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The map label for this gene is pyrE [H]

Identifier: 222109448

GI number: 222109448

Start: 247399

End: 248109

Strand: Direct

Name: pyrE [H]

Synonym: Dtpsy_0228

Alternate gene names: 222109448

Gene position: 247399-248109 (Clockwise)

Preceding gene: 222109446

Following gene: 222109449

Centisome position: 6.52

GC content: 66.24

Gene sequence:

>711_bases
ATGGTGACAGACAGCGCGCAGACGGTGGAACAAGGGGCGAGCCAAGCCCGCCTGGCGCAGGATTTCGTGCGGTTTGCTGT
GGATTCGGGGGTGCTGCGCTTTGGTGAATTCAAGACCAAGGCAGGCCGCATGAGCCCGTATTTCTTCAACGCCGGTCTGT
TCGACGACGGCGCCAAGCTCGGGCGGCTGGCGCAATTCTATGCACAAGCCCTGCTGGCCAGCGGCGTGGAGTTCGACATG
GTCTTCGGCCCCGCCTACAAAGGCATTCCGCTGGCCGCCACGGTGGCCGTGGAGCTGGCGCGCCTGGGCAAGAACGTGCC
CTTTGCCTACAACCGCAAAGAGGCCAAGGACCACGGCGAGGGCGGCACGCTGGTGGGCGCGCCGCTCCAGGGCAAGGTGC
TCATCATCGACGACGTGATGAGCGCCGGCACCGCCGCGCGCGAGTCCATCGCGCTGATCCGCGCCGCGGGTGCCACGCCG
CACGCCATTGCGATCGCCCTCGACCGCCAGGAGAAGGCCACCGAGAACGGGCAGGACGTGGACCACAGCGCCGTGCAGTA
CGTGCGCCGTGAACTGGGCATGCAGGTTTGCGCTATCGCCAAGCTGGCAGACTTATTGCAATACCTATCGGCGGGTGGCG
GCGATACGCAGATGCGCGAGCACCACGAGCGGGTGCTGGCCTATCGCCAGCGCTACGGCGTGAACGACTGA

Upstream 100 bases:

>100_bases
ATCCGGCCGGCTTTGGGCAATCCATGCCTCGACCCCTTTGGACGTGGCCGAGCGGATGCCGTTGAGGTTGAGACTGGTTA
ATTTGAACAAGGATGCATCC

Downstream 100 bases:

>100_bases
AAACAACGGCAGCAGCCAGGAGGGCAGGGGTTTTGAAAGCAGGCACACGACACGCGGGCTGGTTCATGGCAGGAGCAACC
GCCGCAGCGCTGGGCCTGTT

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MVTDSAQTVEQGASQARLAQDFVRFAVDSGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKLGRLAQFYAQALLASGVEFDM
VFGPAYKGIPLAATVAVELARLGKNVPFAYNRKEAKDHGEGGTLVGAPLQGKVLIIDDVMSAGTAARESIALIRAAGATP
HAIAIALDRQEKATENGQDVDHSAVQYVRRELGMQVCAIAKLADLLQYLSAGGGDTQMREHHERVLAYRQRYGVND

Sequences:

>Translated_236_residues
MVTDSAQTVEQGASQARLAQDFVRFAVDSGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKLGRLAQFYAQALLASGVEFDM
VFGPAYKGIPLAATVAVELARLGKNVPFAYNRKEAKDHGEGGTLVGAPLQGKVLIIDDVMSAGTAARESIALIRAAGATP
HAIAIALDRQEKATENGQDVDHSAVQYVRRELGMQVCAIAKLADLLQYLSAGGGDTQMREHHERVLAYRQRYGVND
>Mature_236_residues
MVTDSAQTVEQGASQARLAQDFVRFAVDSGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKLGRLAQFYAQALLASGVEFDM
VFGPAYKGIPLAATVAVELARLGKNVPFAYNRKEAKDHGEGGTLVGAPLQGKVLIIDDVMSAGTAARESIALIRAAGATP
HAIAIALDRQEKATENGQDVDHSAVQYVRRELGMQVCAIAKLADLLQYLSAGGGDTQMREHHERVLAYRQRYGVND

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=182, Percent_Identity=25.8241758241758, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790073, Length=216, Percent_Identity=51.8518518518518, Blast_Score=219, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17508631, Length=160, Percent_Identity=35, Blast_Score=77, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6323530, Length=219, Percent_Identity=47.0319634703196, Blast_Score=189, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6323927, Length=220, Percent_Identity=43.6363636363636, Blast_Score=177, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 25380; Mature: 25380

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTDSAQTVEQGASQARLAQDFVRFAVDSGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCCHHHH
GRLAQFYAQALLASGVEFDMVFGPAYKGIPLAATVAVELARLGKNVPFAYNRKEAKDHGE
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
GGTLVGAPLQGKVLIIDDVMSAGTAARESIALIRAAGATPHAIAIALDRQEKATENGQDV
CCCEEECCCCCCEEEEECHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCCCCC
DHSAVQYVRRELGMQVCAIAKLADLLQYLSAGGGDTQMREHHERVLAYRQRYGVND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVTDSAQTVEQGASQARLAQDFVRFAVDSGVLRFGEFKTKAGRMSPYFFNAGLFDDGAKL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCEEEECCCCCCHHHH
GRLAQFYAQALLASGVEFDMVFGPAYKGIPLAATVAVELARLGKNVPFAYNRKEAKDHGE
HHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCC
GGTLVGAPLQGKVLIIDDVMSAGTAARESIALIRAAGATPHAIAIALDRQEKATENGQDV
CCCEEECCCCCCEEEEECHHHCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHCCCCCCC
DHSAVQYVRRELGMQVCAIAKLADLLQYLSAGGGDTQMREHHERVLAYRQRYGVND
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA