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The map label for this gene is serA [H]

Identifier: 222110007

GI number: 222110007

Start: 821954

End: 823183

Strand: Direct

Name: serA [H]

Synonym: Dtpsy_0792

Alternate gene names: 222110007

Gene position: 821954-823183 (Clockwise)

Preceding gene: 222110000

Following gene: 222110008

Centisome position: 21.65

GC content: 66.5

Gene sequence:

>1230_bases
ATGGCCAAGACTTCCCTGGATAAAAGCAAGATCAAGTTCCTGTTGCTGGAGGGCATCCATGCCTCTGCGGTGGAAGTGTT
GCGGTCCGCGGGGTATACGCAGGTCGAGGTGCTGGCCGGGGCGCTGGAGGGCGAGGAACTGCGCCGCAAGATCGCCGACG
TGCACTTCATTGGCATCCGCTCGCGCACGCAGCTCACGGCGGACGTGTTCGCGCATGCGCACAAGCTCGTGGCCGTGGGG
TGCTTTTGCATCGGCACCAACCAGGTAGACCTGAACGCTGCGCGCGAGCGCGGCATCGCCGTGTTCAACGCGCCGTATTC
CAACACCCGCTCCGTGGCCGAGCTGGTGCTGGCCGAGGCCATCCTGCTGCTGCGCGGCGTGCCCGAGAAGAATGCCGCGG
CCCACCGCGGCGGCTGGCTCAAGAGCGCCACGAACGCCTACGAGATCCGCGGCAAGACGCTGGGCATCGTGGGCTATGGC
TCCATCGGCACCCAGCTGTCGGTGCTGGCCGAGGCGCTGGGCATGCACGTGATCTTCCACGACGTGGTGCACAAGCTGCC
GCTGGGCAATGCGCGCCAGGTCGGTTCGCTGCACGAGCTGCTGGGCCAGGCCGACATCGTGACCCTGCACGTGCCTGAGC
TGCCTTCCACCCAGTGGATGATTGGCGCCGCCGAGATCGCGGCCATGAAGCCGGGCGGCATCCTCATCAACGCCTCGCGC
GGCACGGTGGTGGAGATCGACCCCCTGGCCCAGGCGCTGAAGGGCGGCAACTTGCTGGGCGCGGCCGTGGACGTGTTCCC
GGTGGAGCCCAAGAGCAACAAGGACGAGTTCGTCTCGCCGCTGCGCGGGCTGGACAACGCCCTCCTCACGCCCCACATCG
GCGGCTCCACCATGGAGGCGCAGGCCAACATCGGCCTGGAGGTGGCGGAAAAGCTCGTCAGGTACAGCGACAACGGCACC
AGCACCTCTTCGGTCAACTTCCCCGAGGTGGCGCTGCCCGAGCATGCCGGCAAGCACCGCCTGCTGCACGTGCACCACAA
CGTGCCGGGCGTGCTCTCGCAGATCAACAGCATCCTGTCGGACAACCACATCAACATCGCGGCGCAGTACCTGCAGACCA
ACGAGAAGATCGGCTATGTGGTGATCGACCTCGACGCGCGCTCGTCCGACCTGGCGCTGGAGAAGCTGGCCCAGGTGCCC
GGCACCATCCGTAGCCGCGTGCTGTATTAA

Upstream 100 bases:

>100_bases
ATGGATGCCGACAGGGATTTGTGCATTGCACAATGATCCCCTCTCCTGTCCAGCGGCGCGCGCCGCTTGGGTGTTTTCAT
TTCCTCTCAATTTGCACGCC

Downstream 100 bases:

>100_bases
ATAGCTATTGTTTTAATAGCTGCTTGCGCTGAATGGGCGGGCGCTGGGGCCTGATTTTGCTCTTGCCCGTTCTTGGCTGT
CCCGCGCCAGCGGCGGGGCT

Product: d-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKTSLDKSKIKFLLLEGIHASAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIRSRTQLTADVFAHAHKLVAVG
CFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYG
SIGTQLSVLAEALGMHVIFHDVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR
GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEAQANIGLEVAEKLVRYSDNGT
STSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILSDNHINIAAQYLQTNEKIGYVVIDLDARSSDLALEKLAQVP
GTIRSRVLY

Sequences:

