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The map label for this gene is accC [H]

Identifier: 222102935

GI number: 222102935

Start: 622613

End: 624601

Strand: Direct

Name: accC [H]

Synonym: Avi_7691

Alternate gene names: 222102935

Gene position: 622613-624601 (Clockwise)

Preceding gene: 222102934

Following gene: 222102936

Centisome position: 98.55

GC content: 60.53

Gene sequence:

>1989_bases
ATGTTTCAGAAAATCCTGATCGCCAATCGCGGCGAAATCGCCTGCCGCATTATCCGAACCGCGCGGCGCATGGGCATTGC
CACCGTTGCCGTCTATTCGCAGGCTGACGCTGACGCACGCCATGTTCGGCTTGCGGATGAGGCCATTCTCATCGGCCCAG
CACCGGCGCGGGAATCCTATCTTGTTGCCGAGAATATTCTTGCCGCTGCCCGTCGCACAGGTGCTGAGGCCATTCACCCC
GGCTACGGCTTTCTATCTGAGAACGACGAGTTTGCCGAAGCTTGCGCTGCCAATGGCATCGCCTTTATCGGGCCGCCCGC
CGCTGCCATCCGTGCCATGGGATCAAAATCGGCAGCAAAAGAGCTGATGGGCAAGGTCGGGGTGCCGCTTGTGCCCGGCT
ATCACGGTGCGGACAATGATCCGGCACGGTTGCGGCGAGAGGGTGATCACATCGGCTATCCCGTATTGATCAAGGCCTCC
GCAGGCGGTGGCGGCAAGGGCATGCGGCGGGTTGATCGCGCAGACGATTTTGCCGATGCGCTGGCATCCTGCCAGCGTGA
AGCGCGCAATGCCTTCGGCGATGATCATGTGCTGATCGAGAAATACATTCTCAAGCCGCGCCACATCGAAATTCAGGTTT
TTGCCGATTCGAGTGGCCACTGCATCCATCTTTATGAGCGCGATTGCTCGGTGCAGCGCCGCCACCAGAAAGTTCTGGAA
GAGGCACCCGCGCCGGGAATGACCGCAGAGCGGCGCGCAGCCATGGGTGCTGCTGCCGTGACGGCAGCAAAGGCGGTTAA
CTATGTCGGTGCCGGAACCGTGGAGTTCATCGTCAATAGCGATGGATCTTTTTACTTCATGGAGATGAACACCCGCCTGC
AAGTGGAGCATCCGGTTACGGAAATGGTGACCGGGCTGGACCTTGTTGAGTGGCAGCTGCGCATTGCCGCAGGCCACCCC
TTGCCCTTGCGGCAGGAGGATGTGCCGCTGATGGGGCATGCCATCGAGGCCCGCATCTATGCCGAGGATGCAGATGCAGG
CTTTCTGCCGTCCATCGGCACCCTCCGACATCTGGGACTGCCGCAGCAAAATGCACATGTGCGCATCGATAGCGCCGTAG
AGACAGGGGATGCGATCTCACCCCATTACGACCCCATGATCGCCAAGCTGATCGTGCATGGAGCAGACCGCAAAGAAGCG
CTAGATCGCATGAGCGAAGCCCTTAGCGCAATCCAGATTGTTGGCCTGACGGCGAATATCGGCTTTCTGCACCGCCTCAT
AAAGACCCCGTCTTTCGCTGAGGCCGATCTCGACACCGGGCTGATTGAGCGCGAACAGGACAGATTGTTTGCCCTATCCC
CCGTGCCTGCCGGGGTCTGGTATCTGGCGGCTTTGCAAGAGCTTTTGCGGGACATTTCTGCCAACCCTGCATCGCCTTGG
GCGCTGGCTGATGGCTGGCGGCTGACCGGCCGGGCGGAACGGCGGATCGCACTGTGCTGCAAAGGCGAAACGGTCACAGT
CACCGCCGTTTTCTCCGGTGAGGGTTGGACTCTGGCCCTGTCCGGCACGGATGAGCCATCGACCTTTGCGCAAGGCCATG
CCAGCCAAAACGGGCCAGCAACGGCGCTCGATGTGCGCATTGGCGAGCGGCGTTACGACGCGACGATCATGATCGATGGG
AACCATCGTCATGTGTTCTATACCGGACAAACCTTTGTGGTGGAACGCTTGCCCGACCTGCAACGTGCCACCGACACCAA
CAGTGGCAGCGGCGGCCTGCGCGCGCCGATGCCCGGCGCGATCATCGCGCTGCTTGCCGAGCCGGGGGTCTCCTTGAAAA
CAGGGGAACCGTTGCTGGTCATGGAGGCAATGAAAATGGAACACACAATAGTTGCGCCATCCGATGGCACGCTTGCCAGC
TTCCATTTTGCGGTTGGCGATCAGGTGGTGGCCGGCGCGGAGCTGGTTGATTTCCAGCCCGCCGCATAA

