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The map label for this gene is php [H]

Identifier: 222102776

GI number: 222102776

Start: 435592

End: 436659

Strand: Direct

Name: php [H]

Synonym: Avi_7477

Alternate gene names: 222102776

Gene position: 435592-436659 (Clockwise)

Preceding gene: 222102775

Following gene: 222102777

Centisome position: 68.95

GC content: 57.68

Gene sequence:

>1068_bases
ATGACCAGTGAACTCTCTGAGGCTCATATCCGCTCCGGCAAAGTGATGACGGTGGCCGGCCCCATCTGCGTGGACGAGAT
GGGCGTAACCTTGATGCACGAGCATATCCTCAACGATTGCCGTTGCTGGTGGCATCAGCCCAAGACGCCTGAGAGGCAAT
ATCTGGCGGAAGGCTTTGTCTGCATGGAAATTCTGGGCGAATTGCGCCAGGACCCCTTCGTCAACAAGCACAATATCACC
CTGGATGACGAGCCTTTGGCGATCACCGAGCTGATGGATTTTGCCAAAGCAGGTGGCAAGACTGTGGTGGAGCCAACCTG
TCAAGGCATTGGCCGAAATCCTCTGGCGCTGCGCCGGATCGCAAAAGCCTCCGGGCTGAATATTGTGATGGGAGCTGGCT
ATTATCTGGCTTCATCCCACCCCGCCAAGGTGGCGGAGATGACGGTGGAGGCCATAGCCGATGAAATTGTGCAGGAAGCG
CTGGTTGGTGTCGATGGCACCGATGTCAAAATCGGCCTGATTGGTGAAATTGGCGTATCGTCTGATTTCACCGCTGAGGA
AGAAAAGTCACTGCGGGCCGCAGCCCAGGCGCAGCTACGCACCGGCCTGCCGCTGATGGTGCATCTGCCGGGCTGGTATC
GGCTGGGTCACAAAGTGCTGGATATTGCCGCAGAAGAAGGGGCAGACCTGCGCCACACGGTGCTGTGCCACATGAACCCA
TCTCATGATGATCTCACCTATCAAGGCGAACTGGCCAGCCGGGGAGCCTTTATTGAATATGACATGATCGGCATGGATTT
TTTCTACGCCGATCAGCAGGTGCAATGCCCCAGCGATGAGGATGCCGCCCGCGCCATCGTCAAGCTGGTGGAGATGGGCC
ATCTCGACCGCATCCTGCTCTCCCATGATGTGTTTTTGAAGATGATGCTCAGCCGCTACGGCGGCAATGGCTACGCCTAT
ATTCTCCGGCATTTCTTGCCGCGCCTCCAGCGTCACGGCCTTGGTGCTGACGCTCTCACCACCCTCATGCGGGGCAATCC
CCGTTCGGTCTTTCAGGCTGCCGCCTGA

Upstream 100 bases:

>100_bases
GCAGATTGTCACGGGCGCGATCATTCTGGTGGCGATCTGGCTGAACACCCGGATCTTTTCCGCAAATTTCCGCTTTGGCG
CAGCGAAGAAGGGGTGAGAT

Downstream 100 bases:

>100_bases
GACCTGTTGCATAGATAAGGAACACATATCATGACAAAGAAAATTCTCCTCGTGGGTGAAAGCTGGGTCAGCTCCGCCAC
CCATTACAAAGGTTTTGACC

Product: resiniferatoxin-binding phosphotriesterase-related protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTSELSEAHIRSGKVMTVAGPICVDEMGVTLMHEHILNDCRCWWHQPKTPERQYLAEGFVCMEILGELRQDPFVNKHNIT
LDDEPLAITELMDFAKAGGKTVVEPTCQGIGRNPLALRRIAKASGLNIVMGAGYYLASSHPAKVAEMTVEAIADEIVQEA
LVGVDGTDVKIGLIGEIGVSSDFTAEEEKSLRAAAQAQLRTGLPLMVHLPGWYRLGHKVLDIAAEEGADLRHTVLCHMNP
SHDDLTYQGELASRGAFIEYDMIGMDFFYADQQVQCPSDEDAARAIVKLVEMGHLDRILLSHDVFLKMMLSRYGGNGYAY
ILRHFLPRLQRHGLGADALTTLMRGNPRSVFQAAA

Sequences:

>Translated_355_residues
MTSELSEAHIRSGKVMTVAGPICVDEMGVTLMHEHILNDCRCWWHQPKTPERQYLAEGFVCMEILGELRQDPFVNKHNIT
LDDEPLAITELMDFAKAGGKTVVEPTCQGIGRNPLALRRIAKASGLNIVMGAGYYLASSHPAKVAEMTVEAIADEIVQEA
LVGVDGTDVKIGLIGEIGVSSDFTAEEEKSLRAAAQAQLRTGLPLMVHLPGWYRLGHKVLDIAAEEGADLRHTVLCHMNP
SHDDLTYQGELASRGAFIEYDMIGMDFFYADQQVQCPSDEDAARAIVKLVEMGHLDRILLSHDVFLKMMLSRYGGNGYAY
ILRHFLPRLQRHGLGADALTTLMRGNPRSVFQAAA
>Mature_354_residues
TSELSEAHIRSGKVMTVAGPICVDEMGVTLMHEHILNDCRCWWHQPKTPERQYLAEGFVCMEILGELRQDPFVNKHNITL
DDEPLAITELMDFAKAGGKTVVEPTCQGIGRNPLALRRIAKASGLNIVMGAGYYLASSHPAKVAEMTVEAIADEIVQEAL
VGVDGTDVKIGLIGEIGVSSDFTAEEEKSLRAAAQAQLRTGLPLMVHLPGWYRLGHKVLDIAAEEGADLRHTVLCHMNPS
HDDLTYQGELASRGAFIEYDMIGMDFFYADQQVQCPSDEDAARAIVKLVEMGHLDRILLSHDVFLKMMLSRYGGNGYAYI
LRHFLPRLQRHGLGADALTTLMRGNPRSVFQAAA

Specific function: Its real enzymatic activity is not yet known. It was tested for general esterase, aminopeptidase, sulfatase, phosphatase, carbonic anhydrase, phosphodiesterase, and phosphotriesterase activities with the following substrates:P- nitrophenyl acetate, L-alan

COG id: COG1735

COG function: function code R; Predicted metal-dependent hydrolase with the TIM-barrel fold

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphotriesterase family [H]

Homologues:

Organism=Homo sapiens, GI20070186, Length=340, Percent_Identity=35, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI47933341, Length=340, Percent_Identity=35, Blast_Score=201, Evalue=7e-52,
Organism=Escherichia coli, GI1789780, Length=281, Percent_Identity=31.6725978647687, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24645325, Length=340, Percent_Identity=28.8235294117647, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017947
- InterPro:   IPR001559 [H]

Pfam domain/function: PF02126 PTE [H]

EC number: NA

Molecular weight: Translated: 39112; Mature: 38981

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS01322 PHOSPHOTRIESTERASE_1 ; PS01323 PHOSPHOTRIESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSELSEAHIRSGKVMTVAGPICVDEMGVTLMHEHILNDCRCWWHQPKTPERQYLAEGFV
CCCCCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
CMEILGELRQDPFVNKHNITLDDEPLAITELMDFAKAGGKTVVEPTCQGIGRNPLALRRI
HHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHHHH
AKASGLNIVMGAGYYLASSHPAKVAEMTVEAIADEIVQEALVGVDGTDVKIGLIGEIGVS
HHHCCCEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
SDFTAEEEKSLRAAAQAQLRTGLPLMVHLPGWYRLGHKVLDIAAEEGADLRHTVLCHMNP
CCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
SHDDLTYQGELASRGAFIEYDMIGMDFFYADQQVQCPSDEDAARAIVKLVEMGHLDRILL
CCCCEEEECCHHCCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
SHDVFLKMMLSRYGGNGYAYILRHFLPRLQRHGLGADALTTLMRGNPRSVFQAAA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCC
>Mature Secondary Structure 
TSELSEAHIRSGKVMTVAGPICVDEMGVTLMHEHILNDCRCWWHQPKTPERQYLAEGFV
CCCCCHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
CMEILGELRQDPFVNKHNITLDDEPLAITELMDFAKAGGKTVVEPTCQGIGRNPLALRRI
HHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCEEECHHHHCCCCCHHHHHHH
AKASGLNIVMGAGYYLASSHPAKVAEMTVEAIADEIVQEALVGVDGTDVKIGLIGEIGVS
HHHCCCEEEEECCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCC
SDFTAEEEKSLRAAAQAQLRTGLPLMVHLPGWYRLGHKVLDIAAEEGADLRHTVLCHMNP
CCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
SHDDLTYQGELASRGAFIEYDMIGMDFFYADQQVQCPSDEDAARAIVKLVEMGHLDRILL
CCCCEEEECCHHCCCCEEEEEEECCEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
SHDVFLKMMLSRYGGNGYAYILRHFLPRLQRHGLGADALTTLMRGNPRSVFQAAA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9548740 [H]