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The map label for this gene is lpxD

Identifier: 222110436

GI number: 222110436

Start: 1296035

End: 1297015

Strand: Direct

Name: lpxD

Synonym: Dtpsy_1233

Alternate gene names: 222110436

Gene position: 1296035-1297015 (Clockwise)

Preceding gene: 222110435

Following gene: 222110437

Centisome position: 34.14

GC content: 65.34

Gene sequence:

>981_bases
GTGAGCTTGCGACTCGGGCAGATCGTCGATGCACTTGGGGGCAGCCTGGAAGGAGGGGAGAGGGATACCGAAATCCTCCG
CATCGCCCCGCTGGAATCCTCCGGCCCGGGTGACCTGTCCTTCCTGAGCAATCCGCGCTACCAGTCACAACTGGCCGCCT
CCCAGGCGGCCTGTGTCATTGTGGCACCCGCGATGCGCAATGCAGCCTTGGAGCGCGGCGCTTGCATCGTTGTGGAGCAG
CCCTACACGTACTTTGCACACGTGACGCAGCTGTGGGTGCGCGCGCATGGCCAAGGTGCGCCTGCGGGCATCCACCCCAG
CGCCGTAGTCGATCCGCAAGCCCGGGTGGCCCCGACAGCCTCGATCGGTCCCCTGTGCGTGGTCGAGCGCGGCGCAGTGA
TTGGAGCGCACACGGTGCTCAAGTCGCGGGTGACGGTCGGCGAGCGTTGCACGGTTGGCGAGCGCTGCATCCTGCACCCT
GGCGTGGTCATCGGGGCCGACGGCTTCGGCTTTGCGCAGCAGCGCGGCGAATGGATCAAGATCGAGCAACTGGGCGCGGT
GCGCATCGGCAACGATGTGGAGATTGGTGCGAACACCTGCATCGACCGCGGAGCGCTCGACGACACGGTCATCGAAGACG
GCGTCAAGCTCGACAACCTGATCCAGATCGCTCACAACGTGCACATCGGCCGCCACACCGCCATGGCGGGCTGTTCCGCG
GTGGCGGGCAGCACCCGCATCGGCGCGCACTGCACGATTGCAGGGGCCGCGTCCATCGTGGGGCACTTGCAGTTGGCGGA
CAATGTGCACATCTCCACCAACACGGTGGTGACGCACTCGATCACGCAACCGGGGCAGTACACCGGGGTGTTTCCCATGG
ACGACAATGCGAAGTGGGAAAAGAACGCGGCCACGCTGCGGCAGCTGTACCGGCTGCGTGAACGCATCAAGGCTCTCGAA
CAAACACGAAAAGACGGCTAG

Upstream 100 bases:

>100_bases
CGTCTACATCAATCCCAAGCACGACATCACCGACAAGGTGATCAAGGCGATGAACGCTGCCAACGGCGGCAAGTAAAGCA
CCGGCACGGGGCAGTAGCGC

Downstream 100 bases:

>100_bases
GCCGCTCACAGAAAAATGATGGATATCCACCAAATTCTCAAACTCCTGCCCCACCGCTATCCGTTCCTGCTGGTGGATCG
GGTGAATGAGCTCGAACGCG

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSLRLGQIVDALGGSLEGGERDTEILRIAPLESSGPGDLSFLSNPRYQSQLAASQAACVIVAPAMRNAALERGACIVVEQ
PYTYFAHVTQLWVRAHGQGAPAGIHPSAVVDPQARVAPTASIGPLCVVERGAVIGAHTVLKSRVTVGERCTVGERCILHP
GVVIGADGFGFAQQRGEWIKIEQLGAVRIGNDVEIGANTCIDRGALDDTVIEDGVKLDNLIQIAHNVHIGRHTAMAGCSA
VAGSTRIGAHCTIAGAASIVGHLQLADNVHISTNTVVTHSITQPGQYTGVFPMDDNAKWEKNAATLRQLYRLRERIKALE
QTRKDG

Sequences:

