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The map label for this gene is alr

Identifier: 222109415

GI number: 222109415

Start: 216398

End: 217495

Strand: Direct

Name: alr

Synonym: Dtpsy_0194

Alternate gene names: 222109415

Gene position: 216398-217495 (Clockwise)

Preceding gene: 222109411

Following gene: 222109416

Centisome position: 5.7

GC content: 72.31

Gene sequence:

>1098_bases
ATGCCGCGCCCCATTCTTGCGACCATCCACCCCGCAGCCGTGCACCACAACCTGGAACGCGCGCGCCGTGCCGCGCCCGA
TGCGCGCGTGTGGGCGGTGGTCAAGGCCAACGCCTACGGCCACGGCATCGAGCGCGTGTTCGAAGGCCTGCGCGCCGCCG
ACGGTTTCGCTTTGCTGGACCTGGCCGAGGCCGAGCGCGTGCGCGCTCTCGGCTGGCGCGGCCCGATCCTGCTGCTGGAG
GGCGTGTTCGAGCCGCGCGACCTGGAGCTATGCTCGCGCCTGGGTCTGTGGCATGCCGTGCACTGCGATGCGCAGATCGA
CTGGCTGGCCGCGCACAAGACGCAGGTGCCGCACCGCGTGTTCCTCAAGATGAACTCCGGCATGAACCGCCTGGGCTTCA
CGCCCGAGCGCTACCGCAGCGCCTGGGCGCGCCTGAACGCGCTGCCCCAGGTGGACGAGATCTCGTGCATGACCCACTTC
AGCGACGCCGACGGCCCGCGCGGCATCGCGCACCAGGTGCAGGCGTTCCAGACCGCCACGCGGGACCTGCCGGGCGAGCG
TTGCATCGCCAACAGCGCCGCGCTGCTGCGCCACGGCGGTGATGCGCAGGTGCGGCTGGACTGGGTGCGCGCGGGCATCG
TGCTGTACGGCAGCGCGCCCGACCATCCCGAGCGCCGCGCGGCCGACTGGGACCTGCAGCCCACCATGACGCTGGCTTCG
CGCATCATCGGCGTGCAGCAGCTGCAGGCGGGCGACACCGTGGGCTACGGCTCGCGCTTCACGGCGCAGGGGCCGCTGGG
CATCGGTGTCGTGGCCTGCGGCTATGCCGACGGTTATCCACGCCACTGCGATACCGGCACGCCCGTGCTGGTAAACGGGG
TGCGCACGCGCACCATCGGGCGCGTGAGCATGGACATGCTGGCCGTGGACCTCACGCCCGTGCCCGGCGCGGGGCTGGGG
GCCGAGGTCACGCTCTGGGGCCGCGCCGCCAACGGCGCCGTGCTGCCCATCGACGAGGTAGCGCAAGCGGGCGGCACCAT
CGGCTACGAGCTGATGTGCGCGCTGGCACCGCGCGTGCCCGTGGTGGTGCAGGACTGA

Upstream 100 bases:

>100_bases
GAAAATTCGAAACACTCCGAGGAGCGACGGGCGGTTATATCACGCGACCCTGCGCGCCCAGTGCCAGAATGGCCCCCGTC
CAGTCCGTAGAAACACCCCC

Downstream 100 bases:

>100_bases
TTCCCTCCATGGTCCGGGTGCGCGGCCGCACGGGCGCCTCGTGGCGCGGCATGCGCCTGCCGCAGCGGCTGCAGGAGGGC
CTGCGCCAGCGCCATGCCCT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MPRPILATIHPAAVHHNLERARRAAPDARVWAVVKANAYGHGIERVFEGLRAADGFALLDLAEAERVRALGWRGPILLLE
GVFEPRDLELCSRLGLWHAVHCDAQIDWLAAHKTQVPHRVFLKMNSGMNRLGFTPERYRSAWARLNALPQVDEISCMTHF
SDADGPRGIAHQVQAFQTATRDLPGERCIANSAALLRHGGDAQVRLDWVRAGIVLYGSAPDHPERRAADWDLQPTMTLAS
RIIGVQQLQAGDTVGYGSRFTAQGPLGIGVVACGYADGYPRHCDTGTPVLVNGVRTRTIGRVSMDMLAVDLTPVPGAGLG
AEVTLWGRAANGAVLPIDEVAQAGGTIGYELMCALAPRVPVVVQD

Sequences:

>Translated_365_residues
MPRPILATIHPAAVHHNLERARRAAPDARVWAVVKANAYGHGIERVFEGLRAADGFALLDLAEAERVRALGWRGPILLLE
GVFEPRDLELCSRLGLWHAVHCDAQIDWLAAHKTQVPHRVFLKMNSGMNRLGFTPERYRSAWARLNALPQVDEISCMTHF
SDADGPRGIAHQVQAFQTATRDLPGERCIANSAALLRHGGDAQVRLDWVRAGIVLYGSAPDHPERRAADWDLQPTMTLAS
RIIGVQQLQAGDTVGYGSRFTAQGPLGIGVVACGYADGYPRHCDTGTPVLVNGVRTRTIGRVSMDMLAVDLTPVPGAGLG
AEVTLWGRAANGAVLPIDEVAQAGGTIGYELMCALAPRVPVVVQD
>Mature_364_residues
PRPILATIHPAAVHHNLERARRAAPDARVWAVVKANAYGHGIERVFEGLRAADGFALLDLAEAERVRALGWRGPILLLEG
VFEPRDLELCSRLGLWHAVHCDAQIDWLAAHKTQVPHRVFLKMNSGMNRLGFTPERYRSAWARLNALPQVDEISCMTHFS
DADGPRGIAHQVQAFQTATRDLPGERCIANSAALLRHGGDAQVRLDWVRAGIVLYGSAPDHPERRAADWDLQPTMTLASR
IIGVQQLQAGDTVGYGSRFTAQGPLGIGVVACGYADGYPRHCDTGTPVLVNGVRTRTIGRVSMDMLAVDLTPVPGAGLGA
EVTLWGRAANGAVLPIDEVAQAGGTIGYELMCALAPRVPVVVQD

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=363, Percent_Identity=52.8925619834711, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790487, Length=360, Percent_Identity=40.2777777777778, Blast_Score=244, Evalue=5e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_ACIET (B9MAN2)

Other databases:

- EMBL:   CP001392
- RefSeq:   YP_002551679.1
- GeneID:   7383458
- GenomeReviews:   CP001392_GR
- KEGG:   dia:Dtpsy_0194
- ProtClustDB:   CLSK951002
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 39431; Mature: 39299

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPILATIHPAAVHHNLERARRAAPDARVWAVVKANAYGHGIERVFEGLRAADGFALLD
CCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
LAEAERVRALGWRGPILLLEGVFEPRDLELCSRLGLWHAVHCDAQIDWLAAHKTQVPHRV
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEECCCEEEEEECCCCCCCEEE
FLKMNSGMNRLGFTPERYRSAWARLNALPQVDEISCMTHFSDADGPRGIAHQVQAFQTAT
EEEECCCCHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RDLPGERCIANSAALLRHGGDAQVRLDWVRAGIVLYGSAPDHPERRAADWDLQPTMTLAS
HCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEEEEECCCCCCCHHCCCCCCCCHHHHHHH
RIIGVQQLQAGDTVGYGSRFTAQGPLGIGVVACGYADGYPRHCDTGTPVLVNGVRTRTIG
HHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEC
RVSMDMLAVDLTPVPGAGLGAEVTLWGRAANGAVLPIDEVAQAGGTIGYELMCALAPRVP
CEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCEECHHHHHHCCCCCCHHHHHHHCCCCC
VVVQD
EEEEC
>Mature Secondary Structure 
PRPILATIHPAAVHHNLERARRAAPDARVWAVVKANAYGHGIERVFEGLRAADGFALLD
CCCEEEECCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
LAEAERVRALGWRGPILLLEGVFEPRDLELCSRLGLWHAVHCDAQIDWLAAHKTQVPHRV
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCEEEEECCCEEEEEECCCCCCCEEE
FLKMNSGMNRLGFTPERYRSAWARLNALPQVDEISCMTHFSDADGPRGIAHQVQAFQTAT
EEEECCCCHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
RDLPGERCIANSAALLRHGGDAQVRLDWVRAGIVLYGSAPDHPERRAADWDLQPTMTLAS
HCCCCCHHHHCCHHHHHCCCCCEEEEEEEEEEEEEECCCCCCCHHCCCCCCCCHHHHHHH
RIIGVQQLQAGDTVGYGSRFTAQGPLGIGVVACGYADGYPRHCDTGTPVLVNGVRTRTIG
HHHHHHHHCCCCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEC
RVSMDMLAVDLTPVPGAGLGAEVTLWGRAANGAVLPIDEVAQAGGTIGYELMCALAPRVP
CEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCEECHHHHHHCCCCCCHHHHHHHCCCCC
VVVQD
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA