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The map label for this gene is hemN [H]

Identifier: 222110222

GI number: 222110222

Start: 1048525

End: 1049907

Strand: Direct

Name: hemN [H]

Synonym: Dtpsy_1008

Alternate gene names: 222110222

Gene position: 1048525-1049907 (Clockwise)

Preceding gene: 222110220

Following gene: 222110223

Centisome position: 27.62

GC content: 57.85

Gene sequence:

>1383_bases
ATGACCGTTGTTACAACAGAGCTCCTGCGTCGCTTTGACGTTCCAGGGCCGCGCTACACCTCTTATCCGACTGCTGATCG
TTTTGTCGAGGCCTTTGGCGAGCGGGAATACATCCTTGCGCTGCAGCAGCGTCGCGTGGGGTCGGTAGCCAAGGCGATGC
CTTTGTCGCTTTATGTCCACATCCCATTTTGTGAATCGCTGTGCTATTACTGCGCGTGTAACAAGATCATTACCCGGCAT
CCAGAGCGGGCAGAGGTCTACTTGCGTTACCTCAGTCGTGAGATCGACCTGCATACGGCGCACTGCGGTGTGGGTCAGCA
TGTGAGCCAGCTGCATTTCGGCGGAGGCACGCCTACTTTTCTGACGGATGACGGTTTGCGCGAACTGATGGGCATGCTGA
GGCGTAGTTTCGTCCTCGTTCCGGGGGGGGAGTACTCCATAGAAGTGGACCCCCGGACCGTGGATGAAGCGCGGCTGGGA
TTGTTGGCGGAGCTGGGTTTCAATCGCCTGAGCTTTGGCGTGCAGGATTTCGACCCTGAAGTACAAAAGGCCGTGCACCG
CATTCAGCCTGCCGAAAAGGTGTTCGCGTTGGTCGATGCGGCTCGGAAGCTCGGGTTTGAATCGGTGAACGTGGATTTGA
TCTACGGGCTGCCGCGCCAGACACCGGAGTCGTTTGATCGCACCTTGGAGCAGGTAGCCGAGCTGCGGCCAGACCGGATC
GCGCTGTATGCGTACGCTCACTTGCCAGAACGCTTCAAGTCGCAGCGACGCATCATCACGGCCGAGTTGCCCATGGCTTC
GGCCAAGGTGTCCATGCTGGCCCGGTCACTTGATGTGTTCCAGGAAGCCGGCTACGTCTACGTGGGCATGGACCATTTTG
CGCTGCCTGACGATGCGCTGGCGGTGGCCAAGCGGCAAGGCAGGCTGCACCGCAATTTCCAAGGCTATAGCACGCAGCCC
GATTGCGACCTGATTGGTCTGGGCGTTTCTGCCATCGGGCGCGTGGGCGCTACTTACAGCCAAAATGTGAAAACGCTGGA
CGAGTATTACGACTGCATTAACCAGGGGCATTTGCCTGTGGTGCGCGGGCTGGCGTTGACCAAGGACGACTTGGTGCGCC
GCGCAGTCATCATGGCGTTGATGTGCCAAGGTGAATTGCTGTTTGAGCCGTTGGAACAGTCCTGGCTGATTGATTTCCGC
AGTTATTTCGATGCGGAATTACAGCAACTGCAAGAAATGGCGGCTCAGGGCTTGGTGAAAATCAGTGATGAGGGCGTTGA
AGTCACGCCCATGGGGTGGTATTTCGTGCGGGGCGTGGCCATGGTGTTCGACAAGTATCTACAGGCTGACCGCAACCGCG
CTCGCTTTTCCCGGATTATTTGA

Upstream 100 bases:

>100_bases
TCAAATTGTCGCCACAAGGACCTTATGGGCGCTTGATCAACGTCAAGGACTCATGGGGGACTCTACGGCACAGTGATATG
AAAGTGCAAGGAATCCCGTC

Downstream 100 bases:

>100_bases
CCCATGCTGTGGGCGATGGCCACGACGGCCTTCCTGATGGGGCTGATGGGAGGGGCACACTGTTTGGCGATGTGTTCTGT
TCCCTGCGCGGCGCTTACGG

Product: coproporphyrinogen iii oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTVVTTELLRRFDVPGPRYTSYPTADRFVEAFGEREYILALQQRRVGSVAKAMPLSLYVHIPFCESLCYYCACNKIITRH
PERAEVYLRYLSREIDLHTAHCGVGQHVSQLHFGGGTPTFLTDDGLRELMGMLRRSFVLVPGGEYSIEVDPRTVDEARLG
LLAELGFNRLSFGVQDFDPEVQKAVHRIQPAEKVFALVDAARKLGFESVNVDLIYGLPRQTPESFDRTLEQVAELRPDRI
ALYAYAHLPERFKSQRRIITAELPMASAKVSMLARSLDVFQEAGYVYVGMDHFALPDDALAVAKRQGRLHRNFQGYSTQP
DCDLIGLGVSAIGRVGATYSQNVKTLDEYYDCINQGHLPVVRGLALTKDDLVRRAVIMALMCQGELLFEPLEQSWLIDFR
SYFDAELQQLQEMAAQGLVKISDEGVEVTPMGWYFVRGVAMVFDKYLQADRNRARFSRII

Sequences:

