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The map label for this gene is arsA [H]

Identifier: 222110547

GI number: 222110547

Start: 1411271

End: 1413031

Strand: Direct

Name: arsA [H]

Synonym: Dtpsy_1347

Alternate gene names: 222110547

Gene position: 1411271-1413031 (Clockwise)

Preceding gene: 222110541

Following gene: 222110550

Centisome position: 37.17

GC content: 64.79

Gene sequence:

>1761_bases
ATGCCATCTCACTTCACCCTTCTGGACGCGCCCACCCGGTACCTGTTCTTCACCGGCAAGGGTGGTGTCGGCAAGACCTC
GGTATCCACAGCGGTTTCCATCGCCTTGGCAGACGCGGGTAAGAAGGTTCTATTGGTCAGTACCGACGCGGCGTCGAACC
TCGATGAAATGCTCGGCATTGCGCTGCGCAACCATCCGGTTCCTGTGCCAGGGGTTCCGGGCCTGATGGTCCTGAACATC
GATCCGGAAGCCGCGTCGCAGAACTACCGTGCCCGTGTCATTGAACAAATGGGCACGCAGGCTACGGCTGAGGAGGTGGA
CCTCGTGCGCGAGCAACTCTCGGGTGCCTGTACCACCGAGATCGCCACCTTCGATGAGTTCTCTCAACTTCTGTCGGAGG
GAGGGCGGGGTTTCGACCATGTCGTGTTCGATACCGCCCCCACGGGCCATACCTTGAGGCTTCTCAGCCTGCCCAAGGCA
TGGAGCGGGTTCCTCAAGGGCAATGACCGCGGAGCATCCTGTCTGGGGCCGCATTCGGGGTTGAAGATGCAGGAGCAGCT
TTTCAACCGGGCGCTGGCATCCCTGAACGACGCTTCGCTCACCACCATTGTTCTGGTGGCGCGGCCTGAGGCGGGAGCGC
TCAACGAAGCCGCCAGGTCTTCAGACGAACTGCGTGAGTTGGGCCTTTCCCACCAGCGCCTGGTGATCAACGCGGTTTTC
AAGGCGCAAGACCCTCGCGATGCCGTCGCCCTGGCCATCGAGGCTCTGGGACAGGAGGCCATGCGGGAGATGCCGCAGGC
GCTGAAACGTCTGGCGGCCGACGTGATTCCCATGCGGCCCGTCGATTCCGTGGGGCTGCAGGCGCTGCGGGCGCTGCTGT
CGCCATCACCGACCGAGGTGCCTGTGGCCGCCCTGGAAGCACCCGACTTCGCGCACCAGAAACTGTCCGCGCTGGTGGCG
GAGCTGGCGCGGGGCGAGCGTGGATTGATCATGGTGATGGGCAAGGGTGGCGTGGGCAAGACCACCATTGCCGCAGCGAT
CGCCCTGGGACTGGTCAAGCTCGGCAAGTCCGTGCACCTGAGCACCACGGACCCCGCCGCCCACCTGGCGGTGACGCTCG
ACGGCGAGATCCCGGGCCTGACCGTCGGGCGCATTGACCCCAAAGCAGAGACCCAGAAATACGTGGACAAGGTCGTTGCC
GCCAAGTCGGCCGGCATGACCCCGGCGGAGAAGGACCTGTTGATGGAAGATCTGCGTTCTCCATGCACGGAGGAAGTGGC
GGTCTTCCACGCGTTCTCGCATGTGGTGTCTCAGGCCCGCAGTGCGTTCGTGGTGCTCGACACCGCGCCCACGGGCCACT
CGCTGCTGCTCATGGATGCCACGGGCGCCTACCACCGCCAGATGGTGCGGGAGTTTGAAGGCAAGGCGTCGGGGCGCATC
ACCACGCCCCTGATGCGGCTGCAGGACCCTGACTACACCAAGATCATTCTGGTGACGTTGCCCGAGGCCACTCCGGTGTC
GCAGGCCGCCGCGCTGAAGGAGGACCTGCAGCGGGCCCGGATCGGCACCTTCGCCTGGGTGGTCAACAAGTCGCTGTTGG
CCAGCAACACCCGCGATCCCCTTCTTCAGGCCCGGTTGAACAGCGAGAGGCGGCAGATGGAGCGGGTTCAAGCATTGGCG
CAAGGCCGGTTCTATCTGATTCCCTGGGCGGCGACCCCGCCCGTGGGCGCAAAGGCGCTGGGGGCTCTGCTGGAGCCTTG
A

Upstream 100 bases:

>100_bases
AACGATATTGGAAGTGTTGTAAATTTCTTCGGTGCAACATTGCGCATGCCTGAGGCAACCCCTTATCCCCGCCCATTCGG
TGCATTGACCACGAACGCTT

Downstream 100 bases:

>100_bases
CCTGCAGAGGCGGCTCTTCCTGGCATGCAAGAGCCTCGCGGGCCGCGGTACACGTTCAGCCCCGGTGCAGCGTCAGGAGG
GGCTCCCGCCAGGCTGCGCC

Product: arsenite-activated ATPase ArsA

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MPSHFTLLDAPTRYLFFTGKGGVGKTSVSTAVSIALADAGKKVLLVSTDAASNLDEMLGIALRNHPVPVPGVPGLMVLNI
DPEAASQNYRARVIEQMGTQATAEEVDLVREQLSGACTTEIATFDEFSQLLSEGGRGFDHVVFDTAPTGHTLRLLSLPKA
WSGFLKGNDRGASCLGPHSGLKMQEQLFNRALASLNDASLTTIVLVARPEAGALNEAARSSDELRELGLSHQRLVINAVF
KAQDPRDAVALAIEALGQEAMREMPQALKRLAADVIPMRPVDSVGLQALRALLSPSPTEVPVAALEAPDFAHQKLSALVA
ELARGERGLIMVMGKGGVGKTTIAAAIALGLVKLGKSVHLSTTDPAAHLAVTLDGEIPGLTVGRIDPKAETQKYVDKVVA
AKSAGMTPAEKDLLMEDLRSPCTEEVAVFHAFSHVVSQARSAFVVLDTAPTGHSLLLMDATGAYHRQMVREFEGKASGRI
TTPLMRLQDPDYTKIILVTLPEATPVSQAAALKEDLQRARIGTFAWVVNKSLLASNTRDPLLQARLNSERRQMERVQALA
QGRFYLIPWAATPPVGAKALGALLEP

Sequences:

>Translated_586_residues
MPSHFTLLDAPTRYLFFTGKGGVGKTSVSTAVSIALADAGKKVLLVSTDAASNLDEMLGIALRNHPVPVPGVPGLMVLNI
DPEAASQNYRARVIEQMGTQATAEEVDLVREQLSGACTTEIATFDEFSQLLSEGGRGFDHVVFDTAPTGHTLRLLSLPKA
WSGFLKGNDRGASCLGPHSGLKMQEQLFNRALASLNDASLTTIVLVARPEAGALNEAARSSDELRELGLSHQRLVINAVF
KAQDPRDAVALAIEALGQEAMREMPQALKRLAADVIPMRPVDSVGLQALRALLSPSPTEVPVAALEAPDFAHQKLSALVA
ELARGERGLIMVMGKGGVGKTTIAAAIALGLVKLGKSVHLSTTDPAAHLAVTLDGEIPGLTVGRIDPKAETQKYVDKVVA
AKSAGMTPAEKDLLMEDLRSPCTEEVAVFHAFSHVVSQARSAFVVLDTAPTGHSLLLMDATGAYHRQMVREFEGKASGRI
TTPLMRLQDPDYTKIILVTLPEATPVSQAAALKEDLQRARIGTFAWVVNKSLLASNTRDPLLQARLNSERRQMERVQALA
QGRFYLIPWAATPPVGAKALGALLEP
>Mature_585_residues
PSHFTLLDAPTRYLFFTGKGGVGKTSVSTAVSIALADAGKKVLLVSTDAASNLDEMLGIALRNHPVPVPGVPGLMVLNID
PEAASQNYRARVIEQMGTQATAEEVDLVREQLSGACTTEIATFDEFSQLLSEGGRGFDHVVFDTAPTGHTLRLLSLPKAW
SGFLKGNDRGASCLGPHSGLKMQEQLFNRALASLNDASLTTIVLVARPEAGALNEAARSSDELRELGLSHQRLVINAVFK
AQDPRDAVALAIEALGQEAMREMPQALKRLAADVIPMRPVDSVGLQALRALLSPSPTEVPVAALEAPDFAHQKLSALVAE
LARGERGLIMVMGKGGVGKTTIAAAIALGLVKLGKSVHLSTTDPAAHLAVTLDGEIPGLTVGRIDPKAETQKYVDKVVAA
KSAGMTPAEKDLLMEDLRSPCTEEVAVFHAFSHVVSQARSAFVVLDTAPTGHSLLLMDATGAYHRQMVREFEGKASGRIT
TPLMRLQDPDYTKIILVTLPEATPVSQAAALKEDLQRARIGTFAWVVNKSLLASNTRDPLLQARLNSERRQMERVQALAQ
GRFYLIPWAATPPVGAKALGALLEP

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17557003, Length=256, Percent_Identity=28.515625, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320103, Length=250, Percent_Identity=30, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24586297, Length=263, Percent_Identity=26.9961977186312, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 62450; Mature: 62318

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSHFTLLDAPTRYLFFTGKGGVGKTSVSTAVSIALADAGKKVLLVSTDAASNLDEMLGI
CCCCEEEEECCCEEEEEECCCCCCCCHHHHHHEEEEECCCCEEEEEECCCCCCHHHHHHH
ALRNHPVPVPGVPGLMVLNIDPEAASQNYRARVIEQMGTQATAEEVDLVREQLSGACTTE
HHHCCCCCCCCCCCEEEEEECHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
IATFDEFSQLLSEGGRGFDHVVFDTAPTGHTLRLLSLPKAWSGFLKGNDRGASCLGPHSG
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCC
LKMQEQLFNRALASLNDASLTTIVLVARPEAGALNEAARSSDELRELGLSHQRLVINAVF
CHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHCCHHHHHHHCCCCHHHHEEHHH
KAQDPRDAVALAIEALGQEAMREMPQALKRLAADVIPMRPVDSVGLQALRALLSPSPTEV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
PVAALEAPDFAHQKLSALVAELARGERGLIMVMGKGGVGKTTIAAAIALGLVKLGKSVHL
CEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEE
STTDPAAHLAVTLDGEIPGLTVGRIDPKAETQKYVDKVVAAKSAGMTPAEKDLLMEDLRS
ECCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PCTEEVAVFHAFSHVVSQARSAFVVLDTAPTGHSLLLMDATGAYHRQMVREFEGKASGRI
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCE
TTPLMRLQDPDYTKIILVTLPEATPVSQAAALKEDLQRARIGTFAWVVNKSLLASNTRDP
ECCHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LLQARLNSERRQMERVQALAQGRFYLIPWAATPPVGAKALGALLEP
HHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
PSHFTLLDAPTRYLFFTGKGGVGKTSVSTAVSIALADAGKKVLLVSTDAASNLDEMLGI
CCCEEEEECCCEEEEEECCCCCCCCHHHHHHEEEEECCCCEEEEEECCCCCCHHHHHHH
ALRNHPVPVPGVPGLMVLNIDPEAASQNYRARVIEQMGTQATAEEVDLVREQLSGACTTE
HHHCCCCCCCCCCCEEEEEECHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHH
IATFDEFSQLLSEGGRGFDHVVFDTAPTGHTLRLLSLPKAWSGFLKGNDRGASCLGPHSG
HHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCC
LKMQEQLFNRALASLNDASLTTIVLVARPEAGALNEAARSSDELRELGLSHQRLVINAVF
CHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHCCHHHHHHHCCCCHHHHEEHHH
KAQDPRDAVALAIEALGQEAMREMPQALKRLAADVIPMRPVDSVGLQALRALLSPSPTEV
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
PVAALEAPDFAHQKLSALVAELARGERGLIMVMGKGGVGKTTIAAAIALGLVKLGKSVHL
CEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEE
STTDPAAHLAVTLDGEIPGLTVGRIDPKAETQKYVDKVVAAKSAGMTPAEKDLLMEDLRS
ECCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PCTEEVAVFHAFSHVVSQARSAFVVLDTAPTGHSLLLMDATGAYHRQMVREFEGKASGRI
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCE
TTPLMRLQDPDYTKIILVTLPEATPVSQAAALKEDLQRARIGTFAWVVNKSLLASNTRDP
ECCHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
LLQARLNSERRQMERVQALAQGRFYLIPWAATPPVGAKALGALLEP
HHHHHHCHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9464374 [H]