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The map label for this gene is lldD [H]

Identifier: 222102477

GI number: 222102477

Start: 74891

End: 76069

Strand: Direct

Name: lldD [H]

Synonym: Avi_7084

Alternate gene names: 222102477

Gene position: 74891-76069 (Clockwise)

Preceding gene: 222102476

Following gene: 222102480

Centisome position: 11.85

GC content: 55.13

Gene sequence:

>1179_bases
ATGGTTTCCGCTCTTTTTGCTTCGGCGGGGCATCGCTTGCGCGATGTCCTATCTCTTGATGATTTCGAGGTTCTGGCGAA
ACGTCATTTGCCGGGGCCGCTCTTTGGATACATTGCCGGGGCAAGCGAGACCAATGCCTCGTTGCGCATGAATGCCGAGG
CGTTCAGGGACATAAGCCTCACGCCACGGGTTCTCAGAAACGTTTCGACCAGAACCACAAAGACAATCTTGTTCGGCGAG
GAATGGAGCGCACCGTTTGGGATCGCGCCGATGGGTATAAGCGCCCTGATGGCCTATCGCGGCGATCTCGTTCTTGCCAA
GGCTGCGCAGGATGCCGGGATTGCCATGATCATGAGCGGCTCATCCCTGATACGGTTGGAGGAGATTATCGAAGCTGCAC
CTCGATCATGGTTTCAAGCCTATCTACCGGGCGAGCCGGACCGGATCGATGGATTGATAGATCGCGTGGCTTCGGCAGGC
TACAAAACTCTTGTTCTGACGGTGGATACCGCCGTACTGGCCAATCGCGAAAACAATATCCGCGCTGGCTTCTCGACACC
TCTTCGGCCAAGCCTTCGTCTTACCTGGCAGGGAATGACCCATCCGGCATGGACGATTGGGACTTTCGCACGAACGATAC
TCACTCACGGCATCCCCCATTTCGAGAATTCGTATGCGACACGCGGCGCGCCGATCATTGCGTCGAACGTCATGCGAGAC
TTCGGCAAGAAGGATCATCTGAGCTGGGGCCATTTCAGCCGTATCAGGCAAAGATGGACGGGGAACCTGGTCGTGAAGGG
GATACTTCATCCCGAAGATGCAGCCATGGCCGCAGAGCGTGGGGCAGATGGTATCATCGTGTCCAACCATGGCGGCAGAC
AACTTGATGGCGCTATAGCCCCGATGAAAGCTCTGCCTGCGATAGTGGATAGAGTAGGATCAGACACGGTCGTCATGATC
GATGGTGGTATTCGTCGGGGGACAGATATGGTAAAAGCCCTCGCGCTTGGTGCAAAATTTGTGTTCGTAGGCAGGCCGTT
CGTCTACGCCGTGGCGGTAGGTTCAAAAGCGGGTGTCGCGAAAGCCACCAGCATTCTTTCAGATGAATTGCATAGGGATA
TGGGGCTGTTGGGTGTGACAGAAATTATTGAGCTTCCATCAATTCTTACTCGCATCTGA

Upstream 100 bases:

>100_bases
CGAAGACTGACATAAAAGGGCGCCGAGAGGTGCCCTTTTTCACTGTCTTCGAGGCAAATCAAAAGGCCCCCTCGGTGGTC
ATCGGTGAAGGCTGAAAATC

Downstream 100 bases:

>100_bases
AATTTCGTTCCGTCGCCAAAACTGGAAAATGGGCTCTGTTGCAAAGATTTCAAATCGAAACGAAATTCCCTAACCTACTT
CGTCAAGCGGCCTGACTTTC

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MVSALFASAGHRLRDVLSLDDFEVLAKRHLPGPLFGYIAGASETNASLRMNAEAFRDISLTPRVLRNVSTRTTKTILFGE
EWSAPFGIAPMGISALMAYRGDLVLAKAAQDAGIAMIMSGSSLIRLEEIIEAAPRSWFQAYLPGEPDRIDGLIDRVASAG
YKTLVLTVDTAVLANRENNIRAGFSTPLRPSLRLTWQGMTHPAWTIGTFARTILTHGIPHFENSYATRGAPIIASNVMRD
FGKKDHLSWGHFSRIRQRWTGNLVVKGILHPEDAAMAAERGADGIIVSNHGGRQLDGAIAPMKALPAIVDRVGSDTVVMI
DGGIRRGTDMVKALALGAKFVFVGRPFVYAVAVGSKAGVAKATSILSDELHRDMGLLGVTEIIELPSILTRI

Sequences:

