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The map label for this gene is argD [H]

Identifier: 222102938

GI number: 222102938

Start: 627075

End: 628355

Strand: Direct

Name: argD [H]

Synonym: Avi_7694

Alternate gene names: 222102938

Gene position: 627075-628355 (Clockwise)

Preceding gene: 222102936

Following gene: 222102940

Centisome position: 99.26

GC content: 58.55

Gene sequence:

>1281_bases
ATGCAGAATTCGCAACTCGCGGCACGCCGCACGAATGCCATCTCCCGCGGCGTCGGCGTGACGACCCAGATTTATGCCGA
ACGGGCCGAAAATGCCGAGATCTGGGATGTCGAAGGCCGCCGTTATATTGATTTTGCTGCCGGGATCGCCGTCGTCAATA
CCGGTCACCGACACCCAAAGGTGATTGCTGCGGTGAAGGCTCAACTCGATTGCTTCACCCATACCTGCCATCAGGTCATC
CCCTATGAGAACTATGTGCGCCTTGCCGAGCGCCTTAACCAGGCAGTACCGGGAAATTTCGAGAAGAAGACGATTTTTGT
GACGACCGGTGCCGAGGCGGTCGAGAACGCCGTCAAGATCGCCAGGGCGGCAACCAACCGGTCTGCCGTCATCGCCTTCA
CCGGCGCCTTCCATGGACGCACCTTCATGGGCATGACGTTGACGGGCAAGGTTACCCCCTACAAGGTTGGCTTCGGGGCG
ATGATGCCGGATGTCTTTCATGTCCCCTTCCCGGTCGAACTGCATGGCCAGACGATGGAGGATTCGTTGGCTGTGCTCGA
CAAGCTCTTTAAGGCTGATGTCGATCCGGAGCGCGTTGCAGCCTTCATCATCGAACCCGTGCAAGGCGAAGGTGGATTTT
ACGAAGTACCCCGACTTTTCATGCAGAAGCTGCGCCAGATTGCCGACAAGCACGGTATCCTGCTGATCGCGGATGAAGTC
CAGACAGGCTTTGCGCGCACCGGCAAGCTTTTCGCCATGGAGCATTTCGGCGTCGTTGCCGATATCACCACAATGGCCAA
GGGCCTCGGTGGCGGCTTCCCCATCGCGGCTGTCACCGGCCGGGCGGACATCATGGACGCACCGGGCCCAGGTGGTCTCG
GCGGCACCTATGGCGGCAATCCGATTGGCATTGCAGCCGGCAATGCCGTCCTCGATGTAATCGAGGAAGAGCAACTAGCA
GATCGCGCCACGTCGCTCGGCAACCGCCTTAAGCAAAGACTTCATTCCCTGTCCGATGCCGTGCCTGAGATCGCCGACAT
CCGCGGTCCCGGCTTCATGAACGCCGTGGAATTCAACCTGCCCGGTTCCAAGACACCGGATGCCGGTTTCACCAACAAGG
TACGGACTATAGCGCTGGAAAAAGGGCTGATTCTTCTGACCTGCGGTGTGTATGGCAATGTCATCCGCTTTCTGGCTCCC
CTGACGATCGACGAGAAAACCTTCGCCGAAGCGCTGGACATCCTTGAAGAGACATTGCGCGTCTGCTCCAAGGATAGTTG
A

Upstream 100 bases:

>100_bases
GGCTGTGTGATGGGCATTGCAAGTCTACCGAAAAAATGTAGAGATTTTCACGATATCATCATTGCAACTTCCGATAACCC
CAGGCTCGAAGGTGTTTTCA

Downstream 100 bases:

>100_bases
CGCTATGACGTCCGGCAGGCGCCCGTTCAGGCCTGAGGGATCAGAGTTGGCTTAGGCATCGGACCGAAAAGTGGGAACCG
GTTTTCGGTCCGATGCTCTA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MQNSQLAARRTNAISRGVGVTTQIYAERAENAEIWDVEGRRYIDFAAGIAVVNTGHRHPKVIAAVKAQLDCFTHTCHQVI
PYENYVRLAERLNQAVPGNFEKKTIFVTTGAEAVENAVKIARAATNRSAVIAFTGAFHGRTFMGMTLTGKVTPYKVGFGA
MMPDVFHVPFPVELHGQTMEDSLAVLDKLFKADVDPERVAAFIIEPVQGEGGFYEVPRLFMQKLRQIADKHGILLIADEV
QTGFARTGKLFAMEHFGVVADITTMAKGLGGGFPIAAVTGRADIMDAPGPGGLGGTYGGNPIGIAAGNAVLDVIEEEQLA
DRATSLGNRLKQRLHSLSDAVPEIADIRGPGFMNAVEFNLPGSKTPDAGFTNKVRTIALEKGLILLTCGVYGNVIRFLAP
LTIDEKTFAEALDILEETLRVCSKDS

Sequences:

>Translated_426_residues
MQNSQLAARRTNAISRGVGVTTQIYAERAENAEIWDVEGRRYIDFAAGIAVVNTGHRHPKVIAAVKAQLDCFTHTCHQVI
PYENYVRLAERLNQAVPGNFEKKTIFVTTGAEAVENAVKIARAATNRSAVIAFTGAFHGRTFMGMTLTGKVTPYKVGFGA
MMPDVFHVPFPVELHGQTMEDSLAVLDKLFKADVDPERVAAFIIEPVQGEGGFYEVPRLFMQKLRQIADKHGILLIADEV
QTGFARTGKLFAMEHFGVVADITTMAKGLGGGFPIAAVTGRADIMDAPGPGGLGGTYGGNPIGIAAGNAVLDVIEEEQLA
DRATSLGNRLKQRLHSLSDAVPEIADIRGPGFMNAVEFNLPGSKTPDAGFTNKVRTIALEKGLILLTCGVYGNVIRFLAP
LTIDEKTFAEALDILEETLRVCSKDS
>Mature_426_residues
MQNSQLAARRTNAISRGVGVTTQIYAERAENAEIWDVEGRRYIDFAAGIAVVNTGHRHPKVIAAVKAQLDCFTHTCHQVI
PYENYVRLAERLNQAVPGNFEKKTIFVTTGAEAVENAVKIARAATNRSAVIAFTGAFHGRTFMGMTLTGKVTPYKVGFGA
MMPDVFHVPFPVELHGQTMEDSLAVLDKLFKADVDPERVAAFIIEPVQGEGGFYEVPRLFMQKLRQIADKHGILLIADEV
QTGFARTGKLFAMEHFGVVADITTMAKGLGGGFPIAAVTGRADIMDAPGPGGLGGTYGGNPIGIAAGNAVLDVIEEEQLA
DRATSLGNRLKQRLHSLSDAVPEIADIRGPGFMNAVEFNLPGSKTPDAGFTNKVRTIALEKGLILLTCGVYGNVIRFLAP
LTIDEKTFAEALDILEETLRVCSKDS

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=34.8894348894349, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI13994255, Length=350, Percent_Identity=35.7142857142857, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=35.0931677018634, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI37574042, Length=414, Percent_Identity=32.1256038647343, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=32.2997416020672, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI226442705, Length=414, Percent_Identity=31.6425120772947, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=28.4009546539379, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI188536080, Length=461, Percent_Identity=27.3318872017354, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38679950, Length=461, Percent_Identity=27.3318872017354, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38679946, Length=461, Percent_Identity=27.3318872017354, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1787560, Length=419, Percent_Identity=57.0405727923628, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1789016, Length=418, Percent_Identity=55.5023923444976, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI1789759, Length=391, Percent_Identity=35.0383631713555, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=33.1632653061224, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI145693181, Length=371, Percent_Identity=33.9622641509434, Blast_Score=178, Evalue=7e-46,
Organism=Escherichia coli, GI1786349, Length=327, Percent_Identity=33.6391437308869, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1786991, Length=391, Percent_Identity=29.6675191815857, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=424, Percent_Identity=32.311320754717, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI25144271, Length=406, Percent_Identity=32.2660098522167, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=455, Percent_Identity=30.5494505494506, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=31.864406779661, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=465, Percent_Identity=23.8709677419355, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=157, Percent_Identity=29.9363057324841, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=32.2660098522167, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6323470, Length=413, Percent_Identity=31.9612590799031, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6321456, Length=437, Percent_Identity=26.5446224256293, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324386, Length=333, Percent_Identity=22.2222222222222, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21357415, Length=406, Percent_Identity=34.2364532019704, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161085790, Length=418, Percent_Identity=33.9712918660287, Blast_Score=191, Evalue=1e-48,
Organism=Drosophila melanogaster, GI28574759, Length=413, Percent_Identity=34.1404358353511, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21356575, Length=411, Percent_Identity=30.9002433090024, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI281366494, Length=380, Percent_Identity=27.1052631578947, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667139, Length=380, Percent_Identity=27.1052631578947, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667143, Length=380, Percent_Identity=27.1052631578947, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 45886; Mature: 45886

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSQLAARRTNAISRGVGVTTQIYAERAENAEIWDVEGRRYIDFAAGIAVVNTGHRHPK
CCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCEEEEECCCEEEEECCCCCCH
VIAAVKAQLDCFTHTCHQVIPYENYVRLAERLNQAVPGNFEKKTIFVTTGAEAVENAVKI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHH
ARAATNRSAVIAFTGAFHGRTFMGMTLTGKVTPYKVGFGAMMPDVFHVPFPVELHGQTME
HHHHCCCCEEEEEEECCCCCEEEEEEEECCCCCEEECCHHHCCCCEECCCCEEECCCCHH
DSLAVLDKLFKADVDPERVAAFIIEPVQGEGGFYEVPRLFMQKLRQIADKHGILLIADEV
HHHHHHHHHHHCCCCHHHEEEHEEEECCCCCCEEHHHHHHHHHHHHHHHHCCEEEEECCH
QTGFARTGKLFAMEHFGVVADITTMAKGLGGGFPIAAVTGRADIMDAPGPGGLGGTYGGN
HCCHHHCCCEEEHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
PIGIAAGNAVLDVIEEEQLADRATSLGNRLKQRLHSLSDAVPEIADIRGPGFMNAVEFNL
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCEEEECC
PGSKTPDAGFTNKVRTIALEKGLILLTCGVYGNVIRFLAPLTIDEKTFAEALDILEETLR
CCCCCCCCCCCCCCEEEEEECCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VCSKDS
HHCCCC
>Mature Secondary Structure
MQNSQLAARRTNAISRGVGVTTQIYAERAENAEIWDVEGRRYIDFAAGIAVVNTGHRHPK
CCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCEEEEECCCEEEEECCCCCCH
VIAAVKAQLDCFTHTCHQVIPYENYVRLAERLNQAVPGNFEKKTIFVTTGAEAVENAVKI
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHH
ARAATNRSAVIAFTGAFHGRTFMGMTLTGKVTPYKVGFGAMMPDVFHVPFPVELHGQTME
HHHHCCCCEEEEEEECCCCCEEEEEEEECCCCCEEECCHHHCCCCEECCCCEEECCCCHH
DSLAVLDKLFKADVDPERVAAFIIEPVQGEGGFYEVPRLFMQKLRQIADKHGILLIADEV
HHHHHHHHHHHCCCCHHHEEEHEEEECCCCCCEEHHHHHHHHHHHHHHHHCCEEEEECCH
QTGFARTGKLFAMEHFGVVADITTMAKGLGGGFPIAAVTGRADIMDAPGPGGLGGTYGGN
HCCHHHCCCEEEHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
PIGIAAGNAVLDVIEEEQLADRATSLGNRLKQRLHSLSDAVPEIADIRGPGFMNAVEFNL
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCEEEECC
PGSKTPDAGFTNKVRTIALEKGLILLTCGVYGNVIRFLAPLTIDEKTFAEALDILEETLR
CCCCCCCCCCCCCCEEEEEECCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
VCSKDS
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]