>Translated_460_residues
MTVVTTELLRRFDVPGPRYTSYPTADRFVEAFGEREYILALQQRRVGSVAKAMPLSLYVHIPFCESLCYYCACNKIITRH
PERAEVYLRYLSREIDLHTAHCGVGQHVSQLHFGGGTPTFLTDDGLRELMGMLRRSFVLVPGGEYSIEVDPRTVDEARLG
LLAELGFNRLSFGVQDFDPEVQKAVHRIQPAEKVFALVDAARKLGFESVNVDLIYGLPRQTPESFDRTLEQVAELRPDRI
ALYAYAHLPERFKSQRRIITAELPMASAKVSMLARSLDVFQEAGYVYVGMDHFALPDDALAVAKRQGRLHRNFQGYSTQP
DCDLIGLGVSAIGRVGATYSQNVKTLDEYYDCINQGHLPVVRGLALTKDDLVRRAVIMALMCQGELLFEPLEQSWLIDFR
SYFDAELQQLQEMAAQGLVKISDEGVEVTPMGWYFVRGVAMVFDKYLQADRNRARFSRII
>Mature_459_residues
TVVTTELLRRFDVPGPRYTSYPTADRFVEAFGEREYILALQQRRVGSVAKAMPLSLYVHIPFCESLCYYCACNKIITRHP
ERAEVYLRYLSREIDLHTAHCGVGQHVSQLHFGGGTPTFLTDDGLRELMGMLRRSFVLVPGGEYSIEVDPRTVDEARLGL
LAELGFNRLSFGVQDFDPEVQKAVHRIQPAEKVFALVDAARKLGFESVNVDLIYGLPRQTPESFDRTLEQVAELRPDRIA
LYAYAHLPERFKSQRRIITAELPMASAKVSMLARSLDVFQEAGYVYVGMDHFALPDDALAVAKRQGRLHRNFQGYSTQPD
CDLIGLGVSAIGRVGATYSQNVKTLDEYYDCINQGHLPVVRGLALTKDDLVRRAVIMALMCQGELLFEPLEQSWLIDFRS
YFDAELQQLQEMAAQGLVKISDEGVEVTPMGWYFVRGVAMVFDKYLQADRNRARFSRII

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=304, Percent_Identity=28.9473684210526, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI87082341, Length=453, Percent_Identity=49.0066225165563, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1789325, Length=287, Percent_Identity=29.2682926829268, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52099; Mature: 51967

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVTTELLRRFDVPGPRYTSYPTADRFVEAFGEREYILALQQRRVGSVAKAMPLSLYVH
CCEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEE
IPFCESLCYYCACNKIITRHPERAEVYLRYLSREIDLHTAHCGVGQHVSQLHFGGGTPTF
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHCCCCCCCCC
LTDDGLRELMGMLRRSFVLVPGGEYSIEVDPRTVDEARLGLLAELGFNRLSFGVQDFDPE
CCCHHHHHHHHHHHHCEEEECCCCEEEEECCCCHHHHHHHHHHHHCCHHHHCCCCCCCHH
VQKAVHRIQPAEKVFALVDAARKLGFESVNVDLIYGLPRQTPESFDRTLEQVAELRPDRI
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
ALYAYAHLPERFKSQRRIITAELPMASAKVSMLARSLDVFQEAGYVYVGMDHFALPDDAL
EEEEHHHCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
AVAKRQGRLHRNFQGYSTQPDCDLIGLGVSAIGRVGATYSQNVKTLDEYYDCINQGHLPV
HHHHHHCHHHCCCCCCCCCCCCCEEECCHHHHHHHCCCHHCCHHHHHHHHHHHCCCCCHH
VRGLALTKDDLVRRAVIMALMCQGELLFEPLEQSWLIDFRSYFDAELQQLQEMAAQGLVK
HHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ISDEGVEVTPMGWYFVRGVAMVFDKYLQADRNRARFSRII
ECCCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure 
TVVTTELLRRFDVPGPRYTSYPTADRFVEAFGEREYILALQQRRVGSVAKAMPLSLYVH
CEEHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEEEEE
IPFCESLCYYCACNKIITRHPERAEVYLRYLSREIDLHTAHCGVGQHVSQLHFGGGTPTF
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCEEECCCCCHHHHHHCCCCCCCCC
LTDDGLRELMGMLRRSFVLVPGGEYSIEVDPRTVDEARLGLLAELGFNRLSFGVQDFDPE
CCCHHHHHHHHHHHHCEEEECCCCEEEEECCCCHHHHHHHHHHHHCCHHHHCCCCCCCHH
VQKAVHRIQPAEKVFALVDAARKLGFESVNVDLIYGLPRQTPESFDRTLEQVAELRPDRI
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCE
ALYAYAHLPERFKSQRRIITAELPMASAKVSMLARSLDVFQEAGYVYVGMDHFALPDDAL
EEEEHHHCHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCHHHH
AVAKRQGRLHRNFQGYSTQPDCDLIGLGVSAIGRVGATYSQNVKTLDEYYDCINQGHLPV
HHHHHHCHHHCCCCCCCCCCCCCEEECCHHHHHHHCCCHHCCHHHHHHHHHHHCCCCCHH
VRGLALTKDDLVRRAVIMALMCQGELLFEPLEQSWLIDFRSYFDAELQQLQEMAAQGLVK
HHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
ISDEGVEVTPMGWYFVRGVAMVFDKYLQADRNRARFSRII
ECCCCEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]