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The map label for this gene is dacC [H]

Identifier: 222109487

GI number: 222109487

Start: 284449

End: 285612

Strand: Direct

Name: dacC [H]

Synonym: Dtpsy_0267

Alternate gene names: 222109487

Gene position: 284449-285612 (Clockwise)

Preceding gene: 222109486

Following gene: 222109488

Centisome position: 7.49

GC content: 65.64

Gene sequence:

>1164_bases
ATGAAGTCTCTTTTGTCCTCCCTGCGAACCTTTGCCTGCGCCGCCCTGATGGCCCCCGCCATCCTCTGGGCGCAGGTGCC
CCAACCGCCGGAGATCGCCGCCCGCAATTACATGCTGGTGGACGTGACGGCCGGCCAGGTGCTGGCGACCAAGGACATCG
ACGCGCCGGTTGAGCAGGCTTCGCTGACCAAGCTCATGACGGGCTATCTGGTCTTTGACGCACTGCGCGCCAAGAAGATC
ACGCTGGAGCAGCGCCTGCCGGTGAGCGAGCGCGCTTGGAAGATGCCGGGTTCGCGCATGTTCATCGATCCCAAGATGCA
GGTTCCGGTGGACGACCTGCTCAAGGGCATGATCGTGCAGTCGGGTAACGACGCCACCGTGGCCCTGGCCGAAGGTGTGG
GCGGTACGGTGGAAAACTTCGTGCGCCTGATGAACGAGCAGGCCAAGGCGCTGGGCATGACGAACACCGCCTACAAGAAC
CCCGAGGGGTTGACGGAGCCCGGCCACACCACCACCGCGCGCGACCTGGCCACGCTGGCCACCCGGCTGATGCAGGACTT
CCCCGAGTACATGCACTACTACTCGACCAAGCAGTACCGCTACGAGGGCACACCCGCCTCCAACAGCAACAACCGCAACA
TGCTGCTGTTCCGCGATCCATCGGTGGACGGCCTGAAGACCGGCCACACCGCCGCCGCGGGCTATTGCCTGGTCGCCACG
TCCAAGCGCGAGTTTCCCAATGTGGGGCAGCGCCGCCTGCTGTCTATCGTGCTGGGGGCCGCGAGCGAGAACGCCCGCGC
CAACGAGAGCCAGAAGCTGCTGAACTGGGGCTACACGGCGTTCGATTCGGTGAAGCTGTTCGACGCTGGCCAGGCTGCCG
CCACGCCCGCCGTGTGGAAGGGCACGCAGAGCACCCTCAAGATCGGCCGCCCTGAAGCCATCGTGATCACCGTGCCTTCG
GGCAGCGCGGGCAAGGTCACGACCGAGATCGTGCGCAAGGACCCGCTGGTCGCGCCCTTCACCAAGGGACAGGCCATCGG
CACGCTGAAGGTGAAGTTGGGTGAGCAGCAGGTGGCCGAGGTGCCCCTGGTGGCGCTGGAGGATGTGGCACAGGCCGGCA
TCTTCGGCCGTGCCTGGGACGCCATTCGCCTCTGGATCAAGTAA

Upstream 100 bases:

>100_bases
CCACCTGCAATCCGCGCCCTGACGGCGCGGCACCTTTCTCTTGTGCCGGCCATGCGGTCGGCCCATTTCTTCTCCCGTTT
CCCGAGTGCCTGTTCCCACC

Downstream 100 bases:

>100_bases
TCGCCACGCTTTGGAGGCGGCTCAGCCGGGGGTTCATCGTCCCCGGATTGCCTGTCCGCTTCCAAACTGGTACATTAGAA
GGCTTTTCGGAATTTCCGAA

Product: serine-type d-ala-d-ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKSLLSSLRTFACAALMAPAILWAQVPQPPEIAARNYMLVDVTAGQVLATKDIDAPVEQASLTKLMTGYLVFDALRAKKI
TLEQRLPVSERAWKMPGSRMFIDPKMQVPVDDLLKGMIVQSGNDATVALAEGVGGTVENFVRLMNEQAKALGMTNTAYKN
PEGLTEPGHTTTARDLATLATRLMQDFPEYMHYYSTKQYRYEGTPASNSNNRNMLLFRDPSVDGLKTGHTAAAGYCLVAT
SKREFPNVGQRRLLSIVLGAASENARANESQKLLNWGYTAFDSVKLFDAGQAAATPAVWKGTQSTLKIGRPEAIVITVPS
GSAGKVTTEIVRKDPLVAPFTKGQAIGTLKVKLGEQQVAEVPLVALEDVAQAGIFGRAWDAIRLWIK

Sequences:

>Translated_387_residues
MKSLLSSLRTFACAALMAPAILWAQVPQPPEIAARNYMLVDVTAGQVLATKDIDAPVEQASLTKLMTGYLVFDALRAKKI
TLEQRLPVSERAWKMPGSRMFIDPKMQVPVDDLLKGMIVQSGNDATVALAEGVGGTVENFVRLMNEQAKALGMTNTAYKN
PEGLTEPGHTTTARDLATLATRLMQDFPEYMHYYSTKQYRYEGTPASNSNNRNMLLFRDPSVDGLKTGHTAAAGYCLVAT
SKREFPNVGQRRLLSIVLGAASENARANESQKLLNWGYTAFDSVKLFDAGQAAATPAVWKGTQSTLKIGRPEAIVITVPS
GSAGKVTTEIVRKDPLVAPFTKGQAIGTLKVKLGEQQVAEVPLVALEDVAQAGIFGRAWDAIRLWIK
>Mature_387_residues
MKSLLSSLRTFACAALMAPAILWAQVPQPPEIAARNYMLVDVTAGQVLATKDIDAPVEQASLTKLMTGYLVFDALRAKKI
TLEQRLPVSERAWKMPGSRMFIDPKMQVPVDDLLKGMIVQSGNDATVALAEGVGGTVENFVRLMNEQAKALGMTNTAYKN
PEGLTEPGHTTTARDLATLATRLMQDFPEYMHYYSTKQYRYEGTPASNSNNRNMLLFRDPSVDGLKTGHTAAAGYCLVAT
SKREFPNVGQRRLLSIVLGAASENARANESQKLLNWGYTAFDSVKLFDAGQAAATPAVWKGTQSTLKIGRPEAIVITVPS
GSAGKVTTEIVRKDPLVAPFTKGQAIGTLKVKLGEQQVAEVPLVALEDVAQAGIFGRAWDAIRLWIK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=397, Percent_Identity=39.7984886649874, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1786851, Length=397, Percent_Identity=35.0125944584383, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082022, Length=362, Percent_Identity=36.4640883977901, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87082054, Length=220, Percent_Identity=32.7272727272727, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 41987; Mature: 41987

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLLSSLRTFACAALMAPAILWAQVPQPPEIAARNYMLVDVTAGQVLATKDIDAPVEQA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEEECCCCEEEECCCCCCHHHH
SLTKLMTGYLVFDALRAKKITLEQRLPVSERAWKMPGSRMFIDPKMQVPVDDLLKGMIVQ
HHHHHHHHHHHHHHHHHHHEEHHHCCCCCHHHHCCCCCEEEECCCCCCCHHHHHHHHEEE
SGNDATVALAEGVGGTVENFVRLMNEQAKALGMTNTAYKNPEGLTEPGHTTTARDLATLA
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TRLMQDFPEYMHYYSTKQYRYEGTPASNSNNRNMLLFRDPSVDGLKTGHTAAAGYCLVAT
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCEEEEEE
SKREFPNVGQRRLLSIVLGAASENARANESQKLLNWGYTAFDSVKLFDAGQAAATPAVWK
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHCCEEEEECCCCCCCCHHHC
GTQSTLKIGRPEAIVITVPSGSAGKVTTEIVRKDPLVAPFTKGQAIGTLKVKLGEQQVAE
CCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEEECCHHHHH
VPLVALEDVAQAGIFGRAWDAIRLWIK
CCHHHHHHHHHCCCCCCCCHHEEEECC
>Mature Secondary Structure
MKSLLSSLRTFACAALMAPAILWAQVPQPPEIAARNYMLVDVTAGQVLATKDIDAPVEQA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEEECCCCEEEECCCCCCHHHH
SLTKLMTGYLVFDALRAKKITLEQRLPVSERAWKMPGSRMFIDPKMQVPVDDLLKGMIVQ
HHHHHHHHHHHHHHHHHHHEEHHHCCCCCHHHHCCCCCEEEECCCCCCCHHHHHHHHEEE
SGNDATVALAEGVGGTVENFVRLMNEQAKALGMTNTAYKNPEGLTEPGHTTTARDLATLA
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TRLMQDFPEYMHYYSTKQYRYEGTPASNSNNRNMLLFRDPSVDGLKTGHTAAAGYCLVAT
HHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCHHCCEEEEEE
SKREFPNVGQRRLLSIVLGAASENARANESQKLLNWGYTAFDSVKLFDAGQAAATPAVWK
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHCCEEEEECCCCCCCCHHHC
GTQSTLKIGRPEAIVITVPSGSAGKVTTEIVRKDPLVAPFTKGQAIGTLKVKLGEQQVAE
CCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEEEECCHHHHH
VPLVALEDVAQAGIFGRAWDAIRLWIK
CCHHHHHHHHHCCCCCCCCHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]