>Translated_326_residues
MSLRLGQIVDALGGSLEGGERDTEILRIAPLESSGPGDLSFLSNPRYQSQLAASQAACVIVAPAMRNAALERGACIVVEQ
PYTYFAHVTQLWVRAHGQGAPAGIHPSAVVDPQARVAPTASIGPLCVVERGAVIGAHTVLKSRVTVGERCTVGERCILHP
GVVIGADGFGFAQQRGEWIKIEQLGAVRIGNDVEIGANTCIDRGALDDTVIEDGVKLDNLIQIAHNVHIGRHTAMAGCSA
VAGSTRIGAHCTIAGAASIVGHLQLADNVHISTNTVVTHSITQPGQYTGVFPMDDNAKWEKNAATLRQLYRLRERIKALE
QTRKDG
>Mature_325_residues
SLRLGQIVDALGGSLEGGERDTEILRIAPLESSGPGDLSFLSNPRYQSQLAASQAACVIVAPAMRNAALERGACIVVEQP
YTYFAHVTQLWVRAHGQGAPAGIHPSAVVDPQARVAPTASIGPLCVVERGAVIGAHTVLKSRVTVGERCTVGERCILHPG
VVIGADGFGFAQQRGEWIKIEQLGAVRIGNDVEIGANTCIDRGALDDTVIEDGVKLDNLIQIAHNVHIGRHTAMAGCSAV
AGSTRIGAHCTIAGAASIVGHLQLADNVHISTNTVVTHSITQPGQYTGVFPMDDNAKWEKNAATLRQLYRLRERIKALEQ
TRKDG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=339, Percent_Identity=38.3480825958702, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_ACIET (B9MGM7)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552700.1
- ProteinModelPortal:   B9MGM7
- SMR:   B9MGM7
- GeneID:   7383135
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_1233
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 34505; Mature: 34374

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRLGQIVDALGGSLEGGERDTEILRIAPLESSGPGDLSFLSNPRYQSQLAASQAACVI
CCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHCCCCCHHHHHHHCCCEEEE
VAPAMRNAALERGACIVVEQPYTYFAHVTQLWVRAHGQGAPAGIHPSAVVDPQARVAPTA
EECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCC
SIGPLCVVERGAVIGAHTVLKSRVTVGERCTVGERCILHPGVVIGADGFGFAQQRGEWIK
CCCCEEEEECCCEEEHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCCHHHHCCCEEE
IEQLGAVRIGNDVEIGANTCIDRGALDDTVIEDGVKLDNLIQIAHNVHIGRHTAMAGCSA
EEECCEEEECCCEEECCHHHHCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHH
VAGSTRIGAHCTIAGAASIVGHLQLADNVHISTNTVVTHSITQPGQYTGVFPMDDNAKWE
HCCCCCCCCEEEEHHHHHHHHEEEECCCEEEECCEEEEEECCCCCCEEEEEECCCCCCCH
KNAATLRQLYRLRERIKALEQTRKDG
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLRLGQIVDALGGSLEGGERDTEILRIAPLESSGPGDLSFLSNPRYQSQLAASQAACVI
CCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCHHCCCCCHHHHHHHCCCEEEE
VAPAMRNAALERGACIVVEQPYTYFAHVTQLWVRAHGQGAPAGIHPSAVVDPQARVAPTA
EECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCC
SIGPLCVVERGAVIGAHTVLKSRVTVGERCTVGERCILHPGVVIGADGFGFAQQRGEWIK
CCCCEEEEECCCEEEHHHHHHHHCCCCCCCCCCCEEEECCCEEEECCCCCHHHHCCCEEE
IEQLGAVRIGNDVEIGANTCIDRGALDDTVIEDGVKLDNLIQIAHNVHIGRHTAMAGCSA
EEECCEEEECCCEEECCHHHHCCCCCCHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHH
VAGSTRIGAHCTIAGAASIVGHLQLADNVHISTNTVVTHSITQPGQYTGVFPMDDNAKWE
HCCCCCCCCEEEEHHHHHHHHEEEECCCEEEECCEEEEEECCCCCCEEEEEECCCCCCCH
KNAATLRQLYRLRERIKALEQTRKDG
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA