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The map label for this gene is csgA [H]

Identifier: 222096882

GI number: 222096882

Start: 3170546

End: 3171250

Strand: Reverse

Name: csgA [H]

Synonym: BCQ_3222

Alternate gene names: 222096882

Gene position: 3171250-3170546 (Counterclockwise)

Preceding gene: 222096883

Following gene: 222096881

Centisome position: 60.82

GC content: 35.89

Gene sequence:

>705_bases
ATGAGAGTTCTAATTACAGGTGGAAATCGCGGATTAGGGTTACAGTTAGTAAAAGTGTTTCATGAAAATGGACATATCGT
TTATCCGTTAGTTAGAACTGAGGTTGCGTTAACACAATTGAAGAAAATGTTTAGTTGCAGATGTTTTCCTATATTGGCAG
ACTTATCGATTGATGAGAGTACGGAGCAAATGAAAAACCAGCTTGAGGAATATACAGAGTATATTGATCTAGTTATAAAT
AACGCAGGAATTACTGGAAAGGAGACTGAGGTTTTACATACAAATTCAGAAGAGTTAACGGACTTATTTAATATTCATTG
CTTAGGTGTAATTCGAGCTGTAAAAGGTACATATGTGGCTTTAGCTAAATCGGATCATCCGAGAATCATAAATGTGTCCT
CTCGGTTAGGTTCATTGCATAAAATGGCGAATAAAGAGTTTCCGCAAGGCCATTTCTCATATTCATATCGAATTGCTAAA
GCTGCACAAAATATGCTAACACTCTGCTTACAACAAGAGTTTGAGAATAAAGGAATAAGTGTAACTGCCATTCATCCTGG
AAAATTAAAGACTGAAATTGGTGCTTTTGATGCGAATATGATTCCGGCTGAAGGAGCAAAAAATATATATGATTGGATAA
TAGATTCAAATGAGGATGTTTCAGGGCAGTTTATTGAGCCAGGTGTAGGTGAATTAAAGTGGTGA

Upstream 100 bases:

>100_bases
GAGCCGGTTTTTCTTTTGAATGCAAGAGAGAGGCGTTTTCATTAGAGAATGGTAAGTGGATGGATTTTCTTATTTATTTT
AAAAATAAGGAGATGAATAT

Downstream 100 bases:

>100_bases
TATACGATCTTGCAATCATTCAGAATCTGTTTGGCCCTTCTAAAAAAGTATTAAATGGCTTACCACATGCAGTGACAATT
GAAGAAATAGAAGAAGACGT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTEVALTQLKKMFSCRCFPILADLSIDESTEQMKNQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMIPAEGAKNIYDWIIDSNEDVSGQFIEPGVGELKW

Sequences:

>Translated_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTEVALTQLKKMFSCRCFPILADLSIDESTEQMKNQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMIPAEGAKNIYDWIIDSNEDVSGQFIEPGVGELKW
>Mature_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTEVALTQLKKMFSCRCFPILADLSIDESTEQMKNQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMIPAEGAKNIYDWIIDSNEDVSGQFIEPGVGELKW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=23.6842105263158, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=205, Percent_Identity=29.7560975609756, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=209, Percent_Identity=26.7942583732057, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17558994, Length=214, Percent_Identity=27.1028037383178, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=201, Percent_Identity=25.8706467661692, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24640547, Length=251, Percent_Identity=27.4900398406374, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26138; Mature: 26138

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTEVALTQLKKMFSCRCFPILADLSIDES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TEQMKNQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAKAAQNMLTLCLQQEFENKGIS
EEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTEIGAFDANMIPAEGAKNIYDWIIDSNEDVSGQFIEPGVGELKW
EEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIVYPLVRTEVALTQLKKMFSCRCFPILADLSIDES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
TEQMKNQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAKAAQNMLTLCLQQEFENKGIS
EEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTEIGAFDANMIPAEGAKNIYDWIIDSNEDVSGQFIEPGVGELKW
EEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]