Click here to switch to the map view.

The map label for this gene is clpP [H]

Identifier: 222096291

GI number: 222096291

Start: 2578841

End: 2579422

Strand: Reverse

Name: clpP [H]

Synonym: BCQ_2631

Alternate gene names: 222096291

Gene position: 2579422-2578841 (Counterclockwise)

Preceding gene: 222096292

Following gene: 222096289

Centisome position: 49.47

GC content: 36.43

Gene sequence:

>582_bases
ATGAATGCAATTCCATATGTAGTAGAACAAACAAAATTAGGAGAACGTTCCTATGATATATATTCAAGGTTATTGAAAGA
CCGCATTATTATAATCGGTTCAGAGATTAATGATCAGGTTGCGAGCAGTGTAGTAGCGCAATTATTATTTTTAGAAGCGG
AAGATGCGGAGAAAGATATATTTCTGTATATTAATAGTCCTGGCGGCTCAACGACAGCAGGATTTGCAATATTAGATACA
ATGAATCTTATTAGACCGGATGTGCAAACGCTTTGTATGGGCTTAGCTGCATCATTTGGTGCCCTTTTACTATTAGCTGG
TGCAAAAGGAAAAAGATTCGCGCTTCCTAATAGTGAAATCATGATTCATCAGCCACTTGGCGGTGTAAAAGGGCAAGCAA
CAGAAATCGAAATTACAGCAAAAAGAATATTGAAATTGAAGCATGACATTAATAAGATTATTGCTGATAGAACAGGACAG
CCAATCGAAAAAATAGCACATGATACGGAAAGAGATTATTTTATGACAGCAGAGGAAGCTAAAGAATATGGGATTGTTGA
TGGGGTCGTTGAGAAAAAATAA

Upstream 100 bases:

>100_bases
GTTACCATCTAAACAGCCAGTCTTATTATTTAATGTGAAACAATCCTCTTCCTACAGTTGTATGCTTTGCGCGGCATAAA
AATTATTGGAGGGATTTAAA

Downstream 100 bases:

>100_bases
CATAAACCAGGCTAGAGAATATGCTCATTCTCTAGCCTGGTTTTTTAATCTTTAATCCATTCATCAACTAACGTTTGGTT
CTTTTTAATCCATTTTCGCG

Product: ATP-dependent clp protease, proteolytic subunit clpp

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIRPDVQTLCMGLAASFGALLLLAGAKGKRFALPNSEIMIHQPLGGVKGQATEIEITAKRILKLKHDINKIIADRTGQ
PIEKIAHDTERDYFMTAEEAKEYGIVDGVVEKK

Sequences:

>Translated_193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIRPDVQTLCMGLAASFGALLLLAGAKGKRFALPNSEIMIHQPLGGVKGQATEIEITAKRILKLKHDINKIIADRTGQ
PIEKIAHDTERDYFMTAEEAKEYGIVDGVVEKK
>Mature_193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIRPDVQTLCMGLAASFGALLLLAGAKGKRFALPNSEIMIHQPLGGVKGQATEIEITAKRILKLKHDINKIIADRTGQ
PIEKIAHDTERDYFMTAEEAKEYGIVDGVVEKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=55.6149732620321, Blast_Score=208, Evalue=2e-54,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=61.139896373057, Blast_Score=255, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17538017, Length=187, Percent_Identity=49.7326203208556, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=54.9738219895288, Blast_Score=217, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21209; Mature: 21209

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSTTAGFAILDTMNLIRPDVQTLCMGLAASFGALLLLAGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCE
MIHQPLGGVKGQATEIEITAKRILKLKHDINKIIADRTGQPIEKIAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEHHHH
KEYGIVDGVVEKK
HHCCCCCCCCCCC
>Mature Secondary Structure
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSTTAGFAILDTMNLIRPDVQTLCMGLAASFGALLLLAGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCE
MIHQPLGGVKGQATEIEITAKRILKLKHDINKIIADRTGQPIEKIAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEHHHH
KEYGIVDGVVEKK
HHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]