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The map label for this gene is gnd [H]

Identifier: 222096846

GI number: 222096846

Start: 3137268

End: 3138161

Strand: Reverse

Name: gnd [H]

Synonym: BCQ_3186

Alternate gene names: 222096846

Gene position: 3138161-3137268 (Counterclockwise)

Preceding gene: 222096847

Following gene: 222096845

Centisome position: 60.18

GC content: 37.36

Gene sequence:

>894_bases
ATGCAAGTAGGATTAATTGGGTTAGGTAAAATGGGATTAAATTTAGGGAAAAATTTAATGGATCATAAACATGAAGTAGC
AGCATTTGATTTAAATGCAAGTGCAGTGGAAGAAATGAAAGAGTACGGGGCTACAGGTACATCTAGTTTAAGTGAACTTG
TTCAGTCATTACAATCACCAAGAATTCTTTGGGTTATGGTACCACACGCTGTTGTTGATTCTGTTATTGATGAGATTACA
CCCCTTTTATCAAAAGGAGATATTTTAATTGAAGCAGGTAATTCACATTATAAAGAGTCTATCCGCCGATATGAGCAATT
AAAGAAAGATGGTATTCACTTTATGGATGCAGGAACTTCTGGCGGAATGGAAGGCGCTCGTAATGGTGCTTGTTACATGA
TCGGAGGAGATCAAGAAGCTTGGGATATCGTTGAACCTATCTTCCGAGATACTGCTGTAGAAAATGGATTCTTATATGCT
GGAAAAGCTGGTAGTGGTCACTTCTTAAAAATGGTTCACAACGGAATTGAATACGGTATGATGGCTGCTATTGGTGAAGG
ATTTGAGATTCTAGAGAAAAGTGAATTTGACTACGATTATGAAAAAGTATCAAGAGTATGGAACAACGGTTCAGTAATCC
GTTCATGGTTAATGGAATTAACTGAAAATGCATTTTCTAAAGATGCAAAACTGGATGAAATTAAGGGTGTTATGCATTCT
TCTGGTGAAGGAAAATGGACAGTAGAAACAGCATTAGACCTTCAAACAGCAACTCCTGTTATCGCAATGTCGTTATTAAT
GCGCTACCGCTCATTAGACAATGATACATTTACAGGAAAAGTAGTAGCAGCTCTGCGCAATGAATTTGGCGGACATGCAG
TAGAAAAGAAATAA

Upstream 100 bases:

>100_bases
AATACCTTTCTGTACATACTAACATTTCAGTGCTGAAAGGTATTCCAGATTGTAGTGATATGAATTTTTAATAAAAGATA
ATTTGAGGAGGAATTATATT

Downstream 100 bases:

>100_bases
ACATCTTAAAAATTTAACTCATTAACGTTTAAAAAATGGAGGGAATGAATCATGAAATTTTTTATTGATACTGCAAATCT
TGAGGACATAAAAAAAGCAT

Product: 6-phosphogluconate dehydrogenase

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGTSSLSELVQSLQSPRILWVMVPHAVVDSVIDEIT
PLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTSGGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGFLYA
GKAGSGHFLKMVHNGIEYGMMAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK

Sequences:

>Translated_297_residues
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGTSSLSELVQSLQSPRILWVMVPHAVVDSVIDEIT
PLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTSGGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGFLYA
GKAGSGHFLKMVHNGIEYGMMAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK
>Mature_297_residues
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGTSSLSELVQSLQSPRILWVMVPHAVVDSVIDEIT
PLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTSGGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGFLYA
GKAGSGHFLKMVHNGIEYGMMAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=291, Percent_Identity=37.1134020618557, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI23308751, Length=177, Percent_Identity=28.8135593220339, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788341, Length=318, Percent_Identity=34.5911949685535, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI145693186, Length=204, Percent_Identity=26.9607843137255, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=37.9310344827586, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321695, Length=294, Percent_Identity=39.4557823129252, Blast_Score=182, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6321977, Length=306, Percent_Identity=38.8888888888889, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24639279, Length=289, Percent_Identity=35.6401384083045, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24655230, Length=221, Percent_Identity=25.3393665158371, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922568, Length=221, Percent_Identity=25.3393665158371, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32651; Mature: 32651

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGTSSLSELVQSLQSP
CCEEEEECCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
RILWVMVPHAVVDSVIDEITPLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTS
CEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCC
GGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGFLYAGKAGSGHFLKMVHNGIEYGM
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCHHHHH
MAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
HHHHCCCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGTSSLSELVQSLQSP
CCEEEEECCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
RILWVMVPHAVVDSVIDEITPLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTS
CEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCC
GGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGFLYAGKAGSGHFLKMVHNGIEYGM
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHCCHHHHH
MAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
HHHHCCCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]