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The map label for this gene is sdaA [H]

Identifier: 222109334

GI number: 222109334

Start: 126432

End: 127820

Strand: Direct

Name: sdaA [H]

Synonym: Dtpsy_0112

Alternate gene names: 222109334

Gene position: 126432-127820 (Clockwise)

Preceding gene: 222109333

Following gene: 222109335

Centisome position: 3.33

GC content: 71.63

Gene sequence:

>1389_bases
ATGGCCGTCAGCGTTTTCGACTTGTTCAAGATCGGCATCGGGCCGTCCAGTTCGCACACCGTGGGGCCCATGCGCGCTGC
GCGGCTGTTCGCGCAGCGGCTGGCGCGCGAGGGGGTGCTGGCGCAGGTGGCGCGCGTGCGCAGCACGCTCTACGGCTCGC
TGGGCGCCACGGGGCGCGGGCACGCGAGCGACCGCGCCGTGCTGCTGGGCCTGGCCGGCCATGCGCCGGACACCGTGGAG
GTGGACGCCATCGAGCCGCTCATCGCCCGCATCCGCAGCCGGCGCCGCCTGCCGCTGGCCGACGGCCCCGAAGTGGCATT
CGCCGAGGCGGCCGACCTGCTGCTGGTACCCGACGTCACGCTGCCACTGCACGCCAACGGCATGCGTTTCGAGGCTTTCG
ATGCGGCGGGCGGCACGCTGGCCGCACAGGTGTACTACTCGGTGGGCGGCGGCTTCATCGTGAGCGAGGAGGCAGCCGCT
GACGCACAGCGCCAGGCCGCCATCGCGCCCGACACCGAGGTGCTGCCGCTGCCCTTTCACAGTGGGGAACAGCTGCTGGC
GCAGGCCGCGGCGCAGGGCGGATCGATCGCGCAGGTGATGCGCCTGAACGAACGCCACTGGCGCACCGACGCCGAGATCG
ACGCCGGCCTGCTCGCCATCTGGCGCGCCATGCAGGACTGCGTGGCGCGCGGCTGCAGCGTGGGCGGCGTGCTGCCCGGC
GGCTTCCAGGTGCGCCGGCGTGCGCCCGCGCTGCACCAGGCGCTGCAGAACGCGCCCGACACCCAGCAGGACCCGCTGCA
GGTGATCGACTGGGTGAACCTGTTCGCCCTGGCCGTGAACGAGGAGAACGCCGCCGGCGGGCGCGTGGTCACGGCCCCCA
CCAATGGCGCGGCGGGCATCGTGCCGGCAGTGCTGCATTACTACTGGCGCTTCATTCCCGGCGCTACCGAGGCTGGCGTG
GTCGACTTCCTGCTCACGGCTGGCGCCATCGGCATCTTGTACAAGGAGAACGCCTCCATCTCGGGCGCCGAGGTGGGCTG
CCAGGGCGAGGTGGGGGTGGCCTGCTCCATGGCTGCGGCGGGCCTGTGCGCCGTGCTGGGCGGCACGCCCGCGCAGGTGG
AGAACGCCGCCGAGATCGGCATGGAGCACCACCTGGGCCTGACCTGCGACCCGGTGGGCGGGCTGGTGCAGATCCCGTGC
ATCGAGCGCAACGCCCTGGCTTCGGTGAAGGCCATCAACGCCGCGCGCATGGCGCTGCATGGCGACGGAACGCACCATGT
GAGCCTGGACCAGGTCATCAAGACCATGCGCGAGACCGGCGCGGACATGATGACCAAGTACAAGGAGACTTCGCGCGGCG
GCCTCGCGGTGAACATCGTGGAGTGCTGA

Upstream 100 bases:

>100_bases
CCGACGGGGCCTGGCTAGGGCGAAACACCCGATTCCCTTGCCATCGCGACCGCGCCAGCATGGCGCACGACCGTAACCCT
TGCCCTCTGGAGTCTTGCCC

Downstream 100 bases:

>100_bases
CGCGGTACGACCCTTAGCGCCCTGTTTCCCATACCTTTTCGCTTTCCATCTGGCCCGCATGCACAACCCCGCTTCGCCCA
CCGATACCCTCCTGCCCGCC

Product: l-serine dehydratase 1

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAARLFAQRLAREGVLAQVARVRSTLYGSLGATGRGHASDRAVLLGLAGHAPDTVE
VDAIEPLIARIRSRRRLPLADGPEVAFAEAADLLLVPDVTLPLHANGMRFEAFDAAGGTLAAQVYYSVGGGFIVSEEAAA
DAQRQAAIAPDTEVLPLPFHSGEQLLAQAAAQGGSIAQVMRLNERHWRTDAEIDAGLLAIWRAMQDCVARGCSVGGVLPG
GFQVRRRAPALHQALQNAPDTQQDPLQVIDWVNLFALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYWRFIPGATEAGV
VDFLLTAGAIGILYKENASISGAEVGCQGEVGVACSMAAAGLCAVLGGTPAQVENAAEIGMEHHLGLTCDPVGGLVQIPC
IERNALASVKAINAARMALHGDGTHHVSLDQVIKTMRETGADMMTKYKETSRGGLAVNIVEC

Sequences:

