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The map label for this gene is mutM

Identifier: 222110042

GI number: 222110042

Start: 859102

End: 859917

Strand: Direct

Name: mutM

Synonym: Dtpsy_0828

Alternate gene names: 222110042

Gene position: 859102-859917 (Clockwise)

Preceding gene: 222110035

Following gene: 222110043

Centisome position: 22.63

GC content: 69.24

Gene sequence:

>816_bases
ATGCCTGAGCTGCCGGAGGTGGAAGTCACGCGGCGCAGCTTCGCTGGCGCGATCGAGGGCGCAACTGTCCGCGGCATTAC
GGTGGGCAAGCCCTTGCGCTGGCCGCTGGGCACGGAGCCCGCAGTATTGGTCGGGCGGCGGGTGTGCGGTGTGCGCCGGC
GCGGCAAATACCTGTTGCTGGATCTGGATGAAGGGCTGCTGCTCATTCACCTGGGCATGTCGGGCAGCTTGCGCTTTGCA
CGCGATCTGCCCGCGCGCGGCGCCCACGATCATTTCGAACTGATAACGGACCACGGCACGCTGCGGCTGCACGACCCGCG
GCGCTTCGGCGCCGTGGTCTGGGCGGCGGGTGAGTCCGATCCCCGTGCGCGCAAGCTGCTCGATGGGTGGGGATTGGAGC
CGCTGGGCGAGGACTTCGCCTTCGAGGCCTTCCACGCGGGGCTGCGCGCCAAACGCACGCCCATCAAGCAACTGCTGCTC
GCTGGCACGGTGGTCGTGGGTGTGGGCAATATCTATGCCTGCGAGGTGCTGTTCCTCGCGGGCATCCGGCCAACCACCCG
CGCTTGCGCGATCGGACCCCAGCGTGCCCGGCGCCTGCACGGCGCAATCCGCGAGGTGCTGGCGCGCGCGGTGGAGCGGG
GCGGCAGCACGCTGCGTGATTTCTCTAGCGCCGACGGCAGCGCCGGGCATTTCCAATTGGAGGCCAATGTCTATGGCCGC
GCGGGCCTGCAGTGTCGCCAGTGCGGTACGCCCGTGCGTCTGTCGCGCCAGGGGCAGCGCAGCACCTATTTCTGTCCGCA
CTGCCAGCGCGCCTGA

Upstream 100 bases:

>100_bases
GCCGCAGCCCAACATGCCAGTGCGACGGCCCTGAAACGAAGAGATTGCACCATCGGCCCATAATAATCCATGGCTCTTGA
ACTTCTTGACGAGTATTGCG

Downstream 100 bases:

>100_bases
CCGGGCTGCCTGGCGGCGGACCGGCGCAATGGCGATGCTATATTGCGCCATCTCCCGCCCACGCGGGCGCTTGCATTGAT
ATCCGGGAGCAAAGTGGGAC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MPELPEVEVTRRSFAGAIEGATVRGITVGKPLRWPLGTEPAVLVGRRVCGVRRRGKYLLLDLDEGLLLIHLGMSGSLRFA
RDLPARGAHDHFELITDHGTLRLHDPRRFGAVVWAAGESDPRARKLLDGWGLEPLGEDFAFEAFHAGLRAKRTPIKQLLL
AGTVVVGVGNIYACEVLFLAGIRPTTRACAIGPQRARRLHGAIREVLARAVERGGSTLRDFSSADGSAGHFQLEANVYGR
AGLQCRQCGTPVRLSRQGQRSTYFCPHCQRA

Sequences:

>Translated_271_residues
MPELPEVEVTRRSFAGAIEGATVRGITVGKPLRWPLGTEPAVLVGRRVCGVRRRGKYLLLDLDEGLLLIHLGMSGSLRFA
RDLPARGAHDHFELITDHGTLRLHDPRRFGAVVWAAGESDPRARKLLDGWGLEPLGEDFAFEAFHAGLRAKRTPIKQLLL
AGTVVVGVGNIYACEVLFLAGIRPTTRACAIGPQRARRLHGAIREVLARAVERGGSTLRDFSSADGSAGHFQLEANVYGR
AGLQCRQCGTPVRLSRQGQRSTYFCPHCQRA
>Mature_270_residues
PELPEVEVTRRSFAGAIEGATVRGITVGKPLRWPLGTEPAVLVGRRVCGVRRRGKYLLLDLDEGLLLIHLGMSGSLRFAR
DLPARGAHDHFELITDHGTLRLHDPRRFGAVVWAAGESDPRARKLLDGWGLEPLGEDFAFEAFHAGLRAKRTPIKQLLLA
GTVVVGVGNIYACEVLFLAGIRPTTRACAIGPQRARRLHGAIREVLARAVERGGSTLRDFSSADGSAGHFQLEANVYGRA
GLQCRQCGTPVRLSRQGQRSTYFCPHCQRA

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=45.0549450549451, Blast_Score=224, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_ACIET (B9ME52)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002552306.1
- GeneID:   7383523
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0828
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29600; Mature: 29468

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 56-56 ACT_SITE 260-260 BINDING 89-89 BINDING 107-107 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVTRRSFAGAIEGATVRGITVGKPLRWPLGTEPAVLVGRRVCGVRRRGKYLLL
CCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
DLDEGLLLIHLGMSGSLRFARDLPARGAHDHFELITDHGTLRLHDPRRFGAVVWAAGESD
ECCCCEEEEEECCCCCEEEHHCCCCCCCCCCEEEEECCCEEEEECCCCCCEEEEECCCCC
PRARKLLDGWGLEPLGEDFAFEAFHAGLRAKRTPIKQLLLAGTVVVGVGNIYACEVLFLA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCHHHHHHHHHH
GIRPTTRACAIGPQRARRLHGAIREVLARAVERGGSTLRDFSSADGSAGHFQLEANVYGR
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEEEEECCC
AGLQCRQCGTPVRLSRQGQRSTYFCPHCQRA
CCCCHHHCCCCCEECCCCCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVEVTRRSFAGAIEGATVRGITVGKPLRWPLGTEPAVLVGRRVCGVRRRGKYLLL
CCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
DLDEGLLLIHLGMSGSLRFARDLPARGAHDHFELITDHGTLRLHDPRRFGAVVWAAGESD
ECCCCEEEEEECCCCCEEEHHCCCCCCCCCCEEEEECCCEEEEECCCCCCEEEEECCCCC
PRARKLLDGWGLEPLGEDFAFEAFHAGLRAKRTPIKQLLLAGTVVVGVGNIYACEVLFLA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHEEECCCHHHHHHHHHH
GIRPTTRACAIGPQRARRLHGAIREVLARAVERGGSTLRDFSSADGSAGHFQLEANVYGR
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEEEEECCC
AGLQCRQCGTPVRLSRQGQRSTYFCPHCQRA
CCCCHHHCCCCCEECCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA