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The map label for this gene is trpC

Identifier: 222109581

GI number: 222109581

Start: 370241

End: 371041

Strand: Direct

Name: trpC

Synonym: Dtpsy_0361

Alternate gene names: 222109581

Gene position: 370241-371041 (Clockwise)

Preceding gene: 222109580

Following gene: 222109582

Centisome position: 9.75

GC content: 67.42

Gene sequence:

>801_bases
ATGTCCGACATCCTGAAGAAAATCTGCGACGTGAAGGTCGAGGAAGTGGCCGCCGCGCAAAAGCGCGTGTCCTTCACCGA
CATGCGCCGCGACGCCGAGAGCCGCGTGCTCACGCGCGACTTCGTGGGCGCGCTGCGCGCCAAGATCGACCAGGGCCAGG
CCGGCGTGATCGCCGAAATCAAGAAGGCCAGCCCCAGCAAGGGCGTGATCCGCGAGGATTTCATCCCGGCCGACATTGCG
CAAAGCTACGCCGAGGGCGACGGCAAGGTCAGCGCGGCCTGCCTGTCGGTGCTGACCGACCGCCAGTTCTTTCAAGGCCA
GCCCGATTACCTGAAGCAGGCACGCGCCAGTTGCCCGCTGCCGGTGCTGCGCAAGGACTTCATGATCGATCCGTACCAGA
TCTACGAGTCGCGCGCCATGGGCGCCGACTGTGTGCTGCTGATCGCCGCCTGCCTCGAGGATGGCCTGATGGCCGAGATG
GAGCAGTTCGCCCGCAGCCTGGACATGGCCGTGCTGGTGGAGGTGCACGACGGCGCCGAGCTGGAGCGCGCGCTGCGCCT
GCAGACGCCGCTCGTGGGCATCAACAACCGCAACCTGCGCACCTTCGAGGTCAGCCTGCAGACCACGCTGGACCTGAAGA
AGGAAGTGCCTGCCGACCGCCTGCTGGTGGCCGAGTCCGGCATCCTTGCGCCGGTGGATGTGCACACGCTGCGCGATGCC
GGCGTGAATGCGTTCCTGGTGGGCGAGGCCTTCATGCGCGCGCCCGACCCGGGGCGGGCGCTGGCCCAGCTGTTCGCCTG
A

Upstream 100 bases:

>100_bases
CACAAGGGCCCGGTACCTCCGCACGAATGAGCGGGACGGGCGCTGGCGCCAGTGCGCGCCGTCACCATTGACGCTCCCTG
CGGGGAGCAAGGAAGCAAGC

Downstream 100 bases:

>100_bases
CGGCCGTAGGCCGGGCGTCCCCCAGGGTTGGGGCGGTGGCGGCATACTGGGCCCATGAAAGTCATCGGGCCGCGTCGATG
AGCCTTGCCTGAGGCGGTTA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSDILKKICDVKVEEVAAAQKRVSFTDMRRDAESRVLTRDFVGALRAKIDQGQAGVIAEIKKASPSKGVIREDFIPADIA
QSYAEGDGKVSAACLSVLTDRQFFQGQPDYLKQARASCPLPVLRKDFMIDPYQIYESRAMGADCVLLIAACLEDGLMAEM
EQFARSLDMAVLVEVHDGAELERALRLQTPLVGINNRNLRTFEVSLQTTLDLKKEVPADRLLVAESGILAPVDVHTLRDA
GVNAFLVGEAFMRAPDPGRALAQLFA

Sequences:

>Translated_266_residues
MSDILKKICDVKVEEVAAAQKRVSFTDMRRDAESRVLTRDFVGALRAKIDQGQAGVIAEIKKASPSKGVIREDFIPADIA
QSYAEGDGKVSAACLSVLTDRQFFQGQPDYLKQARASCPLPVLRKDFMIDPYQIYESRAMGADCVLLIAACLEDGLMAEM
EQFARSLDMAVLVEVHDGAELERALRLQTPLVGINNRNLRTFEVSLQTTLDLKKEVPADRLLVAESGILAPVDVHTLRDA
GVNAFLVGEAFMRAPDPGRALAQLFA
>Mature_265_residues
SDILKKICDVKVEEVAAAQKRVSFTDMRRDAESRVLTRDFVGALRAKIDQGQAGVIAEIKKASPSKGVIREDFIPADIAQ
SYAEGDGKVSAACLSVLTDRQFFQGQPDYLKQARASCPLPVLRKDFMIDPYQIYESRAMGADCVLLIAACLEDGLMAEME
QFARSLDMAVLVEVHDGAELERALRLQTPLVGINNRNLRTFEVSLQTTLDLKKEVPADRLLVAESGILAPVDVHTLRDAG
VNAFLVGEAFMRAPDPGRALAQLFA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=256, Percent_Identity=39.0625, Blast_Score=155, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6322638, Length=234, Percent_Identity=39.7435897435897, Blast_Score=151, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_ACIET (B9MBS5)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002551845.1
- GeneID:   7385369
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0361
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29154; Mature: 29023

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILKKICDVKVEEVAAAQKRVSFTDMRRDAESRVLTRDFVGALRAKIDQGQAGVIAEI
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KKASPSKGVIREDFIPADIAQSYAEGDGKVSAACLSVLTDRQFFQGQPDYLKQARASCPL
HHCCCCCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
PVLRKDFMIDPYQIYESRAMGADCVLLIAACLEDGLMAEMEQFARSLDMAVLVEVHDGAE
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCHH
LERALRLQTPLVGINNRNLRTFEVSLQTTLDLKKEVPADRLLVAESGILAPVDVHTLRDA
HHHHHHHHCCEEECCCCCEEEEEEEHHHHHHHHHHCCHHHEEEECCCCCCCCHHHHHHHC
GVNAFLVGEAFMRAPDPGRALAQLFA
CCCEEEECHHHHCCCCHHHHHHHHHC
>Mature Secondary Structure 
SDILKKICDVKVEEVAAAQKRVSFTDMRRDAESRVLTRDFVGALRAKIDQGQAGVIAEI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
KKASPSKGVIREDFIPADIAQSYAEGDGKVSAACLSVLTDRQFFQGQPDYLKQARASCPL
HHCCCCCCCHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCC
PVLRKDFMIDPYQIYESRAMGADCVLLIAACLEDGLMAEMEQFARSLDMAVLVEVHDGAE
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEEEECCCHH
LERALRLQTPLVGINNRNLRTFEVSLQTTLDLKKEVPADRLLVAESGILAPVDVHTLRDA
HHHHHHHHCCEEECCCCCEEEEEEEHHHHHHHHHHCCHHHEEEECCCCCCCCHHHHHHHC
GVNAFLVGEAFMRAPDPGRALAQLFA
CCCEEEECHHHHCCCCHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA