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The map label for this gene is hbpA [H]

Identifier: 222109879

GI number: 222109879

Start: 686703

End: 688283

Strand: Direct

Name: hbpA [H]

Synonym: Dtpsy_0663

Alternate gene names: 222109879

Gene position: 686703-688283 (Clockwise)

Preceding gene: 222109878

Following gene: 222109880

Centisome position: 18.09

GC content: 62.87

Gene sequence:

>1581_bases
ATGCGAATCAATGCCTTGATCCTTTCTCTTGCGGCGGCCTGCGCGGCGGCCGTGGTTCCAGCGGCGCATGCCAAGACCTT
CAAGTGGGCCAGCCAGGGCGAAATCGCCACCTGGGATATCCACTCCCAAAACAACGCGCTGCAAAACGCCATCCATTCGT
ATGTGTACGAAAGCCTGGTCTACTACAACAGCCGTACCTTCGAGGTCGAGCCCATGCTGGCGACGGCGTGGCGAGAGGTC
AGCCCCACACAAGTGCGTTTCACGCTGCGCCAGGGCGTGAAGTTCCACGATGGTTCCGCCTTCACGGCCGATGACGCCGT
GTACTCGCTGCAGCGCGCCATGTCCAAGACATCGAACTACACGCCGTATGTGCAAGGCATCGACAAGGTGGTGAAGGTGG
ATGCGCAGACCATCGACATCTTCCTCAAGTCGCCCAACCCCGTGCTGCTGCGGCAGATGACCGAGTTGCGCATGATGAGC
AAGGCCTGGGCCGAGAAGAACCGATCGGTGGAGCCGAAGGACATCAAGGGCACCGATGAGAACTTCGCCCATCGCAACGC
CATGGGCACGGGCCCCTATACGCTGGAGACATGGCAACCCGACGTGAAGATGGTCTTCAAGCGCAATCCGAACTGGTGGG
GCCAGATGGAAGGCAATGTGACCGAGATCGTCTACACCCCCATCAAGTCGGCCGCCACGCGCATTGCCGCCCTTCTGTCG
GGTGAGGTGGACCTGGTGCTGGACCCCTCACCGCAGGATCTGCCCCGCCTGCGCTCGTCGGGCACCATCAAGGTGGTGGA
CGGGCTGGAGAACCGTACCATCTTCCTGGGCATGGACCAGTTCCGGGATGAACTCGTGGGCTCCAACATCAAGGGCAAGA
ACCCCTTGAAGGACCTGCGCGTGCGCAAGGCGCTGTACCAGTCCATCGACGCCAATGCCCTCACGCGCAACATCCTGCGC
GGCCTGGGCAAGCCGACTGGTACCCTGGTGGCGCCGCAGGTCGCAGGCTGGTCGGAGGCCGTGGGCAAGCGCATGCCCTA
CGACGTCGAGGCCGCGAAGAAGCTGCTGGCCGAGGCCGGCTATGCCGACGGTTTCGAGGTGGACTTCGCCTGTCCCAACA
ATCGCTACATCAACGACGAGGCCATCTGCCAGGCGGTCACCGCCATGTGGGCGCGCATCGGTGTGAAGGCCAAGCTGCGC
ACGCTGCCGCTGGTGACCTACTTTCCCATGATCCAGCGCAGCGAAGCCAGCATCTACATGCTGGGTTGGGGCGTGCCGAC
CTTTGACGCGCTGTACAGCCTGCAATCGCTGGTGCGCAGCGTAGGCACTGGTGGCGATGGCAACTACAACGTGGGCCGCT
ACCGCAATGAGCGCATGGACTACCTGGTGGACCGCATCAAGGCCGAGACGGACGCTCCGGTGCGCGCGCGCATGCTGACC
GAGGCGCTGCAGCTCTCCAACGACACGGTCTCGCACCTGCCGCTGTACGACCAGGTCATCCCCTGGGCCATGAAGAAGAA
TGTGGAGCTGGTGCATCGTGCCGACAACCGCATCGACATGCGCACCGTCAAGCTCCAGTGA

Upstream 100 bases:

>100_bases
ATGAATGGCGGCGCATCTGCGATGCACCATTTCAGGGATTTCCCTTTGCCAGTGGCCACGGCCACGCTGTAGTCGCTCCT
TTCTATAAAAGAGGATTCCC

Downstream 100 bases:

>100_bases
GCGGCCGTGCCATAACGTACCGCCTGCGTGCGGAAAGCCCCTGCGCAGGCGAACCACGGCCAGTCTAAGCACCCGGCCGC
TGCGGGGACGAGCCTTGGCT

Product: family 5 extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MRINALILSLAAACAAAVVPAAHAKTFKWASQGEIATWDIHSQNNALQNAIHSYVYESLVYYNSRTFEVEPMLATAWREV
SPTQVRFTLRQGVKFHDGSAFTADDAVYSLQRAMSKTSNYTPYVQGIDKVVKVDAQTIDIFLKSPNPVLLRQMTELRMMS
KAWAEKNRSVEPKDIKGTDENFAHRNAMGTGPYTLETWQPDVKMVFKRNPNWWGQMEGNVTEIVYTPIKSAATRIAALLS
GEVDLVLDPSPQDLPRLRSSGTIKVVDGLENRTIFLGMDQFRDELVGSNIKGKNPLKDLRVRKALYQSIDANALTRNILR
GLGKPTGTLVAPQVAGWSEAVGKRMPYDVEAAKKLLAEAGYADGFEVDFACPNNRYINDEAICQAVTAMWARIGVKAKLR
TLPLVTYFPMIQRSEASIYMLGWGVPTFDALYSLQSLVRSVGTGGDGNYNVGRYRNERMDYLVDRIKAETDAPVRARMLT
EALQLSNDTVSHLPLYDQVIPWAMKKNVELVHRADNRIDMRTVKLQ

Sequences:

>Translated_526_residues
MRINALILSLAAACAAAVVPAAHAKTFKWASQGEIATWDIHSQNNALQNAIHSYVYESLVYYNSRTFEVEPMLATAWREV
SPTQVRFTLRQGVKFHDGSAFTADDAVYSLQRAMSKTSNYTPYVQGIDKVVKVDAQTIDIFLKSPNPVLLRQMTELRMMS
KAWAEKNRSVEPKDIKGTDENFAHRNAMGTGPYTLETWQPDVKMVFKRNPNWWGQMEGNVTEIVYTPIKSAATRIAALLS
GEVDLVLDPSPQDLPRLRSSGTIKVVDGLENRTIFLGMDQFRDELVGSNIKGKNPLKDLRVRKALYQSIDANALTRNILR
GLGKPTGTLVAPQVAGWSEAVGKRMPYDVEAAKKLLAEAGYADGFEVDFACPNNRYINDEAICQAVTAMWARIGVKAKLR
TLPLVTYFPMIQRSEASIYMLGWGVPTFDALYSLQSLVRSVGTGGDGNYNVGRYRNERMDYLVDRIKAETDAPVRARMLT
EALQLSNDTVSHLPLYDQVIPWAMKKNVELVHRADNRIDMRTVKLQ
>Mature_526_residues
MRINALILSLAAACAAAVVPAAHAKTFKWASQGEIATWDIHSQNNALQNAIHSYVYESLVYYNSRTFEVEPMLATAWREV
SPTQVRFTLRQGVKFHDGSAFTADDAVYSLQRAMSKTSNYTPYVQGIDKVVKVDAQTIDIFLKSPNPVLLRQMTELRMMS
KAWAEKNRSVEPKDIKGTDENFAHRNAMGTGPYTLETWQPDVKMVFKRNPNWWGQMEGNVTEIVYTPIKSAATRIAALLS
GEVDLVLDPSPQDLPRLRSSGTIKVVDGLENRTIFLGMDQFRDELVGSNIKGKNPLKDLRVRKALYQSIDANALTRNILR
GLGKPTGTLVAPQVAGWSEAVGKRMPYDVEAAKKLLAEAGYADGFEVDFACPNNRYINDEAICQAVTAMWARIGVKAKLR
TLPLVTYFPMIQRSEASIYMLGWGVPTFDALYSLQSLVRSVGTGGDGNYNVGRYRNERMDYLVDRIKAETDAPVRARMLT
EALQLSNDTVSHLPLYDQVIPWAMKKNVELVHRADNRIDMRTVKLQ

Specific function: Important role in heme acquisition or metabolism [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=531, Percent_Identity=27.3069679849341, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1789397, Length=518, Percent_Identity=24.7104247104247, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1787052, Length=512, Percent_Identity=24.609375, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1787495, Length=525, Percent_Identity=23.2380952380952, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081878, Length=448, Percent_Identity=24.3303571428571, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789887, Length=510, Percent_Identity=24.5098039215686, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1787762, Length=464, Percent_Identity=23.7068965517241, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1787551, Length=356, Percent_Identity=22.4719101123595, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786256, Length=144, Percent_Identity=31.9444444444444, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 58907; Mature: 58907

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRINALILSLAAACAAAVVPAAHAKTFKWASQGEIATWDIHSQNNALQNAIHSYVYESLV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
YYNSRTFEVEPMLATAWREVSPTQVRFTLRQGVKFHDGSAFTADDAVYSLQRAMSKTSNY
HCCCCEEEECCHHHHHHCCCCCHHEEEEHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCC
TPYVQGIDKVVKVDAQTIDIFLKSPNPVLLRQMTELRMMSKAWAEKNRSVEPKDIKGTDE
CHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NFAHRNAMGTGPYTLETWQPDVKMVFKRNPNWWGQMEGNVTEIVYTPIKSAATRIAALLS
HHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHC
GEVDLVLDPSPQDLPRLRSSGTIKVVDGLENRTIFLGMDQFRDELVGSNIKGKNPLKDLR
CCEEEEECCCCCHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHCCCCCCCCCHHHHH
VRKALYQSIDANALTRNILRGLGKPTGTLVAPQVAGWSEAVGKRMPYDVEAAKKLLAEAG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHCCCCCCCHHHHHHHHHHCC
YADGFEVDFACPNNRYINDEAICQAVTAMWARIGVKAKLRTLPLVTYFPMIQRSEASIYM
CCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCEEE
LGWGVPTFDALYSLQSLVRSVGTGGDGNYNVGRYRNERMDYLVDRIKAETDAPVRARMLT
EECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
EALQLSNDTVSHLPLYDQVIPWAMKKNVELVHRADNRIDMRTVKLQ
HHHHHCCCCHHHCCCHHHHHCHHHHCCCHHEECCCCCEEEEEEEEC
>Mature Secondary Structure
MRINALILSLAAACAAAVVPAAHAKTFKWASQGEIATWDIHSQNNALQNAIHSYVYESLV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
YYNSRTFEVEPMLATAWREVSPTQVRFTLRQGVKFHDGSAFTADDAVYSLQRAMSKTSNY
HCCCCEEEECCHHHHHHCCCCCHHEEEEHHCCCEECCCCCCCHHHHHHHHHHHHHHCCCC
TPYVQGIDKVVKVDAQTIDIFLKSPNPVLLRQMTELRMMSKAWAEKNRSVEPKDIKGTDE
CHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NFAHRNAMGTGPYTLETWQPDVKMVFKRNPNWWGQMEGNVTEIVYTPIKSAATRIAALLS
HHHHHCCCCCCCEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHC
GEVDLVLDPSPQDLPRLRSSGTIKVVDGLENRTIFLGMDQFRDELVGSNIKGKNPLKDLR
CCEEEEECCCCCHHHHHCCCCCEEEEECCCCCEEEEEHHHHHHHHHCCCCCCCCCHHHHH
VRKALYQSIDANALTRNILRGLGKPTGTLVAPQVAGWSEAVGKRMPYDVEAAKKLLAEAG
HHHHHHHHCCHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHCCCCCCCHHHHHHHHHHCC
YADGFEVDFACPNNRYINDEAICQAVTAMWARIGVKAKLRTLPLVTYFPMIQRSEASIYM
CCCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHCCCCCCEEE
LGWGVPTFDALYSLQSLVRSVGTGGDGNYNVGRYRNERMDYLVDRIKAETDAPVRARMLT
EECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHH
EALQLSNDTVSHLPLYDQVIPWAMKKNVELVHRADNRIDMRTVKLQ
HHHHHCCCCHHHCCCHHHHHCHHHHCCCHHEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]