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The map label for this gene is parE [H]

Identifier: 222097051

GI number: 222097051

Start: 3341199

End: 3343121

Strand: Reverse

Name: parE [H]

Synonym: BCQ_3391

Alternate gene names: 222097051

Gene position: 3343121-3341199 (Counterclockwise)

Preceding gene: 222097052

Following gene: 222097050

Centisome position: 64.12

GC content: 39.16

Gene sequence:

>1923_bases
GTGTTAGAAGGACTTGAAGCCGTTCGAAAACGCCCGGGTATGTATATCGGGAGCACGGACAGCCGTGGATTGCATCATTT
AGTATACGAAATAGTAGATAACTCCGTTGATGAAGCGTTAGCGGGATTTGGCGACGAAATTTCTGTCGTAATACATAAAG
ATAATAGTATTAGCGTTATAGATAAAGGGCGAGGAATGCCTACGGGAATGCATAAGCTTGGAAAACCTACACCAGAAGTT
ATTTTAACTGTACTTCATGCCGGTGGTAAGTTTGGTCAAGGTGGTTACAAAACGAGTGGTGGTTTACACGGTGTTGGGGC
GTCAGTTGTAAACGCCTTATCTGAATGGTTAGTCGTAACGATTAAGCGTGACGGAAATATTTATGAACAACGCTTTGAAA
ATGGCGGTGTTCCTGTAACGACGCTTGAGAAAATCGGAAAGACGAAAGAATCTGGTACGACAATGCATTTCAAACCAGAT
ACAACGATTTTCAGCACAACAAATTACAATTATGAAACATTATGTGAGAGATTACGTGAATCTGCATTCTTATTAAAAGG
GATGAAAATCTCAATAAAAGATGAAAGAAATGATTTAGAAGATGTCTTTCATTATGAAACAGGAATTGAAGCTTTCGTTT
CCTATTTAAACGAAGAAAAAGATTCAATTCACCCAGTGGTATACTTCACTGGTGAACAAAATGGGATTGAAGCAGAACTA
GCATTTCAATTTAACGATGGCTACTCAGAAAATATTCTTTCGTTTGTAAATAATGTACGTACAAAAGATGGTGGAACACA
TGAAGCTGGATTTAAGACAGCGATGACGCGTGTGTTCAATGAGTATGCTCGCAAAGTTTCACTATTAAAAGAAAAAGATA
AAAACTTAGAAGGTACAGATATTCGTGAAGGTGTAGCGGCTATCGTTTCTGTACGTGTACCAGAAGAAGTACTTCAGTTT
GAAGGACAAACGAAAGGGAAACTAGGTACAAGTGAAGCTCGTTCTTCAATTGATGCCATTGTATCAGAGCATTTGGCTTA
CTTTTTAGAAGAAAACCCGGACGTAGCTACACTTCTTGTGAGAAAAGCAATTAAAGCAGCGCAAGCACGTGAAGCTGCTC
GTAAAGCGAGAGAGGAAGCGCGTACTGGTAAAAAGAAAAAGAAATCAGAAGGTACATTAAGTGGTAAGTTAACACCTGCA
CAATCACGTAACCCGCAGAAAAATGAACTATACCTAGTAGAGGGTGACTCTGCCGGTGGTTCTGCAAAACAAGGGCGAGA
TCGACGCTTCCAAGCGGTATTACCATTGCGTGGTAAAGTAATTAATACAGAAAAAGCAAAGCTTGCTGATATCTTTAAAA
ATGAAGAGATTAATACAATTATTTATGCGATTGGCGGCGGTGTAGGCAATGAATTCGATGTGGAAGACATTAACTACGAT
AAAGTTGTCATTATGACCGATGCCGATACAGACGGAGCGCATATTCAAGTATTGTTATTAACATTCTTCTACAGATATAT
GAAACCACTTATCGAAGCTGGTAAAGTGTTTATCGCACTTCCTCCTTTATACAAAGTAAGTAAAGGAAAAGGAAAAAGTG
AAGTAATTGAATACGCATGGTCGGATGATGAATTAGATGAAGTAACGAAAAAAGTTGGAAAAGGTTACATGTTACAGCGT
TATAAAGGACTTGGCGAAATGAATGCGGATCAATTATGGGAAACAACGATGAATCCTGAAACGCGTACATTAATTCGCGT
GAAAATTGATGATGCAGCGAGGGCAGAGCGCCGCGTTACAACATTAATGGGTGATAAAGTAGAACCGCGCCGTAAATGGA
TTGAGCGCAATGTACAGTTTGGTATGCAAGAAGAAGGAAATATTTTAGAAAATGAAATGATTATGGAGACGGAGGTGGAA
TAA

Upstream 100 bases:

>100_bases
CGTTATTCTATAATAGAAACATATGTTCTGATTTTGGATTAGGAAAGGGGCAAGGAGTTTGGCGAAGCATCAGTTCCAAT
ATAATGAAGATGCGATTCAA

Downstream 100 bases:

>100_bases
CATGCAAGCAGAGAAGTTTCATGACCTCCCGCTTGAAGACGTGTTAGGTGATCGCTTTGCACGTTATAGTAAATATATTA
TTCAAGATCGCGCACTTCCA

Product: DNA topoisomerase iv subunit b

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 640; Mature: 640

Protein sequence:

>640_residues
MLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVIDKGRGMPTGMHKLGKPTPEV
ILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPD
TTIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPVVYFTGEQNGIEAEL
AFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTDIREGVAAIVSVRVPEEVLQF
EGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPA
QSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGGVGNEFDVEDINYD
KVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAWSDDELDEVTKKVGKGYMLQR
YKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE

Sequences:

>Translated_640_residues
MLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVIDKGRGMPTGMHKLGKPTPEV
ILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPD
TTIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPVVYFTGEQNGIEAEL
AFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTDIREGVAAIVSVRVPEEVLQF
EGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPA
QSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGGVGNEFDVEDINYD
KVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAWSDDELDEVTKKVGKGYMLQR
YKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
>Mature_640_residues
MLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVIDKGRGMPTGMHKLGKPTPEV
ILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVTIKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPD
TTIFSTTNYNYETLCERLRESAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPVVYFTGEQNGIEAEL
AFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTDIREGVAAIVSVRVPEEVLQF
EGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLVRKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPA
QSRNPQKNELYLVEGDSAGGSAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGGVGNEFDVEDINYD
KVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAWSDDELDEVTKKVGKGYMLQR
YKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVTTLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=661, Percent_Identity=24.2057488653555, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913406, Length=603, Percent_Identity=25.8706467661692, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI48994957, Length=552, Percent_Identity=52.1739130434783, Blast_Score=529, Evalue=1e-151,
Organism=Escherichia coli, GI1789408, Length=649, Percent_Identity=38.2126348228043, Blast_Score=414, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17535065, Length=670, Percent_Identity=24.7761194029851, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI212645845, Length=600, Percent_Identity=25.1666666666667, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI212645657, Length=248, Percent_Identity=27.4193548387097, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=642, Percent_Identity=27.1028037383178, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17136538, Length=666, Percent_Identity=24.9249249249249, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71339; Mature: 71339

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVI
CCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCEEEE
DKGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVT
ECCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEE
IKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPDTTIFSTTNYNYETLCERLRE
EECCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHH
SAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPVVYFTGEQNGIEAEL
HHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
AFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTD
EEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
IREGVAAIVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLV
HHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGG
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
SAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGGVGNEFDVEDINYD
CCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
KVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAW
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHEECC
SDDELDEVTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVT
CCCHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHH
TLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
HHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCEEEEECCC
>Mature Secondary Structure
MLEGLEAVRKRPGMYIGSTDSRGLHHLVYEIVDNSVDEALAGFGDEISVVIHKDNSISVI
CCCCHHHHHHCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCEEEE
DKGRGMPTGMHKLGKPTPEVILTVLHAGGKFGQGGYKTSGGLHGVGASVVNALSEWLVVT
ECCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEEE
IKRDGNIYEQRFENGGVPVTTLEKIGKTKESGTTMHFKPDTTIFSTTNYNYETLCERLRE
EECCCCHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEECCCCCHHHHHHHHHH
SAFLLKGMKISIKDERNDLEDVFHYETGIEAFVSYLNEEKDSIHPVVYFTGEQNGIEAEL
HHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEE
AFQFNDGYSENILSFVNNVRTKDGGTHEAGFKTAMTRVFNEYARKVSLLKEKDKNLEGTD
EEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
IREGVAAIVSVRVPEEVLQFEGQTKGKLGTSEARSSIDAIVSEHLAYFLEENPDVATLLV
HHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RKAIKAAQAREAARKAREEARTGKKKKKSEGTLSGKLTPAQSRNPQKNELYLVEGDSAGG
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCC
SAKQGRDRRFQAVLPLRGKVINTEKAKLADIFKNEEINTIIYAIGGGVGNEFDVEDINYD
CCCCCCCCCEEEECCCCCEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCC
KVVIMTDADTDGAHIQVLLLTFFYRYMKPLIEAGKVFIALPPLYKVSKGKGKSEVIEYAW
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHEECC
SDDELDEVTKKVGKGYMLQRYKGLGEMNADQLWETTMNPETRTLIRVKIDDAARAERRVT
CCCHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHH
TLMGDKVEPRRKWIERNVQFGMQEEGNILENEMIMETEVE
HHHCCCCCHHHHHHHHHHCCCCCCCCCCHHCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]