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The map label for this gene is tdh [H]

Identifier: 222102470

GI number: 222102470

Start: 67729

End: 68790

Strand: Reverse

Name: tdh [H]

Synonym: Avi_7076

Alternate gene names: 222102470

Gene position: 68790-67729 (Counterclockwise)

Preceding gene: 222102471

Following gene: 222102469

Centisome position: 10.89

GC content: 53.01

Gene sequence:

>1062_bases
ATGTCAACTACTATGCAAGTCATCGAACTCAACGGCCCTAATCGGCTCTCGATCTCACAGCGCCAAGTGCCAGAGACCCC
TGTAGATGGCGTTCTGCTTAAGACATCGGCCGTCTCGATTTGTTCTACTGACATCTCGCATTATCATGGCAATCTCCTTG
CCGAGGACTACCCGGTGATCCTTGGCCACGAATATAGCGGTATCGTCGTTGATGTCGGTCCCGAATGCCCGTCCTCCCTC
CAAGGACAACGCCTTGCTTATTTCGGCCAAACAGATTTCGGCGGGATGGCAGAATACCGGGCTTTGCGTCCCCTTTTCGC
CGGAGATCTGCGATCATCACCTTTCAAGACAGGCCGCTTTTTCAAAGATGATGAACGGGCGGCGGCGATTACGCTTCCAG
ACGAGATCTCGGACAGTGATGCGCCCCTGATCGAGCCGATTACAGCGGTCTTGAGATCGATCCTTACCCATCCACCCGCC
GTTGGAAACCGAGTGTTAGTTCTTGGCGGTGGACCGTGCGGTGCGATCGCCGGCGCTATATTGCAGACCCTCTATGCAAC
GAAGTCGGTTGCTGTTCTTGAACGCAATCAGGCACGCCAGGAAATTGCGCGAAGCCAGTATGCAAATTTCGTATTCGGTT
CTGCAGAAGAGTTACGAGAGTCGGATGACGATGCATTTGATTATGTGTTTGACGCTCTACCGCCTTTGGTCAACATAGAA
GCAGACTCATGCCCTCGTCGCGCGGCGATGCGGGCTGCCAAGCCGGGTTCCAAATATGTACTCTATGGTGCGTCCCAGAC
GCTCCAGCAATTCGATACATGGTTGCTGCTAGCGAAGGGCATTACGCTTGCCTCGGCCGCTTTCGACGTTGACCATTTTC
CGATGTACAAGACGGCATTCGTCATGAAGACCGCAAAGGAACTGTTGCTCCGACGGATTATCGATCCGGGCTGGATGATG
ACGAACCATATGTCCTTTTGGCGTCCGCAGGAGGTCATTCAGTTCTTCGCCGAATATTACACAACTCCTCATCTCAAGAC
GGTAATTCACTTTGACCAATAA

Upstream 100 bases:

>100_bases
CCCATCTCCCCAGATATTGCACTGCACTAGAAGCGATCCAAGAGAGATCGCACACATGATGGACATCCAAGGAAATTTTT
TCCCAAAAAGGAGTTCCTCA

Downstream 100 bases:

>100_bases
TCGTTTACTGCTTGGAGTATCGGCCAGCATATCATTTTTCTTCTGGGGTATGCTGGGCGTCTCTATTGGCGCACTTCTCC
CTAATGCCATGGAGACCTTT

Product: zinc-binding dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSTTMQVIELNGPNRLSISQRQVPETPVDGVLLKTSAVSICSTDISHYHGNLLAEDYPVILGHEYSGIVVDVGPECPSSL
QGQRLAYFGQTDFGGMAEYRALRPLFAGDLRSSPFKTGRFFKDDERAAAITLPDEISDSDAPLIEPITAVLRSILTHPPA
VGNRVLVLGGGPCGAIAGAILQTLYATKSVAVLERNQARQEIARSQYANFVFGSAEELRESDDDAFDYVFDALPPLVNIE
ADSCPRRAAMRAAKPGSKYVLYGASQTLQQFDTWLLLAKGITLASAAFDVDHFPMYKTAFVMKTAKELLLRRIIDPGWMM
TNHMSFWRPQEVIQFFAEYYTTPHLKTVIHFDQ