Upstream 100 bases:

>100_bases
GCCGAGGCACGGATGAAGCCCGCGAGGGTCTTTCGGCCTTTCTGGAAAAACGCAAACCCGGCTGGATCGCGGATCGGAAA
GAAGGGTGAAGGATCAAACC

Downstream 100 bases:

>100_bases
GGACAAGATCATGCACCAAACCAGCGGCGACAACATCGTCATTGTCGAGGTCGGCCCAAGAGACGGCTTGCAAAACGAAG
CCGCTATTGTTTCCACCGAT

Product: acetyl-CoA carboxylase biotin carboxylase

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MFQKILIANRGEIACRIIRTARRMGIATVAVYSQADADARHVRLADEAILIGPAPARESYLVAENILAAARRTGAEAIHP
GYGFLSENDEFAEACAANGIAFIGPPAAAIRAMGSKSAAKELMGKVGVPLVPGYHGADNDPARLRREGDHIGYPVLIKAS
AGGGGKGMRRVDRADDFADALASCQREARNAFGDDHVLIEKYILKPRHIEIQVFADSSGHCIHLYERDCSVQRRHQKVLE
EAPAPGMTAERRAAMGAAAVTAAKAVNYVGAGTVEFIVNSDGSFYFMEMNTRLQVEHPVTEMVTGLDLVEWQLRIAAGHP
LPLRQEDVPLMGHAIEARIYAEDADAGFLPSIGTLRHLGLPQQNAHVRIDSAVETGDAISPHYDPMIAKLIVHGADRKEA
LDRMSEALSAIQIVGLTANIGFLHRLIKTPSFAEADLDTGLIEREQDRLFALSPVPAGVWYLAALQELLRDISANPASPW
ALADGWRLTGRAERRIALCCKGETVTVTAVFSGEGWTLALSGTDEPSTFAQGHASQNGPATALDVRIGERRYDATIMIDG
NHRHVFYTGQTFVVERLPDLQRATDTNSGSGGLRAPMPGAIIALLAEPGVSLKTGEPLLVMEAMKMEHTIVAPSDGTLAS
FHFAVGDQVVAGAELVDFQPAA

Sequences:

