALRYHAHDAAARDLAQWMGLQPAVAQVLH
EEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PALPGSPGHAQWKALCGAANGGQGAAAGLFSVVIDARHSQAQVDAFCDGLRLFKLGYSWG
HCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCC
GPMSLVVPYDLPSMRTGATAHLRPGTVVRFSVGLEAVDDLRADLAQAMHQAFGTA
CCEEEEEECCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQPSTPDLSTRLIHHEYTPPQGFHAPQPAVHKASTVIFPNVAAMRAREWKDKSSYTYGL
CCCCCCCCHHHHEEEECCCCCCCCCCCCCCHHCCCEEECCCHHHHHHHHCCCCCCEEEEC
HGTPTTYQLEERLATLEGGLQCLLVPSGLAAISTVSLALLRQGDEVLIPDNAYGPNKALA
CCCCCHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHH
EVELRHYGIRHRIYDPLDPADLASKITDATRLVWLEAPGSVTLEFPDLVEQVRICRARGV
HHHHHHHCHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCEEEECHHHHHHHHHHHHCCC
ATVLDNTWGAGLAFAPFDLLGHGAGAEGALGVDVSVHALTKYPSGGGDVLMGSITTRDEG
CEECCCCCCCCEEECCHHHHCCCCCCCCCEECEEEEEEEECCCCCCCCEEEEEEEECCCC
LHLRIKLTHMRLGLGVGANDVEAVLRALPSMALRYHAHDAAARDLAQWMGLQPAVAQVLH
EEEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
PALPGSPGHAQWKALCGAANGGQGAAAGLFSVVIDARHSQAQVDAFCDGLRLFKLGYSWG
HCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCC
GPMSLVVPYDLPSMRTGATAHLRPGTVVRFSVGLEAVDDLRADLAQAMHQAFGTA
CCEEEEEECCCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]