Click here to switch to the map view.

The map label for this gene is yvaE [H]

Identifier: 222096763

GI number: 222096763

Start: 3060912

End: 3061274

Strand: Reverse

Name: yvaE [H]

Synonym: BCQ_3103

Alternate gene names: 222096763

Gene position: 3061274-3060912 (Counterclockwise)

Preceding gene: 222096764

Following gene: 222096761

Centisome position: 58.71

GC content: 31.96

Gene sequence:

>363_bases
GTGCAGTGGATTTATTTATGTTTAGCAATTTTATTTGAGGTAGCAGGTACAACTGCGATGAAACTATCTGATGGATTAAC
GAAACTTGTACCAAGCATTCTTATTTTTGTATTTTATGTAGTAAGTTTTGCATTTCTGTCATTTGCATTAAAAGGGATGG
AGATGTCCGTTGCATATGCGGTGTGGTCAGGTATGGGAATTGTAACGATTACAACAATTGGTTTTATTTATTTTGGAGAA
AGTATCAATATAATTAAGATACTAGCAATTCTTTTTATTTTAATTGGAGTCGTAATATTAAATTTTAATAGTACGGCACA
TGAAGCGAAGAAAAAAGAAATGGTGGAGGAACGTATACATTGA

Upstream 100 bases:

>100_bases
TTATTGAAAAGAGTGATTATACATTGGGAAGTATGCTTGAATCGATTATGGACATGTTACTATATGGCATTTCTAATTCG
AAATAGAAGGTGGGAGAGTA

Downstream 100 bases:

>100_bases
ATCGATTAAAGTATTTTTTCCTTATTACTGATGTTGGGTTTGTTGTATATTGGCTCATAACAATTTTTCATATGATTCCG
CAAGAATATTTGTTTAAAGA

Product: multidrug resistance protein, smr family

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 120; Mature: 120

Protein sequence:

>120_residues
MQWIYLCLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINIIKILAILFILIGVVILNFNSTAHEAKKKEMVEERIH

Sequences:

>Translated_120_residues
MQWIYLCLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINIIKILAILFILIGVVILNFNSTAHEAKKKEMVEERIH
>Mature_120_residues
MQWIYLCLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYAVWSGMGIVTITTIGFIYFGE
SINIIKILAILFILIGVVILNFNSTAHEAKKKEMVEERIH

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=108, Percent_Identity=41.6666666666667, Blast_Score=82, Evalue=1e-17,
Organism=Escherichia coli, GI87082378, Length=104, Percent_Identity=33.6538461538462, Blast_Score=74, Evalue=2e-15,
Organism=Escherichia coli, GI1787884, Length=112, Percent_Identity=37.5, Blast_Score=67, Evalue=2e-13,
Organism=Escherichia coli, GI1787883, Length=97, Percent_Identity=32.9896907216495, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 13376; Mature: 13376

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWIYLCLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSGMGIVTITTIGFIYFGESINIIKILAILFILIGVVILNFNSTAHEAKKKEMVEERIH
HHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQWIYLCLAILFEVAGTTAMKLSDGLTKLVPSILIFVFYVVSFAFLSFALKGMEMSVAYA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VWSGMGIVTITTIGFIYFGESINIIKILAILFILIGVVILNFNSTAHEAKKKEMVEERIH
HHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]