>Translated_662_residues
MFQKILIANRGEIACRIIRTARRMGIATVAVYSQADADARHVRLADEAILIGPAPARESYLVAENILAAARRTGAEAIHP
GYGFLSENDEFAEACAANGIAFIGPPAAAIRAMGSKSAAKELMGKVGVPLVPGYHGADNDPARLRREGDHIGYPVLIKAS
AGGGGKGMRRVDRADDFADALASCQREARNAFGDDHVLIEKYILKPRHIEIQVFADSSGHCIHLYERDCSVQRRHQKVLE
EAPAPGMTAERRAAMGAAAVTAAKAVNYVGAGTVEFIVNSDGSFYFMEMNTRLQVEHPVTEMVTGLDLVEWQLRIAAGHP
LPLRQEDVPLMGHAIEARIYAEDADAGFLPSIGTLRHLGLPQQNAHVRIDSAVETGDAISPHYDPMIAKLIVHGADRKEA
LDRMSEALSAIQIVGLTANIGFLHRLIKTPSFAEADLDTGLIEREQDRLFALSPVPAGVWYLAALQELLRDISANPASPW
ALADGWRLTGRAERRIALCCKGETVTVTAVFSGEGWTLALSGTDEPSTFAQGHASQNGPATALDVRIGERRYDATIMIDG
NHRHVFYTGQTFVVERLPDLQRATDTNSGSGGLRAPMPGAIIALLAEPGVSLKTGEPLLVMEAMKMEHTIVAPSDGTLAS
FHFAVGDQVVAGAELVDFQPAA
>Mature_662_residues
MFQKILIANRGEIACRIIRTARRMGIATVAVYSQADADARHVRLADEAILIGPAPARESYLVAENILAAARRTGAEAIHP
GYGFLSENDEFAEACAANGIAFIGPPAAAIRAMGSKSAAKELMGKVGVPLVPGYHGADNDPARLRREGDHIGYPVLIKAS
AGGGGKGMRRVDRADDFADALASCQREARNAFGDDHVLIEKYILKPRHIEIQVFADSSGHCIHLYERDCSVQRRHQKVLE
EAPAPGMTAERRAAMGAAAVTAAKAVNYVGAGTVEFIVNSDGSFYFMEMNTRLQVEHPVTEMVTGLDLVEWQLRIAAGHP
LPLRQEDVPLMGHAIEARIYAEDADAGFLPSIGTLRHLGLPQQNAHVRIDSAVETGDAISPHYDPMIAKLIVHGADRKEA
LDRMSEALSAIQIVGLTANIGFLHRLIKTPSFAEADLDTGLIEREQDRLFALSPVPAGVWYLAALQELLRDISANPASPW
ALADGWRLTGRAERRIALCCKGETVTVTAVFSGEGWTLALSGTDEPSTFAQGHASQNGPATALDVRIGERRYDATIMIDG
NHRHVFYTGQTFVVERLPDLQRATDTNSGSGGLRAPMPGAIIALLAEPGVSLKTGEPLLVMEAMKMEHTIVAPSDGTLAS
FHFAVGDQVVAGAELVDFQPAA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=669, Percent_Identity=47.3841554559043, Blast_Score=594, Evalue=1e-170,
Organism=Homo sapiens, GI65506442, Length=682, Percent_Identity=42.375366568915, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI189095269, Length=682, Percent_Identity=42.375366568915, Blast_Score=497, Evalue=1e-140,
Organism=Homo sapiens, GI295821183, Length=675, Percent_Identity=41.4814814814815, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI106049528, Length=458, Percent_Identity=42.1397379912664, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI106049295, Length=458, Percent_Identity=42.1397379912664, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI106049292, Length=458, Percent_Identity=42.1397379912664, Blast_Score=348, Evalue=7e-96,
Organism=Homo sapiens, GI38679960, Length=718, Percent_Identity=31.6155988857939, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI38679977, Length=718, Percent_Identity=31.6155988857939, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI38679967, Length=718, Percent_Identity=31.6155988857939, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI38679971, Length=716, Percent_Identity=31.7039106145251, Blast_Score=290, Evalue=4e-78,
Organism=Homo sapiens, GI38679974, Length=716, Percent_Identity=31.7039106145251, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=33.4653465346535, Blast_Score=259, Evalue=7e-69,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=50.6726457399103, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71987519, Length=660, Percent_Identity=45.6060606060606, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17567343, Length=692, Percent_Identity=41.7630057803468, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17562816, Length=458, Percent_Identity=42.5764192139738, Blast_Score=345, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=29.7830374753452, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=29.7830374753452, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=28.5132382892057, Blast_Score=202, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=43.8478747203579, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319695, Length=560, Percent_Identity=39.1071428571429, Blast_Score=325, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6321376, Length=457, Percent_Identity=43.3260393873085, Blast_Score=320, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6324343, Length=729, Percent_Identity=29.6296296296296, Blast_Score=263, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6323863, Length=456, Percent_Identity=33.3333333333333, Blast_Score=237, Evalue=5e-63,
Organism=Drosophila melanogaster, GI24651757, Length=665, Percent_Identity=47.8195488721804, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24651759, Length=628, Percent_Identity=46.8152866242038, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24652212, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652210, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652214, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI19921944, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652216, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI281363050, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652224, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652222, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652220, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24652218, Length=462, Percent_Identity=42.2077922077922, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI161076409, Length=706, Percent_Identity=29.4617563739377, Blast_Score=246, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24586458, Length=706, Percent_Identity=29.4617563739377, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI161076407, Length=706, Percent_Identity=29.4617563739377, Blast_Score=245, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24586460, Length=706, Percent_Identity=29.4617563739377, Blast_Score=245, Evalue=7e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 71062; Mature: 71062

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQKILIANRGEIACRIIRTARRMGIATVAVYSQADADARHVRLADEAILIGPAPARESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEECCEEEECCCCCCCCC
LVAENILAAARRTGAEAIHPGYGFLSENDEFAEACAANGIAFIGPPAAAIRAMGSKSAAK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
ELMGKVGVPLVPGYHGADNDPARLRREGDHIGYPVLIKASAGGGGKGMRRVDRADDFADA
HHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
LASCQREARNAFGDDHVLIEKYILKPRHIEIQVFADSSGHCIHLYERDCSVQRRHQKVLE
HHHHHHHHHHCCCCCCEEHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPAPGMTAERRAAMGAAAVTAAKAVNYVGAGTVEFIVNSDGSFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMVTGLDLVEWQLRIAAGHPLPLRQEDVPLMGHAIEARIYAEDADAGFLPSIGTLRHLGL
HHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHCCC
PQQNAHVRIDSAVETGDAISPHYDPMIAKLIVHGADRKEALDRMSEALSAIQIVGLTANI
CCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCH
GFLHRLIKTPSFAEADLDTGLIEREQDRLFALSPVPAGVWYLAALQELLRDISANPASPW
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
ALADGWRLTGRAERRIALCCKGETVTVTAVFSGEGWTLALSGTDEPSTFAQGHASQNGPA
EECCCEEECCCCCCEEEEEECCCEEEEEEEECCCCEEEEECCCCCCCHHHCCCCCCCCCC
TALDVRIGERRYDATIMIDGNHRHVFYTGQTFVVERLPDLQRATDTNSGSGGLRAPMPGA
EEEEEEECCEEECEEEEEECCCEEEEEECCEEEEHHCCCHHHHCCCCCCCCCCCCCCCCE
IIALLAEPGVSLKTGEPLLVMEAMKMEHTIVAPSDGTLASFHFAVGDQVVAGAELVDFQP
EEEEEECCCCCEECCCCEEEEEHHCCCEEEECCCCCCEEEEEEECCCCEECCCEEECCCC
AA
CC
>Mature Secondary Structure
MFQKILIANRGEIACRIIRTARRMGIATVAVYSQADADARHVRLADEAILIGPAPARESY
CCCEEEEECCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEECCEEEECCCCCCCCC
LVAENILAAARRTGAEAIHPGYGFLSENDEFAEACAANGIAFIGPPAAAIRAMGSKSAAK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
ELMGKVGVPLVPGYHGADNDPARLRREGDHIGYPVLIKASAGGGGKGMRRVDRADDFADA
HHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
LASCQREARNAFGDDHVLIEKYILKPRHIEIQVFADSSGHCIHLYERDCSVQRRHQKVLE
HHHHHHHHHHCCCCCCEEHHHHHCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPAPGMTAERRAAMGAAAVTAAKAVNYVGAGTVEFIVNSDGSFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCEEEECCCHH
EMVTGLDLVEWQLRIAAGHPLPLRQEDVPLMGHAIEARIYAEDADAGFLPSIGTLRHLGL
HHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHCCC
PQQNAHVRIDSAVETGDAISPHYDPMIAKLIVHGADRKEALDRMSEALSAIQIVGLTANI
CCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEEECCH
GFLHRLIKTPSFAEADLDTGLIEREQDRLFALSPVPAGVWYLAALQELLRDISANPASPW
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCC
ALADGWRLTGRAERRIALCCKGETVTVTAVFSGEGWTLALSGTDEPSTFAQGHASQNGPA
EECCCEEECCCCCCEEEEEECCCEEEEEEEECCCCEEEEECCCCCCCHHHCCCCCCCCCC
TALDVRIGERRYDATIMIDGNHRHVFYTGQTFVVERLPDLQRATDTNSGSGGLRAPMPGA
EEEEEEECCEEECEEEEEECCCEEEEEECCEEEEHHCCCHHHHCCCCCCCCCCCCCCCCE
IIALLAEPGVSLKTGEPLLVMEAMKMEHTIVAPSDGTLASFHFAVGDQVVAGAELVDFQP
EEEEEECCCCCEECCCCEEEEEHHCCCEEEECCCCCCEEEEEEECCCCEECCCEEECCCC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]