>Translated_392_residues
MVSALFASAGHRLRDVLSLDDFEVLAKRHLPGPLFGYIAGASETNASLRMNAEAFRDISLTPRVLRNVSTRTTKTILFGE
EWSAPFGIAPMGISALMAYRGDLVLAKAAQDAGIAMIMSGSSLIRLEEIIEAAPRSWFQAYLPGEPDRIDGLIDRVASAG
YKTLVLTVDTAVLANRENNIRAGFSTPLRPSLRLTWQGMTHPAWTIGTFARTILTHGIPHFENSYATRGAPIIASNVMRD
FGKKDHLSWGHFSRIRQRWTGNLVVKGILHPEDAAMAAERGADGIIVSNHGGRQLDGAIAPMKALPAIVDRVGSDTVVMI
DGGIRRGTDMVKALALGAKFVFVGRPFVYAVAVGSKAGVAKATSILSDELHRDMGLLGVTEIIELPSILTRI
>Mature_392_residues
MVSALFASAGHRLRDVLSLDDFEVLAKRHLPGPLFGYIAGASETNASLRMNAEAFRDISLTPRVLRNVSTRTTKTILFGE
EWSAPFGIAPMGISALMAYRGDLVLAKAAQDAGIAMIMSGSSLIRLEEIIEAAPRSWFQAYLPGEPDRIDGLIDRVASAG
YKTLVLTVDTAVLANRENNIRAGFSTPLRPSLRLTWQGMTHPAWTIGTFARTILTHGIPHFENSYATRGAPIIASNVMRD
FGKKDHLSWGHFSRIRQRWTGNLVVKGILHPEDAAMAAERGADGIIVSNHGGRQLDGAIAPMKALPAIVDRVGSDTVVMI
DGGIRRGTDMVKALALGAKFVFVGRPFVYAVAVGSKAGVAKATSILSDELHRDMGLLGVTEIIELPSILTRI

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=372, Percent_Identity=37.3655913978495, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI7705393, Length=372, Percent_Identity=37.3655913978495, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI11068137, Length=378, Percent_Identity=33.3333333333333, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1790033, Length=369, Percent_Identity=38.4823848238482, Blast_Score=238, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI193208036, Length=378, Percent_Identity=32.5396825396825, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32566217, Length=291, Percent_Identity=30.9278350515464, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323587, Length=390, Percent_Identity=32.3076923076923, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI281363140, Length=376, Percent_Identity=35.6382978723404, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI78707190, Length=376, Percent_Identity=35.6382978723404, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI78707188, Length=376, Percent_Identity=35.6382978723404, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42289; Mature: 42289

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSALFASAGHRLRDVLSLDDFEVLAKRHLPGPLFGYIAGASETNASLRMNAEAFRDISL
CCCHHHHHCCHHHHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCCEEEECHHHHHCCCC
TPRVLRNVSTRTTKTILFGEEWSAPFGIAPMGISALMAYRGDLVLAKAAQDAGIAMIMSG
CHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECC
SSLIRLEEIIEAAPRSWFQAYLPGEPDRIDGLIDRVASAGYKTLVLTVDTAVLANRENNI
CCHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHHEECCCCCE
RAGFSTPLRPSLRLTWQGMTHPAWTIGTFARTILTHGIPHFENSYATRGAPIIASNVMRD
ECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
FGKKDHLSWGHFSRIRQRWTGNLVVKGILHPEDAAMAAERGADGIIVSNHGGRQLDGAIA
CCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCC
PMKALPAIVDRVGSDTVVMIDGGIRRGTDMVKALALGAKFVFVGRPFVYAVAVGSKAGVA
CHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCEEEEEEECCCCCHH
KATSILSDELHRDMGLLGVTEIIELPSILTRI
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSALFASAGHRLRDVLSLDDFEVLAKRHLPGPLFGYIAGASETNASLRMNAEAFRDISL
CCCHHHHHCCHHHHHHHCCCHHHHHHHHCCCCCHHHHEECCCCCCCEEEECHHHHHCCCC
TPRVLRNVSTRTTKTILFGEEWSAPFGIAPMGISALMAYRGDLVLAKAAQDAGIAMIMSG
CHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCEEEEECC
SSLIRLEEIIEAAPRSWFQAYLPGEPDRIDGLIDRVASAGYKTLVLTVDTAVLANRENNI
CCHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHHEECCCCCE
RAGFSTPLRPSLRLTWQGMTHPAWTIGTFARTILTHGIPHFENSYATRGAPIIASNVMRD
ECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
FGKKDHLSWGHFSRIRQRWTGNLVVKGILHPEDAAMAAERGADGIIVSNHGGRQLDGAIA
CCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCC
PMKALPAIVDRVGSDTVVMIDGGIRRGTDMVKALALGAKFVFVGRPFVYAVAVGSKAGVA
CHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCCEEEEEEECCCCCHH
KATSILSDELHRDMGLLGVTEIIELPSILTRI
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA