| Definition | Acidovorax ebreus TPSY chromosome, complete genome. |
|---|---|
| Accession | NC_011992 |
| Length | 3,796,573 |
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The map label for this gene is fadH [H]
Identifier: 222109348
GI number: 222109348
Start: 142846
End: 143652
Strand: Direct
Name: fadH [H]
Synonym: Dtpsy_0126
Alternate gene names: 222109348
Gene position: 142846-143652 (Clockwise)
Preceding gene: 222109347
Following gene: 222109349
Centisome position: 3.76
GC content: 70.38
Gene sequence:
>807_bases ATGGCTGAGTTCTCCTCCTTCGCAGGCCGCCACGTCTTCGTGGCCGGCGGCACCAGCGGCATCAACCTCGGCATCGCCCA GGCGTTTGCACGCGCGGGCGCCCACGTGGTGGTCATGAGCCGCTCGCCCGACAAGGTGCAGCAGGCGGCCGAAGGCCTGC GCGCGCTGGGTGCGCAGGCGCTGGGTATCAGTGCCGACGTGCGCGACCCCGCTGCGGTGGACGCCGCGCTGCGCCAGGCG CATGCGCAGTTCGGTGACATCGACGTGCTGATCTCCGGCGCAGCGGGCAACTTCATCGCGCCCGCGGCCGACCTGTCGCC CAACGGCTTCAAGACCGTGATCGACATCGACCTGAACGGCAGCTTCCACGTGCTGCGCCTGGCGTACCCGATGCTCAAGA AACCGGGCGCCAGCGTCATCAACATCTCGGCGCCGCAGGGCGTGAACCCCACCATGTACCAGGTGCATGCCTGCGCCGCC AAGGCCGGCATCGACATGATGACGCGCGTGCTGGCCATGGAATGGGGCGAGGTGGGCGTGCGCGTGAACGCCATCGCGCC CGGCCCGATTGGCGACACCGAGGGCATGCGGCGCCTGGCGCCCACGCCCGAGGCACTGGCCAACGCGGTCGCCACCGTGC CGCTGCAGCGCATGGGCACGCTCGATGACATTGCGAACATGGCGCTGTTCCTCTCGTCGCCACAGGCGGGCTACGTGACG GGCGCCGTGATTCCCGTGGACGGTGGCTCGTCGCTACGCGGCGGGCGCGACATGCGCGCGTCGTACGTGCCGCGGAGCGC GGCATGA
Upstream 100 bases:
>100_bases GGCGCCCGAGCAGTTTTCGCAGATGGTGGAGCGCGACCGGCAGGACTGGGGCGCGCTGATCCGCAGCCAGAAGCTGCAGC TGGACTGAAAGGAGGGCGCC
Downstream 100 bases:
>100_bases GCCAGGTATACGAGCGCATCGTTTTCGAGGTGCAGGACGGCGTGGCCACGCTGACCCTGAGCAACCCCGCCAAGCGCAAC GCCTTCGACCCCGCCATGCG
Product: short-chain dehydrogenase/reductase sdr
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 268; Mature: 267
Protein sequence:
>268_residues MAEFSSFAGRHVFVAGGTSGINLGIAQAFARAGAHVVVMSRSPDKVQQAAEGLRALGAQALGISADVRDPAAVDAALRQA HAQFGDIDVLISGAAGNFIAPAADLSPNGFKTVIDIDLNGSFHVLRLAYPMLKKPGASVINISAPQGVNPTMYQVHACAA KAGIDMMTRVLAMEWGEVGVRVNAIAPGPIGDTEGMRRLAPTPEALANAVATVPLQRMGTLDDIANMALFLSSPQAGYVT GAVIPVDGGSSLRGGRDMRASYVPRSAA
Sequences:
>Translated_268_residues MAEFSSFAGRHVFVAGGTSGINLGIAQAFARAGAHVVVMSRSPDKVQQAAEGLRALGAQALGISADVRDPAAVDAALRQA HAQFGDIDVLISGAAGNFIAPAADLSPNGFKTVIDIDLNGSFHVLRLAYPMLKKPGASVINISAPQGVNPTMYQVHACAA KAGIDMMTRVLAMEWGEVGVRVNAIAPGPIGDTEGMRRLAPTPEALANAVATVPLQRMGTLDDIANMALFLSSPQAGYVT GAVIPVDGGSSLRGGRDMRASYVPRSAA >Mature_267_residues AEFSSFAGRHVFVAGGTSGINLGIAQAFARAGAHVVVMSRSPDKVQQAAEGLRALGAQALGISADVRDPAAVDAALRQAH AQFGDIDVLISGAAGNFIAPAADLSPNGFKTVIDIDLNGSFHVLRLAYPMLKKPGASVINISAPQGVNPTMYQVHACAAK AGIDMMTRVLAMEWGEVGVRVNAIAPGPIGDTEGMRRLAPTPEALANAVATVPLQRMGTLDDIANMALFLSSPQAGYVTG AVIPVDGGSSLRGGRDMRASYVPRSAA
Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]
Homologues:
Organism=Homo sapiens, GI10190704, Length=242, Percent_Identity=50, Blast_Score=216, Evalue=1e-56, Organism=Homo sapiens, GI4503301, Length=251, Percent_Identity=36.2549800796813, Blast_Score=153, Evalue=1e-37, Organism=Homo sapiens, GI19923817, Length=251, Percent_Identity=29.8804780876494, Blast_Score=140, Evalue=1e-33, Organism=Homo sapiens, GI32483357, Length=255, Percent_Identity=30.1960784313725, Blast_Score=99, Evalue=5e-21, Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=29.2, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI5031737, Length=250, Percent_Identity=29.6, Blast_Score=94, Evalue=9e-20, Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=31.6017316017316, Blast_Score=94, Evalue=2e-19, Organism=Homo sapiens, GI40254986, Length=205, Percent_Identity=31.219512195122, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=29.045643153527, Blast_Score=81, Evalue=1e-15, Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=27.4900398406374, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=9e-13, Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=27.3809523809524, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI4758504, Length=259, Percent_Identity=27.7992277992278, Blast_Score=66, Evalue=4e-11, Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=31.0077519379845, Blast_Score=124, Evalue=8e-30, Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=32.1138211382114, Blast_Score=113, Evalue=2e-26, Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=31.8548387096774, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=30.4878048780488, Blast_Score=98, Evalue=5e-22, Organism=Escherichia coli, GI1789208, Length=246, Percent_Identity=28.8617886178862, Blast_Score=96, Evalue=3e-21, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=26.8, Blast_Score=95, Evalue=5e-21, Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=25.7936507936508, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1788459, Length=244, Percent_Identity=27.0491803278689, Blast_Score=78, Evalue=7e-16, Organism=Escherichia coli, GI1787545, Length=263, Percent_Identity=28.8973384030418, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI2367365, Length=244, Percent_Identity=27.0491803278689, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=26.7441860465116, Blast_Score=75, Evalue=4e-15, Organism=Escherichia coli, GI1789057, Length=249, Percent_Identity=26.9076305220884, Blast_Score=74, Evalue=8e-15, Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=28.4552845528455, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI1787820, Length=185, Percent_Identity=28.1081081081081, Blast_Score=66, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17536651, Length=250, Percent_Identity=34.8, Blast_Score=138, Evalue=4e-33, Organism=Caenorhabditis elegans, GI17561272, Length=232, Percent_Identity=39.6551724137931, Blast_Score=136, Evalue=1e-32, Organism=Caenorhabditis elegans, GI17536025, Length=250, Percent_Identity=34.4, Blast_Score=135, Evalue=2e-32, Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=26.8199233716475, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71994600, Length=250, Percent_Identity=29.6, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=27.6515151515151, Blast_Score=97, Evalue=6e-21, Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=26.9662921348315, Blast_Score=95, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=27.8195488721804, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17560676, Length=247, Percent_Identity=27.9352226720648, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=31.3492063492063, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI25147288, Length=252, Percent_Identity=31.7460317460317, Blast_Score=91, Evalue=7e-19, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=26.8939393939394, Blast_Score=91, Evalue=9e-19, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=28.1954887218045, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=25.9109311740891, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17562906, Length=269, Percent_Identity=26.7657992565056, Blast_Score=88, Evalue=5e-18, Organism=Caenorhabditis elegans, GI17544670, Length=276, Percent_Identity=28.6231884057971, Blast_Score=84, Evalue=9e-17, Organism=Caenorhabditis elegans, GI71982365, Length=192, Percent_Identity=30.2083333333333, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=26.6666666666667, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI71994604, Length=249, Percent_Identity=25.7028112449799, Blast_Score=81, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17562908, Length=273, Percent_Identity=24.5421245421245, Blast_Score=80, Evalue=1e-15, Organism=Caenorhabditis elegans, GI17558628, Length=217, Percent_Identity=30.4147465437788, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=26.615969581749, Blast_Score=75, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17531453, Length=267, Percent_Identity=25.0936329588015, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17560332, Length=279, Percent_Identity=25.089605734767, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17538480, Length=270, Percent_Identity=27.4074074074074, Blast_Score=74, Evalue=8e-14, Organism=Caenorhabditis elegans, GI17560220, Length=268, Percent_Identity=26.1194029850746, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17565030, Length=271, Percent_Identity=24.7232472324723, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=24.4360902255639, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=23.5955056179775, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324126, Length=247, Percent_Identity=41.2955465587045, Blast_Score=184, Evalue=1e-47, Organism=Saccharomyces cerevisiae, GI6322861, Length=195, Percent_Identity=27.6923076923077, Blast_Score=66, Evalue=5e-12, Organism=Drosophila melanogaster, GI23397609, Length=253, Percent_Identity=32.8063241106719, Blast_Score=120, Evalue=6e-28, Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=31.7269076305221, Blast_Score=112, Evalue=2e-25, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=28.1124497991968, Blast_Score=105, Evalue=4e-23, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=27.9527559055118, Blast_Score=100, Evalue=8e-22, Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=30.2788844621514, Blast_Score=99, Evalue=3e-21, Organism=Drosophila melanogaster, GI21357673, Length=197, Percent_Identity=31.9796954314721, Blast_Score=95, Evalue=6e-20, Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=29.718875502008, Blast_Score=92, Evalue=2e-19, Organism=Drosophila melanogaster, GI24644337, Length=254, Percent_Identity=29.9212598425197, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=27.3092369477912, Blast_Score=90, Evalue=1e-18, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=26.6666666666667, Blast_Score=68, Evalue=5e-12, Organism=Drosophila melanogaster, GI21356301, Length=194, Percent_Identity=29.3814432989691, Blast_Score=65, Evalue=4e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.3.1.34 [H]
Molecular weight: Translated: 27529; Mature: 27398
Theoretical pI: Translated: 7.73; Mature: 7.73
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 4.1 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 3.7 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAEFSSFAGRHVFVAGGTSGINLGIAQAFARAGAHVVVMSRSPDKVQQAAEGLRALGAQA CCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCHHH LGISADVRDPAAVDAALRQAHAQFGDIDVLISGAAGNFIAPAADLSPNGFKTVIDIDLNG CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCEEEEEEECCC SFHVLRLAYPMLKKPGASVINISAPQGVNPTMYQVHACAAKAGIDMMTRVLAMEWGEVGV CEEEHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE RVNAIAPGPIGDTEGMRRLAPTPEALANAVATVPLQRMGTLDDIANMALFLSSPQAGYVT EEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHEEECCCCCCEEE GAVIPVDGGSSLRGGRDMRASYVPRSAA EEEEEECCCCCCCCCCCCHHHCCCCCCC >Mature Secondary Structure AEFSSFAGRHVFVAGGTSGINLGIAQAFARAGAHVVVMSRSPDKVQQAAEGLRALGAQA CCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCHHH LGISADVRDPAAVDAALRQAHAQFGDIDVLISGAAGNFIAPAADLSPNGFKTVIDIDLNG CCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEECCCCCCCCCCCEEEEEEECCC SFHVLRLAYPMLKKPGASVINISAPQGVNPTMYQVHACAAKAGIDMMTRVLAMEWGEVGV CEEEHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE RVNAIAPGPIGDTEGMRRLAPTPEALANAVATVPLQRMGTLDDIANMALFLSSPQAGYVT EEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHCCHHHCCCHHHHHHHHEEECCCCCCEEE GAVIPVDGGSSLRGGRDMRASYVPRSAA EEEEEECCCCCCCCCCCCHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9384377 [H]