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The map label for this gene is mdtA [H]

Identifier: 222110338

GI number: 222110338

Start: 1179084

End: 1180337

Strand: Direct

Name: mdtA [H]

Synonym: Dtpsy_1125

Alternate gene names: 222110338

Gene position: 1179084-1180337 (Clockwise)

Preceding gene: 222110336

Following gene: 222110339

Centisome position: 31.06

GC content: 72.01

Gene sequence:

>1254_bases
ATGACCCACCCTGTCGCACAGCGCGCCGCGGGCCTGCCGGGCCCGTCTTCATTGCAACCCCGCCGCGGGGTTTTTTTGTG
GCCGCCGCGTGGCGGCGTGGCGGGTGCTGCACTGGTGCTGGCCGTGGCTGCCTTGGCGCTGGCGGGATGTTCGCGCCGCG
AGCCGGCGCCAGAGCCGGTGCGCGCGGTGAAACTGCTCACCGTGGGCGTGGCGCCCCTGCAGATGCATCTGGAGTACGCG
GGCGAGGTGCGCGCGCGCGTGGAGTCGCGCCTGGGTTTTCGCGTGGCCGGCAAGATCGTGCAGCGCCAGGCCGAGCTGGG
CCAGCGCGTGCAGGCCGGCCAGGTGTTGGCGCAGCTGGATCCGCGCGACTATGAGCTGGCTGCGCAGGCCGCGCGCGCCC
AGGTGGCGTCCGCCACCACGCAGCGTGATTTGGCCGCGGCGGATTTCGAGCGCTTTTCCAAGCTGCGCGCGCAGAACTTC
ATCAGCGGGGCGGAGCTGGACCGCCGCCAGGCTCAGCTGAAGGCCGCGCAGGCTTCGCTGGACCAGGCGCGCGCGCAGCT
CGCTTCCCAGGGCAACCAGACCGAGTACACACGCCTGGTGGCGGATGCGCCGGGGGTGGTGACGTCGGTTGACGCCGAGC
CCGGCCAGGTGGTGTCTGCGGGCACGCCGGTGGTGCGCATTGCTCGCGACGGCCCGCGCGACGCGGTGTTCTCGGTGCCG
GAGGACAAGGTGGGCCAGTTGCGCGTAGGGCAGGCCGTGCAGGTGCGCGCCTGGTCGGGCGACGCGCTGCTGCAGGGCCG
GGTGCGCGAGGTGGCGGCCAGCGCCGATCCGGTGACGCGCACCTTCCTCGTGAAAGTGGCGGTGGAGGGCGCGGACGTGC
CGCCGCTGGGCGCCACCGTGTATGTGGCGCCGCAGGTGCTGGCGCGGGGCGGTGTGCAGGCGATCAAGCTGCCCACCAGC
GCCCTGCGCCAGGAGGGCGGCCAGACGGTGGTGTGGGTCTATGAGGCCAAGGACGGCAGTGCCACCGGCACCGTGCGCCT
GCAGCCGGTGCAGATCGCCACGGCCGACGGCAACGAGGCCGTGATCGCCGCCGGCCTCACCCCCGGCATGCAGGTGGTGG
CCACGGGTGTGCATGTGCTGGCTCCGGGACAGGTGGTGACGGTTTACAAGCCAAAAACGGCTCCAACGCCCGAAGGACAA
GCGCTACCAGCTATTAATAATGAAGCGCCAGCGGCCTCCGCTGCCGCTCGCTGA

Upstream 100 bases:

>100_bases
CGGGATGCTTCACGCGGCCATTGTCGTGCTTGACAAGAGCGACCGGCCTCTCATAGATTACTAACCAGTCAGTCAGTAAT
TTGGCATACCGGATGTTTCC

Downstream 100 bases:

>100_bases
GGAGCCACCCCATGCAGCAGACGCAGCCCAAGCAGGGCTTTAACCTGTCGCGCTGGGCGCTGGAACATGCCGCGCTCACG
CGCTACCTGATGGTGGTGCT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTHPVAQRAAGLPGPSSLQPRRGVFLWPPRGGVAGAALVLAVAALALAGCSRREPAPEPVRAVKLLTVGVAPLQMHLEYA
GEVRARVESRLGFRVAGKIVQRQAELGQRVQAGQVLAQLDPRDYELAAQAARAQVASATTQRDLAAADFERFSKLRAQNF
ISGAELDRRQAQLKAAQASLDQARAQLASQGNQTEYTRLVADAPGVVTSVDAEPGQVVSAGTPVVRIARDGPRDAVFSVP
EDKVGQLRVGQAVQVRAWSGDALLQGRVREVAASADPVTRTFLVKVAVEGADVPPLGATVYVAPQVLARGGVQAIKLPTS
ALRQEGGQTVVWVYEAKDGSATGTVRLQPVQIATADGNEAVIAAGLTPGMQVVATGVHVLAPGQVVTVYKPKTAPTPEGQ
ALPAINNEAPAASAAAR

