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The map label for this gene is parE [H]

Identifier: 222110142

GI number: 222110142

Start: 948933

End: 950915

Strand: Direct

Name: parE [H]

Synonym: Dtpsy_0928

Alternate gene names: 222110142

Gene position: 948933-950915 (Clockwise)

Preceding gene: 222110135

Following gene: 222110143

Centisome position: 24.99

GC content: 67.17

Gene sequence:

>1983_bases
ATGGCAGTCAAACCCGCATCCACCTCCGCCAGCGACTACTCCGAAGGCTCGATCCGCGTCCTCAAGGGACTGGAGCCCGT
CAAGCAGCGGCCGGGCATGTACACCCGCACCGACAACCCCCTGCACATCATCCAGGAGGTGCTGGACAACGCGGCCGACG
AGGCACTGGCGGGCTTTGGCAAGAAGATCAAGGTGACCTTGCACACCGACGGCTCGGTGAGCGTGGAGGACGACGGCCGG
GGTATTCCGTTCGGCCTGCATCCCGAGGAGAACGCACCGGTGGTGGAACTGGTGTTCACCCGCCTGCACGCGGGCGGCAA
GTTCGACAAGGGCAAGGGCGGGGCCTACAGCTTCTCGGGCGGCCTGCATGGTGTGGGCGTAAGCGTCACCAACGCCCTGG
CCACCCGGCTGGAGGTGGCCACCCACCGCGAGGGCCAGGTGGCGCGCCTGGTGTTTGCGGGCGGCGATGTGACCGAGCCG
CTGGCGGCGCGCCCGCTGCAGGCGGGCGAGCGCAAGCAGGGCACCACCGTGCGCGTCTGGCCCGACGCCAAATACTTTGA
GTCCAGCAACCTTCCGATGGGCGAGCTGACGCACTTGCTGCGCAGCAAGGCGGTGCTCATGCCCGGCGTTACGGTGCAAC
TGGTCAATGAAAAGACGCGCGACACCCAGACCTGGCAGTACAAGGGCGGTCTGCGCGACTACCTGGCGCAGACGCTGAGC
GCTGACCCGGTGATCCCGCTGTTCGAGGGCGAGGGCTTCGCCGACCGCCACAACGAGAGCTTTGCCGAGGGCGAGGGCGC
CGCATGGTGTGTGGCCTTCACCGAGGAAGGCCAGCCGGTGCGCGAGAGCTACGTGAACCTGATCCCCACCAGCGCCGGCG
GCACCCATGAAAGCGGCCTGCGCGACGGCCTGTTCAACGCGGTCAAGAGTTTCATCGAGCTGCACTCGCTCCTGCCCAAG
GGGGTGAAGCTGCTGCCCGAGGACGTGTTTGCGCGCGCCAGCTATGTGCTGGCGGCCAAGGTGCTGGACCCACAGTTCCA
GGGGCAGATCAAGGAGCGGCTGAACTCGCGCGACGCCGTGCGGCTGGTGTCCAGCTTCGTGCGCCCGGCGCTGGAGCTGT
GGCTGAACCAGCACGTGGAATACGGCAAGAAGCTGGCCGAACTGGCCATCAAGGCCGCGCAGACACGGCAAAAGGCCGGC
CAGAAGGTCGAAAAGCGCAAGGGCTCGGGCGTGGCCGTGCTGCCCGGCAAGCTCACCGACTGCGAAAGCCGTGACCTGGC
CTACAACGAGGTCTTCCTGGTCGAGGGCGACTCGGCCGGCGGCAGCGCCAAGATGGGCCGCGACAAGGAAAGCCAGGCCA
TCCTGCCGCTGCGCGGCAAGGTGCTCAACACCTGGGAGGTCGACCGCGACCGCCTGTTTGCCAACACCGAGGTGCATGAC
ATCTCGGTAGCCATCGGCGTGGACCCGCACGGCCCGAGCGACACCCCCGACCTGTCCGGCCTGCGCTACGGCAAGATCTG
CATCCTCTCCGACGCGGACGTGGACGGCTCGCACATCCAGGTGCTGCTGCTCACGCTGTTCTTCCGCCACTTCCCCAAGC
TCATCGAGGCCGGCCATATCTTTGTCGCCCGGCCACCGCTGTTCCGCGTGGACGTGCCGGCGCGCGGCAAGAAGCCAGCG
GCCAAGGTGTATGCGCTGGATGAATCCGAGCTGGAAAGCATCCTCGACAAGTGCGCCAAGGACGGCGTGCCGCGCGAGAA
GTGCCAGATCAGCCGCTTCAAGGGCCTGGGCGAAATGAACGCCGAGCAGCTGTGGGAGACCACGCTCAACCCCGACACGC
GCCGCCTGCTGCCGGTGCAGTTGGGCACGTTCGACTTCTCCGCCACCGAGGGCCTGATCACCAAGCTCATGGGCAAGGGC
GAGGCCGCCGCGCGCCGCGAGCTCATGGAGCTGCACGGCGACCTGGTGGATGTGGACATCTGA

Upstream 100 bases:

>100_bases
AAAACCCGTTTCGCCTGCTTGGCGCCCCCTGTGCAGCACGCTGGCGGGGCAAGAAAGCGTCACCATCCTGGTTTTATATC
CAGCACTACAATCCGCCGCC

Downstream 100 bases:

>100_bases
CGAAGGCACTCGCCATGACTGCGCGCCTGGGATACCGTATGCGTAACAGCCTTTTGGGGCTTTTGCGCACGGCTGGCATG
TGCTGCGCGCTCCTTTTTTT

Product: DNA topoisomerase IV subunit b

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 660; Mature: 659

Protein sequence:

>660_residues
MAVKPASTSASDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGFGKKIKVTLHTDGSVSVEDDGR
GIPFGLHPEENAPVVELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALATRLEVATHREGQVARLVFAGGDVTEP
LAARPLQAGERKQGTTVRVWPDAKYFESSNLPMGELTHLLRSKAVLMPGVTVQLVNEKTRDTQTWQYKGGLRDYLAQTLS
ADPVIPLFEGEGFADRHNESFAEGEGAAWCVAFTEEGQPVRESYVNLIPTSAGGTHESGLRDGLFNAVKSFIELHSLLPK
GVKLLPEDVFARASYVLAAKVLDPQFQGQIKERLNSRDAVRLVSSFVRPALELWLNQHVEYGKKLAELAIKAAQTRQKAG
QKVEKRKGSGVAVLPGKLTDCESRDLAYNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVDRDRLFANTEVHD
ISVAIGVDPHGPSDTPDLSGLRYGKICILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHIFVARPPLFRVDVPARGKKPA
AKVYALDESELESILDKCAKDGVPREKCQISRFKGLGEMNAEQLWETTLNPDTRRLLPVQLGTFDFSATEGLITKLMGKG
EAAARRELMELHGDLVDVDI

Sequences:

>Translated_660_residues
MAVKPASTSASDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGFGKKIKVTLHTDGSVSVEDDGR
GIPFGLHPEENAPVVELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALATRLEVATHREGQVARLVFAGGDVTEP
LAARPLQAGERKQGTTVRVWPDAKYFESSNLPMGELTHLLRSKAVLMPGVTVQLVNEKTRDTQTWQYKGGLRDYLAQTLS
ADPVIPLFEGEGFADRHNESFAEGEGAAWCVAFTEEGQPVRESYVNLIPTSAGGTHESGLRDGLFNAVKSFIELHSLLPK
GVKLLPEDVFARASYVLAAKVLDPQFQGQIKERLNSRDAVRLVSSFVRPALELWLNQHVEYGKKLAELAIKAAQTRQKAG
QKVEKRKGSGVAVLPGKLTDCESRDLAYNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVDRDRLFANTEVHD
ISVAIGVDPHGPSDTPDLSGLRYGKICILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHIFVARPPLFRVDVPARGKKPA
AKVYALDESELESILDKCAKDGVPREKCQISRFKGLGEMNAEQLWETTLNPDTRRLLPVQLGTFDFSATEGLITKLMGKG
EAAARRELMELHGDLVDVDI
>Mature_659_residues
AVKPASTSASDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGFGKKIKVTLHTDGSVSVEDDGRG
IPFGLHPEENAPVVELVFTRLHAGGKFDKGKGGAYSFSGGLHGVGVSVTNALATRLEVATHREGQVARLVFAGGDVTEPL
AARPLQAGERKQGTTVRVWPDAKYFESSNLPMGELTHLLRSKAVLMPGVTVQLVNEKTRDTQTWQYKGGLRDYLAQTLSA
DPVIPLFEGEGFADRHNESFAEGEGAAWCVAFTEEGQPVRESYVNLIPTSAGGTHESGLRDGLFNAVKSFIELHSLLPKG
VKLLPEDVFARASYVLAAKVLDPQFQGQIKERLNSRDAVRLVSSFVRPALELWLNQHVEYGKKLAELAIKAAQTRQKAGQ
KVEKRKGSGVAVLPGKLTDCESRDLAYNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVDRDRLFANTEVHDI
SVAIGVDPHGPSDTPDLSGLRYGKICILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHIFVARPPLFRVDVPARGKKPAA
KVYALDESELESILDKCAKDGVPREKCQISRFKGLGEMNAEQLWETTLNPDTRRLLPVQLGTFDFSATEGLITKLMGKGE
AAARRELMELHGDLVDVDI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=641, Percent_Identity=24.804992199688, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI19913406, Length=601, Percent_Identity=24.2928452579035, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1789408, Length=651, Percent_Identity=49.0015360983103, Blast_Score=615, Evalue=1e-177,
Organism=Escherichia coli, GI48994957, Length=595, Percent_Identity=38.3193277310924, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17535065, Length=628, Percent_Identity=24.8407643312102, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI212645845, Length=563, Percent_Identity=24.5115452930728, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI212645657, Length=150, Percent_Identity=32.6666666666667, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=601, Percent_Identity=24.9584026622296, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136538, Length=658, Percent_Identity=24.1641337386018, Blast_Score=112, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71906; Mature: 71774

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKPASTSASDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGFG
CCCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
KKIKVTLHTDGSVSVEDDGRGIPFGLHPEENAPVVELVFTRLHAGGKFDKGKGGAYSFSG
CEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECC
GLHGVGVSVTNALATRLEVATHREGQVARLVFAGGDVTEPLAARPLQAGERKQGTTVRVW
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHCCCCCCCCCCCCEEEEC
PDAKYFESSNLPMGELTHLLRSKAVLMPGVTVQLVNEKTRDTQTWQYKGGLRDYLAQTLS
CCCHHHCCCCCCHHHHHHHHHHCCEECCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHC
ADPVIPLFEGEGFADRHNESFAEGEGAAWCVAFTEEGQPVRESYVNLIPTSAGGTHESGL
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEEECCCCCCCHHHH
RDGLFNAVKSFIELHSLLPKGVKLLPEDVFARASYVLAAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHH
RLVSSFVRPALELWLNQHVEYGKKLAELAIKAAQTRQKAGQKVEKRKGSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
CESRDLAYNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVDRDRLFANTEVHD
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEEEEECCHHHEEECCCEEE
ISVAIGVDPHGPSDTPDLSGLRYGKICILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHI
EEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDVPARGKKPAAKVYALDESELESILDKCAKDGVPREKCQISRFKGLGEMN
EEECCCEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AEQLWETTLNPDTRRLLPVQLGTFDFSATEGLITKLMGKGEAAARRELMELHGDLVDVDI
HHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
AVKPASTSASDYSEGSIRVLKGLEPVKQRPGMYTRTDNPLHIIQEVLDNAADEALAGFG
CCCCCCCCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
KKIKVTLHTDGSVSVEDDGRGIPFGLHPEENAPVVELVFTRLHAGGKFDKGKGGAYSFSG
CEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEECC
GLHGVGVSVTNALATRLEVATHREGQVARLVFAGGDVTEPLAARPLQAGERKQGTTVRVW
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHCCCCCCCCCCCCEEEEC
PDAKYFESSNLPMGELTHLLRSKAVLMPGVTVQLVNEKTRDTQTWQYKGGLRDYLAQTLS
CCCHHHCCCCCCHHHHHHHHHHCCEECCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHC
ADPVIPLFEGEGFADRHNESFAEGEGAAWCVAFTEEGQPVRESYVNLIPTSAGGTHESGL
CCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHEEECCCCCCCHHHH
RDGLFNAVKSFIELHSLLPKGVKLLPEDVFARASYVLAAKVLDPQFQGQIKERLNSRDAV
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHH
RLVSSFVRPALELWLNQHVEYGKKLAELAIKAAQTRQKAGQKVEKRKGSGVAVLPGKLTD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
CESRDLAYNEVFLVEGDSAGGSAKMGRDKESQAILPLRGKVLNTWEVDRDRLFANTEVHD
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCEEEEEECCHHHEEECCCEEE
ISVAIGVDPHGPSDTPDLSGLRYGKICILSDADVDGSHIQVLLLTLFFRHFPKLIEAGHI
EEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCE
FVARPPLFRVDVPARGKKPAAKVYALDESELESILDKCAKDGVPREKCQISRFKGLGEMN
EEECCCEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AEQLWETTLNPDTRRLLPVQLGTFDFSATEGLITKLMGKGEAAARRELMELHGDLVDVDI
HHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]