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The map label for this gene is czrA [H]

Identifier: 222110348

GI number: 222110348

Start: 1196556

End: 1196912

Strand: Direct

Name: czrA [H]

Synonym: Dtpsy_1139

Alternate gene names: 222110348

Gene position: 1196556-1196912 (Clockwise)

Preceding gene: 222110344

Following gene: 222110355

Centisome position: 31.52

GC content: 58.54

Gene sequence:

>357_bases
ATGAATACAAGTAAGCCATTCAGTACCCCACCGAAGGGTCCCAGCGCCGATTTGGAATCGCTGTCACAGAATGACGTGAC
CATCTTGGCTGAGACATTCCGCCTCCTGGGTGACCCGTCCCGGCTGAGAATCATGCTGTGCTGCATGAAAGGCTCTTCCT
CGGTCGGGGACATCGCTGAAACCCTCGAACTCTCGCAGTCGCTGGTGAGCCACCACCTGCGGCTGCTGCGCGGTGCTCGC
CTGGTCAAGGGCGTGCGCCAAGCCAAACAGATCTTCTATGAGGTGGCGGACAAGCACGTGAACCAGGTGCTGCTGGATAT
GGCCACCCACATCGCGGAAGACCACAACGACGAGTAA

Upstream 100 bases:

>100_bases
AGGCTCGCACTGGTTCTTTGCTGCGCGCGCCTAAGCGGCCGCTGCCTTGTTAATTCTGAAGGGCGAAAACAGCCATTCGA
GGTTAGGAAATATTTTAAAA

Downstream 100 bases:

>100_bases
CTGTTGGGCATAGCATGCCGTTGCGGCGTGGCCTACGTTCCATGGCGATATGCGCCCCACCGCCCGCAGCTGCGTTCGGT
GAGGTGGTTTGGATGCCGCT

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 118; Mature: 118

Protein sequence:

>118_residues
MNTSKPFSTPPKGPSADLESLSQNDVTILAETFRLLGDPSRLRIMLCCMKGSSSVGDIAETLELSQSLVSHHLRLLRGAR
LVKGVRQAKQIFYEVADKHVNQVLLDMATHIAEDHNDE

Sequences:

>Translated_118_residues
MNTSKPFSTPPKGPSADLESLSQNDVTILAETFRLLGDPSRLRIMLCCMKGSSSVGDIAETLELSQSLVSHHLRLLRGAR
LVKGVRQAKQIFYEVADKHVNQVLLDMATHIAEDHNDE
>Mature_118_residues
MNTSKPFSTPPKGPSADLESLSQNDVTILAETFRLLGDPSRLRIMLCCMKGSSSVGDIAETLELSQSLVSHHLRLLRGAR
LVKGVRQAKQIFYEVADKHVNQVLLDMATHIAEDHNDE

Specific function: Metal-responsive transcriptional regulator that represses transcription of cadA and the czcD-trkA operon by binding specifically to their promoter. Binding of zinc causes the repressor to dissociate from the DNA [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 13041; Mature: 13041

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSKPFSTPPKGPSADLESLSQNDVTILAETFRLLGDPSRLRIMLCCMKGSSSVGDIAE
CCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHH
TLELSQSLVSHHLRLLRGARLVKGVRQAKQIFYEVADKHVNQVLLDMATHIAEDHNDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTSKPFSTPPKGPSADLESLSQNDVTILAETFRLLGDPSRLRIMLCCMKGSSSVGDIAE
CCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHH
TLELSQSLVSHHLRLLRGARLVKGVRQAKQIFYEVADKHVNQVLLDMATHIAEDHNDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]