Sequences:

>Translated_353_residues
MSTTMQVIELNGPNRLSISQRQVPETPVDGVLLKTSAVSICSTDISHYHGNLLAEDYPVILGHEYSGIVVDVGPECPSSL
QGQRLAYFGQTDFGGMAEYRALRPLFAGDLRSSPFKTGRFFKDDERAAAITLPDEISDSDAPLIEPITAVLRSILTHPPA
VGNRVLVLGGGPCGAIAGAILQTLYATKSVAVLERNQARQEIARSQYANFVFGSAEELRESDDDAFDYVFDALPPLVNIE
ADSCPRRAAMRAAKPGSKYVLYGASQTLQQFDTWLLLAKGITLASAAFDVDHFPMYKTAFVMKTAKELLLRRIIDPGWMM
TNHMSFWRPQEVIQFFAEYYTTPHLKTVIHFDQ
>Mature_352_residues
STTMQVIELNGPNRLSISQRQVPETPVDGVLLKTSAVSICSTDISHYHGNLLAEDYPVILGHEYSGIVVDVGPECPSSLQ
GQRLAYFGQTDFGGMAEYRALRPLFAGDLRSSPFKTGRFFKDDERAAAITLPDEISDSDAPLIEPITAVLRSILTHPPAV
GNRVLVLGGGPCGAIAGAILQTLYATKSVAVLERNQARQEIARSQYANFVFGSAEELRESDDDAFDYVFDALPPLVNIEA
DSCPRRAAMRAAKPGSKYVLYGASQTLQQFDTWLLLAKGITLASAAFDVDHFPMYKTAFVMKTAKELLLRRIIDPGWMMT
NHMSFWRPQEVIQFFAEYYTTPHLKTVIHFDQ

Specific function: Not Known; Probable Catabolic Enzyme. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=342, Percent_Identity=23.3918128654971, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1790045, Length=201, Percent_Identity=29.3532338308458, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI226510992, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737897, Length=261, Percent_Identity=24.904214559387, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137530, Length=206, Percent_Identity=26.2135922330097, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 39002; Mature: 38871

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTMQVIELNGPNRLSISQRQVPETPVDGVLLKTSAVSICSTDISHYHGNLLAEDYPVI
CCCCEEEEEECCCCEECCCHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEECCCCCEE
LGHEYSGIVVDVGPECPSSLQGQRLAYFGQTDFGGMAEYRALRPLFAGDLRSSPFKTGRF
EECCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
FKDDERAAAITLPDEISDSDAPLIEPITAVLRSILTHPPAVGNRVLVLGGGPCGAIAGAI
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHH
LQTLYATKSVAVLERNQARQEIARSQYANFVFGSAEELRESDDDAFDYVFDALPPLVNIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCEEECC
ADSCPRRAAMRAAKPGSKYVLYGASQTLQQFDTWLLLAKGITLASAAFDVDHFPMYKTAF
CCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHH
VMKTAKELLLRRIIDPGWMMTNHMSFWRPQEVIQFFAEYYTTPHLKTVIHFDQ
HHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure 
STTMQVIELNGPNRLSISQRQVPETPVDGVLLKTSAVSICSTDISHYHGNLLAEDYPVI
CCCEEEEEECCCCEECCCHHCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEECCCCCEE
LGHEYSGIVVDVGPECPSSLQGQRLAYFGQTDFGGMAEYRALRPLFAGDLRSSPFKTGRF
EECCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
FKDDERAAAITLPDEISDSDAPLIEPITAVLRSILTHPPAVGNRVLVLGGGPCGAIAGAI
CCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHH
LQTLYATKSVAVLERNQARQEIARSQYANFVFGSAEELRESDDDAFDYVFDALPPLVNIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHCCCEEECC
ADSCPRRAAMRAAKPGSKYVLYGASQTLQQFDTWLLLAKGITLASAAFDVDHFPMYKTAF
CCCCHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHH
VMKTAKELLLRRIIDPGWMMTNHMSFWRPQEVIQFFAEYYTTPHLKTVIHFDQ
HHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA