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The map label for this gene is cat2 [H]

Identifier: 222109362

GI number: 222109362

Start: 158355

End: 159635

Strand: Direct

Name: cat2 [H]

Synonym: Dtpsy_0141

Alternate gene names: 222109362

Gene position: 158355-159635 (Clockwise)

Preceding gene: 222109361

Following gene: 222109363

Centisome position: 4.17

GC content: 73.15

Gene sequence:

>1281_bases
ATGAGCGTATTGGCCGAACGTTTGCAGGCACTGATCCGCCCCGGCGACACGCTGTGGTGGGGCCAGGCCACGGCCGAGCC
GCTGACGCTCACGCGCGCCGTGGTGCAGCAGCGCCACGCGCTGGCGCAGGGCGGGCGGCTGCGCGTGTTCGTGGGCATCG
GCGCGTCGGACACGCTGCAGCCCGGGCAGGCCGACGCCATCGATTTCTTCGGCTATGCCGCGGGCGGGCCGCATCGCGCC
CTGGCCCAGGCCGGCGTGCTGGACATCCTGCCCAGCCACTATTCCCATCTGCCGGGTCTGATCCGCGCGGGGGTGCTGCC
GGTCGACGTGGTGCTGCTGCAGGTGTCGCCGCCCGATGCACAGGGCCGCTACAGCCTGGGGCTGGTGCAGGAATACCTGC
CCGCCGCCATCGAGCGCGCGCGTGTGGTGATCGCCGAGGTGCACCCCGACGTGCCCTGGACGCACGGCGGCCTGCACCTG
CAGGCCAGCGACTTCGCGCTGCTCATCGACGCCGAGCACCCGCCGCTGGACCAGAGCCGCAGCGCGCCCGGCCCGGTGGA
GCAGGCCATTGCGCGCCATGTGGCGGGGTGGGTGGAGGACGGCGCCACGCTGCAGCTGGGCATCGGCAACCTGCCCGAGG
CCGTGCTGGCCGCGTTGCACGGCCACCGCGACCTGGGCCTGCACAGCGGCGCGGTAGGCGACGGCATTGCCGCTCTGGCC
GAAGCCGGCGTGCTCACCAACGCCAGGAAGAGCCTGGACACCGGCGTGGGTATCGGCGGCATCCTCATGGGCGGCGAGCG
CCTGCGCCGCTGGGCGCACCGCAACCCACAGATCGAGCTGCGCGGCACCGACTACACGCACGACCCCGCGGTGCTGGCCG
CCAGCCACAAGCTCACCGCCATCAACGCGGCCATCGAGGTAGACCTCACGGGCCAGATCAACGCCGAGGTGGCTGCCGGC
TGCTACGTGGGCGCCGTGGGCGGCGCGGTGGACTTCCTGCGCGGCGCTGCCCGCAGCAAAGGCGGCCTGCCCATCGTGGC
GCTGCCCGCCACCGCCAAGGGCAAGACGCGCATCGTGGCGCAGCTCTCGGGCCCGGTGAGCACGCCGCGTAGCGACGCGG
GCCTGATCGTCACCGAGCATGGCGTGGCCGACCTGCGCGGCCAGACGCTGTCGCGCCGCGTGCGCCGGCTGATCGACATC
GCCGCCCCCGAACACCGCGCCGACCTGGAGCGCCAGGCCCACGACACGCTGCGCCGCTGTGGCGCGGTATTTCAAATTTG
A

Upstream 100 bases:

>100_bases
ACGGCGTCCGCTGGCATGGCCTGCTCCGCGGCCATCGGACCGGTGCCGGCGCGCCAGTTTCATGAGTTGCGGGTGGCGCG
CTGCGCCATGGATGGCTGAT

Downstream 100 bases:

>100_bases
TAGCTATTAGCGCATGTCAGATAAGCGCTAGCGGCCATTTTCATTCATATTTCAAGGAGCAACACCATGCGCAGAGCCGC
CATCGTCACCCCCGTCCGCA

Product: acetyl-CoA hydrolase/transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MSVLAERLQALIRPGDTLWWGQATAEPLTLTRAVVQQRHALAQGGRLRVFVGIGASDTLQPGQADAIDFFGYAAGGPHRA
LAQAGVLDILPSHYSHLPGLIRAGVLPVDVVLLQVSPPDAQGRYSLGLVQEYLPAAIERARVVIAEVHPDVPWTHGGLHL
QASDFALLIDAEHPPLDQSRSAPGPVEQAIARHVAGWVEDGATLQLGIGNLPEAVLAALHGHRDLGLHSGAVGDGIAALA
EAGVLTNARKSLDTGVGIGGILMGGERLRRWAHRNPQIELRGTDYTHDPAVLAASHKLTAINAAIEVDLTGQINAEVAAG
CYVGAVGGAVDFLRGAARSKGGLPIVALPATAKGKTRIVAQLSGPVSTPRSDAGLIVTEHGVADLRGQTLSRRVRRLIDI
AAPEHRADLERQAHDTLRRCGAVFQI

Sequences:

>Translated_426_residues
MSVLAERLQALIRPGDTLWWGQATAEPLTLTRAVVQQRHALAQGGRLRVFVGIGASDTLQPGQADAIDFFGYAAGGPHRA
LAQAGVLDILPSHYSHLPGLIRAGVLPVDVVLLQVSPPDAQGRYSLGLVQEYLPAAIERARVVIAEVHPDVPWTHGGLHL
QASDFALLIDAEHPPLDQSRSAPGPVEQAIARHVAGWVEDGATLQLGIGNLPEAVLAALHGHRDLGLHSGAVGDGIAALA
EAGVLTNARKSLDTGVGIGGILMGGERLRRWAHRNPQIELRGTDYTHDPAVLAASHKLTAINAAIEVDLTGQINAEVAAG
CYVGAVGGAVDFLRGAARSKGGLPIVALPATAKGKTRIVAQLSGPVSTPRSDAGLIVTEHGVADLRGQTLSRRVRRLIDI
AAPEHRADLERQAHDTLRRCGAVFQI
>Mature_425_residues
SVLAERLQALIRPGDTLWWGQATAEPLTLTRAVVQQRHALAQGGRLRVFVGIGASDTLQPGQADAIDFFGYAAGGPHRAL
AQAGVLDILPSHYSHLPGLIRAGVLPVDVVLLQVSPPDAQGRYSLGLVQEYLPAAIERARVVIAEVHPDVPWTHGGLHLQ
ASDFALLIDAEHPPLDQSRSAPGPVEQAIARHVAGWVEDGATLQLGIGNLPEAVLAALHGHRDLGLHSGAVGDGIAALAE
AGVLTNARKSLDTGVGIGGILMGGERLRRWAHRNPQIELRGTDYTHDPAVLAASHKLTAINAAIEVDLTGQINAEVAAGC
YVGAVGGAVDFLRGAARSKGGLPIVALPATAKGKTRIVAQLSGPVSTPRSDAGLIVTEHGVADLRGQTLSRRVRRLIDIA
APEHRADLERQAHDTLRRCGAVFQI

Specific function: Unknown

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=214, Percent_Identity=29.4392523364486, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32563853, Length=419, Percent_Identity=34.3675417661098, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17538151, Length=426, Percent_Identity=32.3943661971831, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21358615, Length=425, Percent_Identity=34.3529411764706, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro [H]

EC number: NA

Molecular weight: Translated: 44711; Mature: 44579

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.2 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLAERLQALIRPGDTLWWGQATAEPLTLTRAVVQQRHALAQGGRLRVFVGIGASDTLQ
CCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
PGQADAIDFFGYAAGGPHRALAQAGVLDILPSHYSHLPGLIRAGVLPVDVVLLQVSPPDA
CCCCCHHHHHEECCCCCHHHHHHCCHHHHHHHHHHHCCHHHHCCCCEEEEEEEEECCCCC
QGRYSLGLVQEYLPAAIERARVVIAEVHPDVPWTHGGLHLQASDFALLIDAEHPPLDQSR
CCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEEEECCEEEEEECCCCCCCCCC
SAPGPVEQAIARHVAGWVEDGATLQLGIGNLPEAVLAALHGHRDLGLHSGAVGDGIAALA
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
EAGVLTNARKSLDTGVGIGGILMGGERLRRWAHRNPQIELRGTDYTHDPAVLAASHKLTA
HHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCCEEE
INAAIEVDLTGQINAEVAAGCYVGAVGGAVDFLRGAARSKGGLPIVALPATAKGKTRIVA
EEEEEEEEECCCCCCCEECCEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEE
QLSGPVSTPRSDAGLIVTEHGVADLRGQTLSRRVRRLIDIAAPEHRADLERQAHDTLRRC
EECCCCCCCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GAVFQI
HHHCCC
>Mature Secondary Structure 
SVLAERLQALIRPGDTLWWGQATAEPLTLTRAVVQQRHALAQGGRLRVFVGIGASDTLQ
CHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCC
PGQADAIDFFGYAAGGPHRALAQAGVLDILPSHYSHLPGLIRAGVLPVDVVLLQVSPPDA
CCCCCHHHHHEECCCCCHHHHHHCCHHHHHHHHHHHCCHHHHCCCCEEEEEEEEECCCCC
QGRYSLGLVQEYLPAAIERARVVIAEVHPDVPWTHGGLHLQASDFALLIDAEHPPLDQSR
CCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCEEEEECCEEEEEECCCCCCCCCC
SAPGPVEQAIARHVAGWVEDGATLQLGIGNLPEAVLAALHGHRDLGLHSGAVGDGIAALA
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
EAGVLTNARKSLDTGVGIGGILMGGERLRRWAHRNPQIELRGTDYTHDPAVLAASHKLTA
HHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHCCCCCEEEECCCCCCCCCEEEECCCEEE
INAAIEVDLTGQINAEVAAGCYVGAVGGAVDFLRGAARSKGGLPIVALPATAKGKTRIVA
EEEEEEEEECCCCCCCEECCEEHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEE
QLSGPVSTPRSDAGLIVTEHGVADLRGQTLSRRVRRLIDIAAPEHRADLERQAHDTLRRC
EECCCCCCCCCCCCEEEEECCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GAVFQI
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]