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The map label for this gene is sqhC [H]

Identifier: 222097011

GI number: 222097011

Start: 3296454

End: 3298307

Strand: Reverse

Name: sqhC [H]

Synonym: BCQ_3351

Alternate gene names: 222097011

Gene position: 3298307-3296454 (Counterclockwise)

Preceding gene: 222097012

Following gene: 222097009

Centisome position: 63.26

GC content: 37.97

Gene sequence:

>1854_bases
TTGTTATTATATGAAAAAGCGCATGAAGAAATAGCGAGAAGAGCAACTGCACTTCAATCGATGCAATGGCAAGATGGTAC
GTGGCGATTTTGTTTTGAAGGAGCTCCGTTAACAGATTGCCATATGATTTTTTTATTAAAATTATTAGGTAGAGATAAAG
AGATAGAACCGTTTGTAAAAAGATTAGCATCACTTCAAACAAATGAAGGAACATGGAAATTGTATGAAGATGAAGTGGGT
GGTAATTTATCTGCTACCATTCAATCTTATGCCGCCTTACTTGCATCAGGAAAATATACAAAAGAAGATGCGAATATGAA
GCGAGCGGAAAATTTCATTAAGGAACGCGGAGGCGTGGCGCGTGCTCATTTTATGACGAAGTTTTTATTAGCGGTTCATG
GAGAATATGAATATCCTTCACTCTTTCATTTGCCAACACCAATCATGTTTCTACAGAATGATTCTCCCCTCAGTATATTT
GAATTGAGTAGCTCAGCACGTATCCATTTAATTCCGATGATGCTCTGTTTAAATAAAAGGTTTCGAGTAGGGAAAAAGTT
ATTGCCAAATTTAAATCACATTGCAGGCGGGGGCGGAGAATGGTTTCGGGAGGAGCGGTCTCCGTTGTTTCAAACGTTAG
TAAGTGATGTAAAACAAATTATCTCGTATCCACTCTCGTTACATCATAAAGGGTATGAGGAAGTCGAACGATTTATGAAA
GAGCGTATTGATGAAAATGGAACGTTATATAGTTACGCAACTGCCTCGTTTTATATGATTTATGCTTTACTTGCGTTAGG
GCATTCTCTTCAATCATCAATAATTCAAAATGCTATAACCGGGATAACATCTTATATATGGAAGATGGAAAGCGGTAATC
ATTTGCAAAACTCTCCTTCAACTGTATGGGATACAGCTTTACTCAGCTATGCGTTACAAGAGGCCCACGTTCCGAAAGAT
AATAAAATGCTTCAAAATGCAACAGCATATTTATTAAAAAAACAGCATACAAAAAAAGCTGATTGGAGCGTACATGCTTC
AGCGCTTACTCCAGGTGGTTGGGGTTTTTCGGATGTAAATACGACAGTTCCAGATGTTGATGATACAACAGCTGTACTAA
GAGTGTTGGCAAGGAGTAGAGGAAACGAAAAGGTAGATCATGCTTGGCAGAAAGGGATTAATTGGGTTAAAGGATTACAA
AATAATGATGGGGGCTGGGGAGCTTTTGAAAAAGGTGTGACGAGCAATATATTAGCAAAATTACCAATCGAAAATGCAAG
TGATATGATTACAGATCCTTCTACACCAGATATTACAGGGAGGGTGTTAGAGTTTTTCGGGACATACGCGCAAAATGAAT
TACCTGAGAAACAAAAACAAAGTGCGATAAATTGGTTAATGAATGTACAAGAGGAAAATGGATCATGGTATGGGAAATGG
GGGATTTGTTATATATATGGTACGTGGGCTGTTATGACAGGCTTACGGTCATTCGGAATTCCATCTAGCAATCCATCATT
AAAACGTGCAGCTTTATGGCTTGAACATATACAGCATAAAGACGGTGGATGGGGAGAATCATGCCACAGTAGTGTGGAGA
AAAGGTTCGTTACTTTACCATTTAGTACACCATCCCAAACGGCATGGGCGCTAGATGCTCTCATTTCTTACTATGATACA
GAAACGCCAATTATTCGAAAAGGTATTTCATATTTGCTTGCGAATCCTTATGTGAATGAAAAATATCCTACTGGAACAGG
TTTACCAGGTGGGTTTTATATTCGTTACCATAGCTATGCCCATATATATCCACTACTTACTTTGGCACATTATATAAAAA
AATATAGAAAATAA

Upstream 100 bases:

>100_bases
AGCAGAACATTTTATATGTTCTGCTTTTCTTTGTATTCATACATATTCAGCTACTTTCTTGAATATCGTTATACGGATTT
CAAAAGGGTGGGTGAGTAAC

Downstream 100 bases:

>100_bases
ACCGAGAGATACCTCTCGGTTTATTTTGTTGGGTAGTAGGTCCCTGTTGAAAAGAATAAGGTTGTGTTTTCCTTATTTTT
CAGTTGACTGGCGTTTTTGA

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MLLYEKAHEEIARRATALQSMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVKRLASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASGKYTKEDANMKRAENFIKERGGVARAHFMTKFLLAVHGEYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREERSPLFQTLVSDVKQIISYPLSLHHKGYEEVERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSIIQNAITGITSYIWKMESGNHLQNSPSTVWDTALLSYALQEAHVPKD
NKMLQNATAYLLKKQHTKKADWSVHASALTPGGWGFSDVNTTVPDVDDTTAVLRVLARSRGNEKVDHAWQKGINWVKGLQ
NNDGGWGAFEKGVTSNILAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQKQSAINWLMNVQEENGSWYGKW
GICYIYGTWAVMTGLRSFGIPSSNPSLKRAALWLEHIQHKDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPIIRKGISYLLANPYVNEKYPTGTGLPGGFYIRYHSYAHIYPLLTLAHYIKKYRK

Sequences:

>Translated_617_residues
MLLYEKAHEEIARRATALQSMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVKRLASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASGKYTKEDANMKRAENFIKERGGVARAHFMTKFLLAVHGEYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREERSPLFQTLVSDVKQIISYPLSLHHKGYEEVERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSIIQNAITGITSYIWKMESGNHLQNSPSTVWDTALLSYALQEAHVPKD
NKMLQNATAYLLKKQHTKKADWSVHASALTPGGWGFSDVNTTVPDVDDTTAVLRVLARSRGNEKVDHAWQKGINWVKGLQ
NNDGGWGAFEKGVTSNILAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQKQSAINWLMNVQEENGSWYGKW
GICYIYGTWAVMTGLRSFGIPSSNPSLKRAALWLEHIQHKDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPIIRKGISYLLANPYVNEKYPTGTGLPGGFYIRYHSYAHIYPLLTLAHYIKKYRK
>Mature_617_residues
MLLYEKAHEEIARRATALQSMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVKRLASLQTNEGTWKLYEDEVG
GNLSATIQSYAALLASGKYTKEDANMKRAENFIKERGGVARAHFMTKFLLAVHGEYEYPSLFHLPTPIMFLQNDSPLSIF
ELSSSARIHLIPMMLCLNKRFRVGKKLLPNLNHIAGGGGEWFREERSPLFQTLVSDVKQIISYPLSLHHKGYEEVERFMK
ERIDENGTLYSYATASFYMIYALLALGHSLQSSIIQNAITGITSYIWKMESGNHLQNSPSTVWDTALLSYALQEAHVPKD
NKMLQNATAYLLKKQHTKKADWSVHASALTPGGWGFSDVNTTVPDVDDTTAVLRVLARSRGNEKVDHAWQKGINWVKGLQ
NNDGGWGAFEKGVTSNILAKLPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQKQSAINWLMNVQEENGSWYGKW
GICYIYGTWAVMTGLRSFGIPSSNPSLKRAALWLEHIQHKDGGWGESCHSSVEKRFVTLPFSTPSQTAWALDALISYYDT
ETPIIRKGISYLLANPYVNEKYPTGTGLPGGFYIRYHSYAHIYPLLTLAHYIKKYRK

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=620, Percent_Identity=23.2258064516129, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI47933395, Length=620, Percent_Identity=23.2258064516129, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI47933397, Length=620, Percent_Identity=23.2258064516129, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI224177556, Length=557, Percent_Identity=22.6211849192101, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321863, Length=288, Percent_Identity=28.125, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 69827; Mature: 69827

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYEKAHEEIARRATALQSMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVK
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHH
RLASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASGKYTKEDANMKRAENFIKERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAVHGEYEYPSLFHLPTPIMFLQNDSPLSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCEEHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREERSPLFQTLVSDVKQIISYPLSLHHKGYEEVERFMK
HHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSLQSSIIQNAITGITSYIWKMESGNHLQNSPS
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TVWDTALLSYALQEAHVPKDNKMLQNATAYLLKKQHTKKADWSVHASALTPGGWGFSDVN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECEECCCCCCCCCCC
TTVPDVDDTTAVLRVLARSRGNEKVDHAWQKGINWVKGLQNNDGGWGAFEKGVTSNILAK
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHCCCCCCCCCCHHHHCCHHHHHHC
LPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQKQSAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHECCCCCEEECC
GICYIYGTWAVMTGLRSFGIPSSNPSLKRAALWLEHIQHKDGGWGESCHSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPIIRKGISYLLANPYVNEKYPTGTGLPGGFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHH
HIYPLLTLAHYIKKYRK
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLYEKAHEEIARRATALQSMQWQDGTWRFCFEGAPLTDCHMIFLLKLLGRDKEIEPFVK
CCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHH
RLASLQTNEGTWKLYEDEVGGNLSATIQSYAALLASGKYTKEDANMKRAENFIKERGGVA
HHHHCCCCCCCEEEEHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
RAHFMTKFLLAVHGEYEYPSLFHLPTPIMFLQNDSPLSIFELSSSARIHLIPMMLCLNKR
HHHHHHHHHHHHCCCCCCCCEEECCCCEEEEECCCCCEEEEECCCCEEHHHHHHHHHHHH
FRVGKKLLPNLNHIAGGGGEWFREERSPLFQTLVSDVKQIISYPLSLHHKGYEEVERFMK
HHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHH
ERIDENGTLYSYATASFYMIYALLALGHSLQSSIIQNAITGITSYIWKMESGNHLQNSPS
HHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TVWDTALLSYALQEAHVPKDNKMLQNATAYLLKKQHTKKADWSVHASALTPGGWGFSDVN
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECEECCCCCCCCCCC
TTVPDVDDTTAVLRVLARSRGNEKVDHAWQKGINWVKGLQNNDGGWGAFEKGVTSNILAK
CCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHCCCCCCCCCCHHHHCCHHHHHHC
LPIENASDMITDPSTPDITGRVLEFFGTYAQNELPEKQKQSAINWLMNVQEENGSWYGKW
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHECCCCCEEECC
GICYIYGTWAVMTGLRSFGIPSSNPSLKRAALWLEHIQHKDGGWGESCHSSVEKRFVTLP
EEEEEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
FSTPSQTAWALDALISYYDTETPIIRKGISYLLANPYVNEKYPTGTGLPGGFYIRYHSYA
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCHH
HIYPLLTLAHYIKKYRK
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]