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The map label for this gene is dxr [H]

Identifier: 222097266

GI number: 222097266

Start: 3568905

End: 3570047

Strand: Reverse

Name: dxr [H]

Synonym: BCQ_3606

Alternate gene names: 222097266

Gene position: 3570047-3568905 (Counterclockwise)

Preceding gene: 222097267

Following gene: 222097265

Centisome position: 68.47

GC content: 38.67

Gene sequence:

>1143_bases
ATGAAAAACATTAGTTTATTAGGTGCAAGCGGATCAATTGGTACACAAACTTTAGATGTATTACGCTCGCACCCAGACCA
ATTCCGTCTCGTTGCTTTTTCTGCAGGGAAAAATATTGACTACGCAGTAAAAGTCATTCAAGAATTTTCTCCGCAAATTG
TCTCTGTGCAAAGAGAGGAAGATGTTTTAAAATTACAAGCTGTCTCTGGTAATACAAAAGTTGTATATGGTAGTGAAGGA
CTTTTAGAAGTAGCATTACATCCAGATGCGGAGATCGTAGTAAATGCTGTTGTAGGTAGCGTAGGGTTGTTACCAACACT
TCGTGCAATTGAGGCGAAAAAAACAATTGGAATTGCAAACAAAGAAACGTTAGTAACTGCAGGGCATCTTGTAATGGAAG
CAGCGCGAAAACATAATGTTTCGTTACTTCCAGTAGACAGTGAACATTCAGCTATTTTTCAATGCTTGAATGGTGAAAAT
GAAAAAAGAATTTCTCGACTAATTATAACGGCTTCTGGTGGAAGTTTCCGTGATAAAACGAGAGATGAATTGCATCATGT
GACCGTAGAAGATGCGCTTCGACATCCAAACTGGTCAATGGGTTCGAAAATTACAATTGATTCTGCTACAATGATGAATA
AGGGGCTAGAAGTAATTGAAGCACATTGGCTTTTTGGTATCCCTTACGAGCAAATCGATGTTGTTTTACATAAAGAAAGT
ATTATTCATTCTATGGTTGAATTTGAAGATCGTAGTGTGATGGCACAGCTTGGCTCACCTGATATGCGAGTGCCAATTCA
ATACGCACTTACATATCCTGATCGATTACCTCTTTCAGACACAAAGCAGTTAAATTTATGGGAAATGGGTACATTGCATT
TTGAGAAAATGAATCAAGAACGTTTCCGTTGCTTGCGCTTTGCGTATGAAGCTGGAAAAACAGGTGGAAGTATGCCAGCT
GTAATGAATGCAGCGAATGAAGTAGCTGTTGAAGCTTTTTTACAAAAGAGAATTGGTTTCTTGACAGTGGAAGACCTCAT
TGAAAAAGCAATGAACCATCACAATGTCATTGCACGTCCAAGCTTAGAGGAAATTCTGGAAATTGATGCAGCCACAAGAC
GGTTTGTGATGGAACAAATTTAG

Upstream 100 bases:

>100_bases
ATGGTGGTATATTAGATCGAACAGATAGTTGGTTATTCGTTTTACCAATTCTCTACTTCTTATTACAATACAATTAATAA
ATGAACGAGGGGTTGGAGTC

Downstream 100 bases:

>100_bases
CAAAGGTGGTATGGAATTGAATACAGCGATTGCCTTTATATTAATTTTCGGTGCACTCGTATTTTTCCATGAGCTAGGGC
ATCTATATTTCGCAAAACGA

Product: 1-deoxy-d-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase 2; 1-deoxyxylulose-5-phosphate reductoisomerase 2; 2-C-methyl-D-erythritol 4-phosphate synthase 2 [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSAGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKVVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEMGTLHFEKMNQERFRCLRFAYEAGKTGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI

Sequences:

>Translated_380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSAGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKVVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEMGTLHFEKMNQERFRCLRFAYEAGKTGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI
>Mature_380_residues
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSAGKNIDYAVKVIQEFSPQIVSVQREEDVLKLQAVSGNTKVVYGSEG
LLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIANKETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGEN
EKRISRLIITASGGSFRDKTRDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEMGTLHFEKMNQERFRCLRFAYEAGKTGGSMPA
VMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARPSLEEILEIDAATRRFVMEQI

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=394, Percent_Identity=41.8781725888325, Blast_Score=304, Evalue=8e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42245; Mature: 42245

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSAGKNIDYAVKVIQEFSPQIVSVQREE
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
DVLKLQAVSGNTKVVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIAN
CEEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKT
CCCEEHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHEEEEEEEEECCCCCCCHH
RDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
HHHHHEEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEHEEECCCHHHHHEEEHHHH
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEMGTLHFEKMNQE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHCHH
RFRCLRFAYEAGKTGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEECC
SLEEILEIDAATRRFVMEQI
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNISLLGASGSIGTQTLDVLRSHPDQFRLVAFSAGKNIDYAVKVIQEFSPQIVSVQREE
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
DVLKLQAVSGNTKVVYGSEGLLEVALHPDAEIVVNAVVGSVGLLPTLRAIEAKKTIGIAN
CEEEEEEECCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KETLVTAGHLVMEAARKHNVSLLPVDSEHSAIFQCLNGENEKRISRLIITASGGSFRDKT
CCCEEHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCCHHEEEEEEEEECCCCCCCHH
RDELHHVTVEDALRHPNWSMGSKITIDSATMMNKGLEVIEAHWLFGIPYEQIDVVLHKES
HHHHHEEEHHHHHCCCCCCCCCEEEECHHHHHHCCHHHEEEHEEECCCHHHHHEEEHHHH
IIHSMVEFEDRSVMAQLGSPDMRVPIQYALTYPDRLPLSDTKQLNLWEMGTLHFEKMNQE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEECCHHHHHHCHH
RFRCLRFAYEAGKTGGSMPAVMNAANEVAVEAFLQKRIGFLTVEDLIEKAMNHHNVIARP
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCEEECC
SLEEILEIDAATRRFVMEQI
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]