>Translated_409_residues
MAKTSLDKSKIKFLLLEGIHASAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIRSRTQLTADVFAHAHKLVAVG
CFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYG
SIGTQLSVLAEALGMHVIFHDVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR
GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEAQANIGLEVAEKLVRYSDNGT
STSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILSDNHINIAAQYLQTNEKIGYVVIDLDARSSDLALEKLAQVP
GTIRSRVLY
>Mature_408_residues
AKTSLDKSKIKFLLLEGIHASAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIRSRTQLTADVFAHAHKLVAVGC
FCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEAILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYGS
IGTQLSVLAEALGMHVIFHDVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASRG
TVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEAQANIGLEVAEKLVRYSDNGTS
TSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILSDNHINIAAQYLQTNEKIGYVVIDLDARSSDLALEKLAQVPG
TIRSRVLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=33.7539432176656, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI145580578, Length=242, Percent_Identity=34.297520661157, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=242, Percent_Identity=34.297520661157, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI61743967, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557497, Length=240, Percent_Identity=32.0833333333333, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=242, Percent_Identity=34.297520661157, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI6912396, Length=279, Percent_Identity=26.5232974910394, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=63.2603406326034, Blast_Score=528, Evalue=1e-151,
Organism=Escherichia coli, GI87082289, Length=264, Percent_Identity=31.8181818181818, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787645, Length=246, Percent_Identity=27.6422764227642, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788660, Length=270, Percent_Identity=30.3703703703704, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=33.1269349845201, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=249, Percent_Identity=30.1204819277108, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=51.9323671497584, Blast_Score=404, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=50, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6324964, Length=242, Percent_Identity=30.5785123966942, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=28.6919831223629, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=319, Percent_Identity=30.7210031347962, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24646446, Length=230, Percent_Identity=33.9130434782609, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646448, Length=230, Percent_Identity=33.9130434782609, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646452, Length=230, Percent_Identity=33.9130434782609, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646450, Length=230, Percent_Identity=33.9130434782609, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI62472511, Length=230, Percent_Identity=33.9130434782609, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28574286, Length=272, Percent_Identity=27.5735294117647, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571528, Length=295, Percent_Identity=28.4745762711864, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574284, Length=289, Percent_Identity=26.9896193771626, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552429, Length=248, Percent_Identity=27.4193548387097, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585514, Length=289, Percent_Identity=26.9896193771626, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=289, Percent_Identity=26.9896193771626, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551003, Length=289, Percent_Identity=26.9896193771626, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585516, Length=301, Percent_Identity=24.9169435215947, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43693; Mature: 43562

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTSLDKSKIKFLLLEGIHASAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIR
CCCCCCCHHHEEEEEECCCCHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHCEEEEEEC
SRTQLTADVFAHAHKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA
CCCHHHHHHHHHHHHHHHEEEEEEECCEEECHHHHHCCEEEEECCCCCHHHHHHHHHHHH
ILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVIFH
HHHHCCCCCCCCCHHCCCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
DVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR
HHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEHHHHEEECCCCEEEECCC
GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEA
CCEEEEHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHCCCCCEECCCCCCCCEEE
QANIGLEVAEKLVRYSDNGTSTSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILS
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHC
DNHINIAAQYLQTNEKIGYVVIDLDARSSDLALEKLAQVPGTIRSRVLY
CCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
AKTSLDKSKIKFLLLEGIHASAVEVLRSAGYTQVEVLAGALEGEELRRKIADVHFIGIR
CCCCCCHHHEEEEEECCCCHHHHHHHHHCCCCEEHHHHHHCCHHHHHHHHHCEEEEEEC
SRTQLTADVFAHAHKLVAVGCFCIGTNQVDLNAARERGIAVFNAPYSNTRSVAELVLAEA
CCCHHHHHHHHHHHHHHHEEEEEEECCEEECHHHHHCCEEEEECCCCCHHHHHHHHHHHH
ILLLRGVPEKNAAAHRGGWLKSATNAYEIRGKTLGIVGYGSIGTQLSVLAEALGMHVIFH
HHHHCCCCCCCCCHHCCCCCCCCCCEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHH
DVVHKLPLGNARQVGSLHELLGQADIVTLHVPELPSTQWMIGAAEIAAMKPGGILINASR
HHHHHCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEHHHHEEECCCCEEEECCC
GTVVEIDPLAQALKGGNLLGAAVDVFPVEPKSNKDEFVSPLRGLDNALLTPHIGGSTMEA
CCEEEEHHHHHHHCCCCEEEEEEEEEECCCCCCHHHHHHHHHCCCCCEECCCCCCCCEEE
QANIGLEVAEKLVRYSDNGTSTSSVNFPEVALPEHAGKHRLLHVHHNVPGVLSQINSILS
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHC
DNHINIAAQYLQTNEKIGYVVIDLDARSSDLALEKLAQVPGTIRSRVLY
CCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]