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The map label for this gene is fabG [C]

Identifier: 222110538

GI number: 222110538

Start: 1401883

End: 1402794

Strand: Direct

Name: fabG [C]

Synonym: Dtpsy_1338

Alternate gene names: 222110538

Gene position: 1401883-1402794 (Clockwise)

Preceding gene: 222110537

Following gene: 222110539

Centisome position: 36.92

GC content: 68.97

Gene sequence:

>912_bases
ATGTCCCTTGATTTCCACGGCCGTGTGGCCATCGTGACGGGTGCGGGTGGCGGCCTGGGCCGTCAGCATGCTTTGGCGCT
GGCAGCGCGTGGCGCCAAGGTGCTGGTCAATGATCTTGGCGGTGCCGTGGACGGTAGCGGCGGCTCGGTGTCCGCCGCGC
AGGCCGTGGTGGACGAGATCCGCGCCGCAGGCGGCGAGGCGCTGGCCAACGGTGCGTCGGTGACCGATTTCGCGGCCGTG
CAGGCCATGGTGCAGCAGGCCATGGACGCGTGGGGTCGCGTGGACATCCTGGTGAACAACGCCGGCATCCTGCGCGACAA
GTCGTTTGCCAAGATGGACATGGCGGACTTCGCCCTCGTGGTCCAGGTCCACCTCATGGGCGCGGCCCATTGCTGCAAGG
CGGTGTGGCCGCACATGCAGGCGCAGAACTATGGGCGCATCGTGATGACGACGTCCTCCACGGGCCTGTACGGCAACTTC
GGCCAGGCCAACTACGGCGCGGCCAAGCTGGCACAGGTGGGGTTGATGCAGACGCTGGCGATCGAAGGGGCCAAGTACGG
CATCCATGTGAACGCCTTGGCACCCACGGCCGCCACCCGCATGACCGAGGGCCTGATGCCCGAGGACGTGCTGGCTGCCC
TCCAGCCCGAGGCGGTGGTGCCCGCCATGCTGGTGTTGGCGCATGAGAGCGCGCCCACGCGCACCATTCTGTGTGCAGGC
GCGGGCACATTCGAGGCCGCGCACATTACGCTCACCCAGGGCATCCACCTGGGACAAGGTGCCGATGTGCCGGAGCAACT
GGCCGCGCGCCTGGCCGAGGTGACGGCCCGCGGAGCGGGTGAGCAGGTACCGCAAAGCGGCGCCGCACAGGGGACGAACG
AGGTGGCGCAGGCCCTGGCTGCGCACCGCTGA

Upstream 100 bases:

>100_bases
TCATCGGCCGGGGCGATTTCTTTTCGCTGCGCGTGTGCCCGGCCACCGGTGGCCGCGGGCCTGCGTGTCTGGTGGCAATC
CTTCGTTCAAAGACTTCAAC

Downstream 100 bases:

>100_bases
CACGGCCTGTCCGGGGCGGTGCTGCCCCGCTGCTACCGTACCGAGAGCGACCGTGCAGAGGCCGGCGGCAGTTCCCCGGT
GTCAGGCTGGCGCTTGATGT

Product: short-chain dehydrogenase/reductase sdr

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSLDFHGRVAIVTGAGGGLGRQHALALAARGAKVLVNDLGGAVDGSGGSVSAAQAVVDEIRAAGGEALANGASVTDFAAV
QAMVQQAMDAWGRVDILVNNAGILRDKSFAKMDMADFALVVQVHLMGAAHCCKAVWPHMQAQNYGRIVMTTSSTGLYGNF
GQANYGAAKLAQVGLMQTLAIEGAKYGIHVNALAPTAATRMTEGLMPEDVLAALQPEAVVPAMLVLAHESAPTRTILCAG
AGTFEAAHITLTQGIHLGQGADVPEQLAARLAEVTARGAGEQVPQSGAAQGTNEVAQALAAHR

Sequences:

>Translated_303_residues
MSLDFHGRVAIVTGAGGGLGRQHALALAARGAKVLVNDLGGAVDGSGGSVSAAQAVVDEIRAAGGEALANGASVTDFAAV
QAMVQQAMDAWGRVDILVNNAGILRDKSFAKMDMADFALVVQVHLMGAAHCCKAVWPHMQAQNYGRIVMTTSSTGLYGNF
GQANYGAAKLAQVGLMQTLAIEGAKYGIHVNALAPTAATRMTEGLMPEDVLAALQPEAVVPAMLVLAHESAPTRTILCAG
AGTFEAAHITLTQGIHLGQGADVPEQLAARLAEVTARGAGEQVPQSGAAQGTNEVAQALAAHR
>Mature_302_residues
SLDFHGRVAIVTGAGGGLGRQHALALAARGAKVLVNDLGGAVDGSGGSVSAAQAVVDEIRAAGGEALANGASVTDFAAVQ
AMVQQAMDAWGRVDILVNNAGILRDKSFAKMDMADFALVVQVHLMGAAHCCKAVWPHMQAQNYGRIVMTTSSTGLYGNFG
QANYGAAKLAQVGLMQTLAIEGAKYGIHVNALAPTAATRMTEGLMPEDVLAALQPEAVVPAMLVLAHESAPTRTILCAGA
GTFEAAHITLTQGIHLGQGADVPEQLAARLAEVTARGAGEQVPQSGAAQGTNEVAQALAAHR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4504505, Length=229, Percent_Identity=55.4585152838428, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI40254992, Length=204, Percent_Identity=33.8235294117647, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI15277342, Length=246, Percent_Identity=30.4878048780488, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4503817, Length=240, Percent_Identity=24.1666666666667, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI40807363, Length=235, Percent_Identity=30.6382978723404, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI7657478, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4758504, Length=231, Percent_Identity=30.7359307359307, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI31542939, Length=284, Percent_Identity=26.4084507042254, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI157739938, Length=191, Percent_Identity=23.5602094240838, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=37.2549019607843, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI87082100, Length=278, Percent_Identity=33.0935251798561, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1787905, Length=196, Percent_Identity=34.6938775510204, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789057, Length=206, Percent_Identity=33.495145631068, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1789208, Length=210, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790717, Length=208, Percent_Identity=27.4038461538462, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082160, Length=210, Percent_Identity=30, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=28.968253968254, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786812, Length=208, Percent_Identity=29.8076923076923, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367175, Length=193, Percent_Identity=33.6787564766839, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17568967, Length=245, Percent_Identity=53.0612244897959, Blast_Score=256, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI25147288, Length=217, Percent_Identity=33.1797235023041, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=29.7435897435897, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=253, Percent_Identity=29.2490118577075, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=234, Percent_Identity=31.6239316239316, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71982365, Length=198, Percent_Identity=30.8080808080808, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=27.6923076923077, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=226, Percent_Identity=27.8761061946903, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=227, Percent_Identity=27.7533039647577, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562910, Length=199, Percent_Identity=28.1407035175879, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=200, Percent_Identity=30, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=225, Percent_Identity=34.2222222222222, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=190, Percent_Identity=28.4210526315789, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=204, Percent_Identity=26.9607843137255, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=210, Percent_Identity=30, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=277, Percent_Identity=49.4584837545126, Blast_Score=264, Evalue=1e-71,
Organism=Drosophila melanogaster, GI18859837, Length=264, Percent_Identity=50.7575757575758, Blast_Score=260, Evalue=8e-70,
Organism=Drosophila melanogaster, GI23397609, Length=193, Percent_Identity=32.1243523316062, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639444, Length=207, Percent_Identity=34.2995169082126, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=31.0880829015544, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357041, Length=192, Percent_Identity=30.7291666666667, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640492, Length=179, Percent_Identity=27.9329608938547, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281364892, Length=179, Percent_Identity=29.0502793296089, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581726, Length=221, Percent_Identity=28.5067873303167, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=224, Percent_Identity=32.1428571428571, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=192, Percent_Identity=31.7708333333333, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357673, Length=273, Percent_Identity=27.8388278388278, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356301, Length=191, Percent_Identity=26.7015706806283, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355631, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30835; Mature: 30703

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDFHGRVAIVTGAGGGLGRQHALALAARGAKVLVNDLGGAVDGSGGSVSAAQAVVDEI
CCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEHHHCCCCCCCCCCCHHHHHHHHHHH
RAAGGEALANGASVTDFAAVQAMVQQAMDAWGRVDILVNNAGILRDKSFAKMDMADFALV
HHCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHH
VQVHLMGAAHCCKAVWPHMQAQNYGRIVMTTSSTGLYGNFGQANYGAAKLAQVGLMQTLA
HHHHHHHHHHHHHHHCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
IEGAKYGIHVNALAPTAATRMTEGLMPEDVLAALQPEAVVPAMLVLAHESAPTRTILCAG
HCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEC
AGTFEAAHITLTQGIHLGQGADVPEQLAARLAEVTARGAGEQVPQSGAAQGTNEVAQALA
CCCCCEEEEEEECCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
AHR
CCC
>Mature Secondary Structure 
SLDFHGRVAIVTGAGGGLGRQHALALAARGAKVLVNDLGGAVDGSGGSVSAAQAVVDEI
CCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEHHHCCCCCCCCCCCHHHHHHHHHHH
RAAGGEALANGASVTDFAAVQAMVQQAMDAWGRVDILVNNAGILRDKSFAKMDMADFALV
HHCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHH
VQVHLMGAAHCCKAVWPHMQAQNYGRIVMTTSSTGLYGNFGQANYGAAKLAQVGLMQTLA
HHHHHHHHHHHHHHHCCCHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHH
IEGAKYGIHVNALAPTAATRMTEGLMPEDVLAALQPEAVVPAMLVLAHESAPTRTILCAG
HCCCEEEEEEEEECCHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEC
AGTFEAAHITLTQGIHLGQGADVPEQLAARLAEVTARGAGEQVPQSGAAQGTNEVAQALA
CCCCCEEEEEEECCEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHH
AHR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]