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The map label for this gene is gmk [H]

Identifier: 222110076

GI number: 222110076

Start: 886766

End: 887386

Strand: Direct

Name: gmk [H]

Synonym: Dtpsy_0862

Alternate gene names: 222110076

Gene position: 886766-887386 (Clockwise)

Preceding gene: 222110075

Following gene: 222110077

Centisome position: 23.36

GC content: 62.48

Gene sequence:

>621_bases
ATGGACTATCCCGGAAATTTGTTTGTAGTCTCTGCCCCCAGCGGGGCGGGTAAATCCAGCTTGGTCAAGGCCCTGCTGGA
GCTGGACTCGCATGTGCAGCCCTCCGTGTCGCACACGACCCGCGCGCCGCGCGGGCAGGAAAAGCACGGCCGCGAGTACT
TCTTCGCTTCCGAGCAGGAGTTCGACGCGATGGTGGCGGCTAACGGCTTCGTCGAGTGGGCGAACGTCCATGGACGCCGT
TATGGAACCTCCCGCAAGGTGATCGAGGAGCGCGTGGCCCAGGGGGCGGACGTGGTCTTGGAAATCGACTTTCAGGGCGC
GCTGCAGATCAAGCAGGCCTTCGCGAACGCCGTGCTGGTCTTTGTGCTGCCGCCCAGCTGGGACGAGTTGCGCGCCCGGC
TGGAACGCCGGGGCGAAGATGCGCCCGACGTGATTGACCTACGCCTGGAGAACGCGGCAGAGGAAATGGCGCAGGCCAGC
AAATTCGACTTCGTTATAATCAATGAGGTCTTTGAGCGAGCGCTTTTCGACCTGAAAACCATCGTTCATGCCCAGCGTCT
CAAGTACGCCGCCCAGCGCCGCGCCCGGGCCGAAACCTTCGAGTCGCTCAATATTCCCTGA

Upstream 100 bases:

>100_bases
CATCAGCGTGGACATGAAGGTGCTGATCGAGCAGATGCGCGAGCAAGTGCAGAACATCGAGTGATAATCCTGTTTTGATA
GCGGCTCACGCACACTCCAT

Downstream 100 bases:

>100_bases
TCCCTGGAGAACACCATGGCCCGCATTACCGTGGAAGACTGCCTCGAGCAGATTCCCAACCGTTTTCAACTGGTGCTCGC
CGCCACCTACCGTGCCCGCA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MDYPGNLFVVSAPSGAGKSSLVKALLELDSHVQPSVSHTTRAPRGQEKHGREYFFASEQEFDAMVAANGFVEWANVHGRR
YGTSRKVIEERVAQGADVVLEIDFQGALQIKQAFANAVLVFVLPPSWDELRARLERRGEDAPDVIDLRLENAAEEMAQAS
KFDFVIINEVFERALFDLKTIVHAQRLKYAAQRRARAETFESLNIP

Sequences:

>Translated_206_residues
MDYPGNLFVVSAPSGAGKSSLVKALLELDSHVQPSVSHTTRAPRGQEKHGREYFFASEQEFDAMVAANGFVEWANVHGRR
YGTSRKVIEERVAQGADVVLEIDFQGALQIKQAFANAVLVFVLPPSWDELRARLERRGEDAPDVIDLRLENAAEEMAQAS
KFDFVIINEVFERALFDLKTIVHAQRLKYAAQRRARAETFESLNIP
>Mature_206_residues
MDYPGNLFVVSAPSGAGKSSLVKALLELDSHVQPSVSHTTRAPRGQEKHGREYFFASEQEFDAMVAANGFVEWANVHGRR
YGTSRKVIEERVAQGADVVLEIDFQGALQIKQAFANAVLVFVLPPSWDELRARLERRGEDAPDVIDLRLENAAEEMAQAS
KFDFVIINEVFERALFDLKTIVHAQRLKYAAQRRARAETFESLNIP

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=37.7142857142857, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=37.7142857142857, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=37.7142857142857, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=28.8888888888889, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=25, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI21361598, Length=190, Percent_Identity=26.8421052631579, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI52630447, Length=189, Percent_Identity=28.042328042328, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118263, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=27.0114942528736, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI111154074, Length=176, Percent_Identity=28.4090909090909, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1790080, Length=192, Percent_Identity=49.4791666666667, Blast_Score=189, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=176, Percent_Identity=38.0681818181818, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508835, Length=176, Percent_Identity=38.0681818181818, Blast_Score=124, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=38.4615384615385, Blast_Score=125, Evalue=5e-30,
Organism=Drosophila melanogaster, GI21356141, Length=158, Percent_Identity=41.1392405063291, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077626, Length=172, Percent_Identity=31.9767441860465, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI116007136, Length=173, Percent_Identity=31.7919075144509, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI85724806, Length=173, Percent_Identity=31.7919075144509, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554481, Length=173, Percent_Identity=31.7919075144509, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554489, Length=173, Percent_Identity=31.7919075144509, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640542, Length=173, Percent_Identity=31.7919075144509, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221330162, Length=164, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330166, Length=164, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221330164, Length=164, Percent_Identity=31.7073170731707, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23102; Mature: 23102

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYPGNLFVVSAPSGAGKSSLVKALLELDSHVQPSVSHTTRAPRGQEKHGREYFFASEQE
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEECCCHH
FDAMVAANGFVEWANVHGRRYGTSRKVIEERVAQGADVVLEIDFQGALQIKQAFANAVLV
HHHHHHHCCCHHHHHHCCHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCEEEE
FVLPPSWDELRARLERRGEDAPDVIDLRLENAAEEMAQASKFDFVIINEVFERALFDLKT
EEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHH
IVHAQRLKYAAQRRARAETFESLNIP
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDYPGNLFVVSAPSGAGKSSLVKALLELDSHVQPSVSHTTRAPRGQEKHGREYFFASEQE
CCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEECCCHH
FDAMVAANGFVEWANVHGRRYGTSRKVIEERVAQGADVVLEIDFQGALQIKQAFANAVLV
HHHHHHHCCCHHHHHHCCHHCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCEEEE
FVLPPSWDELRARLERRGEDAPDVIDLRLENAAEEMAQASKFDFVIINEVFERALFDLKT
EEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHH
IVHAQRLKYAAQRRARAETFESLNIP
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA