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The map label for this gene is tyrB [H]

Identifier: 222102805

GI number: 222102805

Start: 468870

End: 470054

Strand: Direct

Name: tyrB [H]

Synonym: Avi_7524

Alternate gene names: 222102805

Gene position: 468870-470054 (Clockwise)

Preceding gene: 222102804

Following gene: 222102807

Centisome position: 74.21

GC content: 55.27

Gene sequence:

>1185_bases
GTGCTTGATACGCTCACAATGCCGCCACCAGACAAAATCCTCGCCTTGATGCCGATTTTTCGACAGGATAGCCGCAGCCA
CAAGCTTGATCTCGGTGTTGGCGTCTATCGTGATGCGTCGGGCATAACCCCTGTGCTGCGGGCTGTCCGAGAGGCCGAAG
CGCGGATGTTACAACACCAGACCACAAAGGCTTATATTGGACCTGCGGGTGATGCACTCTATTGCGATCTCATGACAAAA
CTGGTCTTTGCGGATCACGCACCAGTTGAGCGCATCCGTGCCATACAGACGCCGGGCGGGGCTGGCGCGCTGACGGTCAT
CTGCGGTCTGATTGCCAAGGCAGCGCCAAACGCAACCTTGCTGGTGCCCGATCCAACATGGGTCAATCATCTATCGATCA
TCGAGGATAATGGTTTGGCGGTGAAACGCTGGCCCTATCTTGATCCCACCACGGGCGGAGTTGATTTCGAGGCGTTGAAG
CAGACCGTTTGCTCGGCAAAAGCGGGTGACGTGATCTTGCTGCATGGTTGCTGTCATAACCCCACCGGCACGGATCTTAA
TCAGGCGCAATGGCGTGAACTTGGCGCACTGTTGGCTGAAAAGGGCGTCGTGCCGTTTATCGACATTGCCTATCAGGGTT
TCGGTGATGGCCTTGATGAAGATGCATTTGGCGTGCGGTACCTCGCCACCTTGGTTCCTGAAATGCTGGTTGCCTCTTCA
TGCTCCAAGAATTTCGGCATCTACCGTGATCGTACAGGCGTGGCCTTTGTACTGGGCCAGACACAGAAACAGGCCGAAAT
TGCTGCCGCACAGATGGTGGTCAGGGCCCGTATTGCCTATTCCATGCCCCCGGATCATGGCTCCCGCATTGTCAGCACCA
TCCTTCAGGATGCGGATCTATCGGCAGACTGGCGAGCAGAACTGGAGGACATGCGCAATAACATCATCGGCCTGCGTCAA
GCGCTTGCCAAGGCGTTCCAACTTAGAACCCAGAGCAACCACTATGATTTCCTTATCGCCAACAAGGGCATGTTTTCAAA
GCTGGGCGTGACACCGCAACAGGTCGAGCGATTGCGCAACGAGTTTGCAATTTACATGGTTGAGGACAGTCGTATCAACA
TTGCGGGGCTGCGCCACGAGCAGATCAACAATTTTGTGGAAGCGGTGGTGAGCGTGACACGCTGA

Upstream 100 bases:

>100_bases
CAGCAGCTTGCCATCATGTCTAGCAGGATTGCATAATCAACATAAACGGTCTCAGACACGGCACACGGTGCCATCATGTG
CACAGCAGAGGACAGATATC

Downstream 100 bases:

>100_bases
AACGCTTATCGCGCAAGGCCCTCATGTAATTTCTTGCCAAACACATCCACCAGCGTTTTCATCACGGCGCGCTCAGCGCC
GGATAGCTCCCGATCAGCGG

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MLDTLTMPPPDKILALMPIFRQDSRSHKLDLGVGVYRDASGITPVLRAVREAEARMLQHQTTKAYIGPAGDALYCDLMTK
LVFADHAPVERIRAIQTPGGAGALTVICGLIAKAAPNATLLVPDPTWVNHLSIIEDNGLAVKRWPYLDPTTGGVDFEALK
QTVCSAKAGDVILLHGCCHNPTGTDLNQAQWRELGALLAEKGVVPFIDIAYQGFGDGLDEDAFGVRYLATLVPEMLVASS
CSKNFGIYRDRTGVAFVLGQTQKQAEIAAAQMVVRARIAYSMPPDHGSRIVSTILQDADLSADWRAELEDMRNNIIGLRQ
ALAKAFQLRTQSNHYDFLIANKGMFSKLGVTPQQVERLRNEFAIYMVEDSRINIAGLRHEQINNFVEAVVSVTR

Sequences:

>Translated_394_residues
MLDTLTMPPPDKILALMPIFRQDSRSHKLDLGVGVYRDASGITPVLRAVREAEARMLQHQTTKAYIGPAGDALYCDLMTK
LVFADHAPVERIRAIQTPGGAGALTVICGLIAKAAPNATLLVPDPTWVNHLSIIEDNGLAVKRWPYLDPTTGGVDFEALK
QTVCSAKAGDVILLHGCCHNPTGTDLNQAQWRELGALLAEKGVVPFIDIAYQGFGDGLDEDAFGVRYLATLVPEMLVASS
CSKNFGIYRDRTGVAFVLGQTQKQAEIAAAQMVVRARIAYSMPPDHGSRIVSTILQDADLSADWRAELEDMRNNIIGLRQ
ALAKAFQLRTQSNHYDFLIANKGMFSKLGVTPQQVERLRNEFAIYMVEDSRINIAGLRHEQINNFVEAVVSVTR
>Mature_394_residues
MLDTLTMPPPDKILALMPIFRQDSRSHKLDLGVGVYRDASGITPVLRAVREAEARMLQHQTTKAYIGPAGDALYCDLMTK
LVFADHAPVERIRAIQTPGGAGALTVICGLIAKAAPNATLLVPDPTWVNHLSIIEDNGLAVKRWPYLDPTTGGVDFEALK
QTVCSAKAGDVILLHGCCHNPTGTDLNQAQWRELGALLAEKGVVPFIDIAYQGFGDGLDEDAFGVRYLATLVPEMLVASS
CSKNFGIYRDRTGVAFVLGQTQKQAEIAAAQMVVRARIAYSMPPDHGSRIVSTILQDADLSADWRAELEDMRNNIIGLRQ
ALAKAFQLRTQSNHYDFLIANKGMFSKLGVTPQQVERLRNEFAIYMVEDSRINIAGLRHEQINNFVEAVVSVTR

Specific function: Shows activities toward both dicarboxylic and aromatic substrates [H]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=34.3434343434343, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI4504067, Length=385, Percent_Identity=30.6493506493506, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI117414139, Length=381, Percent_Identity=24.1469816272966, Blast_Score=118, Evalue=7e-27,
Organism=Escherichia coli, GI1787159, Length=395, Percent_Identity=41.7721518987342, Blast_Score=330, Evalue=8e-92,
Organism=Escherichia coli, GI1790488, Length=386, Percent_Identity=38.3419689119171, Blast_Score=288, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71981858, Length=392, Percent_Identity=35.4591836734694, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI25147133, Length=394, Percent_Identity=34.2639593908629, Blast_Score=253, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17569539, Length=400, Percent_Identity=30.25, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17569537, Length=399, Percent_Identity=26.0651629072682, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI25147136, Length=206, Percent_Identity=34.4660194174757, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17550384, Length=267, Percent_Identity=28.0898876404494, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323055, Length=410, Percent_Identity=31.9512195121951, Blast_Score=224, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322743, Length=425, Percent_Identity=28, Blast_Score=179, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=34.0050377833753, Blast_Score=244, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24580970, Length=400, Percent_Identity=33.75, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI19920542, Length=395, Percent_Identity=34.1772151898734, Blast_Score=244, Evalue=6e-65,
Organism=Drosophila melanogaster, GI24654046, Length=387, Percent_Identity=32.5581395348837, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI19922362, Length=387, Percent_Identity=32.5581395348837, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 43168; Mature: 43168

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDTLTMPPPDKILALMPIFRQDSRSHKLDLGVGVYRDASGITPVLRAVREAEARMLQHQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHH
TTKAYIGPAGDALYCDLMTKLVFADHAPVERIRAIQTPGGAGALTVICGLIAKAAPNATL
CCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEE
LVPDPTWVNHLSIIEDNGLAVKRWPYLDPTTGGVDFEALKQTVCSAKAGDVILLHGCCHN
EECCCCHHCEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCC
PTGTDLNQAQWRELGALLAEKGVVPFIDIAYQGFGDGLDEDAFGVRYLATLVPEMLVASS
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
CSKNFGIYRDRTGVAFVLGQTQKQAEIAAAQMVVRARIAYSMPPDHGSRIVSTILQDADL
CCCCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
SADWRAELEDMRNNIIGLRQALAKAFQLRTQSNHYDFLIANKGMFSKLGVTPQQVERLRN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCHHHHHHHHC
EFAIYMVEDSRINIAGLRHEQINNFVEAVVSVTR
CEEEEEEECCEEEEEECCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDTLTMPPPDKILALMPIFRQDSRSHKLDLGVGVYRDASGITPVLRAVREAEARMLQHQ
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCEEECCCCCCHHHHHHHHHHHHHHHHHH
TTKAYIGPAGDALYCDLMTKLVFADHAPVERIRAIQTPGGAGALTVICGLIAKAAPNATL
CCCEEECCCCCHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEE
LVPDPTWVNHLSIIEDNGLAVKRWPYLDPTTGGVDFEALKQTVCSAKAGDVILLHGCCHN
EECCCCHHCEEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCC
PTGTDLNQAQWRELGALLAEKGVVPFIDIAYQGFGDGLDEDAFGVRYLATLVPEMLVASS
CCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
CSKNFGIYRDRTGVAFVLGQTQKQAEIAAAQMVVRARIAYSMPPDHGSRIVSTILQDADL
CCCCCCCEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
SADWRAELEDMRNNIIGLRQALAKAFQLRTQSNHYDFLIANKGMFSKLGVTPQQVERLRN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCHHHHHHHHC
EFAIYMVEDSRINIAGLRHEQINNFVEAVVSVTR
CEEEEEEECCEEEEEECCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9058208; 9665848; 9930977 [H]