>Translated_462_residues
MAVSVFDLFKIGIGPSSSHTVGPMRAARLFAQRLAREGVLAQVARVRSTLYGSLGATGRGHASDRAVLLGLAGHAPDTVE
VDAIEPLIARIRSRRRLPLADGPEVAFAEAADLLLVPDVTLPLHANGMRFEAFDAAGGTLAAQVYYSVGGGFIVSEEAAA
DAQRQAAIAPDTEVLPLPFHSGEQLLAQAAAQGGSIAQVMRLNERHWRTDAEIDAGLLAIWRAMQDCVARGCSVGGVLPG
GFQVRRRAPALHQALQNAPDTQQDPLQVIDWVNLFALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYWRFIPGATEAGV
VDFLLTAGAIGILYKENASISGAEVGCQGEVGVACSMAAAGLCAVLGGTPAQVENAAEIGMEHHLGLTCDPVGGLVQIPC
IERNALASVKAINAARMALHGDGTHHVSLDQVIKTMRETGADMMTKYKETSRGGLAVNIVEC
>Mature_461_residues
AVSVFDLFKIGIGPSSSHTVGPMRAARLFAQRLAREGVLAQVARVRSTLYGSLGATGRGHASDRAVLLGLAGHAPDTVEV
DAIEPLIARIRSRRRLPLADGPEVAFAEAADLLLVPDVTLPLHANGMRFEAFDAAGGTLAAQVYYSVGGGFIVSEEAAAD
AQRQAAIAPDTEVLPLPFHSGEQLLAQAAAQGGSIAQVMRLNERHWRTDAEIDAGLLAIWRAMQDCVARGCSVGGVLPGG
FQVRRRAPALHQALQNAPDTQQDPLQVIDWVNLFALAVNEENAAGGRVVTAPTNGAAGIVPAVLHYYWRFIPGATEAGVV
DFLLTAGAIGILYKENASISGAEVGCQGEVGVACSMAAAGLCAVLGGTPAQVENAAEIGMEHHLGLTCDPVGGLVQIPCI
ERNALASVKAINAARMALHGDGTHHVSLDQVIKTMRETGADMMTKYKETSRGGLAVNIVEC

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=460, Percent_Identity=55, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1788116, Length=462, Percent_Identity=54.978354978355, Blast_Score=477, Evalue=1e-136,
Organism=Escherichia coli, GI1789161, Length=461, Percent_Identity=54.880694143167, Blast_Score=466, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48201; Mature: 48069

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVSVFDLFKIGIGPSSSHTVGPMRAARLFAQRLAREGVLAQVARVRSTLYGSLGATGRG
CEEEHEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
HASDRAVLLGLAGHAPDTVEVDAIEPLIARIRSRRRLPLADGPEVAFAEAADLLLVPDVT
CCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEHHCCCCEEEECCCE
LPLHANGMRFEAFDAAGGTLAAQVYYSVGGGFIVSEEAAADAQRQAAIAPDTEVLPLPFH
EEECCCCCEEEEECCCCCEEEEEEEEECCCCEEEECHHHHHHHHCCCCCCCCCEEECCCC
SGEQLLAQAAAQGGSIAQVMRLNERHWRTDAEIDAGLLAIWRAMQDCVARGCSVGGVLPG
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GFQVRRRAPALHQALQNAPDTQQDPLQVIDWVNLFALAVNEENAAGGRVVTAPTNGAAGI
CHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEECCCCCCCHH
VPAVLHYYWRFIPGATEAGVVDFLLTAGAIGILYKENASISGAEVGCQGEVGVACSMAAA
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
GLCAVLGGTPAQVENAAEIGMEHHLGLTCDPVGGLVQIPCIERNALASVKAINAARMALH
HHHHHHCCCHHHHHHHHHHCHHHCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHEEEE
GDGTHHVSLDQVIKTMRETGADMMTKYKETSRGGLAVNIVEC
CCCCCEEEHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
AVSVFDLFKIGIGPSSSHTVGPMRAARLFAQRLAREGVLAQVARVRSTLYGSLGATGRG
EEEHEEHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
HASDRAVLLGLAGHAPDTVEVDAIEPLIARIRSRRRLPLADGPEVAFAEAADLLLVPDVT
CCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCEEHHCCCCEEEECCCE
LPLHANGMRFEAFDAAGGTLAAQVYYSVGGGFIVSEEAAADAQRQAAIAPDTEVLPLPFH
EEECCCCCEEEEECCCCCEEEEEEEEECCCCEEEECHHHHHHHHCCCCCCCCCEEECCCC
SGEQLLAQAAAQGGSIAQVMRLNERHWRTDAEIDAGLLAIWRAMQDCVARGCSVGGVLPG
CCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GFQVRRRAPALHQALQNAPDTQQDPLQVIDWVNLFALAVNEENAAGGRVVTAPTNGAAGI
CHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHEEEEECCCCCCCCEEEECCCCCCCHH
VPAVLHYYWRFIPGATEAGVVDFLLTAGAIGILYKENASISGAEVGCQGEVGVACSMAAA
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
GLCAVLGGTPAQVENAAEIGMEHHLGLTCDPVGGLVQIPCIERNALASVKAINAARMALH
HHHHHHCCCHHHHHHHHHHCHHHCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHEEEE
GDGTHHVSLDQVIKTMRETGADMMTKYKETSRGGLAVNIVEC
CCCCCEEEHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]