Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 222109456

GI number: 222109456

Start: 254944

End: 256884

Strand: Direct

Name: mrdA [H]

Synonym: Dtpsy_0236

Alternate gene names: 222109456

Gene position: 254944-256884 (Clockwise)

Preceding gene: 222109455

Following gene: 222109464

Centisome position: 6.72

GC content: 68.01

Gene sequence:

>1941_bases
ATGACCGAACTGCGCAATGCCGAGGCCGATGTCTGGCACTTTCGCCTGCGCGTGTTCGTCGTGGGCGTGGTGGTGCTGCT
GGCATTCCTGCTGATCGTTGCGCGCCTGGTGGTGCTGCAGGTGGTGCGTCACGAGGACCTCGCGGACCAGGCCGAGAGCA
ACCGCACGGCGGTCGTGCCCATCGTGCCCAACCGCGGCCTCATCCTGGACCGCAACGGCGTGGTGCTGGCCACCAACTAC
TCGGCATACACGCTGGAGATCACGCCCTCGCGGACCATGGACCTGGAGGCGACGATCGACGCGCTGGCCGAGGTCGTGGA
CATCCAGCCGCGCGACCGGCGCCGCTTCAAGCGTCTGCGCGAGGAGTCGCGCAGCTTCGACTCCCTGCCCATTCGCACAC
GGCTGTCGGACGAAGAGGTGGCGCGCTTTGCGGCGCAGCGCTACCGCTTCCCCGGCGTGGACATCAAGGCGCGGCTGTTT
CGCAACTACCCGCTGGGCGAGGTGGCGAGCCACGCCATCGGCTACATCGGCCGCATCAACCAGCGCGAAAAGGAGCGCAT
CGAGGACTCGGACGATGCGGCCAACTACCGCGGCACGGACTACATCGGCAAGCTGGGGGTGGAGCAGAGCTTCGAATCCA
CGCTCCACGGCCAGACGGGGTTCGAGCGCATGGAGACCTCGGCCGGCGGGCATGCCGTGCGGCGCCTGAACAGCCATCCG
GCGACGCCGGGCAACACGGTGATGCTGTCGCTGGACATCAAGCTGCAAAAGCTGATCGAGGACATGTTCGGCGAGCGCCG
CGGCGCTCTGGTAGCGCTGGACCCGCGCAACGGCGAGGTGCTGGCGCTGGTGTCCAAACCCACGTTCGACCCCAACCTGT
TCGTCGAGGGCATCGACCAGGAAAACTGGCAGGCGCTCAACGAGTCCATCAACAAGCCGCTGCTCAACCGCGCGCTGCGC
GGCACCTACCCTCCCGGCTCCACCTACAAGCCCTTCATGGCGCTGGCCGCGCTGGAGCTGGGCAAGCGCACGGCGGGGCA
GGTGTTCAACGACCCGGGCTATTACAACTATGGCGGGCGCACCTTCCGCAGCCATGAAGGCGGCCTGGGCGGCGTGGACA
TGCACCGCGCCATCCAGTATTCGAGCAACACCTATTTCTATTCGCTGGCCGTGGAGATGGGTGTGGACGCCATCCACGAC
TTCATGAAGCCGCTGGGCTTCGGGCAGATCACCGGCATCGACCTCGGGGGCGAAGTGCGCGGCGTGCTGCCCAGCACCGA
GTGGAAGCGCAACACCTACAAGCGCCCGGAGGCCAAGCGCTGGTACTCGGGCGAGACAGTGTCGCTGGGCATCGGCCAGG
GCTACAACAACTTCACCATGCTGCAGCTGGCCGTGGCCGAGGCCACGCTGGCCAACGGCGGCACCCGCCACCGTCCGCAC
CTGATCAAGGCCGTGAAAGACCAGGTGGGCGGGCAGGTGACCGAGGTGCAGCAGCCCCCCGGCGAGCGCCTGGGCTACAA
CCCCAAGCATGTGGCGATCGTGAACAACGCGCTGATGGCCGTGAACCAGGCGGGCACGGGGCGGCGTGTGTTCGCGGGCG
CGCCCTACACCTCGGCGGGCAAAACCGGTACGGCGCAGGCGGTGAGCCTGGGGCAGAACGTGCGGTACAACGCCAAGCTG
CTGGAGGAGCACCAGCGCGACCACTCCCTTTTTGCCGCGTTCGCACCCGTGGAGGAGCCCCGCATCGCCGTGGCCGTGAT
CGTGGAGAACGCGGGCTTTGGCGCGGCGGCGGCGGCGCCCATCGTGCGCCGCGTGTTCGACTACTGGCTGCTGGGCCAGT
ACCCGAGCGAGCAAGACCTGGCGGCCGTCTCCAAGGGGCAGGCCGGTGCTCCCATGGGCACGCCGCGCAACGTGGCGGAC
GTGCCGCTCGCGATGCCCTGA

Upstream 100 bases:

>100_bases
GCCGCTGGCCAGCTGGGTGCTGCTGGCGCCCCAGCGCCGCCCGCCCGACCGCGATGAAAACCGGCCGCTGTGAGCGCGCA
GGGGTGAAGGGCCGCCGCGG

Downstream 100 bases:

>100_bases
GGGCTCTTGCGCCCGATCAGGGCGCGGAAGGACGCGCCAGTGCGCGCGGCGGCGGCAACTGGCTCACCACCAGTGCACAG
ACAATCAGCGCCGCGCCCGC

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 646; Mature: 645

Protein sequence:

>646_residues
MTELRNAEADVWHFRLRVFVVGVVVLLAFLLIVARLVVLQVVRHEDLADQAESNRTAVVPIVPNRGLILDRNGVVLATNY
SAYTLEITPSRTMDLEATIDALAEVVDIQPRDRRRFKRLREESRSFDSLPIRTRLSDEEVARFAAQRYRFPGVDIKARLF
RNYPLGEVASHAIGYIGRINQREKERIEDSDDAANYRGTDYIGKLGVEQSFESTLHGQTGFERMETSAGGHAVRRLNSHP
ATPGNTVMLSLDIKLQKLIEDMFGERRGALVALDPRNGEVLALVSKPTFDPNLFVEGIDQENWQALNESINKPLLNRALR
GTYPPGSTYKPFMALAALELGKRTAGQVFNDPGYYNYGGRTFRSHEGGLGGVDMHRAIQYSSNTYFYSLAVEMGVDAIHD
FMKPLGFGQITGIDLGGEVRGVLPSTEWKRNTYKRPEAKRWYSGETVSLGIGQGYNNFTMLQLAVAEATLANGGTRHRPH
LIKAVKDQVGGQVTEVQQPPGERLGYNPKHVAIVNNALMAVNQAGTGRRVFAGAPYTSAGKTGTAQAVSLGQNVRYNAKL
LEEHQRDHSLFAAFAPVEEPRIAVAVIVENAGFGAAAAAPIVRRVFDYWLLGQYPSEQDLAAVSKGQAGAPMGTPRNVAD
VPLAMP

Sequences:

>Translated_646_residues
MTELRNAEADVWHFRLRVFVVGVVVLLAFLLIVARLVVLQVVRHEDLADQAESNRTAVVPIVPNRGLILDRNGVVLATNY
SAYTLEITPSRTMDLEATIDALAEVVDIQPRDRRRFKRLREESRSFDSLPIRTRLSDEEVARFAAQRYRFPGVDIKARLF
RNYPLGEVASHAIGYIGRINQREKERIEDSDDAANYRGTDYIGKLGVEQSFESTLHGQTGFERMETSAGGHAVRRLNSHP
ATPGNTVMLSLDIKLQKLIEDMFGERRGALVALDPRNGEVLALVSKPTFDPNLFVEGIDQENWQALNESINKPLLNRALR
GTYPPGSTYKPFMALAALELGKRTAGQVFNDPGYYNYGGRTFRSHEGGLGGVDMHRAIQYSSNTYFYSLAVEMGVDAIHD
FMKPLGFGQITGIDLGGEVRGVLPSTEWKRNTYKRPEAKRWYSGETVSLGIGQGYNNFTMLQLAVAEATLANGGTRHRPH
LIKAVKDQVGGQVTEVQQPPGERLGYNPKHVAIVNNALMAVNQAGTGRRVFAGAPYTSAGKTGTAQAVSLGQNVRYNAKL
LEEHQRDHSLFAAFAPVEEPRIAVAVIVENAGFGAAAAAPIVRRVFDYWLLGQYPSEQDLAAVSKGQAGAPMGTPRNVAD
VPLAMP
>Mature_645_residues
TELRNAEADVWHFRLRVFVVGVVVLLAFLLIVARLVVLQVVRHEDLADQAESNRTAVVPIVPNRGLILDRNGVVLATNYS
AYTLEITPSRTMDLEATIDALAEVVDIQPRDRRRFKRLREESRSFDSLPIRTRLSDEEVARFAAQRYRFPGVDIKARLFR
NYPLGEVASHAIGYIGRINQREKERIEDSDDAANYRGTDYIGKLGVEQSFESTLHGQTGFERMETSAGGHAVRRLNSHPA
TPGNTVMLSLDIKLQKLIEDMFGERRGALVALDPRNGEVLALVSKPTFDPNLFVEGIDQENWQALNESINKPLLNRALRG
TYPPGSTYKPFMALAALELGKRTAGQVFNDPGYYNYGGRTFRSHEGGLGGVDMHRAIQYSSNTYFYSLAVEMGVDAIHDF
MKPLGFGQITGIDLGGEVRGVLPSTEWKRNTYKRPEAKRWYSGETVSLGIGQGYNNFTMLQLAVAEATLANGGTRHRPHL
IKAVKDQVGGQVTEVQQPPGERLGYNPKHVAIVNNALMAVNQAGTGRRVFAGAPYTSAGKTGTAQAVSLGQNVRYNAKLL
EEHQRDHSLFAAFAPVEEPRIAVAVIVENAGFGAAAAAPIVRRVFDYWLLGQYPSEQDLAAVSKGQAGAPMGTPRNVADV
PLAMP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=632, Percent_Identity=40.1898734177215, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1786272, Length=611, Percent_Identity=27.4959083469722, Blast_Score=142, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71170; Mature: 71039

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELRNAEADVWHFRLRVFVVGVVVLLAFLLIVARLVVLQVVRHEDLADQAESNRTAVVP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
IVPNRGLILDRNGVVLATNYSAYTLEITPSRTMDLEATIDALAEVVDIQPRDRRRFKRLR
EECCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
EESRSFDSLPIRTRLSDEEVARFAAQRYRFPGVDIKARLFRNYPLGEVASHAIGYIGRIN
HHHCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
QREKERIEDSDDAANYRGTDYIGKLGVEQSFESTLHGQTGFERMETSAGGHAVRRLNSHP
HHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCC
ATPGNTVMLSLDIKLQKLIEDMFGERRGALVALDPRNGEVLALVSKPTFDPNLFVEGIDQ
CCCCCEEEEEECHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCCEEECCCC
ENWQALNESINKPLLNRALRGTYPPGSTYKPFMALAALELGKRTAGQVFNDPGYYNYGGR
HHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCEECCCCC
TFRSHEGGLGGVDMHRAIQYSSNTYFYSLAVEMGVDAIHDFMKPLGFGQITGIDLGGEVR
EEECCCCCCCCCCHHHHEEECCCEEEEEEEHHHCHHHHHHHHHHCCCCCEEEEECCCCEE
GVLPSTEWKRNTYKRPEAKRWYSGETVSLGIGQGYNNFTMLQLAVAEATLANGGTRHRPH
ECCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHHHHHCCCCCCCHH
LIKAVKDQVGGQVTEVQQPPGERLGYNPKHVAIVNNALMAVNQAGTGRRVFAGAPYTSAG
HHHHHHHHHCCEEEECCCCCCHHCCCCCCEEEEECCHHHEEECCCCCCEEEECCCCCCCC
KTGTAQAVSLGQNVRYNAKLLEEHQRDHSLFAAFAPVEEPRIAVAVIVENAGFGAAAAAP
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCHHHHHH
IVRRVFDYWLLGQYPSEQDLAAVSKGQAGAPMGTPRNVADVPLAMP
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TELRNAEADVWHFRLRVFVVGVVVLLAFLLIVARLVVLQVVRHEDLADQAESNRTAVVP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
IVPNRGLILDRNGVVLATNYSAYTLEITPSRTMDLEATIDALAEVVDIQPRDRRRFKRLR
EECCCCEEEECCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
EESRSFDSLPIRTRLSDEEVARFAAQRYRFPGVDIKARLFRNYPLGEVASHAIGYIGRIN
HHHCCCCCCCCEECCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
QREKERIEDSDDAANYRGTDYIGKLGVEQSFESTLHGQTGFERMETSAGGHAVRRLNSHP
HHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCC
ATPGNTVMLSLDIKLQKLIEDMFGERRGALVALDPRNGEVLALVSKPTFDPNLFVEGIDQ
CCCCCEEEEEECHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEECCCCCCCCEEECCCC
ENWQALNESINKPLLNRALRGTYPPGSTYKPFMALAALELGKRTAGQVFNDPGYYNYGGR
HHHHHHHHHHCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCCCCEECCCCC
TFRSHEGGLGGVDMHRAIQYSSNTYFYSLAVEMGVDAIHDFMKPLGFGQITGIDLGGEVR
EEECCCCCCCCCCHHHHEEECCCEEEEEEEHHHCHHHHHHHHHHCCCCCEEEEECCCCEE
GVLPSTEWKRNTYKRPEAKRWYSGETVSLGIGQGYNNFTMLQLAVAEATLANGGTRHRPH
ECCCCCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEHHHHHHHHCCCCCCCHH
LIKAVKDQVGGQVTEVQQPPGERLGYNPKHVAIVNNALMAVNQAGTGRRVFAGAPYTSAG
HHHHHHHHHCCEEEECCCCCCHHCCCCCCEEEEECCHHHEEECCCCCCEEEECCCCCCCC
KTGTAQAVSLGQNVRYNAKLLEEHQRDHSLFAAFAPVEEPRIAVAVIVENAGFGAAAAAP
CCCCHHHHHHCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCEEEEEEEECCCCCHHHHHH
IVRRVFDYWLLGQYPSEQDLAAVSKGQAGAPMGTPRNVADVPLAMP
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]