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The map label for this gene is pgi [H]

Identifier: 222109891

GI number: 222109891

Start: 701788

End: 703404

Strand: Direct

Name: pgi [H]

Synonym: Dtpsy_0675

Alternate gene names: 222109891

Gene position: 701788-703404 (Clockwise)

Preceding gene: 222109890

Following gene: 222109898

Centisome position: 18.48

GC content: 66.6

Gene sequence:

>1617_bases
ATGAATTTTGACGATCCCCGCACCCGCTGCGACCACACGACCGCGTGGCAGCGCCTGCGTGCCCATTACGAAAGCGCCGG
CCGCAGCTTCGACCTGCGCGCCGCATTTGCGCAGGATGCGCAGCGTTTCGAGCGCTTCAGCCAGGACGCTCCGCATGTGT
TTGCGGACCTGTCCAAGAACCTGATCGACGCGCCCACCGAAGCGCTGCTGCTGCAGCTGGCGCGTGAATGCGGCGTGGTG
GCCTACCGCGATGCGATGTTCGAGGGCCGACCGATCAACAACACCGAGCAGCGCGCGGTGATGCATTGGTTGTTGCGAAA
ACCGGCTCCAGGGCATACAGGTCAAGCGCGAGTAGCTATCGATACAGTAGCGCCTGAAATCGCCTCTGCCTTGCACGACG
TGCACGCCATGCTGGAGGACATGCTGGCCCTCGCCGAGCGCGTGCGCGCTGACGACGGCATCACCGACATCGTGAACATC
GGCATCGGCGGCTCGGACCTGGGGCCGGCGATGGTGGTCAAGGCACTGGACGACCTGCGCCACCCGGGCAAGCGCCTGCA
CTTCATCTCCAACGTGGACGGCATGGAGCTGGGCAGCCTGTTGCGCCAGCTGCGGCCCGAAAGCACGCTGTTCCTCATTG
CGTCGAAGACCTTCACCACCGCCGAGACCATGTCCAACGCACAGGCGGCGCGGGCATGGTTCCTGGACCAGGGCGGCAGC
GAGGACGCGCGGGCGCGGCTGCCGCTGGCGCGCCATTTCTATGCGCTGACGACCAACCTGGAAGCGGCGGCGCAGTTCGG
CATCACCACCACGTTGGGCTTCTGGGACTGGGTGGGCGGACGCTATTCGCTGTGGTCCGCCATCGGGCTGCCGATTGCCA
TTGCCGTGGGTGCGCCGCACTTTCGCGCACTGCTGGCGGGTGCACATGCGATGGACGAGCATTTCCGCACCGCGCCGTTG
GAATCCAACCTGCCCGTGCGGCTGGCGCTGCTGGACCTGTGGTACCGCAATTTCCACGACTTCTCCAGCCGCAGCATGGC
ACCTTATAGCCATGGCCTGCGCCGCCTGCCGGCGTACCTGCAGCAATTGGAGATGGAGAGCAACGGCAAGGGGGTGGATG
CGCACGGCCAGCCGCTGCCCTATGCCACTTCTGCCGTGGTCTGGGGCGAGCCGGGCACCAATGGGCAGCATGCGTTCTTT
CAGATGATCCACCAGGGGCCCGACACCGTGCCCGTGGAGTTCATCGCGCTACGCGAGCCGGGGCGTGATTTGCCGGACCA
GCACCCGCGTCTGGTGGCCAACGCTTTGGCCCAGGCACGGGCGCTGATGATGGGACGGCCCGAAGAGGCCGACGGCCACC
GGCGCTTCAGCGGCAACCGGCCGAGCACATTTCTGGTGCTGGAGCGTCTGGACCCGGCGTCGCTAGGCGCGCTGATCGCG
CTGTACGAGCACCGCGTGTTCACCAGCGGGGCGCTCTGGGGCATCAACAGCTTCGATCAGTGGGGTGTGGAACTGGGCAA
AGGCATCGCCAAGGATCTGGAGCCGCGTCTGGCCACGGGGGATGTGCAGGGGCTGGACCCGTCCAGCGCGGGGCTGTTGC
GCCGTCTGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGCTCAATGCCGACGCCATGGCCACCGAGAAGCTGGCCGAAGGCATCCGCGCATTTGCGGCGGACGCGGCCAAGCTGGAA
CAACTGATGCAAGCCGCTGC

Downstream 100 bases:

>100_bases
AACGGGGTGCGCTTCCCGCTCTGACGGGGCTCAGGCGCGCGCTGCCTGGGGCATGGCCGGCGCATCATCTACAGGCGCCG
GCTGGAGTTCTGGAGCCAGG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MNFDDPRTRCDHTTAWQRLRAHYESAGRSFDLRAAFAQDAQRFERFSQDAPHVFADLSKNLIDAPTEALLLQLARECGVV
AYRDAMFEGRPINNTEQRAVMHWLLRKPAPGHTGQARVAIDTVAPEIASALHDVHAMLEDMLALAERVRADDGITDIVNI
GIGGSDLGPAMVVKALDDLRHPGKRLHFISNVDGMELGSLLRQLRPESTLFLIASKTFTTAETMSNAQAARAWFLDQGGS
EDARARLPLARHFYALTTNLEAAAQFGITTTLGFWDWVGGRYSLWSAIGLPIAIAVGAPHFRALLAGAHAMDEHFRTAPL
ESNLPVRLALLDLWYRNFHDFSSRSMAPYSHGLRRLPAYLQQLEMESNGKGVDAHGQPLPYATSAVVWGEPGTNGQHAFF
QMIHQGPDTVPVEFIALREPGRDLPDQHPRLVANALAQARALMMGRPEEADGHRRFSGNRPSTFLVLERLDPASLGALIA
LYEHRVFTSGALWGINSFDQWGVELGKGIAKDLEPRLATGDVQGLDPSSAGLLRRLAA

Sequences:

>Translated_538_residues
MNFDDPRTRCDHTTAWQRLRAHYESAGRSFDLRAAFAQDAQRFERFSQDAPHVFADLSKNLIDAPTEALLLQLARECGVV
AYRDAMFEGRPINNTEQRAVMHWLLRKPAPGHTGQARVAIDTVAPEIASALHDVHAMLEDMLALAERVRADDGITDIVNI
GIGGSDLGPAMVVKALDDLRHPGKRLHFISNVDGMELGSLLRQLRPESTLFLIASKTFTTAETMSNAQAARAWFLDQGGS
EDARARLPLARHFYALTTNLEAAAQFGITTTLGFWDWVGGRYSLWSAIGLPIAIAVGAPHFRALLAGAHAMDEHFRTAPL
ESNLPVRLALLDLWYRNFHDFSSRSMAPYSHGLRRLPAYLQQLEMESNGKGVDAHGQPLPYATSAVVWGEPGTNGQHAFF
QMIHQGPDTVPVEFIALREPGRDLPDQHPRLVANALAQARALMMGRPEEADGHRRFSGNRPSTFLVLERLDPASLGALIA
LYEHRVFTSGALWGINSFDQWGVELGKGIAKDLEPRLATGDVQGLDPSSAGLLRRLAA
>Mature_538_residues
MNFDDPRTRCDHTTAWQRLRAHYESAGRSFDLRAAFAQDAQRFERFSQDAPHVFADLSKNLIDAPTEALLLQLARECGVV
AYRDAMFEGRPINNTEQRAVMHWLLRKPAPGHTGQARVAIDTVAPEIASALHDVHAMLEDMLALAERVRADDGITDIVNI
GIGGSDLGPAMVVKALDDLRHPGKRLHFISNVDGMELGSLLRQLRPESTLFLIASKTFTTAETMSNAQAARAWFLDQGGS
EDARARLPLARHFYALTTNLEAAAQFGITTTLGFWDWVGGRYSLWSAIGLPIAIAVGAPHFRALLAGAHAMDEHFRTAPL
ESNLPVRLALLDLWYRNFHDFSSRSMAPYSHGLRRLPAYLQQLEMESNGKGVDAHGQPLPYATSAVVWGEPGTNGQHAFF
QMIHQGPDTVPVEFIALREPGRDLPDQHPRLVANALAQARALMMGRPEEADGHRRFSGNRPSTFLVLERLDPASLGALIA
LYEHRVFTSGALWGINSFDQWGVELGKGIAKDLEPRLATGDVQGLDPSSAGLLRRLAA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=555, Percent_Identity=44.5045045045045, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI296080693, Length=548, Percent_Identity=42.1532846715328, Blast_Score=405, Evalue=1e-113,
Organism=Escherichia coli, GI1790457, Length=551, Percent_Identity=44.2831215970962, Blast_Score=458, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71996703, Length=549, Percent_Identity=43.8979963570128, Blast_Score=434, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71996708, Length=549, Percent_Identity=43.8979963570128, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319673, Length=553, Percent_Identity=44.8462929475588, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24651916, Length=565, Percent_Identity=44.4247787610619, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24651914, Length=565, Percent_Identity=44.4247787610619, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI17737445, Length=565, Percent_Identity=44.4247787610619, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 59243; Mature: 59243

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFDDPRTRCDHTTAWQRLRAHYESAGRSFDLRAAFAQDAQRFERFSQDAPHVFADLSKN
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LIDAPTEALLLQLARECGVVAYRDAMFEGRPINNTEQRAVMHWLLRKPAPGHTGQARVAI
HHCCCHHHHHHHHHHHCCCEEEHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEE
DTVAPEIASALHDVHAMLEDMLALAERVRADDGITDIVNIGIGGSDLGPAMVVKALDDLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCCHHHHHHHHHHHH
HPGKRLHFISNVDGMELGSLLRQLRPESTLFLIASKTFTTAETMSNAQAARAWFLDQGGS
CCCHHEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCC
EDARARLPLARHFYALTTNLEAAAQFGITTTLGFWDWVGGRYSLWSAIGLPIAIAVGAPH
CCHHHCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHH
FRALLAGAHAMDEHFRTAPLESNLPVRLALLDLWYRNFHDFSSRSMAPYSHGLRRLPAYL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QQLEMESNGKGVDAHGQPLPYATSAVVWGEPGTNGQHAFFQMIHQGPDTVPVEFIALREP
HHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
GRDLPDQHPRLVANALAQARALMMGRPEEADGHRRFSGNRPSTFLVLERLDPASLGALIA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHH
LYEHRVFTSGALWGINSFDQWGVELGKGIAKDLEPRLATGDVQGLDPSSAGLLRRLAA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MNFDDPRTRCDHTTAWQRLRAHYESAGRSFDLRAAFAQDAQRFERFSQDAPHVFADLSKN
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LIDAPTEALLLQLARECGVVAYRDAMFEGRPINNTEQRAVMHWLLRKPAPGHTGQARVAI
HHCCCHHHHHHHHHHHCCCEEEHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEE
DTVAPEIASALHDVHAMLEDMLALAERVRADDGITDIVNIGIGGSDLGPAMVVKALDDLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEECCCCCCCCHHHHHHHHHHHH
HPGKRLHFISNVDGMELGSLLRQLRPESTLFLIASKTFTTAETMSNAQAARAWFLDQGGS
CCCHHEEEECCCCHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCC
EDARARLPLARHFYALTTNLEAAAQFGITTTLGFWDWVGGRYSLWSAIGLPIAIAVGAPH
CCHHHCCHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCEEEEECCHH
FRALLAGAHAMDEHFRTAPLESNLPVRLALLDLWYRNFHDFSSRSMAPYSHGLRRLPAYL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QQLEMESNGKGVDAHGQPLPYATSAVVWGEPGTNGQHAFFQMIHQGPDTVPVEFIALREP
HHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEEECCC
GRDLPDQHPRLVANALAQARALMMGRPEEADGHRRFSGNRPSTFLVLERLDPASLGALIA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHH
LYEHRVFTSGALWGINSFDQWGVELGKGIAKDLEPRLATGDVQGLDPSSAGLLRRLAA
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA