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The map label for this gene is ycgH [H]

Identifier: 222096595

GI number: 222096595

Start: 2868473

End: 2869816

Strand: Reverse

Name: ycgH [H]

Synonym: BCQ_2935

Alternate gene names: 222096595

Gene position: 2869816-2868473 (Counterclockwise)

Preceding gene: 222096596

Following gene: 222096592

Centisome position: 55.04

GC content: 33.48

Gene sequence:

>1344_bases
ATGACCTGTCATGATGCTAAGAACGAAACGAAAGAAAAAAAAGATTTAAAATGGTGGCAACTCTCACTTATTGGGATTGG
TTGTACAATAGGGACCGGTTTCTTTTTAGGATCCAGTATAGGAATTAAAATAGGTGGTTCGTCAATTATTCTTATTCTTA
TATTAACTAGATTTACTACTTATATTGTATTTGAAGCATTGGCAAAAATGGCTGTAGAAGATCCGCAAAAAGGATCTTTT
CGTATATACTCAAAAAAAGCTTTTGGAAATTGGGCGGGTTTTAGTCATGGATGGACATATTGGTGTTCTGAACTGCTTAT
TATGGGCAGCCAGTTAAGTGCGTTAGGAATCTTTTCACGTTACTGGTTTCCTAAGATACCACTATGGATATTTGCTGCTA
TATATGGAGTAGCGGCTATATTAATTATTTTTATAGGGGTAAAGATATTCGAACGTTTAGAGAAATGGATGGCTATTATA
AAAATCGCTGCTATTATGGGGTTTATTGTAATTGCTATTTTAGTTATTTTAGGATTTATAAAGGGTGGTTTATATAAAGC
ACAAATTCCGCGGAATTTCAAAGATTGGTTCCCAAATGGATTAAAAGGCACTTGGTCCTCTCTAATTTATGCATTTTATG
CATTTGGAGGAATCGAAATTATGGGGTTAATGACAATAAGACTGAAAGACCCTAAAGATGCACAAAAATCAGGAAGAGTA
ATGTTAATGATTTTAACGATTATTTACGTAGTCTCTTTAGGGTTGGCAATTATGATGGTACCATTAAACCAGTTTAATAC
GAAAGAAAGTCCTTTTGTAATAGCGTTACAAGACTATAATTTACCGTATGTGCCATTTATTTTAAATGTAGTATTAATTT
TAGCGGGCTTTTCAACGTTAGTTGGTTCATTATTTGCGGTGACAAGTGTATTAATGAACTTAGCTGAAGAGGGTGATGCA
CCTGCGATGTTTGCGAAAAAAAACAAGAAGAATATCTCTTTTCCAGCTTTAATTCTTATCATAATGGGGCTTGGTGCTTC
TATCCTTAGCGCTTTATTACTACCGAAAAATATATATGAATATGTAACAACTGCAGCTGGATTGATGTTGTTGTATACAT
GGAGTTTAATTCTTCTTTCCTTTTGGAGATTAATGAATCCAAAAGGTTGGATGCAGATAAAAAGTATTATTGGTCTTATT
ATGATTGCACTAGCTGTTAGTGGAACACTATTGCAAAAAACAACGCGTTTTGGTTTCCTTGTGAGCTTGTTGTTTTTAGG
AATAGTTATTATCGTTACTATAATTGTTCATTTTGTCTCAAGAAAAAGGAATACAGCTATATGA

Upstream 100 bases:

>100_bases
TAAAGGCTCATAATGTCACTGATGTTGTTGAAAAGCTTGCTGAGAAGTACTTAAGTGATCATGAGGGGCATTCTCAAAAT
GAATAAAGGAGAATCGTGAT

Downstream 100 bases:

>100_bases
AGTATCTTTCTTTTACTCCATGAATAGTATGTCAGAACAAAATAATAGAAGTTATTGAAAAATGATTTGGTAAGTTTGAA
AACCAAAATATAATCCATAA

Product: ycgh

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTRFTTYIVFEALAKMAVEDPQKGSF
RIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIMGFIVIAILVILGFIKGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIMGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNTAI

Sequences:

>Translated_447_residues
MTCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTRFTTYIVFEALAKMAVEDPQKGSF
RIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIMGFIVIAILVILGFIKGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIMGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNTAI
>Mature_446_residues
TCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTRFTTYIVFEALAKMAVEDPQKGSFR
IYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIK
IAAIMGFIVIAILVILGFIKGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRVM
LMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDAP
AMFAKKNKKNISFPALILIIMGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIM
IALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNTAI

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=29.6943231441048, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786302, Length=387, Percent_Identity=28.1653746770026, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1790653, Length=399, Percent_Identity=27.8195488721804, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1786789, Length=381, Percent_Identity=27.8215223097113, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=22.8260869565217, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=26.2254901960784, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789017, Length=379, Percent_Identity=26.3852242744063, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI48994972, Length=387, Percent_Identity=26.8733850129199, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788480, Length=399, Percent_Identity=26.3157894736842, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17532491, Length=389, Percent_Identity=22.6221079691517, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=405, Percent_Identity=27.4074074074074, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320772, Length=394, Percent_Identity=26.1421319796954, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=25.1889168765743, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=393, Percent_Identity=26.2086513994911, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6324990, Length=409, Percent_Identity=26.6503667481663, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321629, Length=403, Percent_Identity=23.0769230769231, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322892, Length=339, Percent_Identity=27.4336283185841, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=24.5700245700246, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=24.8756218905473, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321053, Length=412, Percent_Identity=24.5145631067961, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324924, Length=382, Percent_Identity=24.3455497382199, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=25.5154639175258, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322967, Length=335, Percent_Identity=25.6716417910448, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324059, Length=351, Percent_Identity=24.2165242165242, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319608, Length=349, Percent_Identity=22.9226361031519, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319543, Length=406, Percent_Identity=22.9064039408867, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24667468, Length=414, Percent_Identity=22.463768115942, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666159, Length=337, Percent_Identity=20.4747774480712, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221512776, Length=337, Percent_Identity=20.4747774480712, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49744; Mature: 49613

Theoretical pI: Translated: 10.39; Mature: 10.39

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTRFTT
CCCCCCCCHHHHHHCCHHHHHHHEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSR
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
YWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIMGFIVIAILVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIMGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSRKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTRFTT
CCCCCCCHHHHHHCCHHHHHHHEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRIYSKKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSR
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
YWFPKIPLWIFAAIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIMGFIVIAILVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIMGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSRKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]