Sequences:

>Translated_417_residues
MTHPVAQRAAGLPGPSSLQPRRGVFLWPPRGGVAGAALVLAVAALALAGCSRREPAPEPVRAVKLLTVGVAPLQMHLEYA
GEVRARVESRLGFRVAGKIVQRQAELGQRVQAGQVLAQLDPRDYELAAQAARAQVASATTQRDLAAADFERFSKLRAQNF
ISGAELDRRQAQLKAAQASLDQARAQLASQGNQTEYTRLVADAPGVVTSVDAEPGQVVSAGTPVVRIARDGPRDAVFSVP
EDKVGQLRVGQAVQVRAWSGDALLQGRVREVAASADPVTRTFLVKVAVEGADVPPLGATVYVAPQVLARGGVQAIKLPTS
ALRQEGGQTVVWVYEAKDGSATGTVRLQPVQIATADGNEAVIAAGLTPGMQVVATGVHVLAPGQVVTVYKPKTAPTPEGQ
ALPAINNEAPAASAAAR
>Mature_416_residues
THPVAQRAAGLPGPSSLQPRRGVFLWPPRGGVAGAALVLAVAALALAGCSRREPAPEPVRAVKLLTVGVAPLQMHLEYAG
EVRARVESRLGFRVAGKIVQRQAELGQRVQAGQVLAQLDPRDYELAAQAARAQVASATTQRDLAAADFERFSKLRAQNFI
SGAELDRRQAQLKAAQASLDQARAQLASQGNQTEYTRLVADAPGVVTSVDAEPGQVVSAGTPVVRIARDGPRDAVFSVPE
DKVGQLRVGQAVQVRAWSGDALLQGRVREVAASADPVTRTFLVKVAVEGADVPPLGATVYVAPQVLARGGVQAIKLPTSA
LRQEGGQTVVWVYEAKDGSATGTVRLQPVQIATADGNEAVIAAGLTPGMQVVATGVHVLAPGQVVTVYKPKTAPTPEGQA
LPAINNEAPAASAAAR

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=317, Percent_Identity=28.391167192429, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87081951, Length=192, Percent_Identity=31.7708333333333, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43347; Mature: 43216

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPVAQRAAGLPGPSSLQPRRGVFLWPPRGGVAGAALVLAVAALALAGCSRREPAPEPV
CCCCHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
RAVKLLTVGVAPLQMHLEYAGEVRARVESRLGFRVAGKIVQRQAELGQRVQAGQVLAQLD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRDYELAAQAARAQVASATTQRDLAAADFERFSKLRAQNFISGAELDRRQAQLKAAQASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
DQARAQLASQGNQTEYTRLVADAPGVVTSVDAEPGQVVSAGTPVVRIARDGPRDAVFSVP
HHHHHHHHHCCCCCHHHEEEECCCCCEEECCCCCCCEEECCCCEEEEECCCCCCCEEECC
EDKVGQLRVGQAVQVRAWSGDALLQGRVREVAASADPVTRTFLVKVAVEGADVPPLGATV
CCCCCCEECCCEEEEEEECCCHHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCCCCCEEE
YVAPQVLARGGVQAIKLPTSALRQEGGQTVVWVYEAKDGSATGTVRLQPVQIATADGNEA
EECHHHHHCCCCEEEECCHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCCE
VIAAGLTPGMQVVATGVHVLAPGQVVTVYKPKTAPTPEGQALPAINNEAPAASAAAR
EEEECCCCCHHHHHCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THPVAQRAAGLPGPSSLQPRRGVFLWPPRGGVAGAALVLAVAALALAGCSRREPAPEPV
CCCHHHHHCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHH
RAVKLLTVGVAPLQMHLEYAGEVRARVESRLGFRVAGKIVQRQAELGQRVQAGQVLAQLD
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRDYELAAQAARAQVASATTQRDLAAADFERFSKLRAQNFISGAELDRRQAQLKAAQASL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
DQARAQLASQGNQTEYTRLVADAPGVVTSVDAEPGQVVSAGTPVVRIARDGPRDAVFSVP
HHHHHHHHHCCCCCHHHEEEECCCCCEEECCCCCCCEEECCCCEEEEECCCCCCCEEECC
EDKVGQLRVGQAVQVRAWSGDALLQGRVREVAASADPVTRTFLVKVAVEGADVPPLGATV
CCCCCCEECCCEEEEEEECCCHHHHHHHHHHHCCCCCHHEEEEEEEEECCCCCCCCCEEE
YVAPQVLARGGVQAIKLPTSALRQEGGQTVVWVYEAKDGSATGTVRLQPVQIATADGNEA
EECHHHHHCCCCEEEECCHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEEECCCCCE
VIAAGLTPGMQVVATGVHVLAPGQVVTVYKPKTAPTPEGQALPAINNEAPAASAAAR
EEEECCCCCHHHHHCCEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA