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The map label for this gene is lon [H]

Identifier: 222110343

GI number: 222110343

Start: 1187297

End: 1189717

Strand: Direct

Name: lon [H]

Synonym: Dtpsy_1130

Alternate gene names: 222110343

Gene position: 1187297-1189717 (Clockwise)

Preceding gene: 222110342

Following gene: 222110344

Centisome position: 31.27

GC content: 57.21

Gene sequence:

>2421_bases
ATGTCCGGACACACACCCCTGCCCGATACGCCCCTGGATCTACCACTGTTGCCTTTGCGCGATGTGGTGGTTTTTCCTCA
TATGGTGATTCCCCTGTTTGTGGGGCGTCCCAAGAGCATCAAGGCGCTGGAAGCCGCCATGGATGCCGATCGACGAATCA
TGCTGGTTGCGCAAAAAGCAGCCGCCAAGGATGAACCGCAGGTTTCGGATATGTTCGAAGTCGGGTGCATATCCACCATC
CTTCAGATGCTGAAGCTTCCCGATGGCACGGTGAAGGTGCTGGTGGAGGGGCAGCAGCGCGCCCACGTTCGCATGGTGCA
TGAATCGGACGTTCACTTCACGGCGACGGTTGAGCCCATGCAGGCGTCCGCCGAGGACGCCGCTTCGAGTGAAATTGAAG
CGCTGCGCCGGGCGGTAATGCAGCAGTTTGATCAGTACGTCAAACTGAATAAAAAGATTCCTCCTGAGATTCTGACTTCC
ATTTCGGCTATCGATGATCCGGGGCGGCTGGCTGACACCATTGCCGCGCACTTGCCGCTCAAGCTGGAGAACAAGCAGGT
TGTTCTCGACTTGGCAGGCGTCAAGCAGCGTCTGGAGAATCTGTTCGAGCAGTTGGACCGCGAAGTGGATATCCTCAATG
TGGATAAGCGCATTCGCGGTCGCGTGAAGCGCCAGATGGAGAAAAACCAGCGGGACTTCTATCTCAACGAACAGGTCAAG
GCGATCCAGAAGGAACTGGGCGAAGGCGAAGAAGGCGCGGATCTTGAGGAGATCGAGAAAAAGATCAAGGCCGCGCGCAT
GCCGGTCGAAGCGCGCAAGAAGGCGGAAGGCGAGCTGAAAAAGCTCAAGCTCATGTCTCCTATGTCTGCCGAAGCCACTG
TGGTTCGCAACTACATTGATGTGCTCACGGGACTGCCCTGGAGCAAGAAGTCCAAGGTCAAGCACGACCTTGCCCATGCA
GAGGCTGTGTTAAACGAGGACCACTATGGCCTGGAAAAGGTGAAAGACCGGATCCTGGAATATCTCGCCGTGCAGCAGCG
GGTGGACAAGGTGAAGGCGCCCATCCTGTGCTTGGTCGGCCCACCGGGTGTGGGCAAGACTTCGCTCGGTCAGTCCATTG
CAAAGGCAACGGGGCGCAAGTACGTGCGTATGGCGCTGGGGGGGATGCGTGACGAAGCAGAGATCCGGGGTCACCGTCGT
ACCTACATTGGGGCGATGCCAGGCAAGGTGTTGCAGAGCCTGGGCAAGGTGGGGGCGCGCAATCCGTTGTTCCTGCTCGA
TGAAATTGACAAACTAGGCATGGACTTTCGAGGTGACCCCTCGAGCGCGTTATTGGAAGTCCTCGATCCTGAGCAGAACC
ACAAGTTCGGCGACCACTATGTGGAGGTCGACTTCGACCTTTCCGATGTCATGTTTGTCGCGACTTCCAACTCGATGAAC
ATCCCGCCGGCGCTACTTGATCGCATGGAGGTGATACGTCTTTCCGGATATACCGAGGACGAAAAAACCAACATTGCCAT
CAAATATTTGCTGCCCAAGCAGATGCAAAACAATGGCGTGAAAGACGCCGAGTTGCAGGTCACGGAATCCGCCGTACGGG
ACATCGTGCGCTACTACACGCGTGAAGCGGGCGTCCGTTCGCTAGAGCGCGAACTCTCCAAAATCTGCCGAAAAGTGGTC
AAGGCAATCCAGCTCAAGAAGCTGACGGCTCCCGTGGAGGTGTCGGCGGACGACTTGCCTGAATACTTGGGAGTGCGCAA
GTACACCTACGGTCGCGCGGAACAGCAGAACCAAGTGGGACAAGTGGTTGGCCTGGCATGGACCGAAGTCGGCGGGGATC
TGCTCACGATCGAGGTCGCGACCATGCCCGGCAAAGGCAACATCCTTCGCACAGGATCGCTGGGCGATGTCATGAAGGAG
TCGGTCGAAGCGGCCCGCACAGTAGTACGTAGCCGTGCGCGCTTACTTGGTATTCGCGATGAGGCGTTCGAGAAGCGAGA
TCTTCATATCCACGTGCCCGATGGTGCGACCCCTAAAGACGGTCCCAGCGCCGGCATTGCGATGACGACGGCGATCGTTT
CTGCGCTGACCGGAATACCGGTCCGCGCAGATGTTGCGATGACGGGGGAGATCACACTGCGCGGAGAGGTCACAGCAATT
GGTGGGCTCAAGGAAAAACTTTTAGCGGCATTGCGTGGAGGGATCAAGACGGTGCTGATTCCTGAAGAAAACGTAAAAGA
CCTCCAGGAAATTCCAGAGAACGTCAAGATGGGGCTGGAGATCATTGCTGTGAAGTGGATCGACAAGGTTCTGGAGATAG
CACTCGAGCGCAAGCCTGTTGCATTGGCAGAGGACGACAGTGCCCAAACCGTGGCGGTGCCTGCCTCCGCCGATGTGTCG
CGGGGCTCCGTGAAACATTGA

Upstream 100 bases:

>100_bases
GCCCGGCGGGCCATGTCGCTAACACCTGGGTGCAGATGCTGCCGGGTTGAAAAATGTGGTCCATGGACCATATTCCATGG
AACTACTAGAGGATTGCCCC

Downstream 100 bases:

>100_bases
TGGAAAAATCTTTGCACTATTCTTGGAGCACGCGAAAAGTACTCTATAATTTCACTTATCGACGCTAAACATGCTACAGT
GTGAGGCTTAGGTAAATGCG

Product: ATP-dependent protease la

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 806; Mature: 805

Protein sequence:

>806_residues
MSGHTPLPDTPLDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMDADRRIMLVAQKAAAKDEPQVSDMFEVGCISTI
LQMLKLPDGTVKVLVEGQQRAHVRMVHESDVHFTATVEPMQASAEDAASSEIEALRRAVMQQFDQYVKLNKKIPPEILTS
ISAIDDPGRLADTIAAHLPLKLENKQVVLDLAGVKQRLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
AIQKELGEGEEGADLEEIEKKIKAARMPVEARKKAEGELKKLKLMSPMSAEATVVRNYIDVLTGLPWSKKSKVKHDLAHA
EAVLNEDHYGLEKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRR
TYIGAMPGKVLQSLGKVGARNPLFLLDEIDKLGMDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
IPPALLDRMEVIRLSGYTEDEKTNIAIKYLLPKQMQNNGVKDAELQVTESAVRDIVRYYTREAGVRSLERELSKICRKVV
KAIQLKKLTAPVEVSADDLPEYLGVRKYTYGRAEQQNQVGQVVGLAWTEVGGDLLTIEVATMPGKGNILRTGSLGDVMKE
SVEAARTVVRSRARLLGIRDEAFEKRDLHIHVPDGATPKDGPSAGIAMTTAIVSALTGIPVRADVAMTGEITLRGEVTAI
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPENVKMGLEIIAVKWIDKVLEIALERKPVALAEDDSAQTVAVPASADVS
RGSVKH

Sequences:

>Translated_806_residues
MSGHTPLPDTPLDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMDADRRIMLVAQKAAAKDEPQVSDMFEVGCISTI
LQMLKLPDGTVKVLVEGQQRAHVRMVHESDVHFTATVEPMQASAEDAASSEIEALRRAVMQQFDQYVKLNKKIPPEILTS
ISAIDDPGRLADTIAAHLPLKLENKQVVLDLAGVKQRLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
AIQKELGEGEEGADLEEIEKKIKAARMPVEARKKAEGELKKLKLMSPMSAEATVVRNYIDVLTGLPWSKKSKVKHDLAHA
EAVLNEDHYGLEKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRR
TYIGAMPGKVLQSLGKVGARNPLFLLDEIDKLGMDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
IPPALLDRMEVIRLSGYTEDEKTNIAIKYLLPKQMQNNGVKDAELQVTESAVRDIVRYYTREAGVRSLERELSKICRKVV
KAIQLKKLTAPVEVSADDLPEYLGVRKYTYGRAEQQNQVGQVVGLAWTEVGGDLLTIEVATMPGKGNILRTGSLGDVMKE
SVEAARTVVRSRARLLGIRDEAFEKRDLHIHVPDGATPKDGPSAGIAMTTAIVSALTGIPVRADVAMTGEITLRGEVTAI
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPENVKMGLEIIAVKWIDKVLEIALERKPVALAEDDSAQTVAVPASADVS
RGSVKH
>Mature_805_residues
SGHTPLPDTPLDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMDADRRIMLVAQKAAAKDEPQVSDMFEVGCISTIL
QMLKLPDGTVKVLVEGQQRAHVRMVHESDVHFTATVEPMQASAEDAASSEIEALRRAVMQQFDQYVKLNKKIPPEILTSI
SAIDDPGRLADTIAAHLPLKLENKQVVLDLAGVKQRLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVKA
IQKELGEGEEGADLEEIEKKIKAARMPVEARKKAEGELKKLKLMSPMSAEATVVRNYIDVLTGLPWSKKSKVKHDLAHAE
AVLNEDHYGLEKVKDRILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRT
YIGAMPGKVLQSLGKVGARNPLFLLDEIDKLGMDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMNI
PPALLDRMEVIRLSGYTEDEKTNIAIKYLLPKQMQNNGVKDAELQVTESAVRDIVRYYTREAGVRSLERELSKICRKVVK
AIQLKKLTAPVEVSADDLPEYLGVRKYTYGRAEQQNQVGQVVGLAWTEVGGDLLTIEVATMPGKGNILRTGSLGDVMKES
VEAARTVVRSRARLLGIRDEAFEKRDLHIHVPDGATPKDGPSAGIAMTTAIVSALTGIPVRADVAMTGEITLRGEVTAIG
GLKEKLLAALRGGIKTVLIPEENVKDLQEIPENVKMGLEIIAVKWIDKVLEIALERKPVALAEDDSAQTVAVPASADVSR
GSVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=564, Percent_Identity=44.8581560283688, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI21396489, Length=681, Percent_Identity=39.3538913362702, Blast_Score=484, Evalue=1e-136,
Organism=Escherichia coli, GI1786643, Length=772, Percent_Identity=67.6165803108808, Blast_Score=1058, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=695, Percent_Identity=38.705035971223, Blast_Score=464, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17556486, Length=541, Percent_Identity=38.6321626617375, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=717, Percent_Identity=39.7489539748954, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI24666867, Length=668, Percent_Identity=41.1676646706587, Blast_Score=497, Evalue=1e-140,
Organism=Drosophila melanogaster, GI221513036, Length=668, Percent_Identity=41.1676646706587, Blast_Score=497, Evalue=1e-140,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88873; Mature: 88742

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGHTPLPDTPLDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMDADRRIMLVAQKA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEHH
AAKDEPQVSDMFEVGCISTILQMLKLPDGTVKVLVEGQQRAHVRMVHESDVHFTATVEPM
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCEEEEEECHH
QASAEDAASSEIEALRRAVMQQFDQYVKLNKKIPPEILTSISAIDDPGRLADTIAAHLPL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCE
KLENKQVVLDLAGVKQRLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
EECCCEEEEEHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHH
AIQKELGEGEEGADLEEIEKKIKAARMPVEARKKAEGELKKLKLMSPMSAEATVVRNYID
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLTGLPWSKKSKVKHDLAHAEAVLNEDHYGLEKVKDRILEYLAVQQRVDKVKAPILCLVG
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRTYIGAMPGKVLQSLGKVGAR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCCC
NPLFLLDEIDKLGMDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
CCEEHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCC
IPPALLDRMEVIRLSGYTEDEKTNIAIKYLLPKQMQNNGVKDAELQVTESAVRDIVRYYT
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REAGVRSLERELSKICRKVVKAIQLKKLTAPVEVSADDLPEYLGVRKYTYGRAEQQNQVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHCCCCCCHHHHHHH
QVVGLAWTEVGGDLLTIEVATMPGKGNILRTGSLGDVMKESVEAARTVVRSRARLLGIRD
HHHHHHHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
EAFEKRDLHIHVPDGATPKDGPSAGIAMTTAIVSALTGIPVRADVAMTGEITLRGEVTAI
HHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECEEEECEEEEEEEEEEC
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPENVKMGLEIIAVKWIDKVLEIALERKPV
CCHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALAEDDSAQTVAVPASADVSRGSVKH
EEECCCCCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SGHTPLPDTPLDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMDADRRIMLVAQKA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEHH
AAKDEPQVSDMFEVGCISTILQMLKLPDGTVKVLVEGQQRAHVRMVHESDVHFTATVEPM
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCEEEEEECHH
QASAEDAASSEIEALRRAVMQQFDQYVKLNKKIPPEILTSISAIDDPGRLADTIAAHLPL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCE
KLENKQVVLDLAGVKQRLENLFEQLDREVDILNVDKRIRGRVKRQMEKNQRDFYLNEQVK
EECCCEEEEEHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHHHHH
AIQKELGEGEEGADLEEIEKKIKAARMPVEARKKAEGELKKLKLMSPMSAEATVVRNYID
HHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VLTGLPWSKKSKVKHDLAHAEAVLNEDHYGLEKVKDRILEYLAVQQRVDKVKAPILCLVG
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PPGVGKTSLGQSIAKATGRKYVRMALGGMRDEAEIRGHRRTYIGAMPGKVLQSLGKVGAR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCEEECCCCHHHHHHHHHHCCC
NPLFLLDEIDKLGMDFRGDPSSALLEVLDPEQNHKFGDHYVEVDFDLSDVMFVATSNSMN
CCEEHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEECCCCC
IPPALLDRMEVIRLSGYTEDEKTNIAIKYLLPKQMQNNGVKDAELQVTESAVRDIVRYYT
CCHHHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
REAGVRSLERELSKICRKVVKAIQLKKLTAPVEVSADDLPEYLGVRKYTYGRAEQQNQVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHCCCCCCHHHHHHH
QVVGLAWTEVGGDLLTIEVATMPGKGNILRTGSLGDVMKESVEAARTVVRSRARLLGIRD
HHHHHHHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHH
EAFEKRDLHIHVPDGATPKDGPSAGIAMTTAIVSALTGIPVRADVAMTGEITLRGEVTAI
HHHCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEECEEEECEEEEEEEEEEC
GGLKEKLLAALRGGIKTVLIPEENVKDLQEIPENVKMGLEIIAVKWIDKVLEIALERKPV
CCHHHHHHHHHHCCCEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ALAEDDSAQTVAVPASADVSRGSVKH
EEECCCCCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]