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The map label for this gene is mutT [H]

Identifier: 222109977

GI number: 222109977

Start: 791433

End: 791879

Strand: Direct

Name: mutT [H]

Synonym: Dtpsy_0762

Alternate gene names: 222109977

Gene position: 791433-791879 (Clockwise)

Preceding gene: 222109976

Following gene: 222109985

Centisome position: 20.85

GC content: 67.79

Gene sequence:

>447_bases
ATGAGCGAATCGACCAGCACGCCACAGCGCAAGCACACCGAGGTCGCCGTGGGCATTCTGCTGCGAGAGGACGGTGCGAT
GCTGTTGTCCACCCGCCCCACGGGCAAGCCCTACGCGGGCTACTGGGAGTTCCCGGGCGGCAAGATCGAAGCCGGGGAAA
CCGTGGAGCAGGCGCTGCGCCGCGAACTCATCGAGGAACTGGGCGTGACCATCGGCCCGGTGGAGGCCTGGAAGGTGACC
GAGCACGACTATCCGCATGCCCTCGTGCGCCTGCACTGGTGCAAGGTGCGCGAATGGAGCGGTGCGTTCGAAATGCGCGA
GGGCCAGACCATGGCCTGGCAGCACTGGCCGCTGCAGGTCAAGCCGGTGCTGCCGGGCGCCTATCCCGTGCTGCAGTGGC
TGGCCGAGGAGCGTGGCGAGGTCTTCGACGCTTCGCTGCTGGCGTGA

Upstream 100 bases:

>100_bases
GCCCGCAGGCGCTGGTGTGGGCGCTGGAGCGCGGCTCGCGCAGCGGCCGCGTGGCCTATCAATTTGCCCGGGATTTCGCA
GGGCGGCAGGGCGAGGGCGC

Downstream 100 bases:

>100_bases
GATGTTGCTTCAAAATACATAGCTGCTTGCGCTTGCTGGATAAGCGCTAGCAAGCCTTTTCTTCAAATATCACGGCTGGC
GCTTGGGATCGCCGAACTCC

Product: nudix hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MSESTSTPQRKHTEVAVGILLREDGAMLLSTRPTGKPYAGYWEFPGGKIEAGETVEQALRRELIEELGVTIGPVEAWKVT
EHDYPHALVRLHWCKVREWSGAFEMREGQTMAWQHWPLQVKPVLPGAYPVLQWLAEERGEVFDASLLA

Sequences:

>Translated_148_residues
MSESTSTPQRKHTEVAVGILLREDGAMLLSTRPTGKPYAGYWEFPGGKIEAGETVEQALRRELIEELGVTIGPVEAWKVT
EHDYPHALVRLHWCKVREWSGAFEMREGQTMAWQHWPLQVKPVLPGAYPVLQWLAEERGEVFDASLLA
>Mature_147_residues
SESTSTPQRKHTEVAVGILLREDGAMLLSTRPTGKPYAGYWEFPGGKIEAGETVEQALRRELIEELGVTIGPVEAWKVTE
HDYPHALVRLHWCKVREWSGAFEMREGQTMAWQHWPLQVKPVLPGAYPVLQWLAEERGEVFDASLLA

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=103, Percent_Identity=37.8640776699029, Blast_Score=68, Evalue=2e-13,
Organism=Escherichia coli, GI1788056, Length=123, Percent_Identity=34.9593495934959, Blast_Score=66, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 16751; Mature: 16620

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESTSTPQRKHTEVAVGILLREDGAMLLSTRPTGKPYAGYWEFPGGKIEAGETVEQALR
CCCCCCCCCHHHHEEEEEEEEECCCCEEEEECCCCCCCCCEEECCCCEEECCHHHHHHHH
RELIEELGVTIGPVEAWKVTEHDYPHALVRLHWCKVREWSGAFEMREGQTMAWQHWPLQV
HHHHHHCCCEECCCCEEEECCCCCCHHHHEEHHHHEECCCCCEEECCCCEEEEEECCEEE
KPVLPGAYPVLQWLAEERGEVFDASLLA
EECCCCHHHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure 
SESTSTPQRKHTEVAVGILLREDGAMLLSTRPTGKPYAGYWEFPGGKIEAGETVEQALR
CCCCCCCCHHHHEEEEEEEEECCCCEEEEECCCCCCCCCEEECCCCEEECCHHHHHHHH
RELIEELGVTIGPVEAWKVTEHDYPHALVRLHWCKVREWSGAFEMREGQTMAWQHWPLQV
HHHHHHCCCEECCCCEEEECCCCCCHHHHEEHHHHEECCCCCEEECCCCEEEEEECCEEE
KPVLPGAYPVLQWLAEERGEVFDASLLA
EECCCCHHHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]