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The map label for this gene is bla [H]

Identifier: 222110726

GI number: 222110726

Start: 1611992

End: 1612882

Strand: Direct

Name: bla [H]

Synonym: Dtpsy_1529

Alternate gene names: 222110726

Gene position: 1611992-1612882 (Clockwise)

Preceding gene: 222110720

Following gene: 222110729

Centisome position: 42.46

GC content: 72.73

Gene sequence:

>891_bases
ATGGACCGAAGAAGCTGGTTGCTGGGTGCCGCGCTGCTGCCCCTGGTAGGTTGTGCCCAAACCGGGGTCGAGAAAAACAG
GGCTCAGGCCACGCAGCAGTTGCAGGCCGCGCTGGGCCGGGTGGAGCAGCGCGTGGGCGGGCGGCTGGGCGTGGCCGTGC
TGGACACGGGCTCGGACGCCCTTGCGACCTACCGCGGCGACGAGCGCTTTGCGCTGTGCAGCACCTTCAAGCTGCTGCTG
GCCGGCCAGGTGCTGCAGCGTGCGGACCAGGGGCTGGAGCGGCTGGATGCACGCGTGCGTTATGGCCGGCACGATCTGGT
GGAATATTCCCCGCGCACCGAGCCGCACGCGGGCGGCGCCGGCATGACCGTGGCCGAGCTGTGCGAGGCCACCATGGTGC
TCAGCGACAACAGCGCCGCCAACCTGCTGCTGCGCCGCCAGGGCGGGCCCGCCGGCCTGACGGCCTGGCTGCGCACGCTG
GGCGATGCGCACACACGGCTGGACCGCATCGAGCCCGCGCTCAACGATGTGCCTGCGGGCGAACTGCGCGACACCACCAC
GCCGCGCGCCATGGTGCACACCGTGCAGAAACTGGTGCTGGGCGATGCGCTGTCTGGCGAGGCACGGGCGCGGTTGCAGG
GCTGGTTGCTGGGCAACCTCACGGGAGACAAGCGGCTGCGCGCGGGCATGCCGGCGGGCTGGCGCATCGGCGAGAAGACC
GGCACCGCCAACGGCACCAGCAACGACGTGGGCGTGGTGTGGCCGGAGGGTGGGGCGCCGGCCGTGGTGGCGTGCTATCT
CACGCAGTGCCCCGCCGCGCCCGCGCAGCGCGACGCGGCGATTGCCGAGGTGGGGTCGCTGGCGGCCGCATGGCTGGCGG
CCGCAGGGTGA

Upstream 100 bases:

>100_bases
TGAAGTTTTTCTAAGGGCTGGTGGCGATTATTGTCGATGGTCAAGCCACTTGTGCCGCCTTATCGTGGCGCCTTCTTTCC
ACACATGACGAGGTAAAACA

Downstream 100 bases:

>100_bases
AGCTCAGAGTTTCTTGACCAGCACCTGGCTCTTGCGGTCCCAGTTGTACTTGCGCTTGCGTGCGTCGGGCAGCCAGTCGG
GGTCCACGGGCGAAAAGCCC

Product: beta-lactamase

Products: NA

Alternate protein names: Carbepenem-hydrolyzing beta-lactamase KPC-2 [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MDRRSWLLGAALLPLVGCAQTGVEKNRAQATQQLQAALGRVEQRVGGRLGVAVLDTGSDALATYRGDERFALCSTFKLLL
AGQVLQRADQGLERLDARVRYGRHDLVEYSPRTEPHAGGAGMTVAELCEATMVLSDNSAANLLLRRQGGPAGLTAWLRTL
GDAHTRLDRIEPALNDVPAGELRDTTTPRAMVHTVQKLVLGDALSGEARARLQGWLLGNLTGDKRLRAGMPAGWRIGEKT
GTANGTSNDVGVVWPEGGAPAVVACYLTQCPAAPAQRDAAIAEVGSLAAAWLAAAG

Sequences:

>Translated_296_residues
MDRRSWLLGAALLPLVGCAQTGVEKNRAQATQQLQAALGRVEQRVGGRLGVAVLDTGSDALATYRGDERFALCSTFKLLL
AGQVLQRADQGLERLDARVRYGRHDLVEYSPRTEPHAGGAGMTVAELCEATMVLSDNSAANLLLRRQGGPAGLTAWLRTL
GDAHTRLDRIEPALNDVPAGELRDTTTPRAMVHTVQKLVLGDALSGEARARLQGWLLGNLTGDKRLRAGMPAGWRIGEKT
GTANGTSNDVGVVWPEGGAPAVVACYLTQCPAAPAQRDAAIAEVGSLAAAWLAAAG
>Mature_296_residues
MDRRSWLLGAALLPLVGCAQTGVEKNRAQATQQLQAALGRVEQRVGGRLGVAVLDTGSDALATYRGDERFALCSTFKLLL
AGQVLQRADQGLERLDARVRYGRHDLVEYSPRTEPHAGGAGMTVAELCEATMVLSDNSAANLLLRRQGGPAGLTAWLRTL
GDAHTRLDRIEPALNDVPAGELRDTTTPRAMVHTVQKLVLGDALSGEARARLQGWLLGNLTGDKRLRAGMPAGWRIGEKT
GTANGTSNDVGVVWPEGGAPAVVACYLTQCPAAPAQRDAAIAEVGSLAAAWLAAAG

Specific function: Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency [H]

COG id: COG2367

COG function: function code V; Beta-lactamase class A

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-A beta-lactamase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466
- InterPro:   IPR000871 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 31159; Mature: 31159

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00141 ASP_PROTEASE ; PS00146 BETA_LACTAMASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRRSWLLGAALLPLVGCAQTGVEKNRAQATQQLQAALGRVEQRVGGRLGVAVLDTGSDA
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCH
LATYRGDERFALCSTFKLLLAGQVLQRADQGLERLDARVRYGRHDLVEYSPRTEPHAGGA
HEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCC
GMTVAELCEATMVLSDNSAANLLLRRQGGPAGLTAWLRTLGDAHTRLDRIEPALNDVPAG
CCHHHHHHHHHHEECCCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELRDTTTPRAMVHTVQKLVLGDALSGEARARLQGWLLGNLTGDKRLRAGMPAGWRIGEKT
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCHHHHCCCCCCCCCCCCC
GTANGTSNDVGVVWPEGGAPAVVACYLTQCPAAPAQRDAAIAEVGSLAAAWLAAAG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDRRSWLLGAALLPLVGCAQTGVEKNRAQATQQLQAALGRVEQRVGGRLGVAVLDTGSDA
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCH
LATYRGDERFALCSTFKLLLAGQVLQRADQGLERLDARVRYGRHDLVEYSPRTEPHAGGA
HEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCC
GMTVAELCEATMVLSDNSAANLLLRRQGGPAGLTAWLRTLGDAHTRLDRIEPALNDVPAG
CCHHHHHHHHHHEECCCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ELRDTTTPRAMVHTVQKLVLGDALSGEARARLQGWLLGNLTGDKRLRAGMPAGWRIGEKT
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHEEEECCCCCHHHHCCCCCCCCCCCCC
GTANGTSNDVGVVWPEGGAPAVVACYLTQCPAAPAQRDAAIAEVGSLAAAWLAAAG
CCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA